By Professor Alexander Swarbrick

Journal articles

Andersson A; Larsson L; Stenbeck L; Salmén F; Ehinger A; Wu S; Al-Eryani G; Roden D; Swarbrick A; Borg Å; Frisén J; Engblom C; Lundeberg J, 2020, 'Spatial Deconvolution of HER2-positive Breast Tumors Reveals Novel Intercellular Relationships', bioRxiv, http://dx.doi.org/10.1101/2020.07.14.200600

Hoque M; Elmaghrabi YA; Köse M; Beevi SS; Jose J; Meneses-Salas E; Blanco-Muñoz P; Conway JRW; Swarbrick A; Timpson P; Tebar F; Enrich C; Rentero C; Grewal T, 2020, 'Annexin A6 improves anti-migratory and anti-invasive properties of tyrosine kinase inhibitors in EGFR overexpressing human squamous epithelial cells', FEBS Journal, 287, pp. 2961 - 2978, http://dx.doi.org/10.1111/febs.15186

Portman N; Milioli HH; Alexandrou S; Coulson R; Yong A; Fernandez KJ; Chia KM; Segara D; Parker A; Haupt S; Haupt Y; Tilley WD; Swarbrick A; Caldon CE; Lim E, 2020, 'MDM2 Inhibition in Combination with Endocrine Therapy and CDK4/6 Inhibition for the Treatment of ER-Positive Breast Cancer', , http://dx.doi.org/10.1101/2020.06.09.140921

Baker LA; Holliday H; Roden D; Krisp C; Wu SZ; Junankar S; Junankar S; Serandour AA; Mohammed H; Nair R; Sankaranarayanan G; Law AMK; McFarland A; Simpson PT; Lakhani S; Dodson E; Selinger C; Anderson L; Samimi G; Hacker NF; Lim E; Ormandy CJ; Naylor MJ; Simpson K; Nikolic I; O'Toole S; Kaplan W; Cowley MJ; Carroll JS; Molloy M; Swarbrick A, 2020, 'Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer', Breast Cancer Research, 22, http://dx.doi.org/10.1186/s13058-020-01306-6

Wu S; Roden D; Al-Eryani G; Bartonicek N; Harvey K; Cazet A; Chan C-L; Junankar S; Hui M; Millar E; Beretov J; Horvath L; Joshua A; Stricker P; Wilmott J; Quek C; Long G; Scolyer R; Yeung B; Segara D; Mak C; Warrier S; Powell J; O'Toole S; Lim E; Swarbrick A, 2020, 'Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis', bioRxiv, http://dx.doi.org/10.1101/2020.06.04.135277

Wu S; Roden D; Wang C; Holliday H; Harvey K; Cazet A; Murphy K; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy J; Junankar S; Chan C-L; Lam E; Hui M; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O’Toole S; Cox T; Timpson P; Lim E; Liu S; Swarbrick A, 2020, 'Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer', bioRxiv, http://dx.doi.org/10.1101/2020.06.04.135327

Owen KL; Gearing LJ; Zanker DJ; Brockwell NK; Khoo WH; Roden DL; Cmero M; Mangiola S; Hong MK; Spurling AJ; McDonald M; Chan CL; Pasam A; Lyons RJ; Duivenvoorden HM; Ryan A; Butler LM; Mariadason JM; Giang Phan T; Hayes VM; Sandhu S; Swarbrick A; Corcoran NM; Hertzog PJ; Croucher PI; Hovens C; Parker BS, 2020, 'Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone', EMBO Reports, 21, http://dx.doi.org/10.15252/embr.202050162

Piggin CL; Roden DL; Law AMK; Molloy MP; Krisp C; Swarbrick A; Naylor MJ; Kalyuga M; Kaplan W; Oakes SR; Gallego-Ortega D; Clark SJ; Carroll JS; Bartonicek N; Ormandy CJ, 2020, 'ELF5 modulates the estrogen receptor cistrome in breast cancer', PLoS Genetics, 16, http://dx.doi.org/10.1371/journal.pgen.1008531

Yang Y; Cooper C; Robbins E; Swarbrick A; Harvey K; Lim E; Mak C; Carmalt H; Warrier S; Chan B; Beith J; Hui M; Gluch L; O’Toole S; Cooper W, 2020, '9. Factors influencing the success rate of patient derived xenograft formation from breast cancer specimens', Pathology, 52, pp. S136 - S136, http://dx.doi.org/10.1016/j.pathol.2020.01.010

Holliday H; Roden D; Junankar S; Wu S; Baker L; Krisp C; Chan C-L; McFarland A; Skhinas J; Cox T; Pal B; Huntington N; Ormandy C; Carroll J; Visvader J; Molloy M; Swarbrick A, 2020, 'Inhibitor of Differentiation 4 (ID4) represses myoepithelial differentiation of mammary stem cells through its interaction with HEB', , http://dx.doi.org/10.1101/2020.04.06.026963

Singh M; Al-Eryani G; Carswell S; Ferguson JM; Blackburn J; Barton K; Roden D; Luciani F; Giang Phan T; Junankar S; Jackson K; Goodnow CC; Smith MA; Swarbrick A, 2019, 'High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-11049-4

Brockwell NK; Rautela J; Owen KL; Gearing LJ; Deb S; Harvey K; Spurling A; Zanker D; Chan CL; Cumming HE; Deng N; Zakhour JM; Duivenvoorden HM; Robinson T; Harris M; White M; Fox J; Ooi C; Kumar B; Thomson J; Potasz N; Swarbrick A; Hertzog PJ; Molloy TJ; Toole SO; Ganju V; Parker BS, 2019, 'Tumor inherent interferon regulators as biomarkers of long-term chemotherapeutic response in TNBC', npj Precision Oncology, 3, http://dx.doi.org/10.1038/s41698-019-0093-2

McCabe M; Gauthier M-E; Chan C-L; Thompson T; De Sousa S; Puttick C; Grady J; Gayevskiy V; Tao J; Ying K; Cipponi A; Deng N; Swarbrick A; Thomas M; kConFab ; Lord R; Johns A; Kohonen-Corish M; O'Toole S; Clark J; Mueller S; Gupta R; McCormack A; Dinger M; Cowley M; Bastick P; Friedlander M; Colley A; Andrews L; Young M-A; Tucker K; Williams R, 2019, 'Development and validation of a targeted gene sequencing panel for application to disparate cancers', Scientific Reports, 9, pp. 17052, http://dx.doi.org/10.1038/s41598-019-52000-3

Castillo L; George S; Lin H-M; Yeung N; Mawson A; Young AI; Law AM; Hastings J; Gallego-Ortega D; Deng N; Croucher D; Swarbrick A; Horvath L; Ormandy CJ; Oakes SR, 2019, 'Flicking the switch off, targeting MCL-1 in the treatment of breast and prostate cancer', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p038

Money A-M; Schaverin J; Aubel P; Neist E; Owens T; Swarbrick A; Taniuchi I; Ormandy CJ; Simpson PT; Naylor MJ, 2019, 'Novel role of CBF[beta] as a regulator of breast cancer phenotype, progression and metastasis', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p037

Roden D; Wu S; Harvey K; Chan C-L; Al-Eryani G; Cazet A; Lim E; Swarbrick A, 2019, 'Single-cell transcriptomics reveals marked heterogeneity for intrinsic molecular subtype and cellular function in estrogen receptor positive breast cancer', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p045

Cazet A; Hui M; Elsworth B; Wu S; Roden D; Chan C-L; O'Toole S; Watkins DN; Taylor R; Cox T; Samuel M; Martin M; Swarbrick A, 2019, 'Targeting stromal remodelling and cancer stem cell plasticity overcomes chemoresistance in metastatic triple negative breast cancer', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p009

Khoo WH; Ledergor G; Weiner A; Roden DL; Terry RL; McDonald MM; Chai RC; De Veirman K; Owen KL; Opperman KS; Vandyke K; Clark JR; Seckinger A; Kovacic N; Nguyen A; Mohanty ST; Pettitt JA; Xiao Y; Corr AP; Seeliger C; Novotny M; Lasken RS; Nguyen TV; Oyajobi BO; Aftab D; Swarbrick A; Parker B; Hewett DR; Hose D; Vanderkerken K; Zannettino ACW; Amit I; Phan TG; Croucher PI, 2019, 'A niche-dependent myeloid transcriptome signature defines dormant myeloma cells', Blood, 134, pp. 30 - 43, http://dx.doi.org/10.1182/blood.2018880930

Chia KM; Milioli H; Portman N; Laven-Law G; Coulson R; Yong A; Segara D; Parker A; Caldon CE; Deng N; Swarbrick A; Tilley WD; Hickey TE; Lim E, 2019, 'Non-canonical AR activity facilitates endocrine resistance in breast cancer', Endocrine-Related Cancer, 26, pp. 251 - 264, http://dx.doi.org/10.1530/ERC-18-0333

Papachristou EK; Kishore K; Holding AN; Harvey K; Roumeliotis TI; Chilamakuri CSR; Omarjee S; Chia KM; Swarbrick A; Lim E; Markowetz F; Eldridge M; Siersbaek R; D’Santos CS; Carroll JS, 2018, 'A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-04619-5

Lin HM; Nikolic I; Yang J; Castillo L; Deng N; Chan CL; Yeung NK; Dodson E; Elsworth B; Spielman C; Lee BY; Boyer Z; Simpson KJ; Daly RJ; Horvath LG; Swarbrick A, 2018, 'MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer', Scientific Reports, 8, http://dx.doi.org/10.1038/s41598-018-26050-y

Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan CL; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel MS; Martín M; Swarbrick A; O'Toole S, 2018, 'Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer', Nature Communications, 9, pp. 2897, http://dx.doi.org/10.1038/s41467-018-05220-6

Holliday H; Baker LA; Junankar SR; Clark SJ; Swarbrick A, 2018, 'Epigenomics of mammary gland development', Breast Cancer Research, 20, http://dx.doi.org/10.1186/s13058-018-1031-x

Rogers S; McCloy RA; Parker BL; Gallego-Ortega D; Law AMK; Chin VT; Conway JRW; Fey D; Millar EKA; O’Toole S; Deng N; Swarbrick A; Chastain PD; Cesare AJ; Timpson P; Caldon CE; Croucher DR; James DE; Watkins DN; Burgess A, 2018, 'MASTL overexpression promotes chromosome instability and metastasis in breast cancer', Oncogene, 37, pp. 4518 - 4533, http://dx.doi.org/10.1038/s41388-018-0295-z

Baker L; Krisp C; Roden D; Holliday H; Wu S; Junankar S; Serandour A; Mohammed H; Nair R; Chan C-L; Yang J; Foreman N; Fitzpatrick B; Sankaranarayanan G; Law AMK; Ormandy C; Naylor M; McFarland A; Simpson P; Lakhani S; O'Toole S; Selinger C; Anderson L; Samimi G; Hacker N; Kaplan W; Carroll J; Molloy M; Swarbrick A, 2018, 'A novel role for the HLH protein Inhibitor of Differentiation 4 (ID4) in the DNA damage response in basal-like breast cancer.', BIORXIV, http://dx.doi.org/10.1101/281196

Wirasinha RC; Vijayan D; Smith NJ; Parnell GP; Swarbrick A; Brink R; King C; Stewart G; Booth DR; Batten M, 2018, 'GPR65 inhibits experimental autoimmune encephalomyelitis through CD4⁺ T cell independent mechanisms that include effects on iNKT cells', Immunology and Cell Biology, 96, pp. 128 - 136, http://dx.doi.org/10.1111/imcb.1031

Singh M; Al-Eryani G; Carswell S; Ferguson J; Blackburn J; Barton K; Roden D; Luciani F; Phan T; Junankar S; Jackson K; Goodnow C; Smith M; Swarbrick A, 2018, 'High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes', , http://dx.doi.org/10.1101/424945

Lin H-M; Nikolic I; Yang J; Castillo L; Deng N; Chan C-L; Yeung N; Dodson E; Elsworth B; Spielman C; Lee B; Boyer Z; Simpson K; Daly R; Horvath L; Swarbrick A, 2018, 'MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer', , http://dx.doi.org/10.1101/273284

Nikolic I; Elsworth B; Dodson E; Wu SZ; Gould CM; Mestdagh P; Marshall GM; Horvath LG; Simpson KJ; Swarbrick A, 2017, 'Discovering cancer vulnerabilities using high-throughput micro-RNA screening', Nucleic Acids Research, 45, pp. 12657 - 12670, http://dx.doi.org/10.1093/nar/gkx1072

Weinberg F; Reischmann N; Fauth L; Taromi S; Mastroianni J; Köhler M; Halbach S; Becker AC; Deng N; Schmitz T; Uhl FM; Herbener N; Riedel B; Beier F; Swarbrick A; Lassmann S; Dengjel J; Zeiser R; Brummer T, 2017, 'The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior', EBioMedicine, 20, pp. 79 - 97, http://dx.doi.org/10.1016/j.ebiom.2017.04.015

Lin HM; Mahon KL; Spielman C; Gurney H; Mallesara G; Stockler MR; Bastick P; Briscoe K; Marx G; Swarbrick A; Horvath LG, 2017, 'Phase 2 study of circulating microRNA biomarkers in castration-resistant prostate cancer', British Journal of Cancer, 116, pp. 1002 - 1011, http://dx.doi.org/10.1038/bjc.2017.50

Rojo F; Ruiz Borrego M; Hui M; Trigo Perez JM; Cazet A; Karsdal MA; Urruticoechea A; Antolin S; García-Saenz JA; O’Toole S; Blach A; Perez-Ramos L; Bezares S; Sánchez-Aragó M; Caballero R; Bager CL; Swarbrick A; Martin Jimenez M, 2017, 'Tumor microenvironment biomarkers as therapeutic strategies for TNBC', Annals of Oncology, 28, pp. v597 - v597, http://dx.doi.org/10.1093/annonc/mdx391.004

Beckers RK; Selinger CI; Vilain R; Madore J; Wilmott JS; Harvey K; Holliday A; Cooper CL; Robbins E; Gillett D; Kennedy CW; Gluch L; Carmalt H; Mak C; Warrier S; Gee HE; Chan C; McLean A; Walker E; McNeil CM; Beith JM; Swarbrick A; Scolyer RA; O'Toole SA, 2016, 'Programmed death ligand 1 expression in triple-negative breast cancer is associated with tumour-infiltrating lymphocytes and improved outcome', Histopathology, 69, pp. 25 - 34, http://dx.doi.org/10.1111/his.12904

Sax MJ; Gasch C; Athota VR; Freeman R; Rasighaemi P; Westcott DE; Day CJ; Nikolic I; Elsworth B; Wei M; Rogers K; Swarbrick A; Mittal V; Pouliot N; Mellick AS, 2016, 'Cancer cell CCL5 mediates bone marrow independent angiogenesis in breast cancer', Oncotarget, 7, pp. 85437 - 85449, http://dx.doi.org/10.18632/oncotarget.13387

Baker LA; Holliday H; Swarbrick A, 2016, 'ID4 controls luminal lineage commitment in normal mammary epithelium and inhibits BRCA1 function in basal-like breast cancer', Endocrine-Related Cancer, 23, pp. R381 - R392, http://dx.doi.org/10.1530/ERC-16-0196

Beckers RK; Selinger C; Vilain R; Madore J; Wilmott JS; Harvey K; Holliday A; Cooper CL; Robbins E; Gillet D; Kennedy CW; Gluch L; Carmalt H; Mak C; Warrier S; Gee HE; Chan C; McLean A; Walker E; McNeil CM; Beith JM; Swarbrick A; Scolyer RA; O'Toole SA, 2016, 'PDl1 expression in triple-negative breast cancer is associated with tumour-infiltrating lymphocytes and improved outcome.', Pathology, 48 Suppl 1, pp. S146 - S147, http://dx.doi.org/10.1016/j.pathol.2015.12.399

Gallego-Ortega D; Ledger A; Roden DL; Law AMK; Magenau A; Kikhtyak Z; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Herrmann D; Salomon R; Young AIJ; Lee BY; Sergio CM; Kaplan W; Piggin C; Conway JRW; Rabinovich B; Millar EKA; Oakes SR; Chtanova T; Swarbrick A; Naylor MJ; O’Toole S; Green AR; Timpson P; Gee JMW; Ellis IO; Clark SJ; Ormandy CJ, 2015, 'ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells', PLoS Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002330

Gee HE; Buffa FM; Harris AL; Toohey JM; Carroll SL; Cooper CL; Beith J; McNeil C; Carmalt H; Mak C; Warrier S; Holliday A; Selinger C; Beckers R; Kennedy C; Graham P; Swarbrick A; Millar EKA; O'Toole SA; Molloy T, 2015, 'MicroRNA-related DNA repair/cell-cycle genes independently associated with relapse after radiation therapy for early breast cancer', International Journal of Radiation Oncology Biology Physics, 93, pp. 1104 - 1114, http://dx.doi.org/10.1016/j.ijrobp.2015.08.046

Phua YW; Nguyen A; Roden DL; Elsworth B; Deng N; Nikolic I; Yang J; Mcfarland A; Russell R; Kaplan W; Cowley MJ; Nair R; Zotenko E; O'Toole S; Tan SX; James DE; Clark SJ; Kouros-Mehr H; Swarbrick A, 2015, 'MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene', Breast Cancer Research, http://dx.doi.org/10.1186/s13058-015-0593-0

Hui M; Cazet A; Jessica Y; Cooper C; McFarland A; Nair R; O'Toole S; Swarbrick A, 2015, 'Targeting the hedgehog signalling pathway in triple negative breast cancer', Annals of Oncology, 26, pp. iii31, http://dx.doi.org/10.1093/annonc/mdv121.02

Junankar S; Baker LA; Roden DL; Nair R; Elsworth B; Gallego-Ortega D; Lacaze P; Cazet A; Nikolic I; Teo WS; Yang J; McFarland A; Harvey K; Naylor MJ; Lakhani SR; Simpson PT; Raghavendra A; Saunus J; Madore J; Kaplan W; Ormandy C; Millar EKA; O'Toole S; Yun K; Swarbrick A, 2015, 'ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype', NATURE COMMUNICATIONS, 6, http://dx.doi.org/10.1038/ncomms7548

Liu PY; Erriquez D; Marshall GM; Tee AE; Polly P; Wong M; Liu B; Bell JL; Zhang XD; Milazzo G; Cheung BB; Fox A; Swarbrick A; Hüttelmaier S; Kavallaris M; Perini G; Mattick JS; Dinger ME; Liu T, 2015, 'Erratum: Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression (Journal of the National Cancer Institute (2014) 106:7 (dju113) DOI: 10.1093/jnci/dju113)', Journal of the National Cancer Institute, 107, http://dx.doi.org/10.1093/jnci/dju359

Junankar S; Baker LA; Roden DL; Nair R; Elsworth B; Gallego-Ortega D; Lacaze P; Cazet A; Nikolic I; Teo WS; Yang J; McFarland A; Harvey K; Naylor MJ; Lakhani SR; Simpson PT; Raghavendra A; Saunus J; Madore J; Kaplan W; Ormandy C; Millar EKA; O'Toole S; Yun K; Swarbrick A, 2015, 'ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms7548

Junankar S; Shay G; Jurczyluk J; Ali N; Down J; Pocock N; Parker A; Nguyen A; Sun S; Kashemirov B; McKenna CE; Croucher PI; Swarbrick A; Weilbaecher K; Phan TG; Rogers MJ, 2015, 'Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer', Cancer Discovery, 5, pp. 35 - 42, http://dx.doi.org/10.1158/2159-8290.CD-14-0621

Ali NA; Wu J; Hochgräfe F; Chan H; Nair R; Ye S; Zhang L; Lyons RJ; Pinese M; Lee HC; Armstrong N; Ormandy CJ; Clark SJ; Swarbrick A; Daly RJ, 2014, 'Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways', Breast Cancer Research, 16, http://dx.doi.org/10.1186/s13058-014-0437-3

Owens TW; Rogers RL; Best SA; Ledger A; Mooney AM; Ferguson A; Shore P; Swarbrick A; Ormandy CJ; Simpson PT; Carroll JS; Visvader JE; Naylor MJ, 2014, 'Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer', Cancer Research, 74, pp. 5277 - 5286, http://dx.doi.org/10.1158/0008-5472.CAN-14-0053

Liu PY; Erriquez D; Marshall GM; Tee AE; Polly P; Wong M; Liu B; Bell JL; Zhang XD; Milazzo G; Cheung BB; Fox A; Swarbrick A; Hüttelmaier S; Kavallaris M; Perini G; Mattick JS; Dinger ME; Liu T, 2014, 'Effects of a Novel Long Noncoding RNA, lncUSMycN, on N-Myc Expression and Neuroblastoma Progression', Journal of the National Cancer Institute, 106, pp. dju113, http://dx.doi.org/10.1093/jnci/dju113

Teo WS; Nair R; Swarbrick A, 2014, 'New insights into the role of ID proteins in breast cancer metastasis: A MET affair', Breast Cancer Research, 16, http://dx.doi.org/10.1186/bcr3654

Lin HM; Castillo L; Mahon KL; Chiam K; Lee BY; Nguyen Q; Boyer MJ; Stockler MR; Pavlakis N; Marx G; Mallesara G; Gurney H; Clark SJ; Swarbrick A; Daly RJ; Horvath LG, 2014, 'Circulating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer', British Journal of Cancer, 110, pp. 2462 - 2471, http://dx.doi.org/10.1038/bjc.2014.181

Nair R; Teo WS; Mittal V; Swarbrick A, 2014, 'ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities', Molecular Therapy, 22, pp. 1407 - 1415, http://dx.doi.org/10.1038/mt.2014.83

Back to profile page