Select Publications

Book Chapters

Kee AJ; Hardeman EC, 2012, 'Thin filament diseases of striated muscle', in Cytoskeleton and Human Disease, Humana Press, Springer, Printforce, The Netherlands, pp. 123 - 140, http://dx.doi.org/10.1007/978-1-61779-788-0_6

Nguyen MA; Hardeman EC, 2008, 'Mouse models for thin filament disease', in Advances in Experimental Medicine and Biology, Springer New York LLC, pp. 66 - 77, http://dx.doi.org/10.1007/978-0-387-84847-1_6

Hardeman E; Arkell R; Brennan K; Dunwoodie S; Esser K; Gordon M; Joya J; Shalhoub C; Sutherland C, 1992, 'Skeletal muscle gene control and transgenic mice', in Kakulas B; Howell J; Roses A (ed.), Duchenne Muscular Dystrophy: Animal Models and Genetic Manipulation, edn. 1, Raven Press Ltd, New York, pp. 237 - 246

Journal articles

Xu X; Wang Y; Bryce NS; Tang K; Meagher NS; Kang EY; Kelemen LE; Köbel M; Ramus SJ; Friedlander M; Ford CE; Hardeman EC; Gunning PW, 2021, 'Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents', British Journal of Cancer, vol. 125, pp. 265 - 276, http://dx.doi.org/10.1038/s41416-021-01420-y

Rae J; Ferguson C; Ariotti N; Webb RI; Cheng HH; Mead JL; Riches JD; Hunter DJB; Martel N; Baltos J; Christopoulos A; Bryce NS; Cagigas ML; Fonseka S; Sayre ME; Hardeman EC; Gunning PW; Gambin Y; Hall TE; Parton RG, 2021, 'A robust method for particulate detection of a genetic tag for 3D electron microscopy', eLife, vol. 10, http://dx.doi.org/10.7554/ELIFE.64630

Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Srivastava P; Potas JR; Hung T; Power C; Hardy P; Ma DD; Kilian KA; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE, 2021, 'Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine', Science Advances, vol. 7, pp. eabd1929 - eabd1929, http://dx.doi.org/10.1126/sciadv.abd1929

Cagigas ML; Bryce NS; Ariotti N; Brayford S; Gunning PW; Hardeman EC, 2021, 'Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation', Nature Materials, http://dx.doi.org/10.1038/s41563-021-01087-z

Rae J; Ferguson C; Ariotti N; Webb R; Cheng H-H; Mead J; Riches J; Hunter DJB; Martel N; Baltos J; Christopoulos A; Bryce N; Cagigas ML; Fonseka S; Hardeman E; Gunning P; Gambin Y; Hall T; Parton R, 2020, 'APEX-Gold: A genetically-encoded particulate marker for robust 3D electron microscopy', , http://dx.doi.org/10.1101/2020.10.06.328831

Slick R; Tinklenberg J; Meng H; Beatka M; Prom M; Ott E; Montanaro F; Zhang L; Granzier H; Hardeman E; Geurts A; Lawlor M, 2020, 'Proteomic profiling in Nemaline myopathy to identify molecular phenotypes that contribute to disease heterogeneity', NEUROMUSCULAR DISORDERS, vol. 30, pp. S54 - S54, http://dx.doi.org/10.1016/j.nmd.2020.08.030

Janco M; Dedova I; Bryce NS; Hardeman EC; Gunning PW, 2020, 'Visualizing the in vitro assembly of tropomyosin/actin filaments using TIRF microscopy', Biophysical Reviews, vol. 12, pp. 879 - 885, http://dx.doi.org/10.1007/s12551-020-00720-6

Wang Y; Stear JH; Swain A; Xu X; Bryce NS; Carnell M; Alieva IB; Dugina VB; Cripe TP; Stehn J; Hardeman EC; Gunning PW, 2020, 'Drug targeting the actin cytoskeleton potentiates the cytotoxicity of low dose vincristine by abrogating actin-mediated repair of spindle defects', Molecular Cancer Research, vol. 18, pp. 1074 - 1087, http://dx.doi.org/10.1158/1541-7786.MCR-19-1122

Hardeman EC; Bryce NS; Gunning PW, 2020, 'Impact of the actin cytoskeleton on cell development and function mediated via tropomyosin isoforms', Seminars in Cell and Developmental Biology, vol. 102, pp. 122 - 131, http://dx.doi.org/10.1016/j.semcdb.2019.10.004

Abouelezz A; Stefen H; Segerstråle M; Micinski D; Minkeviciene R; Lahti L; Hardeman EC; Gunning PW; Hoogenraad CC; Taira T; Fath T; Hotulainen P, 2020, 'Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment', iScience, vol. 23, http://dx.doi.org/10.1016/j.isci.2020.101053

Manstein DJ; Meiring JCM; Hardeman EC; Gunning PW, 2020, 'Actin–tropomyosin distribution in non-muscle cells', Journal of Muscle Research and Cell Motility, vol. 41, pp. 11 - 22, http://dx.doi.org/10.1007/s10974-019-09514-0

Amorim NML; Kee A; Coster ACF; Lucas C; Bould S; Daniel S; Weir JM; Mellett NA; Barbour J; Meikle PJ; Cohn RJ; Turner N; Hardeman EC; Simar D, 2020, 'Irradiation impairs mitochondrial function and skeletal muscle oxidative capacity: significance for metabolic complications in cancer survivors', Metabolism: clinical and experimental, vol. 103, pp. 154025, http://dx.doi.org/10.1016/j.metabol.2019.154025

Hardeman EC; Gunning PW, 2020, 'Life and death agendas of actin filaments', Nature Materials, vol. 19, pp. 135 - 136, http://dx.doi.org/10.1038/s41563-019-0583-1

Meiring JCM; Bryce NS; Niño JLG; Gabriel A; Tay SS; Hardeman EC; Biro M; Gunning PW, 2019, 'Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments', Scientific Reports, vol. 9, http://dx.doi.org/10.1038/s41598-019-42977-2

Bryce NS; Failes TW; Stehn JR; Baker K; Zahler S; Arzhaeva Y; Bischof L; Lyons C; Dedova I; Arndt GM; Gaus K; Goult BT; Hardeman EC; Gunning PW; Lock JG, 2019, 'High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained', Cell Systems, vol. 9, pp. 496 - 507.e5, http://dx.doi.org/10.1016/j.cels.2019.09.002

Slick R; Tinklenberg J; Vanden Avond M; Beatka M; Meng H; Seibers E; Geurts A; Granzier H; Hardeman E; Zhang L; Montanaro F; Nowak K; Lawlor M, 2019, 'Proteomic profiling in nemaline myopathy to identify molecular phenotypes', NEUROMUSCULAR DISORDERS, vol. 29, pp. S93 - S93, http://dx.doi.org/10.1016/j.nmd.2019.06.210

Ross JA; Levy Y; Ripolone M; Kolb JS; Turmaine M; Holt M; Lindqvist J; Claeys KG; Weis J; Monforte M; Tasca G; Moggio M; Figeac N; Zammit PS; Jungbluth H; Fiorillo C; Vissing J; Witting N; Granzier H; Zanoteli E; Hardeman EC; Wallgren-Pettersson C; Ochala J, 2019, 'Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy', Acta Neuropathologica, vol. 138, pp. 477 - 495, http://dx.doi.org/10.1007/s00401-019-02034-8

Meiring JCM; Bryce NS; Lastra Cagigas M; Benda A; Whan RM; Ariotti N; Parton RG; Stear JH; Hardeman EC; Gunning PW, 2019, 'Colocation of Tpm3.1 and myosin IIa heads defines a discrete subdomain in stress fibres', Journal of cell science, vol. 132, http://dx.doi.org/10.1242/jcs.228916

Janco M; Rynkiewicz MJ; Li L; Hook J; Eiffe E; Ghosh A; Böcking T; Lehman WJ; Hardeman EC; Gunning PW, 2019, 'Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1', Scientific reports, vol. 9, pp. 11262, http://dx.doi.org/10.1038/s41598-019-47592-9

Bryce NS; Hardeman EC; Gunning PW; Lock JG, 2019, 'Chemical biology approaches targeting the actin cytoskeleton through phenotypic screening', Current Opinion in Chemical Biology, vol. 51, pp. 40 - 47, http://dx.doi.org/10.1016/j.cbpa.2019.02.013

Ebrahim S; Chen D; Weiss M; Malec L; Ng Y; Rebustini I; Krystofiak E; Hu L; Liu J; Masedunskas A; Hardeman E; Gunning P; Kachar B; Weigert R, 2019, 'Dynamic polyhedral actomyosin lattices remodel micron-scale curved membranes during exocytosis in live mice', Nature Cell Biology, vol. 21, pp. 933 - 939, http://dx.doi.org/10.1038/s41556-019-0365-7

Kee AJ; Chagan J; Chan JY; Bryce NS; Lucas CA; Zeng J; Hook J; Treutlein H; Laybutt DR; Stehn JR; Gunning PW; Hardeman EC, 2018, 'On-target action of anti-tropomyosin drugs regulates glucose metabolism', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-22946-x

Meiring JCM; Bryce NS; Wang Y; Taft MH; Manstein DJ; Liu Lau S; Stear J; Hardeman EC; Gunning PW, 2018, 'Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton', Current Biology, vol. 28, pp. 2331 - 2337.e5, http://dx.doi.org/10.1016/j.cub.2018.05.053

Gunning PW; Hardeman EC, 2018, 'Tropomyosin-directed tuning of myosin motor function: Insights from mutagenesis', Cytoskeleton, vol. 75, pp. 147 - 149, http://dx.doi.org/10.1002/cm.21441

Masedunskas A; Appaduray MA; Lucas CA; Cagigas ML; Heydecker M; Holliday M; Meiring JCM; Hook J; Kee A; White M; Thomas P; Zhang Y; Adelstein RS; Meckel T; Böcking T; Weigert R; Bryce NS; Gunning PW; Hardeman EC, 2018, 'Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice', Journal of Cell Science, vol. 131, http://dx.doi.org/10.1242/jcs.212654

Gunning PW; Hardeman EC, 2018, 'Fundamental differences', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.34477

Siebers E; Tinklenberg J; Meng H; Ayres S; Vanden Avond M; Slick R; Nowake K; Granzier H; Hardeman E; Montanaro F; Lawlor M, 2018, 'CONGENITAL MYOPATHIES: NEMALINE AND TITINOPATHIES', Neuromuscular Disorders, vol. 28, pp. S102 - S103, http://dx.doi.org/10.1016/j.nmd.2018.06.282

Suchowerska AK; Fok S; Stefen H; Gunning PW; Hardeman EC; Power J; Fath T, 2017, 'Developmental profiling of tropomyosin expression in mouse brain reveals Tpm4.2 as the major post-synaptic tropomyosin in the mature brain', Frontiers in Cellular Neuroscience, vol. 11, http://dx.doi.org/10.3389/fncel.2017.00421

Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N; Vennin C; Conway JRW; Boulghourjian A; Zaratzian A; Law AM; Gallego-Ortega D; Ormandy CJ; Walters SN; Grey ST; Bailey J; Chtanova T; Quinn JMW; Baldock PA; Croucher PI; Schwarz JP; Mrowinska A; Zhang L; Herzog H; Masedunskas A; Hardeman EC; Gunning PW; del Monte-Nieto G; Harvey RP; Samuel MS; Pajic M; McGhee EJ; Johnsson AKE; Sansom OJ; Welch HCE; Morton JP; Strathdee D; Anderson KI; Timpson P, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, vol. 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022

Kee AJ; Bryce NS; Yang L; Polishchuk E; Schevzov G; Weigert R; Polishchuk R; Gunning PW; Hardeman EC, 2017, 'ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2', Cytoskeleton, vol. 74, pp. 379 - 389, http://dx.doi.org/10.1002/cm.21405

Currier MA; Stehn JR; Swain A; Chen D; Hook J; Eiffe E; Heaton A; Brown D; Nartker BA; Eaves DW; Kloss N; Treutlein H; Zeng J; Alieva IB; Dugina VB; Hardeman EC; Gunning PW; Cripe TP, 2017, 'Identification of cancer-targeted tropomyosin inhibitors and their synergy with microtubule drugs', Molecular Cancer Therapeutics, vol. 16, pp. 1555 - 1565, http://dx.doi.org/10.1158/1535-7163.MCT-16-0873

Pleines I; Woods J; Chappaz S; Kew V; Foad N; Ballester-Beltrán J; Aurbach K; Lincetto C; Lane RM; Schevzov G; Alexander WS; Hilton DJ; Astle WJ; Downes K; Nurden P; Westbury SK; Mumford AD; Obaji SG; Collins PW; BioResource N; Delerue F; Ittner LM; Bryce NS; Holliday M; Lucas CA; Hardeman EC; Ouwehand WH; Gunning PW; Turro E; Tijssen MR; Kile BT, 2017, 'Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia', Journal of Clinical Investigation, vol. 127, pp. 814 - 829, http://dx.doi.org/10.1172/JCI86154

Gunning PW; Hardeman EC, 2017, 'Tropomyosins', Current Biology, vol. 27, pp. R8 - R13, http://dx.doi.org/10.1016/j.cub.2016.11.033

Kee AJ; Bryce NS; Yang L; Polishchuk E; Schevzov G; Weigert R; Polishchuk R; Gunning PW; Hardeman EC, 2017, 'Cover Image, Volume 74, Issue 10', Cytoskeleton, vol. 74, pp. C4 - C4, http://dx.doi.org/10.1002/cm.21413

Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Warren SC; Timpson P; Stear JH; Gunning PW; Hardeman EC, 2016, 'Recruitment kinetics of tropomyosin tpm3.1 to actin filament bundles in the cytoskeleton is independent of actin filament kinetics', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0168203

Akladios B; Mendoza-Reinoso V; Samuel MS; Hardeman EC; Khosrotehrani K; Key B; Beverdam A, 2016, 'Epidermal YAP2-5SA-ΔC Drives β-Catenin Activation to Promote Keratinocyte Proliferation in the Mouse Skin in vivo', Journal of Investigative Dermatology, vol. 137, pp. 716 - 726, http://dx.doi.org/10.1016/j.jid.2016.10.029

Liang H; Akladios B; Canales CP; Francis R; Hardeman EH; Beverdam A, 2016, 'CUBIC protocol visualizes protein expression at single cell resolution in whole mount skin preparations', Journal of Visualized Experiments, vol. 2016, http://dx.doi.org/10.3791/54401

Corley SM; Canales CP; Carmona-Mora P; Mendoza-Reinosa V; Beverdam A; Hardeman EC; Wilkins MR; Palmer SJ, 2016, 'RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome', BMC Genomics, vol. 17, http://dx.doi.org/10.1186/s12864-016-2801-4

Tinklenberg J; Meng H; Yang L; Liu F; Hoffmann RG; DasGupta M; Allen KP; Beggs AH; Hardeman EC; Pearsall RS; Fitts RH; Lawlor MW, 2016, 'Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy', American Journal of Pathology, vol. 186, pp. 1568 - 1581, http://dx.doi.org/10.1016/j.ajpath.2016.02.008

Tinklenberg J; Meng H; Yang L; Liu F; Hoffmann RG; Dasgupta M; Allen KP; Beggs AH; Hardeman EC; Pearsall RS; Fitts RH; Lawlor MW, 2016, 'Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy', AMERICAN JOURNAL OF PATHOLOGY, vol. 186, pp. 1568 - 1581, http://dx.doi.org/10.1016/j.ajpath.2016.02.008

Brayford S; Bryce NS; Schevzov G; Haynes EM; Bear JE; Hardeman EC; Gunning PW, 2016, 'Tropomyosin promotes lamellipodial persistence by collaborating with Arp2/3 at the leading edge', Current Biology, vol. 26, pp. 1312 - 1318, http://dx.doi.org/10.1016/j.cub.2016.03.028

Lindqvist J; Levy Y; Pati-Alam A; Hardeman EC; Gregorevic P; Ochala J, 2016, 'Modulating myosin restores muscle function in a mouse model of nemaline myopathy', Annals of Neurology, vol. 79, pp. 717 - 725, http://dx.doi.org/10.1002/ana.24619

Bonello TT; Janco M; Hook J; Byun A; Appaduray M; Dedova I; Hitchcock-DeGregori S; Hardeman EC; Stehn JR; Böcking T; Gunning PW, 2016, 'A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep19816

Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, vol. 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020

Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC, 2016, 'Corrigendum to An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake [Traic, (2015), 16, 7, 691-711]', Traffic, vol. 17, pp. 80 - 81, http://dx.doi.org/10.1111/tra.12342

Carmona-Mora P; Widagdo J; Tomasetig F; Canales CP; Cha Y; Lee W; Alshawaf A; Dottori M; Whan RM; Hardeman EC; Palmer SJ, 2015, 'The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation', Human Genetics, vol. 134, pp. 1099 - 1115, http://dx.doi.org/10.1007/s00439-015-1591-0

Gunning PW; Hardeman EC; Lappalainen P; Mulvihill DP, 2015, 'Tropomyosin - master regulator of actin filament function in the cytoskeleton', Journal of Cell Science, vol. 128, pp. 2965 - 2974, http://dx.doi.org/10.1242/jcs.172502


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