By Dr Paul Timpson

Journal articles

Muller PAJ; Trinidad AG; Timpson P; Morton JP; Zanivan S; Van Den Berghe PVE; Nixon C; Karim SA; Caswell PT; Noll JE; Coffill CR; Lane DP; Sansom OJ; Neilsen PM; Norman JC; Vousden KH, 2013, 'Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion', Oncogene, 32, pp. 1252 - 1265, http://dx.doi.org/10.1038/onc.2012.148

Tang H; Li A; Bi J; Veltman DM; Zech T; Spence HJ; Yu X; Timpson P; Insall RH; Frame MC; MacHesky LM, 2013, 'Loss of scar/WAVE complex promotes N-WASP- and FAK-dependent invasion', Current Biology, 23, pp. 107 - 117, http://dx.doi.org/10.1016/j.cub.2012.11.059

Spence HJ; Timpson P; Tang HR; Insall RH; Machesky LM, 2012, 'Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions', Biochemical Journal, 448, pp. 35 - 42, http://dx.doi.org/10.1042/BJ20112206

Yu X; Zech T; McDonald L; Gonzalez EG; Li A; Macpherson I; Schwarz JP; Spence H; Futó K; Timpson P; Nixon C; Ma Y; Anton IM; Visegrády B; Insall RH; Oien K; Blyth K; Norman JC; Machesky LM, 2012, 'N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods', Journal of Cell Biology, 199, pp. 527 - 544, http://dx.doi.org/10.1083/jcb.201203025

Macintosh RL; Timpson P; Thorburn J; Anderson KI; Thorburn A; Ryan KM, 2012, 'Inhibition of autophagy impairs tumor cell invasion in an organotypic model', Cell Cycle, 11, pp. 2022 - 2029, http://dx.doi.org/10.4161/cc.20424

Dawson JC; Timpson P; Kalna G; Machesky LM, 2012, 'Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells', Oncogene, 31, pp. 1781 - 1793, http://dx.doi.org/10.1038/onc.2011.376

Dozynkiewicz MA; Jamieson NB; MacPherson I; Grindlay J; vandenBerghe PVE; vonThun A; Morton JP; Gourley C; Timpson P; Nixon C; McKay CJ; Carter R; Strachan D; Anderson K; Sansom OJ; Caswell PT; Norman JC, 2012, 'Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression', Developmental Cell, 22, pp. 131 - 145, http://dx.doi.org/10.1016/j.devcel.2011.11.008

Lindsay CR; Lawn S; Campbell AD; Faller WJ; Rambow F; Mort RL; Timpson P; Li A; Cammareri P; Ridgway RA; Morton JP; Doyle B; Hegarty S; Rafferty M; Murphy IG; McDermott EW; Sheahan K; Pedone K; Finn AJ; Groben PA; Thomas NE; Hao H; Carson C; Norman JC; MacHesky LM; Gallagher WM; Jackson IJ; Van Kempen L; Beermann F; Der C; Larue L; Welch HC; Ozanne BW; Sansom OJ, 2011, 'P-Rex1 is required for efficient melanoblast migration and melanoma metastasis', Nature Communications, 2, http://dx.doi.org/10.1038/ncomms1560

Timpson P; McGhee EJ; Erami Z; Nobis M; Quinn JA; Edward M; Anderson KI, 2011, 'Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context.', Journal of visualized experiments : JoVE

Timpson P; Mcghee EJ; Erami Z; Nobis M; Quinn JA; Edward M; Anderson KI, 2011, 'Organotypic Collagen I Assay: A Malleable Platform to Assess Cell Behaviour in a 3-Dimensional Context', Journal of Visualized Experiments, http://dx.doi.org/10.3791/3089-v

Timpson P; Mcghee EJ; Anderson KI, 2011, 'Imaging molecular dynamics in vivo - from cell biology to animal models', Journal of Cell Science, 124, pp. 2877 - 2890, http://dx.doi.org/10.1242/jcs.085191

Isherwood B; Timpson P; Mcghee EJ; Anderson KI; Canel M; Serrels A; Brunton VG; Carragher NO, 2011, 'Live cell in vitro and in vivo imaging applications: Accelerating drug discovery', Pharmaceutics, 3, pp. 141 - 170, http://dx.doi.org/10.3390/pharmaceutics3020141

Timpson P; McGhee EJ; Morton JP; Von Kriegsheim A; Schwarz JP; Karim SA; Doyle B; Quinn JA; Carragher NO; Edward M; Olson MF; Frame MC; Brunton VG; Sansom OJ; Anderson KI, 2011, 'Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53', Cancer Research, 71, pp. 747 - 757, http://dx.doi.org/10.1158/0008-5472.CAN-10-2267

Samuel MS; Lopez JI; McGhee EJ; Croft DR; Strachan D; Timpson P; Munro J; Schröder E; Zhou J; Brunton VG; Barker N; Clevers H; Sansom OJ; Anderson KI; Weaver VM; Olson MF, 2011, 'Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth', Cancer Cell, 19, pp. 776 - 791, http://dx.doi.org/10.1016/j.ccr.2011.05.008

McGhee EJ; Morton JP; von Kriegsheim A; Schwarz JP; Karim SA; Carragher NO; Sansom OJ; Anderson KI; Timpson P, 2011, 'FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion', Small GTPases, 2, pp. 239 - 244, http://dx.doi.org/10.4161/sgtp.2.4.17275

Canel M; Serrels A; Miller D; Timpson P; Serrels B; Frame MC; Brunton VG, 2010, 'Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: Effects on e-cadherin dynamics', Cancer Research, 70, pp. 9413 - 9422, http://dx.doi.org/10.1158/0008-5472.CAN-10-1454

Morton JP; Karim SA; Graham K; Timpson P; Jamieson N; Athineos D; Doyle B; McKay C; Heung MY; Oien KA; Frame MC; Evans TRJ; Sansom OJ; Brunton VG, 2010, 'Dasatinib Inhibits the Development of Metastases in a Mouse Model of Pancreatic Ductal Adenocarcinoma', Gastroenterology, 139, pp. 292 - 303, http://dx.doi.org/10.1053/j.gastro.2010.03.034

Morton JP; Timpson P; Karim SA; Ridgway RA; Athineos D; Doyle B; Jamieson NB; Oien KA; Lowy AM; Brunton VG; Frame MC; Evans TRJ; Sansom OJ, 2010, 'Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer', Proceedings of the National Academy of Sciences of the United States of America, 107, pp. 246 - 251, http://dx.doi.org/10.1073/pnas.0908428107

Timpson P; Serrels A; Canel M; Frame MC; Brunton VG; Anderson KI, 2009, 'Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo.', Cell adhesion & migration, 3, pp. 351 - 354

Serreis A; Timpson P; Canel M; Schwarz JP; Carragher NO; Frame MC; Brunton VG; Anderson KI, 2009, 'Real-time study of E-cadherin and membrane dynamics in living animals: Implications for disease modeling and drug development', Cancer Research, 69, pp. 2714 - 2719, http://dx.doi.org/10.1158/0008-5472.CAN-08-4308

Timpson P; Serrels A; Canel M; Frame MC; Brunton VG; Anderson KI, 2009, 'Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo', Cell Adhesion and Migration, 3, http://dx.doi.org/10.4161/cam.3.4.9460

Vila de Muga S; Timpson P; Cubells L; Evans R; Hayes TE; Rentero C; Hegemann A; Reverter M; Lelschner ; Pol A; Tebar F; Daly RJ; Enrich C; Grewal T, 2009, 'Annexin A6 inhibits Ras signalling in breast cancer cells', Oncogene, 28, pp. 363 - 377, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18850003

Brummer T; Larance M; Abreu MTH; Lyons RJ; Timpson P; Emmerich CH; Fleuren EDG; Lehrbach GM; Schramek D; Guilhaus M; James DE; Daly RJ, 2009, 'The docking protein and proto-oncogene product Gab2 is regulated via a novel negative feedback mechanism mediated by 14-3-3 binding.', Cell communication and signaling : CCS, 7, pp. A12 - A12, http://dx.doi.org/10.1186/1478-811X-7-S1-A12

Brummer T; Larance MC; Abreu M; Lyons RJ; Timpson P; Emmerich C; Fleuren E; Lehrbach GM; Schramek D; Guilhaus M; James DE; Daly RJ, 2008, 'Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein', European Molecular Biology Organization, 27, pp. 2305 - 2316

Llado A; Timpson P; Vila de Muga S; Moreto J; Pol A; Grewal T; Daly RJ; Enrich C; Tebar F, 2008, 'Protein kinase C delta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin', Molecular Biology of the Cell, 19, pp. 17 - 29

Timpson P; Wilson A; Lehrbach GM; Sutherland RL; Musgrove EA; Daly RJ, 2007, 'Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib', Cancer research, 67, pp. 9304 - 9314

Ardern H; Sandilands E; Machesky LM; Timpson P; Frame MC; Brunton VG, 2006, 'Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex', Cell Motility and the Cytoskeleton, 63, pp. 6 - 13, http://dx.doi.org/10.1002/cm.20101

Timpson P; Lynch DK; Schramek D; Walker F; Daly RJ, 2005, 'Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor', Cancer research, 65, pp. 3273 - 3280

Daly RJ; Timpson P, 2005, 'Distinction at the leading edge of the cell', BioEssays, 27, pp. 349 - 352

Gourlay CW; Carpp LN; Timpson P; Winder SJ; Ayscough KR, 2004, 'A role for the actin cytoskeleton in cell death and aging in yeast', Journal of Cell Biology, 164, pp. 803 - 809, http://dx.doi.org/10.1083/jcb.200310148

Timpson P; Jones GE; Frame MC; Brunton VG, 2001, 'Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity', Current Biology, 11, pp. 1836 - 1846, http://dx.doi.org/10.1016/S0960-9822(01)00583-8

Chalmers RM; Sturdee AP; Mellors P; Nicholson V; Lawlor F; Kenny F; Timpson P, 1997, 'Cryptosporidium parvum in environmental samples in the Sligo area, Republic of Ireland: A preliminary report', Letters in Applied Microbiology, 25, pp. 380 - 384, http://dx.doi.org/10.1046/j.1472-765X.1997.00248.x

Williams J; Stewart P; Timpson P, 1996, 'Characterization of rainbow trout, Oncorhynchus mykiss (Walbaum), serum creatine kinase isoenzymes and isoforms by means of electrophoresis and isoelectric focusing', Journal of Fish Diseases, 19, pp. 441 - 447, http://dx.doi.org/10.1111/j.1365-2761.1996.tb00384.x

Conference Papers

Golo M; Finkbeiner M; Piastra-Facon F; Heu C; Colakoglu F; Tay S; Herrmann D; Whan R; Timpson P; Kempe D; Biro M, 2024, '1354 The impact of the pancreatic tumour microenvironment on cytotoxic T lymphocyte migration and tumour eradication', in Regular and Young Investigator Award Abstracts, BMJ Publishing Group Ltd, pp. A1517 - A1517, presented at SITC 39th Annual Meeting (SITC 2024) Abstracts, http://dx.doi.org/10.1136/jitc-2024-sitc2024.1354

Pinho AV; Van Bulck M; Chantrill L; Arshi M; Herrmann D; Vennin C, 2019, 'ROBO2 is a stroma suppressor gene in the pancreas through regulation of TGF-beta', in CANCER IMMUNOLOGY RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A100

Warren SC; Magenau A; Nobis M; Herrmann D; Mélénec P; Anderson KI; Sansom OJ; Morton JP; Welch HC; Timpson P, 2018, 'Unmixing spectrally overlapping FRET biosensors in vivo using multispectral FLIM (Conference Presentation)', in Periasamy A; So PT; Xie XS; König K (eds.), Multiphoton Microscopy in the Biomedical Sciences XVIII, SPIE, pp. 23 - 23, presented at Multiphoton Microscopy in the Biomedical Sciences XVIII, 27 January 2018 - 01 February 2018, http://dx.doi.org/10.1117/12.2290152

Lindsay CR; Lawn S; Campbell A; Faller W; Rambow F; Mort R; Timpson P; Li A; Cammareri P; Rafferty M; Murphy I; McDermott E; Sheahan K; Gallacher W; Van Kempen L; Beermann F; Der C; Larue L; Welch H; Ozanne B; Sansom O, 2011, 'Abstract B147: P-Rex1 is required for efficient melanoma metastasis.', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. B147 - B147, http://dx.doi.org/10.1158/1535-7163.targ-11-b147

Brunton VG; Serrels A; Timpson P; Canel M; Frame MC; Anderson KI, 2009, 'real-time study of E-cadherin dynamics in live animals using photo-activation and -bleaching', in CLINICAL & EXPERIMENTAL METASTASIS, SPRINGER, pp. 909 - 909, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271722300190&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Brunton VG; Timpson P; Carragher NO; Machesky L; Frame MC, 2001, 'Association of Scar with the Src tyrosine kinase consequences for Scar regulation', in BRITISH JOURNAL OF CANCER, CHURCHILL LIVINGSTONE, pp. 22 - 22, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000170065300080&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Posters

Chin V; Nagrial A; Chang D; Chantrill L; Cowley M; Wu J; Spielman C; Steinmann A; Pinese M; Pettitt J; Johns A; Gill A; Timpson P; Biankin A; Pajic M, 2013, 'From function genomics to precision medicine: the therapeutic potential of targeting rock signalling in pancreatic cancer', Chicago, IL, Vol. 9, pp. 53 - 53, presented at ASCO Annual Meeting, Chicago, IL, 31 May 2013 - 04 June 2013, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000329462300024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Presentations

Chou A; Chin VT; Nagrial AM; Gill AJ; Timpson P; Chang DK; Waddell N; Wu J; Grimmond SM; Biankin AV; Pajic M, 2014, 'From functional genomics to precision medicine: Using well annotated models to define personalised treatment strategies for pancreatic cancer', https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341276000017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

Murphy KJ; Reed DA; Chambers CR; Channon LM; Pajic M; Herrmann D; Timpson P, 2024, 'Abstract B037: Anti-fibrotic FAK ‘priming’ to improve contemporary chemotherapy in pancreatic cancer', in Cancer Research, American Association for Cancer Research (AACR), Vol. 84, pp. B037 - B037, http://dx.doi.org/10.1158/1538-7445.panca2023-b037

Pinho AV; Bulck MV; Chantrill L; Arshi M; Sklyarova T; Herrmann D; Vennin C; Gallego-Ortega D; Mawson A; Giry-Laterriere M; Magenau A; Baeyens L; Gill AJ; Phillips P; Timpson P; Biankin AV; Wu J; Rooman I, 2018, 'ROBO2 is a Stroma Suppressor Gene in the Pancreas Through Regulation of TGF-beta', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 47, pp. 1417 - 1417, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449304600212&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chin VT; Nagrial A; Conway J; Vennin C; Chantrill LA; Chou A; Steinmann A; Gill AJ; Humprhis J; Drury A; Froio D; Morgan A; Biankin A; Timpson P; Pajic M, 2017, 'Effect of Rho/ROCK pathway inhibition on metastasis-free and overall survival in biomarker selected, orthotopic, patient-derived models of pancreatic cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, IL, Chicago, Vol. 35, presented at 53rd Annual Clinical Science Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Symposium on Old Targets, New Drugs - Her2 and MET, IL, Chicago, 02 June 2017 - 07 June 2017, http://dx.doi.org/10.1200/JCO.2017.35.15_suppl.e15759

Huo CW; Chew G; Waltham M; Ingman W; Brown K; Timpson P; Khoo C; Fox S; Hill P; Chen S; Price J; Nguyen CH; Williams ED; Henderson M; Thompson EW; Britt K, 2016, 'THE BIOLOGY UNDERLYING MAMMOGRAPHIC DENSITY AND PRECLINICAL MOUSE MODELS TO TEST NEW THERAPIES', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, Vol. 12, pp. 100 - 101, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387769900121&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Ooms LM; Binge LC; Rahman P; Conway JR; Ferguson DT; Fedele CG; Gurung R; Vieusseux JL; Chai RC; Price JT; Tiganis T; Timpson P; McLean CA; Mitchell CA, 2015, 'REGULATION OF PI3K/AKT-DEPENDENT BREAST CANCER GROWTH AND METASTASIS', in JOURNAL OF GENE MEDICINE, WILEY-BLACKWELL, AUSTRALIA, Univ Melbourne, Univ Coll, Parkville, Vol. 17, pp. 177 - 178, presented at 9th Biennial Meeting of the Australasian-Gene-and-Cell-Therapy-Society (AGCTS), AUSTRALIA, Univ Melbourne, Univ Coll, Parkville, 29 April 2015 - 01 May 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000362592700009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chin VT; Conway J; Nagrial A; Chantrill LA; Chou A; Steinmann A; Gill A; Pinese M; Wu J; Johns A; Dury A; Biankin A; Timpson P; Pajic M, 2015, 'Targeting the Rho-ROCK pathway to treat pancreatic cancer: The use of unique preclinical models to ascertain the effects on cancer growth and metastasis', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, CA, San Francisco, Vol. 33, presented at Gastrointestinal Cancers Symposium, CA, San Francisco, 15 January 2015 - 17 January 2015, http://dx.doi.org/10.1200/jco.2015.33.3_suppl.312

Macpherson IR; Rainero E; van den Berghe PVE; Speirs C; Dozynkiewicz MA; Chaudhary S; Kalna G; Edwards J; Timpson P; Norman JC, 2014, 'CLIC3 controls delivery of late endosomal MT1-MMP to the ventral plasma membrane and dictates invasion and metastasis in estrogen receptor-negative breast cancer', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, SCOTLAND, Glasgow, Vol. 50, pp. S112 - S112, presented at 9th European Breast Cancer Conference (EBCC), SCOTLAND, Glasgow, 19 March 2014 - 21 March 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335106700240&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chin VT; Nagrial A; Chantrill LA; Chang DK; Chou A; Humprhis J; Cowley M; Wu J; DiPetro R; Watson C; Spielman C; Steinmann A; Pinese M; Pettitt J; Johns A; Waddell N; Grimmond S; Timpson P; Biankin AV; Pajic M, 2013, 'From functional genomics to precision medicine: The therapeutic potential of targeting ROCK signaling in pancreatic cancer.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, Vol. 31, presented at 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 31 May 2013 - 04 June 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335419603693&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Doyle B; Tan EH; Timpson P; Machesky LM; Ridgway RR; Jeffery RR; Poulsom B; Morton JP; Sansom OJ, 2012, 'The Tumor Suppressor ARF Can Promote Invasion in the Absence of p53 Activity', in MODERN PATHOLOGY, NATURE PUBLISHING GROUP, CANADA, Vancouver, Vol. 25, pp. 461A - 461A, presented at 101st Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, CANADA, Vancouver, 17 March 2012 - 23 March 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000299986902434&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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