Researcher

Professor Edna Hardeman

My Expertise

Cell Biology, Actin Cytoskeleton, Tropomyosin, Intravital Imaging

Field of Research (FoR)

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Biography

Professor Edna Hardeman is the Head of the Cellular and Genetic Medicine Unit in the School of Medical Sciences

Research Interests

The Cellular and Genetic Medicine Unit (CGMU) is engaged in a range of research activities that span the basic biology of the actin/tropomyosin cytoskeleton and how it regulates basic cellular functions such as signalling, migration, glucose transport, through to drug development of ...view more

Professor Edna Hardeman is the Head of the Cellular and Genetic Medicine Unit in the School of Medical Sciences

Research Interests

The Cellular and Genetic Medicine Unit (CGMU) is engaged in a range of research activities that span the basic biology of the actin/tropomyosin cytoskeleton and how it regulates basic cellular functions such as signalling, migration, glucose transport, through to drug development of  anti-cytoarchitecture/anti-cancer drugs.

Current research projects are:

  • Development of anti-tropomyosin drugs as anti-cancer agents
  • Actin/tropomyosin regulation of GLUT4 trafficking using intracellular intravital imaging
  • Single molecule intravital imaging of the actin/tropomyosin network during exocytosis

Biography

Prof Hardeman received her doctorate from the Department of Biological Sciences, Stanford University and then took up a postdoctoral fellowship in the Department of Pharmacology, Stanford Medical School. She established her laboratory, the Muscle Development Unit at the Children’s Medical Research Institute in Sydney, and has built an international reputation defining mechanisms of muscle gene regulation, and generating mouse models for human skeletal muscle diseases and trialling therapies as part of an international consortium of the European Neuromuscular Centre. She also established her pre-eminence in the physiology of the actin/tropomyosin cytoskeleton using genetically modified mice. Her research underpins our understanding of the function of the cancer-associated tropomyosin in both normal and childhood cancer tissue.

In 2009 she moved to the University of New South Wales to take up a Research Chair in Anatomy and establish the Cellular and Genetic Medicine Unit. Notable achievements include: developing the human skeletal alpha-actin promoter for skeletal muscle-specific expression in animal models of human disease and for gene therapy, the identification of a novel pulsatory, stochastic mode of gene transcription that contributed a new mechanism to the field of gene regulation and the generation of mouse models for nemaline myopathy and identification of therapies.

As a member of the collaborative team that identified tropomyosins as the gatekeepers of actin filament function she established the physiological role of the cancer associated tropomyosin, Tpm3.1. She has been a member of the team which identified Tpm3.1 as druggable target for cancer therapy and was responsible for demonstrating the safety of using these drugs to treat the childhood cancer, neuroblastoma, in a mouse model. She has expanded this work to the development of additional anti-tropomyosin drugs to treat a range of human disease indications.

Qualifications

BA (Interdisc Arts, Hons) & BSc (Hons) The University of Texas at Austin; PhD Stanford University

Current Appointments & Positions Held

  • Professor, Head of Cell Biology, Department of Pathology, School of Medical Sciences
  • Chair, Australian National Health & Medical Research Council (NHMRC) Animal Welfare Committee
  • Member, Australian National Health & Medical Research Council (NHMRC) Research Quality Steering Committee
  • Member, Hunter Cell Biology Meeting Committee
  • Committee Member, Australian and New Zealand Society for Cell and Developmental Biology

Membership in Societies

  • Australian and New Zealand Society for Cell and Developmental Biology
  • American Society for Cell Biology
  • Australian Society for Biochemistry and Molecular Biology
  • Australian Society for Medical Research

Research keywords
Cell Biology, Cancer, Actin Cytoskeleton, Tropomyosin, Imaging


My Research Supervision


Currently supervising

Nadia Amorim, PhD

Anita Chitsaz, PhD

Maria Lastra Cagigas, Scientia PhD Scholar

Xing Xu, PhD

Marco Heydecker, PhD

Gabriel Moldovan, Honours

 

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Location

School of Medical Sciences
Wallace Wurth Building C27
Cnr High St & Botany St
Sydney, NSW 2052
Australia

Contact

+61 2 9385 3760
50022

Research Activities