By Dr Yoshiro Okubo

Journal articles

Ichimiya T; Suhara T; Sudo Y; Okubo Y; Nakayama K; Nankai M; Inoue M; Yasuno F; Takano A; Maeda J; Shibuya H, 2002, 'Serotonin transporter binding in patients with mood disorders: A PET study with [¹¹C](+)McN5652', Biological Psychiatry, 51, pp. 715 - 722, http://dx.doi.org/10.1016/S0006-3223(01)01351-8

Watanabe Y; Kobayashi E; Okubo Y; Suwazono Y; Kido T; Nogawa K, 2002, 'Relationship between cadmium concentration in rice and renal dysfunction in individual subjects of the Jinzu River basin determined using a logistic regression analysis', TOXICOLOGY, 172, pp. 93 - 101, http://dx.doi.org/10.1016/S0300-483X(01)00557-1

Adachi N; Onuma T; Hara T; Matsuura M; Okubo Y; Kato M; Oana Y, 2002, 'Frequency and age-related variables in interictal psychoses in localization-related epilepsies', Epilepsy Research, 48, pp. 25 - 31, http://dx.doi.org/10.1016/S0920-1211(01)00329-1

Ishiguro H; Okubo Y; Ohtsuki T; Yamakawa-Kobayashi K; Arinami T, 2002, 'Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: Possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 114, pp. 15 - 23, http://dx.doi.org/10.1002/ajmg.1620

Sassa T; Suhara T; Ikehira H; Obata T; Girard F; Tanada S; Okubo Y, 2002, '¹⁹F-magnetic resonance spectroscopy and chemical shift imaging for schizophrenic patients using haloperidol decanoate', Psychiatry and Clinical Neurosciences, 56, pp. 637 - 642, http://dx.doi.org/10.1046/j.1440-1819.2002.01068.x

Suhara T; Okubo Y; Yasuno F; Sudo Y; Inoue M; Ichimiya T; Nakashima Y; Nakayama K; Tanada S; Suzuki K; Halldin C; Farde L, 2002, 'Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia', Archives of General Psychiatry, 59, pp. 25 - 30, http://dx.doi.org/10.1001/archpsyc.59.1.25

Matsuda T; Kobayashi E; Okubo Y; Suwazono Y; Kido T; Nishijo M; Nakagawa H; Nogawa K, 2002, 'Association between renal dysfunction and mortality among inhabitants in the region around the Jinzu River basin polluted by cadmium', ENVIRONMENTAL RESEARCH, 88, pp. 156 - 163, http://dx.doi.org/10.1006/enrs.2002.4336

Kobayashi E; Okubo Y; Suwazono Y; Kido T; Nishijo M; Nakagawa H; Nogawa K, 2002, 'Association between urinary calcium excretion level and mortality in inhabitants of the Jinzu River basin area of Japan', BIOLOGICAL TRACE ELEMENT RESEARCH, 89, pp. 145 - 153, http://dx.doi.org/10.1385/BTER:89:2:145

Tsukadaira A; Okubo Y; Ogasawara H; Urushibata K; Honda T; Miura I; Kubo K, 2002, 'Chromosomal aberrations in intravascular lymphomatosis', AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 25, pp. 178 - 181, http://dx.doi.org/10.1097/00000421-200204000-00015

Furukawa H; Fujita H; Kokubu I; Yamamoto Y; Sasaki S; Chodon T; Okubo Y; Sugihara T; Kuzumaki N, 2002, 'Identification of a novel gelsolin truncate in the vertical and metastatic phase malignant melanomas', MELANOMA RESEARCH, 12, pp. 523 - 528, http://dx.doi.org/10.1097/00008390-200212000-00001

Kobayashi E; Okubo Y; Suwazono Y; Kido T; Nishijo M; Nakagawa H; Nogawa K, 2002, 'Influence of years engaged in agriculture and number of pregnancies and deliveries on mortality of inhabitants of the Jinzu River basin area, Japan', OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 59, pp. 847 - 850, http://dx.doi.org/10.1136/oem.59.12.847

Okubo Y; Hamada J; Takahashi Y; Tada M; Tsutsumida A; Furuuchi K; Aoyama T; Sugihara T; Moriuchi T, 2002, 'Transduction of HOXD3-antisense into human melanoma cells results in decreased invasive and motile activities', CLINICAL & EXPERIMENTAL METASTASIS, 19, pp. 503 - 511, http://dx.doi.org/10.1023/A:1020346211686

Okubo Y; Saijo T; Oda K, 2001, 'A review of MRI studies of progressive brain changes in schizophrenia', Journal of Medical and Dental Sciences, 48, pp. 61 - 67

Obayashi S; Matsushima E; Okubo Y; Ohkura T; Kojima T; Kakuma T, 2001, 'Relationship between exploratory eye movements and clinical course in schizophrenic patients', European Archives of Psychiatry and Clinical Neuroscience, 251, pp. 211 - 216, http://dx.doi.org/10.1007/s004060170029

Hamada J; Omatsu T; Okada F; Furuuchi K; Okubo Y; Takahashi Y; Tada M; Miyazaki YJ; Taniguchi Y; Shirato H; Miyasaka K; Moriuchi T, 2001, 'Overexpression of homeobox gene HOXD3 induces coordinate expression of metastasis-related genes in human lung cancer cells', INTERNATIONAL JOURNAL OF CANCER, 93, pp. 516 - 525, http://dx.doi.org/10.1002/ijc.1357

Inoue M; Suhara T; Sudo Y; Okubo Y; Yasuno F; Kishimoto T; Yoshikawa K; Tanada S, 2001, 'Age-related reduction of extrastriatal dopamine D2 receptor measured by PET', Life Sciences, 69, pp. 1079 - 1084, http://dx.doi.org/10.1016/S0024-3205(01)01205-X

Girard F; Suhara T; Sassa T; Okubo Y; Obata T; Ikehira H; Sudo Y; Koga M; Yoshioka H; Yoshida K, 2001, '⁷Li 2D CSI of human brain on a clinical scanner', Magnetic Resonance Materials in Physics, Biology and Medicine, 13, pp. 1 - 7, http://dx.doi.org/10.1016/S1352-8661(01)00117-X

Yoshikawa T; Kikuchi M; Saito K; Watanabe A; Yamada K; Shibuya H; Nankai M; Kurumaji A; Hattori E; Ishiguro H; Shimizu H; Okubo Y; Toru M; Detera-Wadleigh SD, 2001, 'Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples', Molecular Psychiatry, 6, pp. 202 - 210, http://dx.doi.org/10.1038/sj.mp.4000835

Nakabayashi T; Uchida S; Maehara T; Hirai N; Nakamura M; Arakaki H; Shimisu H; Okubo Y, 2001, 'Absence of sleep spindles in human medial and basal temporal lobes', Psychiatry and Clinical Neurosciences, 55, pp. 57 - 65, http://dx.doi.org/10.1046/j.1440-1819.2001.00785.x

Saijo T; Abe T; Someya Y; Sassa T; Sudo Y; Suhara T; Shuno T; Asai K; Okubo Y, 2001, 'Ten year progressive ventricular enlargement in schizophrenia: An MRI morphometrical study', Psychiatry and Clinical Neurosciences, 55, pp. 41 - 47, http://dx.doi.org/10.1046/j.1440-1819.2001.00783.x

Uchida S; Maehara T; Hirai N; Okubo Y; Shimizu H, 2001, 'Cortical oscillations in human medial temporal lobe during wakefulness and all-night sleep', Brain Research, 891, pp. 7 - 19, http://dx.doi.org/10.1016/S0006-8993(00)03154-1

Ishiguro H; Ohtsuki T; Okubo Y; Kurumaji A; Arinami T, 2001, 'Association analysis of the pituitary adenyl cyclase activating peptide gene (PACAP) on chromosome 18p11 with schizophrenia and bipolar disorders', Journal of Neural Transmission, 108, pp. 849 - 854, http://dx.doi.org/10.1007/s007020170034

Suhara T; Yasuno F; Sudo Y; Yamamoto M; Inoue M; Okubo Y; Suzuki K, 2001, 'Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking', NeuroImage, 13, pp. 891 - 895, http://dx.doi.org/10.1006/nimg.2001.0761

Yasuno F; Suhara T; Okubo Y; Sudo Y; Inoue M; Ichimiya T; Tanada S, 2001, 'Dose relationship of limbic-cortical D2-dopamine receptor occupancy with risperidone', Psychopharmacology, 154, pp. 112 - 114, http://dx.doi.org/10.1007/s002130000643

Ito H; Sudo Y; Suhara T; Okubo Y; Halldin C; Farde L, 2001, 'Error analysis for quantification of [¹¹C]FLB 457 binding to extrastriatal D2 dopamine receptors in the human brain', NeuroImage, 13, pp. 531 - 539, http://dx.doi.org/10.1006/nimg.2000.0717

Okubo Y; Suhara T, 2001, 'Receptor occupancy and antipsychotic drug action measured by PET and SPECT', Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 103, pp. 329 - 340

Ichimiya T; Okubo Y; Suhara T; Sudo Y, 2001, 'Reduced volume of the cerebellar vermis in neuroleptic-naive schizophrenia', Biological Psychiatry, 49, pp. 20 - 27, http://dx.doi.org/10.1016/S0006-3223(00)01081-7

Yasuno F; Suhara T; Sudo Y; Yamamoto M; Inoue M; Okubo Y; Suzuki K, 2001, 'Relation among dopamine D2 receptor binding, obesity and personality in normal human subjects', Neuroscience Letters, 300, pp. 59 - 61, http://dx.doi.org/10.1016/S0304-3940(01)01552-X

Osawa T; Kobayashi E; Okubo Y; Suwazono Y; Kido T; Nogawa K, 2001, 'A retrospective study on the relation between renal dysfunction and cadmium concentration in rice in individual hamlets in the Jinzu River basin, Toyama prefecture, Japan', ENVIRONMENTAL RESEARCH, 86, pp. 51 - 59, http://dx.doi.org/10.1006/enrs.2001.4248

Takashi S; Okubo Y; Horie S, 2001, 'Contribution of CD54 to human eosinophil and neutrophil superoxide production', JOURNAL OF APPLIED PHYSIOLOGY, 91, pp. 613 - 622, http://dx.doi.org/10.1152/jappl.2001.91.2.613

Tsukadaira A; Okubo Y; Horie S; Koyama S, 2001, 'Theophylline inhibits TNF-α-induced CD4 expression on human eosinophils and CD4+eosinophil migration', INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 125, pp. 335 - 343, http://dx.doi.org/10.1159/000053835

Adachi N; Matsuura M; Okubo Y; Oana Y; Takei N; Kato M; Hara T; Onuma T, 2000, 'Predictive variables of interictal psychosis in epilepsy', Neurology, 55, pp. 1310 - 1314, http://dx.doi.org/10.1212/WNL.55.9.1310

Kikuchi M; Saito K; Watanabe A; Yamada K; Shibuya H; Nankai M; Kurumaji A; Hattori E; Ishiguro H; Shimizu H; Okubo Y; Toru M; Detera-Wadleigh SD; Yoshikawa T, 2000, 'Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples', American Journal of Medical Genetics - Neuropsychiatric Genetics, 96, pp. 477

Hara K; Terasaki O; Okubo Y, 2000, 'Dipole estimation of alpha EEG during alcohol ingestion in males genotypes for ALDH2', Life Sciences, 67, pp. 1163 - 1173, http://dx.doi.org/10.1016/S0024-3205(00)00707-4

Okubo Y; Suhara T; Suzuki K; Kobayashi K; Inoue O; Terasaki O; Someya Y; Sassa T; Sudo Y; Matsushima E; Iyo M; Tateno Y; Toru M, 2000, 'Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography', Life Sciences, 66, pp. 2455 - 2464, http://dx.doi.org/10.1016/S0024-3205(00)80005-3

Kurumaji A; Nomoto H; Yoshikawa T; Okubo Y; Toru M, 2000, 'An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample', Journal of Neural Transmission, 107, pp. 491 - 500, http://dx.doi.org/10.1007/s007020070090

Matsuura M; Adachi N; Oana Y; Okubo Y; Hara T; Onuma T, 2000, 'Proposal for a New Five-Axis Classification Scheme for Psychoses of Epilepsy', Epilepsy and Behavior, 1, pp. 343 - 352, http://dx.doi.org/10.1006/ebeh.2000.0113

Someya Y; Obata T; Suhara T; Ota Y; Ikehira H; Tanada S; Hirakawa K; Okubo Y; Sasaki Y, 2000, 'Seizure frequency and bilateral temporal abnormalities: A proton magnetic resonance spectroscopy of temporal lobe epilepsy', Seizure, 9, pp. 274 - 279, http://dx.doi.org/10.1053/seiz.2000.0396

Soejima K; Yamaguchi K; Kohda E; Takeshita K; Ito Y; Matsubara H; Oguma T; Inoue T; Okubo Y; Amakawa K; Tateno H; Shiomi T, 2000, 'Longitudinal follow-up study of smoking-induced lung density changes by high-resolution computed tomography', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 161, pp. 1264 - 1273, http://dx.doi.org/10.1164/ajrccm.161.4.9905040

Suwazono Y; Kobayashi E; Okubo Y; Nogawa K; Kido T; Nakagawa H, 2000, 'Renal effects of cadmium exposure in cadmium nonpolluted areas in Japan', ENVIRONMENTAL RESEARCH, 84, pp. 44 - 55, http://dx.doi.org/10.1006/enrs.2000.4086

Takashi S; Okubo Y; Horie S; Momose T; Tsukadaira A; Agematsu K; Sekiguchi M, 2000, 'Spontaneous B-cell IgE production in a patient with remarkable eosinophilia and hyper IgE', ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 85, pp. 150 - 155, http://dx.doi.org/10.1016/S1081-1206(10)62456-8

Bergström KA; Halldin C; Savonen A; Okubo Y; Hiltunen J; Nobuhara K; Swahn CG; Karlsson P; McPherson D; Knapp FF; Larsson S; Schnell PO; Farde L, 1999, 'Iodine-123 labelled Z-(R,R)-IQNP: A potential radioligand for visualization of M1 and M2 muscarinic acetylcholine receptors in Alzheimer's disease', European Journal of Nuclear Medicine, 26, pp. 1482 - 1485, http://dx.doi.org/10.1007/s002590050482

Hirai N; Uchida S; Maehara T; Okubo Y; Shimizu H, 1999, 'Beta-1 (10-20 Hz) cortical oscillations observed in the human medial temporal lobe', NeuroReport, 10, pp. 3055 - 3059, http://dx.doi.org/10.1097/00001756-199909290-00033

Hirai N; Uchida S; Maehara T; Okubo Y; Shimizu H, 1999, 'Enhanced gamma (30-150 Hz) frequency in the human medial temporal lobe', Neuroscience, 90, pp. 1149 - 1155, http://dx.doi.org/10.1016/S0306-4522(98)00513-2

Sudo Y; Suhara T; Suzuki K; Okubo Y; Yoshikawa K; Uchida S; Sassa T; Okauchi T; Sasaki Y; Matsushita M, 1999, 'Muscarinic receptor occupancy by biperiden in living human brain', Life Sciences, 64, pp. PL99 - PL104, http://dx.doi.org/10.1016/S0024-3205(98)00613-4

Suhara T; Sudo Y; Okauchi T; Maeda J; Kawabe K; Suzuki K; Okubo Y; Nakashima Y; Ito H; Tanada S; Halldin C; Farde L, 1999, 'Extrastriatal dopamine D2 receptor density and affinity in the human brain measured by 3D PET', International Journal of Neuropsychopharmacology, 2, pp. 73 - 82, http://dx.doi.org/10.1017/S1461145799001431

Ito H; Okubo Y; Halldin C; Farde L, 1999, 'Mapping of central D2 dopamine receptors in man using [¹¹C]raclopride: PET with anatomic standardization technique', NeuroImage, 9, pp. 235 - 242, http://dx.doi.org/10.1006/nimg.1998.0401

Helfenbein J; Sandell J; Halldin C; Chalon S; Emond P; Okubo Y; Chou YH; Frangin Y; Douziech L; Gareau L; Swahn CG; Besnard JC; Farde L; Guilloteau D, 1999, 'PET examination of three potent cocaine derivatives as specific radioligands for the serotonin transporter', Nuclear Medicine and Biology, 26, pp. 491 - 499, http://dx.doi.org/10.1016/S0969-8051(99)00004-9

Okubo Y; Olsson H; Ito H; Lofti M; Suhara T; Halldin C; Farde L, 1999, 'PET mapping of extrastriatal D2-like dopamine receptors in the human brain using an anatomic standardization technique and [¹¹C]FLB 457', NeuroImage, 10, pp. 666 - 674, http://dx.doi.org/10.1006/nimg.1999.0502

Ishiguro H; Ohtsuki T; Toru M; Itokawa M; Aoki J; Shibuya H; Kurumaji A; Okubo Y; Iwawaki A; Ota K; Shimizu H; Hamaguchi H; Arinami T, 1998, 'Association between polymorphisms in the type 1 sigma receptor gene and schizophrenia', Neuroscience Letters, 257, pp. 45 - 48, http://dx.doi.org/10.1016/S0304-3940(98)00797-6

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