By Professor Elgene Lim

Journal articles

Lim E; Ni M; Cao S; Hazra A; Tamimi RM; Brown M, 2014, 'Importance of breast cancer subtype in the development of androgen-receptor-directed therapy', Current Breast Cancer Reports, 6, pp. 71 - 78, http://dx.doi.org/10.1007/s12609-014-0140-5

Chen X; Iliopoulos D; Zhang Q; Tang Q; Greenblatt MB; Hatziapostolou M; Lim E; Tam WL; Ni M; Chen Y; Mai J; Shen H; Hu DZ; Adoro S; Hu B; Song M; Tan C; Landis MD; Ferrari M; Shin SJ; Brown M; Chang JC; Liu XS; Glimcher LH, 2014, 'XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway', Nature, 508, pp. 103 - 107, http://dx.doi.org/10.1038/nature13119

Tam WL; Lu H; Buikhuisen J; Soh BS; Lim E; Reinhardt F; Wu ZJ; Krall JA; Bierie B; Guo W; Chen X; Liu XS; Brown M; Lim B; Weinberg RA, 2013, 'Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells', Cancer Cell, 24, pp. 347 - 364, http://dx.doi.org/10.1016/j.ccr.2013.08.005

McLaughlin SK; Olsen SN; Dake B; De Raedt T; Lim E; Bronson RT; Beroukhim R; Polyak K; Brown M; Kuperwasser C; Cichowski K, 2013, 'The RasGAP Gene, RASAL2, Is a Tumor and Metastasis Suppressor', Cancer Cell, 24, pp. 365 - 378, http://dx.doi.org/10.1016/j.ccr.2013.08.004

Tichy JR; Lim E; Anders CK, 2013, 'Breast cancer in adolescents and young adults: A review with a focus on biology', Jnccn Journal of the National Comprehensive Cancer Network, 11, pp. 1060 - 1069, http://dx.doi.org/10.6004/jnccn.2013.0128

Buchwalter G; Hickey MM; Cromer A; Selfors LM; Gunawardane RN; Frishman J; Jeselsohn R; Lim E; Chi D; Fu X; Schiff R; Brown M; Brugge JS, 2013, 'PDEF Promotes Luminal Differentiation and Acts as a Survival Factor for ER-Positive Breast Cancer Cells', Cancer Cell, 23, pp. 753 - 767, http://dx.doi.org/10.1016/j.ccr.2013.04.026

Ni M; Chen Y; Fei T; Li D; Lim E; Liu XS; Brown M, 2013, 'Amplitude modulation of androgen signaling by c-MYC', Genes and Development, 27, pp. 734 - 748, http://dx.doi.org/10.1101/gad.209569.112

Lim E; He HH; Chi D; Yeung TY; Schnitt S; Liu SX; Garber J; Richardson A; Brown M, 2012, 'Differences in estrogen receptor signaling in non-malignant primary ER-positive breast epithelial cells and breast cancer.', CANCER RESEARCH, 72, http://dx.doi.org/10.1158/0008-5472.SABCS12-PD01-08

Shen RR; Zhou AY; Kim E; Lim E; Habelhah H; Hahn WC, 2012, 'IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation', Molecular and Cellular Biology, 32, pp. 4756 - 4768, http://dx.doi.org/10.1128/MCB.00468-12

Lim E; Ni M; Hazra A; Tamimi R; Brown M, 2012, 'Elucidating the role of androgen receptors and breast cancer.', Clinical Investigation, 2, pp. 1003 - 1011

Lim E; Metzger-Filho O; Winer EP, 2012, 'Natural history of hormone receptor positive breast cancer', Oncology (Williston Park), 26, pp. 688 - 694

Lim E; Lin NU, 2012, 'New insights and emerging therapies in breast cancer brain metastases', Oncology (Williston Park), 26, pp. 652 - 659

Lim E; He HH; Chi D; Garber JE; Richardson A; Brown M, 2012, 'Estrogen receptor (ER) signaling in normal, BRCA (B) 1 and B2 mutation associated, and ER-positive breast cancer (BC) mammary cells.', Journal of Clinical Oncology, 30, pp. 576 - 576, http://dx.doi.org/10.1200/jco.2012.30.15_suppl.576

Oakes SR; Vaillant F; Lim E; Lee L; Breslin K; Feleppa F; Deb S; Ritchie ME; Takano E; Ward T; Fox SB; Generali D; Smyth GK; Strasser A; Huang DCS; Visvader JE; Lindeman GJ, 2012, 'Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737', Proceedings of the National Academy of Sciences of the United States of America, 109, pp. 2766 - 2771, http://dx.doi.org/10.1073/pnas.1104778108

Oakes SR; Vaillant F; Lim E; Lee L; Breslin K; Feleppa F; Deb S; Ritchie ME; Takano E; Ward T; Fox SB; Generali D; Smyth GK; Strasser A; Huang DCS; Visvader JE; Lindeman GJ, 2012, 'Targeting BCL-2–expressing basal-like breast cancer with BH3-mimetics', Hereditary cancer in clinical practice, 10, pp. A25 - A25, http://dx.doi.org/10.1186/1897-4287-10-s2-a25

Ni M; Chen Y; Bailey ST; Imai Y; Liu XS; Brown M, 2011, 'Abstract 941: Targeting androgen receptor in estrogen receptor-negative breast cancer', Cancer Research, 71, pp. 941 - 941, http://dx.doi.org/10.1158/1538-7445.am2011-941

Ni M; Chen Y; Lim E; Wimberly H; Bailey ST; Imai Y; Rimm DL; Shirley Liu X; Brown M, 2011, 'Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer', Cancer Cell, 20, pp. 119 - 131, http://dx.doi.org/10.1016/j.ccr.2011.05.026

Lindeman G; Asselin-Labat M-L; Lim E; Vaillant F; Wu D; Pal B; Sheridan J; Martin J; Smyth G; Visvader J, 2011, 'Breast stem and progenitor cells in cancer - Therapeutic implications', BREAST, 20, pp. S6 - S6, http://dx.doi.org/10.1016/S0960-9776(11)70020-0

Lim E; Winer EP, 2011, 'Will preoperative trials change future clinical practice?', Clinical Investigation, 1, pp. 59 - 73, http://dx.doi.org/10.4155/cli.10.3

Wu D; Lim E; Vaillant F; Asselin-Labat ML; Visvader JE; Smyth GK, 2010, 'ROAST: Rotation gene set tests for complex microarray experiments', Bioinformatics, 26, pp. 2176 - 2182, http://dx.doi.org/10.1093/bioinformatics/btq401

Lim E; Wu D; Pal B; Bouras T; Asselin-Labat ML; Vaillant F; Yagita H; Lindeman GJ; Smyth GK; Visvader JE, 2010, 'Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways', Breast Cancer Research, 12, http://dx.doi.org/10.1186/bcr2560

Lim E; Vaillant F; Wu D; Forrest NC; Pal B; Hart AH; Asselin-Labat ML; Gyorki DE; Ward T; Partanen A; Feleppa F; Huschtscha LI; Thorne HJ; Fox SB; Yan M; French JD; Brown MA; Smyth GK; Visvader JE; Lindeman GJ, 2009, 'Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers', Nature Medicine, 15, pp. 907 - 913, http://dx.doi.org/10.1038/nm.2000

Lim E; Vaillant F; Wu D; Forrest N; Pal B; Gyorki D; Smyth GK; Visvader J; Lindeman G, 2009, 'Investigation of human mammary stem and progenitor subpopulations from BRCA1 mutation carriers and noncarriers', Journal of Clinical Oncology, 27, pp. 504 - 504, http://dx.doi.org/10.1200/jco.2009.27.15_suppl.504

Lim E; Thomson BNJ; Heinze S; Chao M; Gunawardana D; Gibbs P, 2007, 'Optimizing the approach to patients with potentially resectable liver metastases from colorectal cancer', ANZ Journal of Surgery, 77, pp. 941 - 947, http://dx.doi.org/10.1111/j.1445-2197.2007.04287.x

Lim E; Rosenthal MA, 2007, 'Diagnosing cancer: changing patterns of care', INTERNAL MEDICINE JOURNAL, 37, pp. 124 - 126, http://dx.doi.org/10.1111/j.1445-5994.2007.01246.x

Lim E; Browning J; MacGregor D; Davis ID; Cebon JS, 2006, 'Antigen expression in desmoplastic melanoma: a comparison of cancer testis antigen with differentiation antigen expression', Melanoma Research: an international journal of rapid communications of basic and clinical research in melanoma, 16, pp. 347 - 355, http://dx.doi.org/10.1097/01.cmr.0000222588.22493.3f

Rodrigues J; Lim E; McLaughlin S; Faragher I; Skinner I; Chao M; Chapman M; Gibbs P, 2006, 'The influence of language spoken on colorectal cancer diagnosis and management [2]', ANZ Journal of Surgery, 76, pp. 671 - 672, http://dx.doi.org/10.1111/j.1445-2197.2006.03799.x

Lim E; Johns J; McLaughlin S; Faragher I; Skinner I; Chao M; Gibbs P, 2005, 'Subsite-Specific Colorectal Cancer in Diabetic and Nondiabetic Patients', Cancer Epidemiology Biomarkers & Prevention, 14, pp. 1579 - 1582, http://dx.doi.org/10.1158/1055-9965.EPI-05-0176

Lim E; Wicks I; Roberts LJ, 2004, 'Intracardiac thrombosis complicating antiphospholipid antibody syndrome.', Intern Med J, 34, pp. 135 - 137, http://dx.doi.org/10.1111/j.1444-0903.2004.00558.x

Conference Papers

Jhaveri K; Nakajima TE; Giordano A; Juric D; Ma C; Unni N; Goetz MP; Kitano S; Loi S; Rugo H; Bidard F-C; Saura C; Lim E; Neven P; O'Shaughnessy J; Bhave M; Tan TJ; Bedard PL; Vanacker H; O'Regan R; Turner NC; Cortes J; Chia S; Campone M; Chau V; Hanley MP; Du L; Lombard A; Ramstetter M; Estrem S; Meric-Bernstam F, 2025, 'A first-in-human phase 1a/b trial of LOXO-783, a potent, highly mutant-selective, brain-penetrant, allosteric PI3Kα H1047R inhibitor in PIK3CA H1047R-mutant advanced breast cancer and other solid tumors: Results from the PIKASSO-01 study', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, pp. PS703 - PS703, http://dx.doi.org/10.1158/1557-3265.SABCS24-PS7-03

Jhaveri K; Neven P; Casalnuovo ML; Kim S-B; Tokunaga E; Aftimos P; Saura C; O'Shaughnessy J; Harbeck N; Carey LA; Curigliano G; Llombart-Cussac A; Lim E; Luz Garcia Tinoco MDL; Sohn J; Mattar A; Zhang Q; Huang C-S; Hung C-C; Rodriguez JLM; Borrego MR; Nakamura R; Pradhan KR; von Laue CC; Barrett E; Cao S; Wang XA; Smyth LM; Bidard F-C, 2024, 'Imlunestrant, an Oral Selective Estrogen Receptor Degrader (SERD), as Monotherapy & Combined with Abemaciclib, for Patients with ER+, HER2-Advanced Breast Cancer (ABC), Pretreated with Endocrine Therapy (ET): Results of the Phase 3 EMBER-3 trial', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, TX, San Antonio, presented at San Antonio Breast Cancer Symposium, TX, San Antonio, 10 December 2024 - 13 December 2024, http://dx.doi.org/10.1158/1557-3265.SABCS24-GS1-01

Lien YTK; Jhaveri K; Turner N; Lim E; Cannon M; Anziano R; Langenhorst J; Yoshida K; Malhi V; Gates M; Eng-Wong J; Li C; Shah M; Pérez-Moreno P; Yu J; Bardia A, 2024, 'Exposure-response analyses of GO39932: a Phase Ia/b study of giredestrant in estrogen receptor-positive, HER2-negative, locally advanced or metastatic breast cancer', in Exposure-response analyses of GO39932: a Phase Ia/b study of giredestrant in estrogen receptor-positive, HER2-negative, locally advanced or metastatic breast cancer, International Society of Pharmacometrics, presented at American Conference of Pharmacometrics, http://dx.doi.org/10.70534/mqct2577

Collier A; Mac Gregor MC; Hilz S; Bardia A; Sohn J; Martin M; Lim E; Martinalbo J; Perez-Moreno PD; Moore HM, 2023, 'Exploratory biomarker analysis of acelERA breast cancer (BC): Phase II study of giredestrant vs. physician's choice of endocrine therapy (PCET) for previously treated, estrogen receptor-positive, HER2-negative advanced BC (ER+, HER2-aBC)', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 02 June 2023 - 06 June 2023

Jhaveri KL; Jeselsohn R; Lim E; Hamilton EP; Yonemori K; Beck JT; Kaufman PA; Sammons S; Bhave MA; Saura C; Calvo E; Meniawy T; Larson T; Ma CX; Garcia-Corbacho J; Cao S; Estrem ST; Milata JL; Nguyen B; Beeram M, 2022, 'A phase 1a/b trial of imlunestrant (LY3484356), an oral selective estrogen receptor degrader (SERD) in ER-positive (ER plus ) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC): Monotherapy results from EMBER.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, ELECTR NETWORK, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), ELECTR NETWORK, 03 June 2022 - 07 June 2022

Lim E; Brufsky A; Rugo HS; Vogel CL; O'Shaughnessy J; Getzenberg RH; Barnette KG; Rodriguez D; Bird G; Steiner MS; Linden HM, 2022, 'Phase 3 ENABLAR-2 study to evaluate enobosarm and abemaciclib combination compared to estrogen-blocking agent for the second-line treatment of AR+, ER+, HER2-metastatic breast cancer in patients who previously received palbociclib and estrogen-blocking agent combination therapy', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, ELECTR NETWORK, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), ELECTR NETWORK, 03 June 2022 - 07 June 2022

Wu SZ; Roden D; Eryani GA; Junankar S; Lim E; Thennavan A; Andersson A; Williams S; Gong J; Fropf R; Fuhrman K; Lundeberg J; Perou C; Swarbrick A, 2021, 'Abstract 129: An integrated multi-omic cellular atlas of human breast cancers', in Cancer Research, American Association for Cancer Research (AACR), pp. 129 - 129, http://dx.doi.org/10.1158/1538-7445.am2021-129

Lim E; Beeram M; Prawira A; Patnaik A; Wang XA; Young SRL; Smyth LM; Hamilton EP, 2021, 'Abstract OT-09-03: EMBER: A phase 1a/b trial of LY3484356, a novel, oral selective estrogen-receptor degrader (SERD), in advanced ER+ breast cancer and endometroid endometrial cancer', in Cancer Research, American Association for Cancer Research (AACR), http://dx.doi.org/10.1158/1538-7445.sabcs20-ot-09-03

Lau B; Segara D; Ong A; Bingham J; Kiely B; Carson E-K; Chen J; Mak C; Warrier S; Hui M; Middleton K; Parker A; Mann B; Lindeman G; Tilley W; Lim E, 2021, 'Abstract OT-09-07: Winpro: A window of opportunity study of endocrine therapy with and without prometrium in postmenopausal women with early stage hormone receptor-positive breast cancer', in Cancer Research, American Association for Cancer Research (AACR), http://dx.doi.org/10.1158/1538-7445.sabcs20-ot-09-07

Palmieri C; Linden H; Birrell S; Lim E; Schwartzberg LS; Rugo HS; Cobb P; Jain K; Vogel C; O’Shaughnessy JA; Getzenberg RH; Steiner MS; Brufsky A; Overmoyer B, 2021, 'Abstract PD8-10: Efficacy and safety of enobosarm, a selective androgen receptor modulator, to target AR in women with advanced ER+/AR+ breast cancer - final results from an international Phase 2 randomized study', in Cancer Research, American Association for Cancer Research (AACR), http://dx.doi.org/10.1158/1538-7445.sabcs20-pd8-10

Portman N; Milioli H; Alexandrou S; Coulson R; Yong A; Fernandez K; Chia K; Halilovic E; Segara D; Parker A; Haupt S; Haupt Y; Tilley W; Swarbrick A; Caldon L; Lim E, 2021, 'Abstract PS18-17: Mdm2 inhibition synergises with endocrine therapy or cdk4/6 inhibition for the treatment of estrogen receptor-positive breast cancer', in Cancer Research, American Association for Cancer Research (AACR), http://dx.doi.org/10.1158/1538-7445.sabcs20-ps18-17

Lim E; Boyle F; Okera M; Loi S; Goksu SS; van Hal G; Gable JC; Price GL; Hossain A; Gainford M; Ezquerra MB, 2020, 'The impact of food on tolerability of abemaciclib in patients with previously treated hormone receptor-positive, HER2-negative, metastatic breast cancer: An open-label, randomized phase 2 study', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, pp. 124 - 125, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000790145400152&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lim E; Milioli HH; Alexandrou S; Coulson R; Yong A; Fernandez KJ; Chia K; Halilovic E; Segara D; Parker A; Haupt S; Haupt Y; Tilley WD; Swarbrick A; Caldon EC; Portman N, 2020, 'MDM2 inhibition in combination with endocrine therapy and CDK4/6 inhibition for the treatment of ER-positive breast cancer', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, pp. 110 - 110

Metzger-Filho O; Mandrekar S; Loibl S; Ciruelos E; Gianni L; Lim E; Miller K; Huang C; Koehler M; Francis P; Valagussa P; Goel S; Prat A; Goetz M; Loi S; Krop I; Carey L; Lanzillotti J; Winer E; Tripathy D; DeMichele A, 2018, 'Abstract OT3-05-07: PATINA: A randomized open label phase III trial to evaluate the efficacy and safety of palbociclib + anti HER2 therapy + endocrine therapy vs anti HER2 therapy + endocrine therapy after induction treatment for hormone receptor positive, HER2 positive metastatic breast cancer', in Cancer Research, American Association for Cancer Research (AACR), http://dx.doi.org/10.1158/1538-7445.sabcs17-ot3-05-07

Lim E; Portman N; Alexandrou S; Haupt S; Haupt Y; Caldon E, 2018, 'Abstract P4-04-12: Therapeutic targeting of CDK4/6 inhibitor resistant breast cancer', in Cancer Research, American Association for Cancer Research (AACR), http://dx.doi.org/10.1158/1538-7445.sabcs17-p4-04-12

Singhal H; Chi D; Lim E; He H; Vadhi R; Rao PK; Long HW; Richardson AL; Garber J; Brown M, 2017, 'Estrogen signaling in mature luminal and luminal progenitor cells of BRCA2 carriers and non-carriers', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, DC, Washington, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), DC, Washington, 01 April 2017 - 05 April 2017, http://dx.doi.org/10.1158/1538-7445.AM2017-LB-257

Johnson S; Johnson N; Chi D; Primack B; Cruz C; Stover D; Greifenberg AK; Cao S; O'Connor K; Baselga J; Balmana J; Serra V; Geyer M; D'Andrea A; Lim E; Shapiro GI, 2014, 'Reversal of primary and acquired PARP-inhibitor resistance in BRCA-mutated triple-negative breast cancers by inhibition of transcriptional cyclin-dependent kinases (CDKs)', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, SPAIN, European Org Res & Treatment Canc, Barcelona, pp. 80 - 80, presented at 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, SPAIN, European Org Res & Treatment Canc, Barcelona, 18 November 2014 - 21 November 2014, http://dx.doi.org/10.1016/S0959-8049(14)70364-8

Lim E; He HH; Chi D; Garber JE; Richardson A; Brown M, 2012, 'Estrogen receptor (ER) signaling in normal, BRCA (B) 1 and B2 mutation associated, and ER-positive breast cancer (BC) mammary cells.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, IL, Chicago, presented at 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 01 June 2012 - 06 June 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000318009800130&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lindeman GJ; Oakes SR; Vaillant F; Lim E; Lee L; Breslin K; Feleppa F; Deb S; Ritchie ME; Takano E; Ward T; Fox SB; Generali D; Smyth GK; Strasser A; Huang DCS; Visvader JE, 2011, 'PD08-02: Targeting BCL-2 Expressing Breast Tumors with BH3-Mimetics – A New Class of Drugs in Breast Cancer?', in Cancer Research, American Association for Cancer Research (AACR), http://dx.doi.org/10.1158/0008-5472.sabcs11-pd08-02

Lindeman GJ; Oakes SR; Vaillant F; Lim E; Lee L; Breslin K; Feleppa F; Deb S; Ritchie ME; Takano E; Ward T; Fox SB; Generali D; Smyth GK; Strasser A; Huang DCS; Visvader JE, 2011, 'Targeting BCL-2 Expressing Breast Tumors with BH3-Mimetics - A New Class of Drugs in Breast Cancer?', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/0008-5472.SABCS11-PDOS-02

Visvader JE; Asselin-Labat M-L; Vaillant F; Lim E; Bouras T; Pal B; Wu D; Smyth G; Lindeman G, 2011, 'Getting abreast of the mammary epithelial hierarchy and breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2011-SY12-03

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