By Dr Paul Timpson

Journal articles

Srijakotre N; Liu HJ; Nobis M; Man J; Yip HYK; Papa A; Abud HE; Anderson KI; Welch HCE; Tiganis T; Timpson P; McLean CA; Ooms LM; Mitchell CA, 2020, 'PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis', Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 28056 - 28067, http://dx.doi.org/10.1073/pnas.2006445117

Wu SZ; Roden DL; Wang C; Holliday H; Harvey K; Cazet AS; Murphy KJ; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy JR; Junankar S; Chan CL; Lam CE; Hui MN; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O'Toole S; Cox TR; Timpson P; Lim E; Liu XS; Swarbrick A, 2020, 'Stromal cell diversity associated with immune evasion in human triple-negative breast cancer', EMBO Journal, 39, pp. embj2019104063, http://dx.doi.org/10.15252/embj.2019104063

Boyle ST; Kular J; Nobis M; Ruszkiewicz A; Timpson P; Samuel MS, 2020, 'Acute compressive stress activates RHO/ROCK-mediated cellular processes', Small GTPases, 11, pp. 354 - 370, http://dx.doi.org/10.1080/21541248.2017.1413496

Nobis M; Herrmann D; Warren SC; Strathdee D; Cox TR; Anderson KI; Timpson P, 2020, 'Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse', Small GTPases, 11, pp. 240 - 247, http://dx.doi.org/10.1080/21541248.2018.1438024

Hoque M; Elmaghrabi YA; Köse M; Beevi SS; Jose J; Meneses-Salas E; Blanco-Muñoz P; Conway JRW; Swarbrick A; Timpson P; Tebar F; Enrich C; Rentero C; Grewal T, 2020, 'Annexin A6 improves anti-migratory and anti-invasive properties of tyrosine kinase inhibitors in EGFR overexpressing human squamous epithelial cells', FEBS Journal, 287, pp. 2961 - 2978, http://dx.doi.org/10.1111/febs.15186

Boyle ST; Poltavets V; Kular J; Pyne NT; Sandow JJ; Lewis AC; Murphy KJ; Kolesnikoff N; Moretti PAB; Tea MN; Tergaonkar V; Timpson P; Pitson SM; Webb AI; Whitfield RJ; Lopez AF; Kochetkova M; Samuel MS, 2020, 'Publisher Correction: ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism (Nature Cell Biology, (2020), 22, 7, (882-895), 10.1038/s41556-020-0523-y)', Nature Cell Biology, 22, pp. 908, http://dx.doi.org/10.1038/s41556-020-0539-3

Boyle ST; Poltavets V; Kular J; Pyne NT; Sandow JJ; Lewis AC; Murphy KJ; Kolesnikoff N; Moretti PAB; Tea MN; Tergaonkar V; Timpson P; Pitson SM; Webb AI; Whitfield RJ; Lopez AF; Kochetkova M; Samuel MS, 2020, 'ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism', Nature Cell Biology, 22, pp. 882 - 895, http://dx.doi.org/10.1038/s41556-020-0523-y

Wu S; Roden D; Wang C; Holliday H; Harvey K; Cazet A; Murphy K; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy J; Junankar S; Chan C-L; Lam E; Hui M; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O’Toole S; Cox T; Timpson P; Lim E; Liu S; Swarbrick A, 2020, 'Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer', bioRxiv, http://dx.doi.org/10.1101/2020.06.04.135327

Kokkinos J; Ignacio RMC; Sharbeen G; Boyer C; Gonzales-Aloy E; Goldstein D; McCarroll JA; Phillips PA, 2020, 'Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs', Biomaterials, 240, http://dx.doi.org/10.1016/j.biomaterials.2019.119742

Cipponi A; Goode DL; Bedo J; McCabe MJ; Pajic M; Croucher DR; Rajal AG; Junankar SR; Saunders DN; Lobachevsky P; Papenfuss AT; Nessem D; Nobis M; Warren SC; Timpson P; Cowley M; Vargas AC; Qiu MR; Generali DG; Keerthikumar S; Nguyen U; Corcoran NM; Long GV; Blay J-Y; Thomas DM; McCabe M, 2020, 'MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer', Science

Ritchie S; Pereira BA; Vennin C; Timpson P, 2020, 'Targeting genetically-tuned CAFs in pancreatic cancer via perlecan manipulation', Expert Opinion on Therapeutic Targets, 24, pp. 171 - 174, http://dx.doi.org/10.1080/14728222.2020.1727887

Wang K; Zhan Y; Huynh N; Dumesny C; Wang X; Asadi K; Herrmann D; Timpson P; Yang Y; Walsh K; Baldwin GS; Nikfarjam M; He H, 2020, 'Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1', Cancer Letters, 472, pp. 8 - 18, http://dx.doi.org/10.1016/j.canlet.2019.12.020

Castillo L; Young AIJ; Mawson A; Schafranek P; Steinmann AM; Nessem D; Parkin A; Johns A; Chou A; Law AMK; Lucas MC; Murphy KJ; Deng N; Gallego-Ortega D; Caldon CE; Timpson P; Pajic M; Ormandy CJ; Oakes SR, 2020, 'MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma', Oncogene, 39, pp. 1821 - 1829, http://dx.doi.org/10.1038/s41388-019-1091-0

Follain G; Herrmann D; Harlepp S; Hyenne V; Osmani N; Warren SC; Timpson P; Goetz JG, 2020, 'Fluids and their mechanics in tumour transit: shaping metastasis', Nature Reviews Cancer, 20, pp. 107 - 124, http://dx.doi.org/10.1038/s41568-019-0221-x

Chitty JL; Skhinas JN; Filipe EC; Wang S; Cupello CR; Grant RD; Yam M; Papanicolaou M; Major G; Zaratzian A; Da Silva AM; Tayao M; Vennin C; Timpson P; Madsen CD; Cox TR, 2020, 'The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development', Cancer Reports, 3, http://dx.doi.org/10.1002/cnr2.1209

Vennin C; Rath N; Pajic M; Olson MF; Timpson P, 2020, 'Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy', Small GTPases, 11, pp. 45 - 52, http://dx.doi.org/10.1080/21541248.2017.1345712

Gonzalez-Rajal A; Marzec K; McCloy R; Nobis M; Chin V; Hastings J; Lai K; Kennerson M; Hughes W; Vaghjiani V; Timpson P; Cain J; Neil Watkins D; Croucher D; Burgess A, 2020, 'A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma', , http://dx.doi.org/10.1101/2020.11.26.400499

Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C; Christ D; Cox T; Timpson P; Phillips P; Whitelock J; Pajic M; Gill A; Croucher D, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6

Christodoulou N; Weberling A; Strathdee D; Anderson KI; Timpson P; Zernicka-Goetz M, 2019, 'Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-11482-5

Pereira BA; Vennin C; Papanicolaou M; Chambers CR; Herrmann D; Morton JP; Cox TR; Timpson P, 2019, 'CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer', Trends in Cancer, 5, pp. 724 - 741, http://dx.doi.org/10.1016/j.trecan.2019.09.010

Valdes-Mora F; Salomon R; Gloss B; Law AMK; Murphy K; Roden DL; Castillo L; Colino-Sanguino Y; Farbehi N; Conway J; Timpson P; Ormandy CJ; Gallego-Ortega D, 2019, 'Characterisation of developmental pathways that drive metastatic progression of breast cancer at single cell resolution', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p022

Parkin A; Man J; Timpson P; Pajic M, 2019, 'Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy', FEBS Journal, 286, pp. 3510 - 3539, http://dx.doi.org/10.1111/febs.15011

Conway JR; Herrmann D; Evans TJ; Morton JP; Timpson P, 2019, 'Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine', Gut, 68, pp. 742 - 758, http://dx.doi.org/10.1136/gutjnl-2018-316822

Kennedy SP; Han JZR; Portman N; Nobis M; Hastings JF; Murphy KJ; Latham SL; Cadell AL; Miladinovic D; Marriott GR; O'Donnell YEI; Shearer RF; Williams JT; Munoz AG; Cox TR; Watkins DN; Saunders DN; Timpson P; Lim E; Kolch W; Croucher DR, 2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, 21, http://dx.doi.org/10.1186/s13058-019-1127-y

Warren S; Magenau A; Nobis M; Mohammed Y; Melenec P; Phan T; Roberts M; Timpson P, 2019, 'Galene: correcting physiological motion blurring at the subcellular level in intravital FLIM data', eLife, 7, http://dx.doi.org/10.7554/eLife.35800

Campbell H; Fleming N; Roth I; Vennin C; Wile A; Mccall J; Mehta S; Williams G; Timpson P; Roux P; Baird M; Braithwaite A, 2019, 'IL-6 signalling mediates tumorigenesis, invasion and metastasis driven by the 33p53 isoform', Nature Communications

Nobis M; Lucas M; Warren S; Murphy K; Herrmann D; Timpson P, 2019, 'Moving molecular mobility to in vivo disease settings', Gastroenterology

Valdes-Mora F; Salomon R; Gloss B; Law AMK; Castillo L; Murphy K; Venhuizen J; Magenau A; Papanicolau M; de la Fuente LR; Roden D; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Oakes S; Sikta N; O’Donoghue S; Cox T; Timpson P; Ormandy C; Gallego-Ortega D, 2019, 'Single cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', , http://dx.doi.org/10.1101/624890

Pinho AV; Van Bulck M; Chantrill L; Arshi M; Sklyarova T; Herrmann D; Vennin C; Gallego-Ortega D; Mawson A; Giry-Laterriere M; Magenau A; Leuckx G; Baeyens L; Gill AJ; Phillips P; Timpson P; Biankin AV; Wu J; Rooman I, 2018, 'ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-07497-z

Chou A; Froio D; Nagrial AM; Parkin A; Murphy KJ; Chin VT; Wohl D; Steinmann A; Stark R; Drury A; Walters SN; Vennin C; Burgess A; Pinese M; Chantrill LA; Cowley MJ; Molloy TJ; Waddell N; Johns A; Grimmond SM; Chang DK; Biankin AV; Sansom OJ; Morton JP; Grey ST; Cox TR; Turchini J; Samra J; Clarke SJ; Timpson P; Gill AJ; Pajic M, 2018, 'Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer', Gut, 67, pp. 2142 - 2155, http://dx.doi.org/10.1136/gutjnl-2017-315144

Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan CL; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel MS; Martín M; Swarbrick A; O'Toole S, 2018, 'Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer', Nature Communications, 9, pp. 2897, http://dx.doi.org/10.1038/s41467-018-05220-6

Campbell H; Fleming N; Roth I; Mehta S; Wiles A; Williams G; Vennin C; Arsic N; Parkin A; Pajic M; Munro F; McNoe L; Black M; McCall J; Slatter TL; Timpson P; Reddel R; Roux P; Print C; Baird MA; Braithwaite AW, 2018, 'Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signaling', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-017-02408-0

Parkin A; Man J; Chou A; Nagrial AM; Samra J; Gill AJ; Timpson P; Pajic M, 2018, 'The Evolving Understanding of the Molecular and Therapeutic Landscape of Pancreatic Ductal Adenocarcinoma.', Diseases, 6, http://dx.doi.org/10.3390/diseases6040103

Young AIJ; Timpson P; Gallego-Ortega D; Ormandy CJ; Oakes SR, 2018, 'Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion', Cell Adhesion and Migration, 12, pp. 513 - 523, http://dx.doi.org/10.1080/19336918.2017.1393591

Kalimutho M; Sinha D; Jeffery J; Nones K; Srihari S; Fernando WC; Duijf PHG; Vennin C; Raninga P; Nanayakkara D; Mittal D; Saunus JM; Lakhani SR; López JA; Spring KJ; Timpson P; Gabrielli B; Waddell N; Khanna KK, 2018, 'CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer', EMBO Molecular Medicine, 10, http://dx.doi.org/10.15252/emmm.201708566

Rogers S; McCloy RA; Parker BL; Gallego-Ortega D; Law AMK; Chin VT; Conway JRW; Fey D; Millar EKA; O’Toole S; Deng N; Swarbrick A; Chastain PD; Cesare AJ; Timpson P; Caldon CE; Croucher DR; James DE; Watkins DN; Burgess A, 2018, 'MASTL overexpression promotes chromosome instability and metastasis in breast cancer', Oncogene, 37, pp. 4518 - 4533, http://dx.doi.org/10.1038/s41388-018-0295-z

Warren SC; Nobis M; Magenau A; Mohammed YH; Herrmann D; Moran I; Vennin C; Conway JRW; Mélénec P; Cox TR; Wang Y; Morton JP; Welch HCE; Strathdee D; Anderson KI; Phan TG; Roberts MS; Timpson P, 2018, 'Removing physiological motion from Intravital and clinical functional imaging data', eLife, 7, http://dx.doi.org/10.7554/eLife.35800

Rath N; Munro J; Cutiongco MF; Jagiełło A; Gadegaard N; McGarry L; Unbekandt M; Michalopoulou E; Kamphorst JJ; Sumpton D; Mackay G; Vennin C; Pajic M; Timpson P; Olson MF, 2018, 'Rho kinase inhibition by AT13148 blocks pancreatic ductal adenocarcinoma invasion and tumor growth', Cancer Research, 78, pp. 3321 - 3336, http://dx.doi.org/10.1158/0008-5472.CAN-17-1339

Conway JRW; Warren SC; Herrmann D; Murphy KJ; Cazet AS; Vennin C; Shearer RF; Killen MJ; Magenau A; Mélénec P; Pinese M; Nobis M; Zaratzian A; Boulghourjian A; Da Silva AM; del Monte-Nieto G; Adam ASA; Harvey RP; Haigh JJ; Wang Y; Croucher DR; Sansom OJ; Pajic M; Caldon CE; Morton JP; Timpson P; del Monte Nieto G; Gallego-Ortega D, 2018, 'Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer', Cell Reports, 23, pp. 3312 - 3326, http://dx.doi.org/10.1016/j.celrep.2018.05.038

Lancaster GI; Langley KG; Berglund NA; Kammoun HL; Reibe S; Estevez E; Weir J; Mellett NA; Pernes G; Conway JRW; Lee MKS; Timpson P; Murphy AJ; Masters SL; Gerondakis S; Bartonicek N; Kaczorowski DC; Dinger ME; Meikle PJ; Bond PJ; Febbraio MA, 2018, 'Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism', Cell Metabolism, 27, pp. 1096 - 1110.e5, http://dx.doi.org/10.1016/j.cmet.2018.03.014

Nobis M; Warren SC; Lucas MC; Murphy KJ; Herrmann D; Timpson P, 2018, 'Molecular mobility and activity in an intravital imaging setting - Implications for cancer progression and targeting', Journal of Cell Science, 131, http://dx.doi.org/10.1242/jcs.206995

Vennin C; Murphy KJ; Morton JP; Cox TR; Pajic M; Timpson P, 2018, 'Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer', Gastroenterology, 154, pp. 820 - 838, http://dx.doi.org/10.1053/j.gastro.2017.11.280

Benthani F; Herrman D; Tran P; Pangon L; Currey N; Lucas M; Allam A; Giry-Laterriere M; Al-Sohaily S; Timpson P; Kohonen-Corish M, 2018, 'Mutated in colorectal cancer protein strengthens the intercellular adhesion of colon cancer cells by complexing with E-cadherin and beta-catenin', Oncogene

Chitty JL; Filipe EC; Lucas MC; Herrmann D; Cox TR; Timpson P, 2018, 'Recent advances in understanding the complexities of metastasis', F1000Research, 7, http://dx.doi.org/10.12688/f1000research.15064.2

Parkin A; Steinmann A; Froio D; Drury A; Vogel N; Murphy K; Deng N; Gill A; Timpson P; Pajic M, 2018, 'PO-046 Dual inhibition of JAK and Src: a novel and promising therapeutic combination for pancreatic cancer', ESMO Open, 3, pp. A245 - A245, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.579

Kohonen-Corish M; Benthani F; Herrmann D; Phuong T; Currey N; Lucas M; Allam A; Al-Sohaily S; Warusavitarne J; Timpson P, 2018, 'PO-168 Loss of the MCC gene expression promotes invasiveness of colon cancer cells', ESMO Open, 3, pp. A86 - A87, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.207

Firatligil B; Bati-Ayaz G; Pesen-Okvur D; Yalcin-Ozuysal O, 2018, 'PO-171 Tissue specific extravasation and invasion of MDA-MB-231 cells in a lab-on-a-chip system', ESMO Open, 3, pp. A88 - A88, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.210

Molloy T; Parkin A; Chou A; Samra J; Timpson P; Gill A; Pajic M, 2018, 'PO-195 Integrative analysis of in vivo models of pancreatic cancer reveals complex mechanisms behind treatment failure and provides new tools for effective targeting', ESMO Open, 3, pp. A303 - A303, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.713

Salaymeh Y; Farago M; Sebban S; Pikarsky E; Katzav S, 2018, 'PO-196 Vav1 and Mutant K-Ras synergize in pancreatic ductal adenocarcinoma development: lessons from mouse models', ESMO Open, 3, pp. A303 - A303, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.714

Murphy K; Vennin C; Cox T; Wang Y; Morton J; Sansom O; Pajic M; Herrmann D; Timpson P, 2018, 'PO-229 Transient tissue ‘priming’ via FAK inhibition to impair pancreatic ductal adenocarcinoma (PDAC) progression to improve sensitivity to gemcitabine/abraxane', ESMO Open, 3, pp. A316 - A317, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.746

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