Select Publications
Journal articles
2015, 'FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation', Cellular and Molecular Life Sciences, 72, pp. 4653 - 4669, http://dx.doi.org/10.1007/s00018-015-1955-6
,2015, 'T-ALL: Home Is where the CXCL12 Is', Cancer Cell, 27, pp. 745 - 746, http://dx.doi.org/10.1016/j.ccell.2015.05.011
,2014, 'ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia', Blood, 124, pp. 3738 - 3747, http://dx.doi.org/10.1182/blood-2014-05-574566
,2014, 'JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model', Blood, 124, pp. 3092 - 3100, http://dx.doi.org/10.1182/blood-2014-04-566687
,2014, 'FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue', FEBS Letters, 588, pp. 3511 - 3517, http://dx.doi.org/10.1016/j.febslet.2014.08.014
,2014, 'Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma', BMC Cancer, 14, pp. 630, http://dx.doi.org/10.1186/1471-2407-14-630
,2014, 'Furin processing dictates ectodomain shedding of human FAT1 cadherin', Experimental Cell Research, 323, pp. 41 - 55, http://dx.doi.org/10.1016/j.yexcr.2014.02.012
,2014, 'A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding', PLoS ONE, 9, pp. e90461, http://dx.doi.org/10.1371/journal.pone.0090461
,2014, 'Sleeping Giants: Emerging Roles for the Fat Cadherins in Health and Disease', Medicinal Research Reviews, 34, pp. 190 - 221, http://dx.doi.org/10.1002/med.21286
,2014, 'FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue', FEBS Letters, http://dx.doi.org/10.1016/j.febslet.2014.08.014
,2013, 'Fat1 cadherin provides a novel minimal residual disease marker in acute lymphoblastic leukemia', Hematology, 18, pp. 315 - 322, http://dx.doi.org/10.1179/1607845413Y.0000000080
,2012, 'The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia', Leukemia, 26, pp. 918 - 926, http://dx.doi.org/10.1038/leu.2011.319
,2011, 'Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress', Oncogene, 30, pp. 3716 - 3726, http://dx.doi.org/10.1038/onc.2011.87
,2011, 'Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products', Journal of Biological Chemistry, 286, pp. 28181 - 28191, http://dx.doi.org/10.1074/jbc.M111.234419
,2011, 'Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo', Pharmacogenomics Journal, 11, pp. 307 - 314, http://dx.doi.org/10.1038/tpj.2010.43
,2010, 'Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum', Biochimica et Biophysica Acta - Molecular Cell Research, 1803, pp. 1298 - 1307, http://dx.doi.org/10.1016/j.bbamcr.2010.07.002
,2010, 'Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion', International Journal of Oncology, 36, pp. 1155 - 1163, http://dx.doi.org/10.3892/ijo-00000598
,2010, 'Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion', International Journal of Oncology, 36, pp. 1155 - 1163, http://dx.doi.org/10.3892/ijo_00000598
,2010, 'Novel protein interactors of urokinase-type plasminogen activator receptor', Biochemical and Biophysical Research Communications, 399, pp. 738 - 743, http://dx.doi.org/10.1016/j.bbrc.2010.08.010
,2008, 'Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress', Cancer Research, 68, pp. 6708 - 6717, http://dx.doi.org/10.1158/0008-5472.CAN-08-0349
,2008, 'Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III β-tubulin levels', FEBS Letters, 582, pp. 267 - 272, http://dx.doi.org/10.1016/j.febslet.2007.12.014
,2008, 'Mutations in GDF6 are associated with vertebral segmentation defects in klippel-feil syndrome', Human Mutation, 29, pp. 1017 - 1027
,2006, 'Gene expression changes in SNAP-stimulated and iNOS-transfected tenocytes-expression of extracellular matrix genes and its implications for tendon-healing', Journal of Orthopaedic Research, 24, pp. 1869 - 1882
,2005, 'Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells', FEBS Journal, 272, pp. 3572 - 3582
,2004, 'Clinical Significance of Urokinase‐Type Plasminogen Activator Receptor (uPAR) Expression in Cancer', ChemInform, 35, http://dx.doi.org/10.1002/chin.200414278
,2004, 'Clinical significance of urokinase-type plasminogen activator receptor (uPAR) expression in cancer', Medicinal Research Reviews, 24, pp. 13 - 39
,2003, 'Expression of urokinase-type plasminogen activator and its receptor is up-regulated during tendon healing', Journal of Orthopaedic Research, 21, pp. 819 - 825
,2002, 'The effect of DNA-alkylating agents on gene expression from two integrated reporter genes in a mouse mammary tumor line', Anti-Cancer Drugs, 13, pp. 271 - 280, http://dx.doi.org/10.1097/00001813-200203000-00009
,2001, 'Evidence for epidermal growth factor receptor-enhanced chemosensitivity in combinations of cisplatin and the new irreversible tyrosine kinase inhibitor CI-1033', Anti-Cancer Drugs, 12, pp. 683 - 690, http://dx.doi.org/10.1097/00001813-200109000-00007
,Conference Papers
2016, 'QUANTITATIVE, HIGH-RESOLUTION PROTEOMICS FOR A SYSTEMS BIOLOGICAL ANALYSIS OF ACUTE MYELOID LEUKEMIA', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 9 - 9, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387772400008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2016, 'ACTIVATED JAK-STAT SIGNALING COOPERATES WITH HOXA9 AND DRIVES LEUKEMIA DEVELOPMENT', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, pp. 322 - 323, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484601163&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2016, 'CHARACTERISATION OF JAK3 KINASE DOMAIN MUTANTS', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, pp. 344 - 344, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484601210&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2016, 'CHARACTERIZATION OF AN EX VIVO T-CELL CULTURE MODEL FOR THE STUDY OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, pp. 28 - 28, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2016, 'HEDGEHOG PATHWAY ACTIVATION IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA PREDICTS RESPONSE TO SMO AND GLI1 INHIBITORS', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, pp. 26 - 26, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2016, 'THE NUP214-ABL1 FUSION COOPERATES WITH TLX1 IN THE DEVELOPMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, pp. 27 - 27, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600057&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2014, 'Transcriptional Antagonism Between the Cooperative Oncogenes TLX1 and NOTCH1 in T-Cell Acute Lymphoblastic Leukemia', in BLOOD, AMER SOC HEMATOLOGY, CA, San Francisco, presented at 56th Annual Meeting of the American-Society-of-Hematology, CA, San Francisco, 06 December 2014 - 09 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349233806079&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2014, 'JAK3 Mutants Transform Hematopoietic Cells through JAK1 Activation Causing T-Cell Acute Lymphoblastic Leukemia in a Bone Marrow Transplant Mouse Model', in BLOOD, AMER SOC HEMATOLOGY, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349242706130&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2014, 'Synergism Between HOXA9 and Mutant JAK3 (M511I) Leads to Rapid Leukemia Development within an in Vivo Murine Bone Marrow Transplant Model', in BLOOD, AMER SOC HEMATOLOGY, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349242706111&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2014, 'Use of Crispr/Cas Genome Editing in Ba/F3 Cells to Generate the Fip1l1-Pdgfra and Nup214-Abl1 Fusion Genes', in BLOOD, AMER SOC HEMATOLOGY, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349242707124&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2014, 'Transcriptional antagonism between the cooperative oncogenes TLX1 and NOTCH1 in T-cell acute lymphoblastic leukemia.', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, presented at AACR Special Conference on Hematologic Malignancies - Translating Discoveries to Novel Therapies, PA, Philadelphia, 20 September 2014 - 23 September 2014, http://dx.doi.org/10.1158/1557-3265.HEMMAL14-B05
,2014, 'ABT-199 MEDIATED INHIBITION OF BCL2 AS A NOVEL THERAPEUTIC STRATEGY IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, ITALY, Milan, pp. 539 - 540, presented at 19th Congress of the European-Hematology-Association, ITALY, Milan, 12 June 2014 - 15 June 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342830902361&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2014, 'PHF6 LOSS DRIVES IL7R ONCOGENE ADDICTION IN T-ALL', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, ITALY, Milan, pp. 1 - 1, presented at 19th Congress of the European-Hematology-Association, ITALY, Milan, 12 June 2014 - 15 June 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342830900003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2013, 'A UNIQUE FAT1 CADHERIN ISOFORM REGULATES THE PROLIFERATION OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL) CELLS', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, pp. 4 - 4, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000445772400011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2013, 'THE ROLE OF JAK3 MUTATIONS IN THE DEVELOPMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA: DEVELOPMENT OF IN VITRO AND IN VIVO MODELS', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, pp. 467 - 467, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000445782800165&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2011, 'Aberrant processing of Fat1 Cadherin in human cancer', in CLINICAL BIOCHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, pp. S12 - S12, http://dx.doi.org/10.1016/j.clinbiochem.2011.08.037
,2008, 'Interaction between urokinase receptor and heat shock protien enhances cell adhesion', in Challenges to Life Sciences: Molecules and cells, Seoul, Korea, pp. 258 - 258, presented at 9th International Congress on Cell Biology, Seoul, Korea, 07 October 2008 - 10 October 2008
,Conference Posters
'P347: COOPERATION OF TLX3 AND FLT3-ITD IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA IS ENHANCED BY TLE4 INACTIVATION', Vol. 6, pp. 247 - 248, http://dx.doi.org/10.1097/01.hs9.0000844276.58126.4d
,Conference Abstracts
2023, 'The AKR1C3-Activated Prodrug, Achm-025, Eradicates Disease in Preclinical Models of Aggressive T-Cell Acute Lymphoblastic Leukemia', in Blood, American Society of Hematology, Vol. 142, pp. 4251 - 4251, http://dx.doi.org/10.1182/blood-2023-181298
,2020, 'Phosphoproteomics Uncovers Synergy between DNA-PK and FLT3 Inhibitors in Acute Myeloid Leukaemia', in BLOOD, AMER SOC HEMATOLOGY, ELECTR NETWORK, Vol. 136, presented at 62nd Annual Meeting of the American-Society-of-Hematology (ASH), ELECTR NETWORK, 05 December 2020 - 08 December 2020, http://dx.doi.org/10.1182/blood-2020-142435
,2019, 'PHF6loss drives IL7R oncogene addiction in TLX1 driven T-ALL', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, GA, Atlanta, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), GA, Atlanta, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.AM2019-3696
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