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Conference Papers
, 2024, 'Exposure-response analyses of GO39932: a Phase Ia/b study of giredestrant in estrogen receptor-positive, HER2-negative, locally advanced or metastatic breast cancer', in Exposure-response analyses of GO39932: a Phase Ia/b study of giredestrant in estrogen receptor-positive, HER2-negative, locally advanced or metastatic breast cancer, International Society of Pharmacometrics, presented at American Conference of Pharmacometrics, http://dx.doi.org/10.70534/mqct2577
, 2023, 'Exploratory biomarker analysis of acelERA breast cancer (BC): Phase II study of giredestrant vs. physician's choice of endocrine therapy (PCET) for previously treated, estrogen receptor-positive, HER2-negative advanced BC (ER+, HER2-aBC)', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 02 June 2023 - 06 June 2023
, 2022, 'A phase 1a/b trial of imlunestrant (LY3484356), an oral selective estrogen receptor degrader (SERD) in ER-positive (ER plus ) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC): Monotherapy results from EMBER.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, ELECTR NETWORK, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), ELECTR NETWORK, 03 June 2022 - 07 June 2022
, 2022, 'Phase 3 ENABLAR-2 study to evaluate enobosarm and abemaciclib combination compared to estrogen-blocking agent for the second-line treatment of AR+, ER+, HER2-metastatic breast cancer in patients who previously received palbociclib and estrogen-blocking agent combination therapy', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, ELECTR NETWORK, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), ELECTR NETWORK, 03 June 2022 - 07 June 2022
, 2021, 'Abstract 129: An integrated multi-omic cellular atlas of human breast cancers', in Cancer Research, American Association for Cancer Research (AACR), pp. 129 - 129, http://dx.doi.org/10.1158/1538-7445.am2021-129
, 2021, 'Abstract OT-09-03: EMBER: A phase 1a/b trial of LY3484356, a novel, oral selective estrogen-receptor degrader (SERD), in advanced ER+ breast cancer and endometroid endometrial cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. ot-09-03-ot-09-03, http://dx.doi.org/10.1158/1538-7445.sabcs20-ot-09-03
, 2021, 'Abstract OT-09-07: Winpro: A window of opportunity study of endocrine therapy with and without prometrium in postmenopausal women with early stage hormone receptor-positive breast cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. ot-09-07-ot-09-07, http://dx.doi.org/10.1158/1538-7445.sabcs20-ot-09-07
, 2021, 'Abstract PD8-10: Efficacy and safety of enobosarm, a selective androgen receptor modulator, to target AR in women with advanced ER+/AR+ breast cancer - final results from an international Phase 2 randomized study', in Cancer Research, American Association for Cancer Research (AACR), pp. pd8-10-pd8-10, http://dx.doi.org/10.1158/1538-7445.sabcs20-pd8-10
, 2021, 'Abstract PS18-17: Mdm2 inhibition synergises with endocrine therapy or cdk4/6 inhibition for the treatment of estrogen receptor-positive breast cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. ps18-17-ps18-17, http://dx.doi.org/10.1158/1538-7445.sabcs20-ps18-17
, 2020, 'The impact of food on tolerability of abemaciclib in patients with previously treated hormone receptor-positive, HER2-negative, metastatic breast cancer: An open-label, randomized phase 2 study', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, pp. 124 - 125, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000790145400152&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2020, 'MDM2 inhibition in combination with endocrine therapy and CDK4/6 inhibition for the treatment of ER-positive breast cancer', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, pp. 110 - 110
, 2018, 'Abstract OT3-05-07: PATINA: A randomized open label phase III trial to evaluate the efficacy and safety of palbociclib + anti HER2 therapy + endocrine therapy vs anti HER2 therapy + endocrine therapy after induction treatment for hormone receptor positive, HER2 positive metastatic breast cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. ot3-05-07-ot3-05-07, http://dx.doi.org/10.1158/1538-7445.sabcs17-ot3-05-07
, 2018, 'Abstract P4-04-12: Therapeutic targeting of CDK4/6 inhibitor resistant breast cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. p4-04-12-p4-04-12, http://dx.doi.org/10.1158/1538-7445.sabcs17-p4-04-12
, 2017, 'Abstract LB-257: Estrogen signaling in mature luminal and luminal progenitor cells of BRCA2 carriers and non-carriers', in Cancer Research, American Association for Cancer Research (AACR), pp. lb-257-lb-257, http://dx.doi.org/10.1158/1538-7445.am2017-lb-257
, 2014, 'Reversal of primary and acquired PARP-inhibitor resistance in BRCA-mutated triple-negative breast cancers by inhibition of transcriptional cyclin-dependent kinases (CDKs)', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, SPAIN, European Org Res & Treatment Canc, Barcelona, pp. 80 - 80, presented at 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, SPAIN, European Org Res & Treatment Canc, Barcelona, 18 November 2014 - 21 November 2014, http://dx.doi.org/10.1016/S0959-8049(14)70364-8
, 2012, 'Estrogen receptor (ER) signaling in normal, BRCA (B) 1 and B2 mutation associated, and ER-positive breast cancer (BC) mammary cells.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, IL, Chicago, presented at 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 01 June 2012 - 06 June 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000318009800130&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2011, 'PD08-02: Targeting BCL-2 Expressing Breast Tumors with BH3-Mimetics – A New Class of Drugs in Breast Cancer?', in Cancer Research, American Association for Cancer Research (AACR), http://dx.doi.org/10.1158/0008-5472.sabcs11-pd08-02
, 2011, 'Targeting BCL-2 Expressing Breast Tumors with BH3-Mimetics - A New Class of Drugs in Breast Cancer?', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/0008-5472.SABCS11-PDOS-02
, 2011, 'Getting abreast of the mammary epithelial hierarchy and breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2011-SY12-03
, 2011, 'Adjuvant chemotherapy in luminal breast cancers', in Breast, pp. S128 - S131, http://dx.doi.org/10.1016/S0960-9776(11)70309-5
, 2010, 'Transcriptome Analyses of Mouse and Human Mammary Cell Subpopulations Reveals Multiple Conserved Genes and Pathways', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/0008-5472.SABCS10-P4-04-03
, 2009, 'Investigation of human mammary stem and progenitor subpopulations from BRCA1 mutation carriers and noncarriers', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, FL, Orlando, presented at 45th Annual Meeting of the American-Society-of-Clinical-Oncology, FL, Orlando, 29 May 2009 - 02 June 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000276606601221&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Conference Posters
, 2022, 'Abstract PD13-07: Activity and biomarker analyses from a phase Ia/b study of giredestrant (GDC-9545; G) with or without palbociclib (palbo) in patients with estrogen receptor-positive, HER2-negative locally advanced/metastatic breast cancer (ER+/HER2- LA/mBC)', Vol. 82, pp. pd13-07-pd13-07, http://dx.doi.org/10.1158/1538-7445.sabcs21-pd13-07
Conference Abstracts
, 2026, 'Patient preference for large language model (LLM)–optimised oncology trial information: A randomised controlled crossover study.', in Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 44, pp. 6 - 6, http://dx.doi.org/10.1200/jco.2026.44.19_suppl.6
, 2026, 'Abstract 44: scSubtype2.0: Predictor of breast cancer molecular subtypes at single cell resolution.', in Cancer Research, American Association for Cancer Research (AACR), Vol. 86, pp. 44 - 44, http://dx.doi.org/10.1158/1538-7445.am2026-44
, 2026, 'Abstract 7282: A comprehensive multiomics atlas of treatment-naïve breast cancer uncovers co-occurring tumor-immune ecosystems driving immune hot and cold phenotypes', in Cancer Research, American Association for Cancer Research (AACR), Vol. 86, pp. 7282 - 7282, http://dx.doi.org/10.1158/1538-7445.am2026-7282
, 2025, 'Abstract GS1-01: Imlunestrant, an Oral Selective Estrogen Receptor Degrader (SERD), as Monotherapy & Combined with Abemaciclib, for Patients with ER+, HER2- Advanced Breast Cancer (ABC), Pretreated with Endocrine Therapy (ET): Results of the Phase 3 EMBER-3 trial', in Clinical Cancer Research, American Association for Cancer Research (AACR), Vol. 31, pp. gs1-01-gs1-01, http://dx.doi.org/10.1158/1557-3265.sabcs24-gs1-01
, 2025, 'Abstract P4-09-19: Exploring cellular heterogeneity of localised breast cancers', in Clinical Cancer Research, American Association for Cancer Research (AACR), Vol. 31, pp. p4-09-19-p4-09-19, http://dx.doi.org/10.1158/1557-3265.sabcs24-p4-09-19
, 2025, 'Abstract PS7-03: A first-in-human phase 1a/b trial of LOXO-783, a potent, highly mutant-selective, brain-penetrant, allosteric PI3Kα H1047R inhibitor in PIK3CA H1047R-mutant advanced breast cancer and other solid tumors: Results from the PIKASSO-01 study', in Clinical Cancer Research, American Association for Cancer Research (AACR), Vol. 31, pp. ps7-03-ps7-03, http://dx.doi.org/10.1158/1557-3265.sabcs24-ps7-03
, 2025, '372P A NATALEE data–based machine learning (ML) model to predict distant recurrence (DR) and treatment (tx) effect in real-world (RW) patients (pts) with HR+/HER2– early breast cancer (EBC) without CDK4/6 inhibitor (CDK4/6i) tx', in Annals of Oncology, Elsevier, Vol. 36, pp. s358, http://dx.doi.org/10.1016/j.annonc.2025.08.797
, 2025, 'P001: Prognostic variables for risk of recurrence in patients (pts) with HR+/HER2–early breast cancer (EBC) using data from the NATALEE trial: a machine learning (ML) model–based analysis', in The Breast, Elsevier, Vol. 80, pp. 103895, http://dx.doi.org/10.1016/j.breast.2025.103895
, 2024, 'Abstract PO5-01-09: Exploring cellular heterogeneity of localised breast cancers', in Cancer Research, American Association for Cancer Research (AACR), Vol. 84, pp. po5-01-09-po5-01-09, http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-01-09
, 2022, 'Selective Androgen Receptor Modulators in combination with CDK4/6 inhibitors demonstrate anti-cancer activity in preclinical treatment resistant ER plus AR plus breast cancer models', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, TX, San Antonio, Vol. 83, presented at San Antonio Breast Cancer Symposium, TX, San Antonio, 06 December 2022 - 10 December 2022, http://dx.doi.org/10.1158/1538-7445.SABCS22-P4-08-16
, 2022, '64Cu-SAR-Bombesin PET-CT imaging in the staging of ER+/PR+/HER2-metastatic breast cancer: Safety, dosimetry, and feasibility in a phase I trial.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, ELECTR NETWORK, Vol. 40, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), ELECTR NETWORK, 03 June 2022 - 07 June 2022
, 2022, '64Cu-SAR-Bombesin PET-CT imaging in the staging of ER+/PR+/HER2- metastatic breast cancer: Safety, dosimetry, and feasibility in a phase I trial.', in Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, pp. 3092 - 3092, http://dx.doi.org/10.1200/jco.2022.40.16_suppl.3092
, 2022, 'A phase 1a/b trial of imlunestrant (LY3484356), an oral selective estrogen receptor degrader (SERD) in ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC): Monotherapy results from EMBER.', in Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, pp. 1021 - 1021, http://dx.doi.org/10.1200/jco.2022.40.16_suppl.1021
, 2022, 'Phase 3 ENABLAR-2 study to evaluate enobosarm and abemaciclib combination compared to estrogen-blocking agent for the second-line treatment of AR+, ER+, HER2- metastatic breast cancer in patients who previously received palbociclib and estrogen-blocking agent combination therapy.', in Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, pp. tps1121 - tps1121, http://dx.doi.org/10.1200/jco.2022.40.16_suppl.tps1121
, 2022, 'Abstract PD2-02: Combination CDK4/6 inhibition and AR agonism suppresses the growth of CDK4/6 inhibitor resistant breast cancers', in Cancer Research, American Association for Cancer Research (AACR), Vol. 82, pp. pd2-02-pd2-02, http://dx.doi.org/10.1158/1538-7445.sabcs21-pd2-02
, 2021, 'Heart failure therapies for the prevention of HER2-monoclonal antibody-mediated cardiotoxicity: A systematic review and meta-analysis', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 17, pp. 119 - 119, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000717281500164&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2021, 'Patient-reported outcomes of medicine access programmes: A sub-study of KARMA (Kisqali Access Registry for Metastatic Breast Cancer in Australia)', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 17, pp. 175 - 176, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000717281500285&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2021, 'Evaluation of pharmacodynamic (PD) and biologic activity in a preoperative window-of-opportunity (WOO) study of giredestrant (GDC-9545) in postmenopausal patients (pts) with estrogen receptor-positive, HER2-negative (ER+/HER2–) operable breast cancer (BC).', in Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 39, pp. 577 - 577, http://dx.doi.org/10.1200/jco.2021.39.15_suppl.577
, 2021, 'Preliminary assessment of the diagnostic value of Cu-64-SAR-Bombesin PET-CT imaging for staging of ER+/PR+HER2-metastatic breast cancer disease: comparison with conventional imaging', in JOURNAL OF NUCLEAR MEDICINE, SOC NUCLEAR MEDICINE INC, Vol. 62, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000713713600278&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2021, 'An integrated multi-omic cellular atlas of human breast cancers.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, Vol. 81, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 10 April 2021 - 21 May 2021
, 2021, '100P Efficacy of enobosarm, a selective androgen receptor (AR) targeting agent, in patients with metastatic AR+/ER+ breast cancer resistant to estrogen receptor targeted agents and CDK 4/6 inhibitor in a phase II clinical study', in Annals of Oncology, Elsevier, Vol. 32, pp. s66, http://dx.doi.org/10.1016/j.annonc.2021.03.114
, 2021, '48P Abemaciclib combined with adjuvant endocrine therapy in patients from Asia with high risk early breast cancer: monarchE', in Annals of Oncology, Elsevier, Vol. 32, pp. s41 - s42, http://dx.doi.org/10.1016/j.annonc.2021.03.062
, 2020, 'Efficacy and safety of enobosarm, a selective androgen receptor modulator, to target AR in women with advanced ER plus /AR plus breast cancer - final results from an international Phase 2 randomized study', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, ELECTR NETWORK, Vol. 81, presented at San Antonio Breast Cancer Virtual Symposium, ELECTR NETWORK, 08 December 2020 - 11 December 2020
, 2020, 'EMBER: A phase 1a/b trial of LY3484356, a novel, oral selective estrogen-receptor degrader (SERD), in advanced ER plus breast cancer and endometroid endometrial cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, ELECTR NETWORK, Vol. 81, presented at San Antonio Breast Cancer Virtual Symposium, ELECTR NETWORK, 08 December 2020 - 11 December 2020
, 2020, 'Mdm2 inhibition synergises with endocrine therapy or cdk4/6 inhibition for the treatment of estrogen receptor-positive breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, ELECTR NETWORK, Vol. 81, presented at San Antonio Breast Cancer Virtual Symposium, ELECTR NETWORK, 08 December 2020 - 11 December 2020
, 2020, 'A phase Ib study to evaluate the oral selective estrogen receptor degrader GDC-9545 alone or combined with palbociclib in metastatic ER-positive HER2-negative breast cancer.', in Journal of Clinical Oncology, American Society of Clinical Oncology, Chicago, presented at American Society of Clinical Oncology, Chicago, 29 May 2020 - 31 May 2020
, 2020, 'Abstract OT2-02-01: A 'real world' experience of CDK4/6 inhibition with ribociclib and endocrine therapy in hormone receptor positive metastatic breast cancer in Australia', in Cancer Research, American Association for Cancer Research (AACR), Vol. 80, pp. ot2-02-01-ot2-02-01, http://dx.doi.org/10.1158/1538-7445.sabcs19-ot2-02-01