Select Publications
Journal articles
2024, 'The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia', Blood Cancer Journal, 14, pp. 192, http://dx.doi.org/10.1038/s41408-024-01180-x
,2024, 'PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia', Nature communications, 15, pp. 9697, http://dx.doi.org/10.1038/s41467-024-54096-2
,2024, 'Overcoming a T-ALL order: A comprehensive study linking genomics to clinical outcomes', HemaSphere, 8, pp. e70027, http://dx.doi.org/10.1002/hem3.70027
,2024, 'The tumor suppressor Fat1 is dispensable for normal murine hematopoiesis', Journal of Leukocyte Biology, 116, pp. 909 - 914, http://dx.doi.org/10.1093/jleuko/qiae128
,2024, 'Less is more: Depleting myeloid-biased HSCs to restore immune function', HemaSphere, 8, pp. e125, http://dx.doi.org/10.1002/hem3.125
,2024, 'Selective targeting of malignant T cells', Nature Cancer, 5, pp. 1 - 2, http://dx.doi.org/10.1038/s43018-024-00778-1
,2024, 'A new mouse model highlights the need for better JAK inhibitors in myeloproliferative neoplasms', HemaSphere, 8, pp. e66 - e66, http://dx.doi.org/10.1002/hem3.66
,2024, 'In vivo activity of the second-generation proteasome inhibitor ixazomib against pediatric T-cell acute lymphoblastic leukemia xenografts', Experimental Hematology, 132, pp. 104176, http://dx.doi.org/10.1016/j.exphem.2024.104176
,2024, 'PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma', Journal of Clinical Investigation, 134, pp. e170329, http://dx.doi.org/10.1172/JCI170329
,2024, 'A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax', HemaSphere, 8, pp. e1, http://dx.doi.org/10.1002/hem3.1
,2023, 'Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma.', Haematologica, 109, http://dx.doi.org/10.3324/haematol.2023.283981
,2023, 'Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia', Science translational medicine, 15, pp. eabm1262 - eabm1262, http://dx.doi.org/10.1126/scitranslmed.abm1262
,2023, 'Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies', Science Signaling, 16, pp. 1 - 18, http://dx.doi.org/10.1126/scisignal.abp9586
,2023, 'Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL', Leukemia, 37, pp. 1 - 5, http://dx.doi.org/10.1038/s41375-023-01843-x
,2023, 'The landscape of alterations affecting epigenetic regulators in T-cell acute lymphoblastic leukemia: Roles in leukemogenesis and therapeutic opportunities', International Journal of Cancer, 154, pp. 1522 - 1536, http://dx.doi.org/10.1002/ijc.34819
,2023, '3D bioprinted alginate-gelatin hydrogel patches containing cardiac spheroids recover heart function in a mouse model of myocardial infarction', Bioprinting, 30, pp. e00263 - e00263, http://dx.doi.org/10.1016/j.bprint.2023.e00263
,2023, 'In vitro and in vivo modelling of mutant JAK3/STAT5 signaling in leukemia', Heliyon, 9, http://dx.doi.org/10.1016/j.heliyon.2023.e22085
,2022, 'Transcriptional Interference Regulates the Evolutionary Development of Speech', Genes, 13, http://dx.doi.org/10.3390/genes13071195
,2022, 'The Promise of Single-cell Technology in Providing New Insights into the Molecular Heterogeneity and Management of Acute Lymphoblastic Leukemia', HemaSphere, 6, pp. E734, http://dx.doi.org/10.1097/HS9.0000000000000734
,2022, 'Optimized flow cytometric detection of transient receptor potential vanilloid-1 (TRPV1) in human hematological malignancies', Medical Oncology, 39, pp. 81, http://dx.doi.org/10.1007/s12032-022-01678-z
,2022, 'HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort', Oncogene, 41, pp. 797 - 808, http://dx.doi.org/10.1038/s41388-021-02126-4
,2021, 'Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia', Nature Communications, 12, pp. 4164, http://dx.doi.org/10.1038/s41467-021-24442-9
,2021, 'BETter insight into PRC2-mutated T-ALL', Blood, 138, pp. 1787 - 1788, http://dx.doi.org/10.1182/blood.2021012677
,2021, 'The XPO1 inhibitor KPT-8602 synergizes with dexamethasone in acute lymphoblastic Leukemia', Clinical Cancer Research, 26, pp. 5747 - 5758, http://dx.doi.org/10.1158/1078-0432.CCR-20-1315
,2021, 'Development of siRNA-loaded lipid nanoparticles targeting long non-coding RNA LINC01257 as a novel and safe therapeutic approach for t(8;21) pediatric acute myeloid leukemia', Pharmaceutics, 13, pp. 1681, http://dx.doi.org/10.3390/pharmaceutics13101681
,2021, 'Quantitative phosphoproteomics uncovers synergy between DNA-PK and FLT3 inhibitors in acute myeloid leukaemia', Leukemia, 35, pp. 1782 - 1787, http://dx.doi.org/10.1038/s41375-020-01050-y
,2020, 'Long Non-coding RNAs: Major Regulators of Cell Stress in Cancer', Frontiers in Oncology, 10, http://dx.doi.org/10.3389/fonc.2020.00285
,2020, 'Evaluating nuclear translocation of surface receptors: recommendations arising from analysis of CD44', Histochemistry and Cell Biology, 153, pp. 77 - 87, http://dx.doi.org/10.1007/s00418-019-01835-y
,2020, 'Shwachman–Bodian–Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia', Leukemia, 34, http://dx.doi.org/10.1038/s41375-020-0814-0
,2020, 'SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome', Leukemia and Lymphoma, 61, pp. 3089 - 3100, http://dx.doi.org/10.1080/10428194.2020.1804560
,2019, 'Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia', Blood, 134, pp. 1323 - 1336, http://dx.doi.org/10.1182/blood.2019000015
,2019, 'FAT1 cadherin controls neuritogenesis during NTera2 cell differentiation', Biochemical and Biophysical Research Communications, 514, pp. 625 - 631, http://dx.doi.org/10.1016/j.bbrc.2019.04.197
,2019, 'T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development', Haematologica, 104, pp. e204 - e207, http://dx.doi.org/10.3324/haematol.2018.198424
,2019, 'Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition', Science Translational Medicine, 11, http://dx.doi.org/10.1126/scitranslmed.aau6246
,2018, 'Correction to: Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia (Leukemia, (2018), 32, 3, (788-800), 10.1038/leu.2017.276)', Leukemia, 32, pp. 2731, http://dx.doi.org/10.1038/s41375-018-0241-7
,2018, 'A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing', Haematologica, 103, pp. e585 - e589, http://dx.doi.org/10.3324/haematol.2018.190587
,2018, 'Malt1 self-cleavage is critical for regulatory T cell homeostasis and anti-tumor immunity in mice', European Journal of Immunology, 48, pp. 1728 - 1738, http://dx.doi.org/10.1002/eji.201847597
,2018, 'The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models', Journal of Hematology and Oncology, 11, pp. 108, http://dx.doi.org/10.1186/s13045-018-0650-0
,2018, 'Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia', Cancer Cell, 34, pp. 271 - 285.e7, http://dx.doi.org/10.1016/j.ccell.2018.07.007
,2018, 'JAK3 mutations and HOXA9 expression are important cooperating events in T-cell acute lymphoblastic leukemia', Molecular and Cellular Oncology, 5, pp. e1458014, http://dx.doi.org/10.1080/23723556.2018.1458014
,2018, 'HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development', Cancer Discovery, 8, pp. 616 - 631, http://dx.doi.org/10.1158/2159-8290.CD-17-0583
,2018, 'Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system', Leukemia, 32, pp. 941 - 951, http://dx.doi.org/10.1038/leu.2017.328
,2018, 'Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia', Leukemia, 32, pp. 788 - 800, http://dx.doi.org/10.1038/leu.2017.276
,2018, 'Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL', Blood, 131, pp. 421 - 425, http://dx.doi.org/10.1182/blood-2017-07-797597
,2018, 'miR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense', Cancer Research, 78, pp. 501 - 515, http://dx.doi.org/10.1158/0008-5472.CAN-16-3105
,2017, 'Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels', FEBS Letters, 591, pp. 667 - 678, http://dx.doi.org/10.1002/1873-3468.12569
,2016, 'Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors', Blood, 128, pp. 2642 - 2654, http://dx.doi.org/10.1182/blood-2016-03-703454
,2016, 'A mitochondrial brake on vascular repair', Nature, 539, pp. 503 - 505, http://dx.doi.org/10.1038/nature20476
,2016, 'Generation of the Fip1l1-Pdgfra fusion gene using CRISPR/Cas genome editing', Leukemia, 30, pp. 1913 - 1916, http://dx.doi.org/10.1038/leu.2016.62
,2015, 'Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia', Leukemia, 29, pp. 2317 - 2327, http://dx.doi.org/10.1038/leu.2015.162
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