By Dr Yoshiro Okubo

Journal articles

Arakawa R; Ito H; Takano A; Takahashi H; Morimoto T; Sassa T; Ohta K; Kato M; Okubo Y; Suhara T, 2008, 'Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia', Psychopharmacology, 197, pp. 229 - 235, http://dx.doi.org/10.1007/s00213-007-1029-z

Takahashi H; Shibuya T; Kato M; Sassa T; Koeda M; Yahata N; Suhara T; Okubo Y, 2008, 'Enhanced activation in the extrastriate body area by goal-directed actions', Psychiatry and Clinical Neurosciences, 62, pp. 214 - 219, http://dx.doi.org/10.1111/j.1440-1819.2008.01757.x

Ikeda Y; Yahata N; Ito I; Nagano M; Toyota T; Yoshikawa T; Okubo Y; Suzuki H, 2008, 'Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia', Schizophrenia Research, 101, pp. 58 - 66, http://dx.doi.org/10.1016/j.schres.2008.01.017

Adachi N; Hara T; Oana Y; Matsuura M; Okubo Y; Akanuma N; Ito M; Kato M; Onuma T, 2008, 'Difference in age of onset of psychosis between epilepsy and schizophrenia', Epilepsy Research, 78, pp. 201 - 206, http://dx.doi.org/10.1016/j.eplepsyres.2007.12.001

Asai Y; Takano A; Ito H; Okubo Y; Matsuura M; Otsuka A; Takahashi H; Ando T; Ito S; Arakawa R; Asai K; Suhara T, 2008, 'GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [¹¹C]Ro15-4513, a radioligand with relatively high affinity for α5 subunit', Schizophrenia Research, 99, pp. 333 - 340, http://dx.doi.org/10.1016/j.schres.2007.10.014

Takahashi H; Kato M; Hayashi M; Okubo Y; Takano A; Ito H; Suhara T, 2007, 'Memory and frontal lobe functions; possible relations with dopamine D2 receptors in the hippocampus', NeuroImage, 34, pp. 1643 - 1649, http://dx.doi.org/10.1016/j.neuroimage.2006.11.008

Ito S; Suhara T; Ito H; Yasuno F; Ichimiya T; Takano A; Maehara T; Matsuura M; Okubo Y, 2007, 'Changes in central 5-HT1A receptor binding in mesial temporal epilepsy measured by positron emission tomography with [¹¹C]WAY100635', Epilepsy Research, 73, pp. 111 - 118, http://dx.doi.org/10.1016/j.eplepsyres.2006.09.003

Koeda M; Takahashi H; Yahata N; Matsuura M; Asai K; Okubo Y; Tanaka H, 2007, 'Neural responses to human voice andhemisphere dominance for lexical-semantic processing: An fMRI study', Methods of Information in Medicine, 46, pp. 247 - 250, http://dx.doi.org/10.1055/s-0038-1625416

Ishiwata K; Oda K; Sakata M; Kimura Y; Kawamura K; Oda K; Sasaki T; Naganawa M; Chihara K; Okubo Y; Ishii K, 2006, 'A feasibility study of [ ¹¹C]SA4503-PET for evaluating sigma 1 receptor occupancy by neuroleptics: The binding of haloperidol to sigma 1 and dopamine D 2-like receptors', Annals of Nuclear Medicine, 20, pp. 569 - 573, http://dx.doi.org/10.1007/BF03026824

Talvik M; Nordström AL; Okubo Y; Olsson H; Borg J; Halldin C; Farde L, 2006, 'Dopamine D2 receptor binding in drug-naïve patients with schizophrenia examined with raclopride-C11 and positron emission tomography', Psychiatry Research - Neuroimaging, 148, pp. 165 - 173, http://dx.doi.org/10.1016/j.pscychresns.2006.05.009

Takano A; Suhara T; Yasuno F; Suzuki K; Takahashi H; Morimoto T; Lee YJ; Kusuhara H; Sugiyama Y; Okubo Y, 2006, 'The antipsychotic sultopride is overdosed - A PET study of drug-induced receptor occupancy in comparison with sulpiride', International Journal of Neuropsychopharmacology, 9, pp. 539 - 545, http://dx.doi.org/10.1017/S1461145705006103

Takahashi H; Matsuura M; Yahata N; Koeda M; Suhara T; Okubo Y, 2006, 'Men and women show distinct brain activations during imagery of sexual and emotional infidelity', NeuroImage, 32, pp. 1299 - 1307, http://dx.doi.org/10.1016/j.neuroimage.2006.05.049

Koeda M; Takahashi H; Yahata N; Asai K; Okubo Y; Tanaka H, 2006, 'A functional MRI study: Cerebral laterality for lexical-semantic processing and human voice perception', American Journal of Neuroradiology, 27, pp. 1472 - 1479

Tanaka Y; Obata T; Sassa T; Yoshitome E; Asai Y; Ikehira H; Suhara T; Okubo Y; Nishikawa T, 2006, 'Quantitative magnetic resonance spectroscopy of schizophrenia: Relationship between decreased N -acetylaspartate and frontal lobe dysfunction', Psychiatry and Clinical Neurosciences, 60, pp. 365 - 372, http://dx.doi.org/10.1111/j.1440-1819.2006.01515.x

Koeda M; Takahashi H; Yahata N; Matsuura M; Asai K; Okubo Y; Tanaka H, 2006, 'Language Processing and Human Voice Perception in Schizophrenia: A Functional Magnetic Resonance Imaging Study', Biological Psychiatry, 59, pp. 948 - 957, http://dx.doi.org/10.1016/j.biopsych.2006.01.013

Takahashi H; Yahata N; Koeda M; Takano A; Asai K; Suhara T; Okubo Y, 2005, 'Effects of dopaminergic and serotonergic manipulation on emotional processing: A pharmacological fMRI study', NeuroImage, 27, pp. 991 - 1001, http://dx.doi.org/10.1016/j.neuroimage.2005.05.039

Yasuno F; Suhara T; Okubo Y; Ichimiya T; Takano A; Sudo Y; Inoue M, 2005, 'Abnormal effective connectivity of dopamine D2 receptor binding in schizophrenia', Psychiatry Research - Neuroimaging, 138, pp. 197 - 207, http://dx.doi.org/10.1016/j.pscychresns.2004.04.005

Yahata N; Takahashi H; Okubo Y, 2005, 'Pharmacological modulations on the human cognitive processes: An fMRI study', Journal of Nippon Medical School, 72, pp. 2 - 3, http://dx.doi.org/10.1272/jnms.72.2

Oda K; Matsushima E; Okubo Y; Ohta K; Murata Y; Koike R; Miyasaka N; Kato M, 2005, 'Abnormal regional cerebral blood flow in systemic lupus erythematosus patients with psychiatric symptoms', Journal of Clinical Psychiatry, 66, pp. 907 - 913, http://dx.doi.org/10.4088/JCP.v66n0714

Uno T; Kobayashi E; Suwazono Y; Okubo Y; Miura K; Sakata K; Okayama A; Ueshima H; Nakagawa H; Nogawa K, 2005, 'Health effects of cadmium exposure in the general environment in Japan with special reference to the lower limit of the benchmark dose as the threshold level of urinary cadmium', SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 31, pp. 307 - 315, http://dx.doi.org/10.5271/sjweh.887

Okubo Y; Ito I; Oda K, 2004, 'Brain imaging of patients with psychiatric diseases', Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 106, pp. 900 - 905

Sakamoto A; Ogawa R; Suzuki H; Kimura M; Okubo Y; Fujiya T, 2004, 'Landiolol attenuates acute hemodynamic responses but does not reduce seizure duration during maintenance electroconvulsive therapy', Psychiatry and Clinical Neurosciences, 58, pp. 630 - 635, http://dx.doi.org/10.1111/j.1440-1819.2004.01322.x

Takahashi H; Yahata N; Koeda M; Matsuda T; Asai K; Okubo Y, 2004, 'Brain activation associated with evaluative processes of guilt and embarrassment: An fMRI study', NeuroImage, 23, pp. 967 - 974, http://dx.doi.org/10.1016/j.neuroimage.2004.07.054

Matsuura M; Adachi N; Oana Y; Okubo Y; Kato M; Nakano T; Takei N, 2004, 'A polydiagnostic and dimensional comparison of epileptic psychoses and schizophrenia spectrum disorders', Schizophrenia Research, 69, pp. 189 - 201, http://dx.doi.org/10.1016/S0920-9964(02)00492-9

Aritake S; Uchiyama M; Tagaya H; Suzuki H; Kuriyama K; Ozaki A; Tan X; Shibui K; Kamei Y; Okubo Y; Takahashi K, 2004, 'Time estimation during nocturnal sleep in human subjects', Neuroscience Research, 49, pp. 387 - 393, http://dx.doi.org/10.1016/j.neures.2004.04.006

Watanabe H; Murata Y; Ohashi I; Oda K; Matsushima E; Okubo Y; Shibuya H, 2004, 'Long-term change in size of cerebral infarction: Predictive value of brain perfusion SPECT using statistical parametric mapping', Cerebrovascular Diseases, 18, pp. 22 - 29, http://dx.doi.org/10.1159/000078604

Takahashi H; Koeda M; Oda K; Matsuda T; Matsushima E; Matsuura M; Asai K; Okubo Y, 2004, 'An fMRI study of differential neural response to affective pictures in schizophrenia', NeuroImage, 22, pp. 1247 - 1254, http://dx.doi.org/10.1016/j.neuroimage.2004.03.028

Yasuno F; Suhara T; Okubo Y; Sudo Y; Inoue M; Ichimiya T; Takano A; Nakayama K; Halldin C; Farde L, 2004, 'Low dopamine D2 receptor binding in subregions of the thalamus in schizophrenia', American Journal of Psychiatry, 161, pp. 1016 - 1022, http://dx.doi.org/10.1176/appi.ajp.161.6.1016

Shirahama Y; Ohta K; Takashima A; Matsushima E; Okubo Y, 2004, 'Magnetic brain activity elicited by visually presented symbols and Japanese characters', NeuroReport, 15, pp. 771 - 775, http://dx.doi.org/10.1097/00001756-200404090-00006

Yasuno F; Suhara T; Ichimiya T; Takano A; Ando T; Okubo Y, 2004, 'Decreased 5-HT1A receptor binding in amygdala of schizophrenia', Biological Psychiatry, 55, pp. 439 - 444, http://dx.doi.org/10.1016/j.biopsych.2003.11.016

Takano A; Suhara T; Ikoma Y; Yasuno F; Maeda J; Ichimiya T; Sudo Y; Inoue M; Okubo Y, 2004, 'Estimation of the time-course of dopamine D2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics', International Journal of Neuropsychopharmacology, 7, pp. 19 - 26, http://dx.doi.org/10.1017/S1461145703003912

Obata T; Someya Y; Suhara T; Ota Y; Hirakawa K; Ikehira H; Tanada S; Okubo Y, 2004, 'Neural damage due to temporal lobe epilepsy: Dual-nuclei (proton and phosphorus) magnetic resonance spectroscopy study', Psychiatry and Clinical Neurosciences, 58, pp. 48 - 53, http://dx.doi.org/10.1111/j.1440-1819.2004.01192.x

Sumiyoshi T; Meltzer HY; Yasuno F; Suhara T; Nakayama T; Ichimiya T; Takano A; Ando T; Inoue M; Maeda J; Suzuki K; Okubo Y, 2004, 'Serotonin 1A receptors in memory function [11] (multiple letters)', American Journal of Psychiatry, 161, pp. 1505 - 1506, http://dx.doi.org/10.1176/appi.ajp.161.8.1505

Yasuno F; Suhara T; Nakayama T; Ichimiya T; Takano A; Ando T; Inoue M; Maeda J; Suzuki K; Okubo Y, 2004, 'Dr. Yasuno and colleagues reply', AMERICAN JOURNAL OF PSYCHIATRY, 161, pp. 1505 - 1506, http://dx.doi.org/10.1176/appi.ajp.161.8.1505-a

Nogawa K; Kobayashi E; Okubo Y; Suwazono Y, 2004, 'Environmental cadmium exposure, adverse effects and preventive measures in Japan', BIOMETALS, 17, pp. 581 - 587, http://dx.doi.org/10.1023/B:BIOM.0000045742.81440.9c

Suwazono Y; Okubo Y; Kobayashi E; Miura K; Morikawa Y; Ishizaki M; Kido T; Nakagawa H; Nogawa K, 2004, 'Lack of association between human G-protein β3 subunit variant and overweight in Japanese workers', OBESITY RESEARCH, 12, pp. 4 - 8, http://dx.doi.org/10.1038/oby.2004.2

Okubo Y; Siddle K; Firth H; O'Rahilly S; Wilson LC; Willatt L; Fukushima T; Takahashi SI; Petry CJ; Saukkonen T; Stanhope R; Dunger DB, 2003, 'Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 88, pp. 5981 - 5988, http://dx.doi.org/10.1210/jc.2002-021080

Halldin C; Erixon-Lindroth N; Pauli S; Chou YH; Okubo Y; Karlsson P; Lundkvist C; Olsson H; Guilloteau D; Emond P; Farde L, 2003, '[¹¹C]PE21: A highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain', European Journal of Nuclear Medicine and Molecular Imaging, 30, pp. 1220 - 1230, http://dx.doi.org/10.1007/s00259-003-1212-3

Shioe K; Ichimiya T; Suhara T; Takano A; Sudo Y; Yasuno F; Hirano M; Shinohara M; Kagami M; Okubo Y; Nankai M; Kanba S, 2003, 'No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by pet', Synapse, 48, pp. 184 - 188, http://dx.doi.org/10.1002/syn.10204

Hossain AKMM; Murata Y; Zhang L; Taura SI; Saitoh Y; Mizusawa H; Oda K; Matsushima E; Okubo Y; Shibuya H, 2003, 'Brain perfusion SPECT in patients with corticobasal degeneration: Analysis using statistical parametric mapping', Movement Disorders, 18, pp. 697 - 703, http://dx.doi.org/10.1002/mds.10415

Suhara T; Takano A; Sudo Y; Ichimiya T; Inoue M; Yasuno F; Ikoma Y; Okubo Y, 2003, 'High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography', Archives of General Psychiatry, 60, pp. 386 - 391, http://dx.doi.org/10.1001/archpsyc.60.4.386

Nakamura M; Uchida S; Maehara T; Kawai K; Hirai N; Nakabayashi T; Arakaki H; Okubo Y; Nishikawa T; Shimizu H, 2003, 'Sleep spindles in human prefrontal cortex: An electrocorticographic study', Neuroscience Research, 45, pp. 419 - 427, http://dx.doi.org/10.1016/S0168-0102(03)00007-5

Ako M; Kawara T; Uchida S; Miyazaki S; Nishihara K; Mukai J; Hirao K; Ako J; Okubo Y, 2003, 'Correlation between electroencephalography and heart rate variability during sleep', Psychiatry and Clinical Neurosciences, 57, pp. 59 - 65, http://dx.doi.org/10.1046/j.1440-1819.2003.01080.x

Yasuno F; Suhara T; Nakayama T; Ichimiya T; Okubo Y; Takano A; Ando T; Inoue M; Maeda J; Suzuki K, 2003, 'Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory', American Journal of Psychiatry, 160, pp. 334 - 340, http://dx.doi.org/10.1176/appi.ajp.160.2.334

Oda K; Okubo Y; Ishida R; Murata Y; Ohta K; Matsuda T; Matsushima E; Ichimiya T; Suhara T; Shibuya H; Nishikawa T, 2003, 'Regional cerebral blood flow in depressed patients with white matter magnetic resonance hyperintensity', Biological Psychiatry, 53, pp. 150 - 156, http://dx.doi.org/10.1016/S0006-3223(02)01548-2

Hayashi Y; Kobayashi E; Okubo Y; Suwazono Y; Kido T; Nogawa K, 2003, 'Excretion levels of urinary calcium and phosphorus among the inhabitants of Cd-polluted Kakehashi River basin of Japan', BIOLOGICAL TRACE ELEMENT RESEARCH, 91, pp. 45 - 55, http://dx.doi.org/10.1385/BTER:91:1:45

Matsuda K; Kobayashi E; Okubo Y; Suwazono Y; Kido T; Nishijo M; Nakagawa H; Nogawa K, 2003, 'Total cadmium intake and mortality among residents in the Jinzu River Basin, Japan', ARCHIVES OF ENVIRONMENTAL HEALTH, 58, pp. 218 - 222, http://dx.doi.org/10.3200/AEOH.58.4.218-222

Nakayama T; Suhara T; Okubo Y; Ichimiya T; Yasuno F; Maeda J; Takano A; Saijo T; Suzuki K, 2002, 'In vivo drug action of tandospirone at 5-HT1A receptor examined using positron emission tomography and neuroendocrine response', Psychopharmacology, 165, pp. 37 - 42, http://dx.doi.org/10.1007/s00213-002-1234-8

Adachi N; Matsuura M; Hara T; Oana Y; Okubo Y; Kato M; Onuma T, 2002, 'Psychoses and epilepsy: Are interictal and postictal psychoses distinct clinical entities?', Epilepsia, 43, pp. 1574 - 1582, http://dx.doi.org/10.1046/j.1528-1157.2002.22402.x

Yamamoto M; Suhara T; Okubo Y; Ichimiya T; Sudo Y; Inoue M; Takano A; Yasuno F; Yoshikawa K; Tanada S, 2002, 'Age-related decline of serotonin transporters in living human brain of healthy males', Life Sciences, 71, pp. 751 - 757, http://dx.doi.org/10.1016/S0024-3205(02)01745-9

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