By Dr Paul Timpson

Journal articles

Timpson P, 2017, 'Cell scientist to watch – Paul Timpson', Journal of Cell Science, 130, pp. 2949 - 2951, http://dx.doi.org/10.1242/JCS.207878

Conway JRW; Warren SC; Timpson P, 2017, 'Context-dependent intravital imaging of therapeutic response using intramolecular FRET biosensors', Methods, 128, pp. 78 - 94, http://dx.doi.org/10.1016/j.ymeth.2017.04.014

Harris NLE; Vennin C; Conway JRW; Vine KL; Pinese M; Cowley MJ; Shearer RF; Lucas MC; Herrmann D; Allam AH; Pajic M; Morton JP; Biankin AV; Ranson M; Timpson P; Saunders DN, 2017, 'SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer', Oncogene, 36, pp. 4288 - 4298, http://dx.doi.org/10.1038/onc.2017.63

Grewal T; Hoque M; Conway JRW; Reverter M; Wahba M; Beevi SS; Timpson P; Enrich C; Rentero C, 2017, 'Annexin A6—A multifunctional scaffold in cell motility', Cell Adhesion and Migration, 11, pp. 288 - 304, http://dx.doi.org/10.1080/19336918.2016.1268318

Johns AL; McKay SH; Humphris JL; Pinese M; Chantrill LA; Mead RS; Tucker K; Andrews L; Goodwin A; Leonard C; High HA; Nones K; Waddell N; Patch AM; Merrett ND; Pavlakis N; Kassahn KS; Samra JS; Miller DK; Chang DK; Pajic M; Pearson JV; Grimmond SM; Zeps N; Gill AJ; Biankin AV; Chin VT; Chou A; Steinmann A; Arshi M; Drury A; Froio D; Morgan A; Timpson P; Hermann D; Vennin C; Warren S; Wu J; Pinho AV; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Wood S; Xu C; Hofmann O; Wilson PJ; Christ A; Bruxner T; Samra S; Arena J; Mittal A; Asghari R; Pavey D; Das A; Cosman PH; Ismail K; O'Connnor C; Williams D; Spigellman A; Lam W; McLeod D; Nagrial AM; Kirk J; James V; Grimison P; Cooper CL; Sandroussi C; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Brooke-Smith ME; Papangelis V; Clouston AD; Martin P; Barbour AP; O'Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Hruban RH; Wolfgang CL; Hodgin M; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C; Bailey P; Martin S; Musgrove EA; Herrmann D, 2017, 'Lost in translation: Returning germline genetic results in genome-scale cancer research', Genome Medicine, 9, pp. 41, http://dx.doi.org/10.1186/s13073-017-0430-4

Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JRW; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AAS; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NLE; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TRJ; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, 9, http://dx.doi.org/10.1126/scitranslmed.aai8504

Grewal T; Hoque M; Conway JRW; Reverter M; Wahba M; Beevi SS; Timpson P; Enrich C; Rentero C, 2017, 'Annexin A6 - a multifunctional scaffold in cell motility.', Cell Adh Migr, http://dx.doi.org/10.1080/19336918.2016.1268318

Herrmann D; Erami Z; Warren S; Nobis M; Magenau A; Lucas M; Vennin C; McGhee EJ; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Karim SA; Campbell AD; Gallego-Ortega D; Evans J; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2017, 'A biosensor mouse to predict the dissociation and spread of pancreatic cancer', CANCER RESEARCH, 77, http://dx.doi.org/10.1158/1538-7445.EPSO16-PR07

Andrlová H; Mastroianni J; Madl J; Kern JS; Melchinger W; Dierbach H; Wernet F; Follo M; Hafsi KT; Has C; Mittapalli VR; Idzko M; Herr R; Brummer T; Ungefroren H; Busch H; Boerries M; Narr A; Ihorst G; Vennin C; Schmitt-Graeff A; Minguet S; Timpson P; Duyster J; Meiss F; Römer W; Zeiser R, 2017, 'Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression', Oncotarget, 8, pp. 42901 - 42916, http://dx.doi.org/10.18632/oncotarget.17160

Chang J; Lucas MC; Leonte LE; Garcia-Montolio M; Singh LB; Findlay AD; Deodhar M; Foot JS; Jarolimek W; Timpson P; Erler JT; Cox TR, 2017, 'Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer', Oncotarget, 8, pp. 26066 - 26078, http://dx.doi.org/10.18632/oncotarget.15257

Young AIJ; Law AMK; Castillo L; Chong S; Cullen HD; Koehler M; Herzog S; Brummer T; Lee EF; Fairlie WD; Lucas MC; Herrmann D; Allam A; Timpson P; Watkins DN; Millar EKA; O'Toole SA; Gallego-Ortega D; Ormandy CJ; Oakes SR, 2016, 'MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib', Breast Cancer Research, 18, http://dx.doi.org/10.1186/s13058-016-0781-6

Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Warren SC; Timpson P; Stear JH; Gunning PW; Hardeman EC, 2016, 'Recruitment kinetics of tropomyosin tpm3.1 to actin filament bundles in the cytoskeleton is independent of actin filament kinetics', PLoS ONE, 11, pp. e0168203, http://dx.doi.org/10.1371/journal.pone.0168203

Roth I; Campbell H; Rubio C; Vennin C; Wilson M; Wiles A; Williams G; Woolley A; Timpson P; Berridge MV; Fleming N; Baird M; Braithwaite AW, 2016, 'The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2', Oncogene, 35, pp. 4981 - 4989, http://dx.doi.org/10.1038/onc.2016.45

Nobis M; Herrmann D; Timpson P; Erami Z; Anderson K, 2016, 'Imaging Molecular Dynamics for Drug Discovery', Physiology News, pp. 27 - 29, http://dx.doi.org/10.36866/pn.104.27

Andrlova H; Mastroianni J; Madl J; Kern JS; Melchinger W; Follo M; Technau-Hafsi K; Mittapali VR; Brummer T; Timpson P; Ungefroren H; Duyster J; Meiss F; Römer W; Zeiser R, 2016, 'Effect of biglycan on melanoma invasiveness via increased tissue stiffness and integrin-β1 expression.', Journal of Clinical Oncology, 34, pp. 11526 - 11526, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.11526

Akerman A; Vennin C; Sharbeen G; Warren SC; Timpson P; Phillips PA, 2016, 'Novel therapeutics and preclinical imaging for pancreatic cancer - View from the lab', Cancer Forum, 40, pp. 16 - 22

Marei H; Carpy A; Woroniuk A; Vennin C; White G; Timpson P; Macek B; Malliri A, 2016, 'Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration', Nature Communications, 7, http://dx.doi.org/10.1038/ncomms10664

García-Melero A; Reverter M; Hoque M; Meneses-Salas E; Koese M; Conway JRW; Johnsen CH; Alvarez-Guaita A; Morales-Paytuvi F; Elmaghrabi YA; Pol A; Tebar F; Murray RZ; Timpson P; Enrich C; Grewal T; Rentero C, 2016, 'Annexin A6 and late endosomal cholesterol modulate integrin recycling and cell migration', Journal of Biological Chemistry, 291, pp. 1320 - 1335, http://dx.doi.org/10.1074/jbc.M115.683557

Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P; Zhang L, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020

Vennin C; Herrmann D; Lucas MC; Timpson P, 2016, 'Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression.', F1000Research, 5, http://dx.doi.org/10.12688/F1000RESEARCH.8090.1

Gallego-Ortega D; Ledger A; Roden DL; Law AMK; Magenau A; Kikhtyak Z; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Herrmann D; Salomon R; Young AIJ; Lee BY; Sergio CM; Kaplan W; Piggin C; Conway JRW; Rabinovich B; Millar EKA; Oakes SR; Chtanova T; Swarbrick A; Naylor MJ; O’Toole S; Green AR; Timpson P; Gee JMW; Ellis IO; Clark SJ; Ormandy CJ, 2015, 'ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells', PLoS Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002330

Kular J; Scheer KG; Pyne NT; Allam AH; Pollard AN; Magenau A; Wright RL; Kolesnikoff N; Moretti PA; Wullkopf L; Stomski FC; Cowin AJ; Woodcock JM; Grimbaldeston MA; Pitson SM; Timpson P; Ramshaw HS; Lopez AF; Samuel MS, 2015, 'A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis', Developmental Cell, 35, pp. 759 - 774, http://dx.doi.org/10.1016/j.devcel.2015.11.026

Vlahov N; Scrace S; Soto MS; Grawenda AM; Bradley L; Pankova D; Papaspyropoulos A; Yee KS; Buffa F; Goding CR; Timpson P; Sibson N; O'Neill E, 2015, 'Alternate RASSF1 transcripts control SRC activity, E-cadherin contacts, and YAP-mediated invasion', Current Biology, 25, pp. 3019 - 3034, http://dx.doi.org/10.1016/j.cub.2015.09.072

Ooms LM; Binge LC; Davies EM; Rahman P; Conway JRW; Gurung R; Ferguson DT; Papa A; Fedele CG; Vieusseux JL; Chai RC; Koentgen F; Price JT; Tiganis T; Timpson P; McLean CA; Mitchell CA, 2015, 'The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis', Cancer Cell, 28, pp. 155 - 169, http://dx.doi.org/10.1016/j.ccell.2015.07.003

Miller BW; Morton JP; Pinese M; Saturno G; Jamieson NB; Mcghee E; Timpson P; Leach J; Mcgarry L; Shanks E; Bailey P; Chang D; Oien K; Karim S; Au A; Steele C; Carter CR; Mckay C; Anderson K; Evans TRJ; Marais R; Springer C; Biankin A; Erler JT; Sansom OJ, 2015, 'Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: Inhibition of LOX abrogates metastasis and enhances drug efficacy', EMBO Molecular Medicine, 7, pp. 1063 - 1076, http://dx.doi.org/10.15252/emmm.201404827

Huo CW; Chew G; Hill P; Huang D; Ingman W; Hodson L; Brown KA; Magenau A; Allam AH; McGhee E; Timpson P; Henderson MA; Thompson EW; Britt K, 2015, 'High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium', Breast Cancer Research, 17, http://dx.doi.org/10.1186/s13058-015-0592-1

Vennin C; Timpson P, 2015, 'Intravital microscopy of cancer: New insights into the spatiotemporal dynamics of the disease', AACR Education book, 2015, pp. 31 - 36, http://dx.doi.org/10.1158/aacr.edb-15-8637

Vennin C; Pajic M; Timpson P, 2015, 'Imaging fibrosis in pancreatic cancer using second harmonic generation', Pancreatology, 15, pp. 200 - 201, http://dx.doi.org/10.1016/j.pan.2015.02.004

Belle L; Ali N; Lonic A; Li X; Paltridge JL; Roslan S; Herrmann D; Conway JRW; Gehling FK; Bert AG; Crocker LA; Tsykin A; Farshid G; Goodall GJ; Timpson P; Daly RJ; Khew-Goodall Y, 2015, 'The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking', Science Signaling, 8, http://dx.doi.org/10.1126/scisignal.2005547

Lee BY; Timpson P; Horvath LG; Daly RJ, 2015, 'FAK signaling in human cancer as a target for therapeutics', Pharmacology & therapeutics, 146, pp. 132 - 149, http://dx.doi.org/10.1016/j.pharmthera.2014.10.001

Chin VT; Nagrial AM; Chou A; Biankin AV; Gill AJ; Timpson P; Pajic M, 2015, 'Rho-associated kinase signalling and the cancer microenvironment: Novel biological implications and therapeutic opportunities', Expert Reviews in Molecular Medicine, 17, http://dx.doi.org/10.1017/erm.2015.17

Hoque M; Rentero C; Conway JR; Murray RZ; Timpson P; Enrich C; Grewal T, 2015, 'The cross-talk of LDL-cholesterol with cell motility: Insights from the niemann pick type C1 mutation and altered integrin trafficking', Cell Adhesion and Migration, 9, pp. 384 - 391, http://dx.doi.org/10.1080/19336918.2015.1019996

Pajic M; Herrmann D; Vennin C; Conway JRW; Chin VT; Johnsson AKE; Welch HCE; Timpson P, 2015, 'The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment', Small GTPases, 6, pp. 123 - 133, http://dx.doi.org/10.4161/21541248.2014.973749

Erami Z; Timpson P; Yao W; Zaidel-Bar R; Anderson KI, 2015, 'There are four dynamically and functionally distinct populations of E-cadherin in cell junctions', Biology Open, 4, pp. 1481 - 1489, http://dx.doi.org/10.1242/bio.014159

Nobis M; McGhee EJ; Herrmann D; Magenau A; Morton JP; Anderson KI; Timpson P, 2014, 'Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging', Cell Adhesion and Migration, 8, pp. 478 - 486, http://dx.doi.org/10.4161/19336918.2014.970004

Tan EH; Morton JP; Timpson P; Tucci P; Melino G; Flores ER; Sansom OJ; Vousden KH; Muller PAJ, 2014, 'Functions of TAp63 and p53 in restraining the development of metastatic cancer', British Dental Journal, 217, pp. 3325 - 3333, http://dx.doi.org/10.1038/onc.2013.287

Johnsson AKE; Dai Y; Nobis M; Baker MJ; McGhee EJ; Walker S; Schwarz JP; Kadir S; Morton JP; Myant KB; Huels DJ; Segonds-Pichon A; Sansom OJ; Anderson KI; Timpson P; Welch HCE, 2014, 'The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues', Cell Reports, 6, pp. 1153 - 1164, http://dx.doi.org/10.1016/j.celrep.2014.02.024

Reverter M; Rentero C; Garcia-Melero A; Hoque M; Vilà de Muga S; Álvarez-Guaita A; Conway JRW; Wood P; Cairns R; Lykopoulou L; Grinberg D; Vilageliu L; Bosch M; Heeren J; Blasi J; Timpson P; Pol A; Tebar F; Murray RZ; Grewal T; Enrich C, 2014, 'Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries', Cell Reports, 7, pp. 883 - 897, http://dx.doi.org/10.1016/j.celrep.2014.03.043

Macpherson IR; Rainero E; Mitchell LE; van den Berghe PVE; Speirs C; Dozynkiewicz MA; Chaudhary S; Kalna G; Edwards J; Timpson P; Norman JC, 2014, 'CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer', Journal of Cell Science, 127, pp. 3893 - 3901, http://dx.doi.org/10.1242/jcs.135947

Conway JRW; Carragher NO; Timpson P, 2014, 'Developments in preclinical cancer imaging: Innovating the discovery of therapeutics', Nature Reviews Cancer, 14, pp. 314 - 328, http://dx.doi.org/10.1038/nrc3724

Herrmann D; Conway JRW; Vennin C; Magenau A; Hughes WG; Morton JP; Timpson P, 2014, 'Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment', Carcinogenesis, 35, pp. 1671 - 1679, http://dx.doi.org/10.1093/carcin/bgu108

Nobis M; Carragher NO; McGhee EJ; Morton JP; Sansom OJ; Anderson KI; Timpson P, 2013, 'Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue', FEBS Journal, 280, pp. 5177 - 5197, http://dx.doi.org/10.1111/febs.12348

Nobis M; McGhee EJ; Morton JP; Schwarz JP; Karim SA; Quinn J; Edward M; Campbell AD; McGarry LC; Evans TRJ; Brunton VG; Frame MC; Carragher NO; Wang Y; Sansom OJ; Timpson P; Anderson KI, 2013, 'Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer', Cancer Research, 73, pp. 4674 - 4686, http://dx.doi.org/10.1158/0008-5472.CAN-12-4545

Myant KB; Cammareri P; McGhee EJ; Ridgway RA; Huels DJ; Cordero JB; Schwitalla S; Kalna G; Ogg EL; Athineos D; Timpson P; Vidal M; Murray GI; Greten FR; Anderson KI; Sansom OJ, 2013, 'ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation', Cell Stem Cell, 12, pp. 761 - 773, http://dx.doi.org/10.1016/j.stem.2013.04.006

Chin VT; Nagrial A; Chantrill LA; Chang DK; Chou A; Humprhis J; Cowley M; Wu J; DiPetro R; Watson C; Spielman C; Steinmann A; Pinese M; Pettitt J; Johns A; Waddell N; Grimmond S; Timpson P; Biankin AV; Pajic M, 2013, 'From functional genomics to precision medicine: The therapeutic potential of targeting ROCK signaling in pancreatic cancer.', Journal of Clinical Oncology, 31, pp. e15029 - e15029, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e15029

Muller PAJ; Trinidad AG; Timpson P; Morton JP; Zanivan S; Van Den Berghe PVE; Nixon C; Karim SA; Caswell PT; Noll JE; Coffill CR; Lane DP; Sansom OJ; Neilsen PM; Norman JC; Vousden KH, 2013, 'Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion', Oncogene, 32, pp. 1252 - 1265, http://dx.doi.org/10.1038/onc.2012.148

Tang H; Li A; Bi J; Veltman DM; Zech T; Spence HJ; Yu X; Timpson P; Insall RH; Frame MC; MacHesky LM, 2013, 'Loss of scar/WAVE complex promotes N-WASP- and FAK-dependent invasion', Current Biology, 23, pp. 107 - 117, http://dx.doi.org/10.1016/j.cub.2012.11.059

Spence HJ; Timpson P; Tang HR; Insall RH; Machesky LM, 2012, 'Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions', Biochemical Journal, 448, pp. 35 - 42, http://dx.doi.org/10.1042/BJ20112206

Yu X; Zech T; McDonald L; Gonzalez EG; Li A; Macpherson I; Schwarz JP; Spence H; Futó K; Timpson P; Nixon C; Ma Y; Anton IM; Visegrády B; Insall RH; Oien K; Blyth K; Norman JC; Machesky LM, 2012, 'N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods', Journal of Cell Biology, 199, pp. 527 - 544, http://dx.doi.org/10.1083/jcb.201203025

Macintosh RL; Timpson P; Thorburn J; Anderson KI; Thorburn A; Ryan KM, 2012, 'Inhibition of autophagy impairs tumor cell invasion in an organotypic model', Cell Cycle, 11, pp. 2022 - 2029, http://dx.doi.org/10.4161/cc.20424

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