By Professor Alexander Swarbrick

Journal articles

Selinger CI; Beckers R; Tran T; Cooper W; Harvey K; Swarbrick A; O’Toole S, 2014, 'MET Copy number in triple negative breast cancers', Pathology, 46, pp. S80 - S81, http://dx.doi.org/10.1097/01.pat.0000443613.80012.22

Swarbrick A; Junankar SR; Batten M, 2013, 'Could the properties of IL-27 make it an ideal adjuvant for anticancer immunotherapy', OncoImmunology, 2, http://dx.doi.org/10.4161/onci.25409

Nair R; Roden DL; Teo WS; McFarland A; Junankar S; Ye S; Nguyen A; Yang J; Nikolic I; Hui M; Morey A; Shah J; Pfefferle AD; Usary J; Selinger C; Baker LA; Armstrong N; Cowley MJ; Naylor MJ; Ormandy CJ; Lakhani SR; Herschkowitz JI; Perou CM; Kaplan W; O'Toole SA; Swarbrick A, 2013, 'c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer', Oncogene, http://dx.doi.org/10.1038/onc.2013.368

Koese M; Rentero C; Kota BP; Hoque M; Cairns R; Wood P; Vilà De Muga S; Reverter M; Alvarez-Guaita A; Monastyrskaya K; Hughes WE; Swarbrick A; Tebar F; Daly RJ; Enrich C; Grewal T, 2013, 'Annexin A6 is a scaffold for PKCα to promote EGFR inactivation', Oncogene, 32, pp. 2858 - 2872, http://dx.doi.org/10.1038/onc.2012.303

Al-Ejeh F; Shi W; Miranda M; Simpson PT; Vargas AC; Song S; Wiegmans AP; Swarbrick A; Welm AL; Brown MP; Chenevix-Trench G; Lakhani SR; Khanna KK, 2013, 'Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor', Journal of Nuclear Medicine, 54, pp. 913 - 921, http://dx.doi.org/10.2967/jnumed.112.111534

Warrier S; Sellinger C; Beith JM; Cazet A; Swarbrick A; Carmalt H; O'Toole S, 2013, 'Claudin-1 as a novel transcriptional target of hedgehog signaling and a predictor for outcome in breast cancer.', Journal of Clinical Oncology, 31, pp. 1053 - 1053, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.1053

Hui M; Cazet A; Nair R; Watkins DN; O'Toole SA; Swarbrick A, 2013, 'The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy', Breast Cancer Research, 15, http://dx.doi.org/10.1186/bcr3401

Croucher DR; Hochgräfe F; Zhang L; Liu L; Lyons RJ; Rickwood D; Tactacan CM; Browne BC; Ali N; Chan H; Shearer R; Gallego-Ortega D; Saunders DN; Swarbrick A; Daly RJ, 2013, 'Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway', Cancer Research, 73, pp. 1969 - 1980, http://dx.doi.org/10.1158/0008-5472.CAN-12-1472

Plummer PN; Freeman R; Taft RJ; Vider J; Sax M; Umer BA; Gao D; Johns C; Mattick JS; Wilton SD; Ferro V; McMillan NAJ; Swarbrick A; Mittal V; Mellick AS, 2013, 'MicroRNAs regulate tumor angiogenesis modulated by endothelial progenitor cells', Cancer Research, 73, pp. 341 - 352, http://dx.doi.org/10.1158/0008-5472.CAN-12-0271

Lee P; Ho KKY; Swarbrick A, 2013, 'Brown Adipose Tissue in Adult Humans: A Metabolic Renaissance', Endocrine Reviews, 34, pp. 413 - 438, http://dx.doi.org/10.1210/er.2012-1081

Natividad KDT; Junankar S; Mohd redzwan N; Wirasinha RC; King C; Brink R; Swarbrick A; Batten ML; Nair R, 2013, 'Interleukin-27 Signaling Promotes Immunity against Endogenously Arising Murine Tumors', PLoS ONE, 8, pp. e57469, http://dx.doi.org/10.1371/journal.pone.0057469

O'Toole S; Beith JM; Millar EKA; West R; McLean A; Cazet A; Swarbrick A; Oakes , 2013, 'Therapeutic targets in triple negative breast cancer', Journal of Clinical Pathology, 66, pp. 530 - 542, http://dx.doi.org/10.1136/jclinpath-2012-201361

McFarland A; Phua Y; Swarbrick A; Nair R, 2012, 'Meeting The 3Rs with the Use of In Vivo Imaging', JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE, 51, pp. 687 - 688, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000313303300243&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

O’Toole S; Machakel D; Millar E; Nair R; Cooper C; Qiu MR; McLeod D; Sutherland R; Watkins N; Swarbrick A, 2012, '35. Hedgehog overexpression is regulated by stromal interactions and predicts for poor outcome in invasive ductal carcinoma', Pathology, 44, pp. S114 - S114, http://dx.doi.org/10.1016/s0031-3025(16)32927-0

Kalyuga M; Gallego-Ortega D; Lee H; Roden DL; Cowley MJ; Caldon CE; Stone A; Allerdice SL; Valdes-Mora F; Rosalind launchbury R; Statham A; Armstrong NJ; Alles MC; Adelaide young A; Egger A; Au W; Piggin CL; Evans C; Ledger A; Brummer T; Oakes SR; Kaplan W; Gee JMW; Robert i nicholson RI; Sutherland RL; Swarbrick A; Naylor MJ; Clark SJ; Carroll JS; Ormandy CJ, 2012, 'ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer', PLoS Biology, 10, pp. e1001461, http://dx.doi.org/10.1371/journal.pbio.1001461

Swarbrick A; Daly RJ, 2012, 'New insights into signalling networks regulating breast cancer stem cells', Breast Cancer Research, 14, pp. 321, http://dx.doi.org/10.1186/bcr3209

O Toole S; Swarbrick A; Sutherland RL, 2009, 'The Hedgehog signalling pathway as a therapeutic target in early breast cancer development', Expert Opinion on Therapeutic Targets, 13, pp. 1095 - 1103

Swarbrick A, 2008, 'Review of: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer', Breast Cancer Online, 11, http://dx.doi.org/10.1017/S1470903108006688

Butt A; Caldon CE; Mcneil CM; Swarbrick A; Musgrove EA; Sutherland RL, 2008, 'Cell cycle machinery: Links with genesis and treatment of breast cancer', Advances in Experimental Medicine and Biology, 630, pp. 189 - 205

Caldon CE; Swarbrick A; Lee CS; Sutherland RL; Musgrove EA, 2008, 'The helix-loop-helix protein Id1 requires cyclin D1 to promote the proliferation of mammary epithelial cell acini', Cancer research, 68, pp. 3026 - 3036, http://dx.doi.org/10.1158/0008-5472.CAN-07-3079

Kairouz R; Parmar J; Lyons RJ; Swarbrick A; Musgrove EA; Daly RJ, 2005, 'Hormonal regulation of the grb14 signal modulator and its role in cellcycle progression of MCF-7 human breast cancer cells', Journal of Cellular Physiology, 203, pp. 85 - 93

Swarbrick A; Akerfeldt M; Lee CS; Sergio CM; Caldon CE; Hunter LJ; Sutherland RL; Musgrove EA; Lee CS, 2005, 'Regulation of cyclin expression and cell cycle progression in breastepithelial cells by the helix-loop-helix protein Id1', Oncogene, 24, pp. 381 - 389

Carroll JS; Lynch DK; Swarbrick A; Renoir JM; Sarcevic B; Daly RJ; Musgrove EA; Sutherland RL, 2003, 'p27^Kip1 induces quiescence and growth factor insensitivity in tamoxifen-treated breast cancer cells', Cancer Research, 63, pp. 4322 - 4326

Sutherland RL; Carroll JS; Sergio CM; Swarbrick A; Musgrove EA, 2003, '97. Steroid regulation of breast cancer cell proliferation', Reproduction, Fertility and Development, 15, pp. 97 - 97, http://dx.doi.org/10.1071/srb03ab97

Carroll JS; Lynch DK; Swarbrick A; Renoir J; Sarcevic B; Daly RJ; Musgrove EA; Sutherland RL, 2003, 'p27Kip1 induces quiescence and growth factor insensitivity in tamoxifen-treated breast cancer cells', Cancer research, 63, pp. 4322 - 4326

Carroll JS; Swarbrick A; Musgrove EA; Sutherland RL, 2002, 'Mechanisms of growth arrest by c-myc antisense oligonucleotides in MCF-7 breast cancer cells: Implications for the antiproliferative effects of antiestrogens', Cancer Research, 62, pp. 3126 - 3131

Wei M; Cohen SM; Silverman AP; Lippard SJ, 2001, 'Effects of spectator ligands on the specific recognition of intrastrand platinum-DNA cross-links by high mobility group box and TATA-binding proteins.', J Biol Chem, 276, pp. 38774 - 38780, http://dx.doi.org/10.1074/jbc.M106374200

Swarbrick A; Lee CSL; Sutherland RL; Musgrove EA, 2000, 'Cooperation of p27(Kip1) and p18(INK4c) in progestin-mediated cell cycle arrest in T-47D breast cancer cells', Molecular and Cellular Biology, 20, pp. 2581 - 2591, http://dx.doi.org/10.1128/MCB.20.7.2581-2591.2000

Swarbrick A; Murby EJ; Hume P, 1997, 'Post-column electrochemical oxidation of leuco malachite green for the analysis of rainbow trout flesh using HPLC with absorbance detection', Journal of Liquid Chromatography and Related Technologies, 20, pp. 2269 - 2280, http://dx.doi.org/10.1080/10826079708006562

Swarbrick A; Lim RL; Upcroft JA; Stewart TS, 1997, 'Nucleotide variation in the cytidine triphosphate synthetase gene of Giardia duodenalis', Journal of Eukaryotic Microbiology, pp. 531 - 534

Conference Papers

Sandarenu P; Chen J; Slapetova I; Browne L; Graham PH; Swarbrick A; Millar EKA; Song Y; Meijering E, 2024, 'Semi-Supervised Variational Autoencoder for Cell Feature Extraction In Multiplexed Immunofluorescence Images', in Proceedings - International Symposium on Biomedical Imaging, http://dx.doi.org/10.1109/ISBI56570.2024.10635107

Wu SZ; Roden D; Eryani GA; Junankar S; Lim E; Thennavan A; Andersson A; Williams S; Gong J; Fropf R; Fuhrman K; Lundeberg J; Perou C; Swarbrick A, 2021, 'Abstract 129: An integrated multi-omic cellular atlas of human breast cancers', in Cancer Research, American Association for Cancer Research (AACR), pp. 129 - 129, http://dx.doi.org/10.1158/1538-7445.am2021-129

Quek C; Silva IP; Al-Eryani G; Mayer A; Bartonicek N; Harvey K; Buckley C; Braubach O; Thompson JF; Stretch JR; Saw RPM; Shannon KF; Menzies AM; Scolyer RA; Long GV; Swarbrick A; Wilmott JS, 2021, 'Abstract 2761: CODEX highly multiplex image mapping to CITEseq datasets reveal the spatial dynamics of the TME during the development of acquired resistant in immunotherapy treated melanoma', in Cancer Research, American Association for Cancer Research (AACR), pp. 2761 - 2761, http://dx.doi.org/10.1158/1538-7445.am2021-2761

Portman N; Milioli H; Alexandrou S; Coulson R; Yong A; Fernandez K; Chia K; Halilovic E; Segara D; Parker A; Haupt S; Haupt Y; Tilley W; Swarbrick A; Caldon L; Lim E, 2021, 'Abstract PS18-17: Mdm2 inhibition synergises with endocrine therapy or cdk4/6 inhibition for the treatment of estrogen receptor-positive breast cancer', in Cancer Research, American Association for Cancer Research (AACR), http://dx.doi.org/10.1158/1538-7445.sabcs20-ps18-17

Lim E; Milioli HH; Alexandrou S; Coulson R; Yong A; Fernandez KJ; Chia K; Halilovic E; Segara D; Parker A; Haupt S; Haupt Y; Tilley WD; Swarbrick A; Caldon EC; Portman N, 2020, 'MDM2 inhibition in combination with endocrine therapy and CDK4/6 inhibition for the treatment of ER-positive breast cancer', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, pp. 110 - 110, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000790145400122&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hui M; Yang J; Foreman N; McFarlane A; Cazet A; O'Toole S; Swarbrick A, 2014, 'TARGETING THE HEDGEHOG SIGNALLING PATHWAY IN TRIPLE NEGATIVE BREAST CANCER', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 128 - 128, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345350900160&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mahon KL; Chiam K; Lee BY; Nguyen Q; Boyer MJ; Stockler M; Pavlakis N; Marx G; Mallesara G; Gurney H; Clark S; Swarbrick A; Daly R; Horvath L, 2014, 'CIRCULATING MICRORNAS ASSOCIATED WITH DOCETAXEL-RESISTANT CASTRATION-RESISTANT PROSTATE CANCER', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 26 - 27, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339716200012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Warrier S; Sellinger C; Beith JM; Cazet A; Swarbrick A; Carmalt H; O'Toole S, 2013, 'Claudin-1 as a novel transcriptional target of hedgehog signaling and a predictor for outcome in breast cancer.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, presented at 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 31 May 2013 - 04 June 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335419600303&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Plummer PN; Balsara S; Umer B; Taft R; Ferro V; Mattick JS; Swarbrick A; McMillan N; Mittal V; Mellick AS, 2013, 'MICRORNAS AS NOVEL ANTI-ANGIOGENESIS THERAPEUTIC TARGETS', in JOURNAL OF GENE MEDICINE, WILEY-BLACKWELL, AUSTRALIA, Univ Technol, Sydney, pp. 321 - 322, presented at 8th Meeting of the Australasian-Gene-Therapy-Society, AUSTRALIA, Univ Technol, Sydney, 08 May 2013 - 10 May 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000325102500023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Natividad KDT; Junankar S; Swarbrick A; Batten M, 2012, 'nterleukin-27 signaling promotes immunity against endogenously arising tumors', in CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, SWITZERLAND, Geneva, pp. 538 - 538, presented at 10th Joint Meeting of the International-Cytokine-Society (ICS) / Meeting of the International-Society-for-Interferon-and-Cytokine-Research (ISICR), SWITZERLAND, Geneva, 11 September 2012 - 14 September 2012, http://dx.doi.org/10.1016/j.cyto.2012.06.148

Teo W; Nair R; McFarland A; Ye S; Mellick A; Lakhani S; Swarbrick A, 2012, 'Dissecting the Role of the Inhibitor of Differentiation 1 in Breast Cancer Metastasis and Characterization of Pathways Controlling Breast Cancer Stem Cell Phenotype', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, Barcelona, SPAIN, pp. S37 - S37, presented at 22nd Biennial Congress of the European-Association-for-Cancer-Research, Barcelona, SPAIN, 07 July 2012 - 10 July 2012, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000313036500138&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Plummer PN; Taft R; Mattick J; McMillan N; Swarbrick A; Brink R; Mittal V; Mellick AS, 2011, 'MICRORNAS AS TOOLS TO TARGET BONE MARROW MEDIATED TUMOUR ANGIOGENESIS', in JOURNAL OF GENE MEDICINE, WILEY, AUSTRALIA, Univ Melbourne, Bio21 Inst, Parkville, pp. 430 - 430, presented at 7th Biennial Meeting of the Australasian-Gene-Therapy-Society, AUSTRALIA, Univ Melbourne, Bio21 Inst, Parkville, 04 May 2011 - 06 May 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000297950900039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Plummer PN; Taft R; Mattick J; McMillan N; Swarbrick A; Brink R; Mittal V; Mellick AS, 2011, 'MICRORNAS AS TOOLS TO TARGET BONE MARROW MEDIATED TUMOUR ANGIOGENESIS', in JOURNAL OF GENE MEDICINE, WILEY, AUSTRALIA, Univ Melbourne, Bio21 Inst, Parkville, pp. 443 - 443, presented at 7th Biennial Meeting of the Australasian-Gene-Therapy-Society, AUSTRALIA, Univ Melbourne, Bio21 Inst, Parkville, 04 May 2011 - 06 May 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000297950900061&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

O'Toole S; Swarbrick A; Millar E; McLeod D; McNeil C; Qiu M; Lopez-Knowles E; Caldon E; Oakes S; Ormandy C; Morey A; Musgrove E; Henshall S; Sutherland R, 2009, 'Aberrent hedgehog signaling is an early event in breast cancer development.', in Cancer Research, American Association for Cancer Research (AACR), pp. 24 - 24, http://dx.doi.org/10.1158/0008-5472.sabcs-24

O Toole SJ; Swarbrick A; Millar E; McLeod D; Mcneil CM; Qiu MR; Lopez-Knowles E; Caldon E; Oakes SR; Ormandy CJ; Morey AL; Musgrove EA; Henshall SM; Sutherland RL, 2009, 'Aberrent hedgehog signaling is an early event in breast cancer development', in Cancer research, American Association Cancer Research, Philadelphia, PA, pp. 70S - 70S

Swarbrick A; Hunter LJ; Lee CS; Sergio CM; Sutherland RL; Musgrove EA, 2002, 'Id1 is a critical target of c-Myc in breast cancer cells', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, CALIFORNIA, SAN FRANCISCO, pp. 433A - 433A, presented at 42nd Annual Meeting of the American-Society-for-Cell-Biology, CALIFORNIA, SAN FRANCISCO, 14 December 2002 - 18 December 2002, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179569102437&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Posters

Baldwin LA; Bartonicek N; Yang J; Wu SZ; Deng N; Roden D; Chan C-L; Al-Eryani G; Zanker DJ; Parker BS; Swarbrick A; Junankar S, 2022, 'Dna barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapy', Vol. 82, http://dx.doi.org/10.1158/1538-7445.SABCS21-P1-04-04

Conference Presentations

Sax MJ; Plummer PN; Gasch C; Freeman R; Day CJ; Wei M; Swarbrick A; Mittal V; Mellick AS, 2015, 'Endothelial C-C chemokine receptor type 5 (CCR5) is required for tumor angiogenesis'

Junankar S; Baker L; Yun K; Swarbrick A, 2014, 'Inhibitor of differentiation 4 (ID4) maintains mammary stem cell homeostasis and identifies a poor-prognosis subset of basal-like breast cancers with a putative stem cell of origin', presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-LB-62

Hui M; Yang J; McFarlane A; Cazet A; Swarbrick A, 2014, 'TARGETING THE HEDGEHOG SIGNALLING PATHWAY IN TRIPLE NEGATIVE BREAST CANCER', https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339716500008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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