By Dr Laura Jane Sharpe

Journal articles

Dimitri A; Livermore N; Sharpe L; Gandevia SC; Mckenzie DK; Butler JE, 2012, 'CBT REDUCES RATINGS OF BREATHING DIFFICULTY IN RESPONSE TO EXTERNAL RESISTIVE LOADS IN PEOPLE WITH COPD', RESPIROLOGY, 17, pp. 32 - 32, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000301120800116&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Luu W; Sharpe LJ; Stevenson J; Brown AJ, 2012, 'Akt acutely activates the cholesterogenic transcription factor SREBP-2.', Biochimica et Biophysica ACTA - Molecular Cell Research, 1823, pp. 458 - 464, http://dx.doi.org/10.1016/j.bbamcr.2011.09.017

Kockx M; Dinnes DL; Huang K; Sharpe LJ; Jessup W; Brown AJ; Kritharides L, 2012, 'Cholesterol accumulation inhibits ER to Golgi transport and protein secretion: Studies of apolipoprotein E and VSVGt', Biochemical Journal, 447, pp. 51 - 60, http://dx.doi.org/10.1042/BJ20111891

Sharpe LJ; Wong J; Garner B; Halliday GM; Brown AJ, 2012, 'Is seladin-1 really a selective Alzheimer's disease indicator?', Journal of Alzheimer's Disease, 30, pp. 35 - 39, http://dx.doi.org/10.3233/JAD-2012-111955

Gelissen IC; Sharpe LJ; Sandoval C; Rao G; Kockx M; Kritharides L; Jessup WK; Brown AJP, 2012, 'Protein kinase A modulates the activity of a major human isoform of ABCG1', Journal of Lipid Research, 53, pp. 2133 - 2140, http://dx.doi.org/10.1194/jlr.M028795

Burns V; Sharpe LJ; Gelissen IC; Brown AJ, 2012, 'Species variation in ABCG1 isoform expression: Implications for the use of animal models in elucidating ABCG1 function', Atherosclerosis, 226, pp. 408 - 411, http://dx.doi.org/10.1016/j.atherosclerosis.2012.12.009

Zerenturk EJ; Sharpe LJ; Brown AJ, 2012, 'Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: Cooperative induction of key enzymes in lipid synthesis by sterol regulatory element binding proteins.', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, 1821, pp. 1350 - 1360, http://dx.doi.org/10.1016/j.bbalip.2012.07.006

Sharpe LJ; Luu W; Brown AJ, 2011, 'Akt phosphorylates Sec24: New clues into the regulation of ER-to-Golgi trafficking', Traffic (Malden), 12, pp. 19 - 27, http://dx.doi.org/10.1111/j.1600-0854.2010.01133.x

Sharpe LJ; Eden J-S; White PA; Brown AJ, 2011, 'Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt', Journal of Virology, 85, pp. 10894 - 10898, http://dx.doi.org/10.1128/JVI.05562-11

Kristiana I; Sharpe LJ; Catts VS; Lutze-mann LH; Brown AJ, 2010, 'Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol.', Journal of Pharmacogenomics, 10, pp. 396 - 407

Krycer JR; Sharpe LJ; Luu W; Brown AJ, 2010, 'The Akt-SREBP nexus: cell signaling meets lipid metabolism.', Trends in Endocrinology and Metabolism, 21, pp. 268 - 278

Sharpe LJ; Du X; Brown AJ, 2008, 'Approaches to investigate the role of signaling in ER-to-golgi transport', Methods in Molecular Biology, 457, pp. 215 - 225, http://dx.doi.org/10.1007/978-1-59745-261-8_16

Sharpe LJ; Brown AJ, 2008, 'Rapamycin down-regulates LDL-receptor expression independently of SREBP-2', Biochemical and Biophysical Research Communications, 373, pp. 670 - 674

Conference Papers

Sharpe LJ; Prabhu AV; Luu W; Brown AJ, 2016, 'Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, CA, San Diego, presented at Experimental Biology Meeting, CA, San Diego, 02 April 2016 - 06 April 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444003020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Zerenturk E; Sharpe LJ; Kristiana I; Brown AJ, 2013, 'DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, MA, Boston, presented at Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), MA, Boston, 20 April 2013 - 24 April 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319883504279&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Luu W; Sharpe LJ; Stevenson J; Brown AJ, 2013, 'Signalling and cholesterol metabolism', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, MA, Boston, presented at Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), MA, Boston, 20 April 2013 - 24 April 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319883503088&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Presentations

Moon H; Sharpe L; Choi E; Bielefeldt-Ohmann H; Nassar Z; Parat M-O; Francois M; Lee CS; Brown A; Russell P; Inder K; Hill M, 2014, 'Hypercholesterolemia promotes prostate cancer PC-3 metastases in orthotopic xenograft mice', presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-4950

Conference Abstracts

Capell-Hattam IM; Fenton NM; Sharpe LJ; Brow AJ, 2022, 'A new kid in the Bloch? The non-catalytic protein ERG28 plays a functional role in mammalian cholesterol synthesis and is co-regulated transcriptionally', in FEBS OPEN BIO, WILEY, Vol. 12, pp. 267 - 267, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000821444603033&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Scott N; Sharpe L; Capell-Hattam I; Gullo S; Luu W; Brown A, 2020, 'The Cholesterol Synthesis Enzyme Lanosterol 14 alpha-Demethylase is Post-Translationally Regulated by the E3 Ubiquitin Ligase MARCH6', in FASEB JOURNAL, WILEY, CA, San Diego, Vol. 34, presented at Annual Meeting on Experimental Biology, CA, San Diego, 04 April 2020 - 07 April 2020, http://dx.doi.org/10.1096/fasebj.2020.34.s1.03882

Capell-Hattam I; Sharpe L; Qian L; Hart-Smith G; Prabhu A; Brown A, 2020, 'Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally', in FASEB JOURNAL, WILEY, CA, San Diego, Vol. 34, presented at Annual Meeting on Experimental Biology, CA, San Diego, 04 April 2020 - 07 April 2020, http://dx.doi.org/10.1096/fasebj.2020.34.s1.02547

Luu W; Zerenturk E; Kristiana I; Sharpe L; Brown A, 2015, 'Signaling Regulates Activity of DHCR24, the Final Enzyme in Cholesterol Synthesis', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Vol. 29, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361470504086&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Prabhu A; Luu W; Sharpe L; Brown A, 2015, 'The Interplay between Cholesterol and Vitamin D Biosynthesis', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Vol. 29, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361470504115&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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