Select Publications

Book Chapters

Cohen-Hallaleh RB; Rickard M; Lim E; Raymond WA; Segara D; Arnold L; Lee AHS; Schmitt FC; Field A, 2020, 'Clinical Management', in In The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology Atlas

Field AS; Raymond WA; Rickard MT; Arnold L; Brachtel EF; Chaiwun B; Chen L; Chong PY; Di Bonito L; Hoda RS; Kurtycz DFI; Lee AHS; Lim E; Ljung B-M; Michelow P; Osamura RY; Pinamonti M; Sauer T; Segara D; Tse GM; Vielh P; Schmitt F, 2020, 'The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology: Introduction and Overview', in The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology, Springer International Publishing, pp. 1 - 9, http://dx.doi.org/10.1007/978-3-030-26883-1_1

Saunders C; Jassal S; Lim E, 2019, 'Breast Cancer: The facts', in Breast Cancer: The Facts, Oxford University Press

Lim E; Goel S; Winer EP, 2015, 'Adjuvant chemotherapy in breast cancer', in Breast disease: Comprehensive management, pp. 335 - 351, http://dx.doi.org/10.1007/978-1-4939-1145-5_23

Journal articles

Wong V; de Boer R; Baron-Hay S; Blum R; Boyle F; Chua S; Clarke K; Cuff K; Green M; Lim E; Mok K; Nott L; Nottage M; Tafreshi A; Tsoi D; Uccellini A; Hong W; Gibbs P; Lok SW, 2022, 'Real-World Outcomes of Ribociclib and Aromatase Inhibitor Use in First Line Hormone Receptor Positive, HER2-Negative Metastatic Breast Cancer', Clinical Breast Cancer, vol. 22, pp. 792 - 800, http://dx.doi.org/10.1016/j.clbc.2022.08.011

Papanicolaou M; Parker AL; Yam M; Filipe EC; Wu SZ; Chitty JL; Wyllie K; Tran E; Mok E; Nadalini A; Skhinas JN; Lucas MC; Herrmann D; Nobis M; Pereira BA; Law AMK; Castillo L; Murphy KJ; Zaratzian A; Hastings JF; Croucher DR; Lim E; Oliver BG; Mora FV; Parker BL; Gallego-Ortega D; Swarbrick A; O’Toole S; Timpson P; Cox TR, 2022, 'Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis', Nature Communications, vol. 13, pp. 4587, http://dx.doi.org/10.1038/s41467-022-32255-7

Lim E; Boyle F; Okera M; Loi S; Goksu SS; van Hal G; Chapman SC; Gable JC; Chen Y; Price GL; Hossain AM; Gainford MC; Ezquerra MB, 2022, 'An open label, randomized phase 2 trial assessing the impact of food on the tolerability of abemaciclib in patients with advanced breast cancer', Breast Cancer Research and Treatment, vol. 195, pp. 275 - 287, http://dx.doi.org/10.1007/s10549-022-06690-5

Nguyen A; Fullard K; Sheehan-Dare G; Tang R; Chan L; Ho B; Dear R; Keane J; Hickey A; Nandurkar R; Chen J; Chen A; Lim E; Emmett L, 2022, 'Diagnostic value of 68Ga-DOTATATE PET-CT imaging for staging of ER+/PR+ HER2- breast cancer patients with metastatic disease: Comparison with conventional imaging with bone scan, diagnostic CT and 18F-FDG PET-CT in a prospective pilot trial', Journal of Medical Imaging and Radiation Oncology, vol. 66, pp. 731 - 737, http://dx.doi.org/10.1111/1754-9485.13342

Wong K; Sheehan-Dare G; Nguyen A; Ho B; Liu V; Lee J; Brown L; Dear R; Chan L; Sharma S; Malaroda A; Smith I; Lim E; Emmett L, 2022, '64Cu-SAR-Bombesin PET-CT Imaging in the Staging of Estrogen/Progesterone Receptor Positive, HER2 Negative Metastatic Breast Cancer Patients: Safety, Dosimetry and Feasibility in a Phase I Trial', Pharmaceuticals, vol. 15, pp. 772 - 772, http://dx.doi.org/10.3390/ph15070772

Berthelet J; Foroutan M; Bhuva DD; Whitfield HJ; El-Saafin F; Cursons J; Serrano A; Merdas M; Lim E; Charafe-Jauffret E; Ginestier C; Ernst M; Hollande F; Anderson RL; Pal B; Yeo B; Davis MJ; Merino D, 2022, 'Computational Screening of Anti-Cancer Drugs Identifies a New BRCA Independent Gene Expression Signature to Predict Breast Cancer Sensitivity to Cisplatin', Cancers, vol. 14, http://dx.doi.org/10.3390/cancers14102404

Morrow RJ; Allam AH; Yeo B; Deb S; Murone C; Lim E; Johnstone CN; Ernst M, 2022, 'Paracrine IL-6 Signaling Confers Proliferation between Heterogeneous Inflammatory Breast Cancer Sub-Clones', Cancers, vol. 14, pp. 2292 - 2292, http://dx.doi.org/10.3390/cancers14092292

Portman N; Lim E, 2022, 'A new sophistication for breast cancer PDXs', Nature Cancer, vol. 3, pp. 138 - 140, http://dx.doi.org/10.1038/s43018-021-00328-z

Haggstrom LR; Vardy JL; Carson EK; Segara D; Lim E; Kiely BE, 2022, 'Effects of Endocrine Therapy on Cognitive Function in Patients with Breast Cancer: A Comprehensive Review', Cancers, vol. 14, pp. 920 - 920, http://dx.doi.org/10.3390/cancers14040920

Brown LJ; Achinger-Kawecka J; Portman N; Clark S; Stirzaker C; Lim E, 2022, 'Epigenetic Therapies and Biomarkers in Breast Cancer', Cancers, vol. 14, pp. 474 - 474, http://dx.doi.org/10.3390/cancers14030474

Dinh P; Graham JD; Elder EN; Kabir M; Doan TB; French J; Meybodi F; Hui R; Wilcken NR; Harnett PR; Hsu J; Stuart KE; Wang T; Ahern V; Brennan M; Fox SB; Dear RF; Lim E; White M; Mann GB; Pathmanathan N, 2022, 'Impact of the EndoPredict genomic assay on treatment decisions for oestrogen receptor-positive early breast cancer patients: benefits of physician selective testing', Breast Cancer Research and Treatment, vol. 191, pp. 501 - 511, http://dx.doi.org/10.1007/s10549-021-06456-5

Downton T; Zhou F; Segara D; Jeselsohn R; Lim E, 2022, 'Oral Selective Estrogen Receptor Degraders (SERDs) in Breast Cancer: Advances, Challenges, and Current Status', Drug Design, Development and Therapy, vol. 16, pp. 2933 - 2948, http://dx.doi.org/10.2147/DDDT.S380925

Martin Jimenez M; Lim E; Chavez Mac Gregor M; Bardia A; Wu J; Zhang Q; Nowecki Z; Cruz F; Safin R; Kim S-B; Schem C; Montero A; Khan S; Bandyopadhyay R; Shivhare M; Patre M; Martinalbo J; Roncoroni L; Pérez-Moreno PD; Sohn J, 2022, '211MO Giredestrant (GDC-9545) vs physician choice of endocrine monotherapy (PCET) in patients (pts) with ER+, HER2– locally advanced/metastatic breast cancer (LA/mBC): Primary analysis of the phase II, randomised, open-label acelERA BC study', Annals of Oncology, vol. 33, pp. S633 - S634, http://dx.doi.org/10.1016/j.annonc.2022.07.250

Alves CL; Ehmsen S; Terp MG; Portman N; Tuttolomondo M; Gammelgaard OL; Hundebøl MF; Kaminska K; Johansen LE; Bak M; Honeth G; Bosch A; Lim E; Ditzel HJ, 2021, 'Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer', Nature Communications, vol. 12, http://dx.doi.org/10.1038/s41467-021-25422-9

Wu SZ; Roden DL; Al-Eryani G; Bartonicek N; Harvey K; Cazet AS; Chan CL; Junankar S; Hui MN; Millar EA; Beretov J; Horvath L; Joshua AM; Stricker P; Wilmott JS; Quek C; Long GV; Scolyer RA; Yeung BZ; Segara D; Mak C; Warrier S; Powell JE; O’Toole S; Lim E; Swarbrick A, 2021, 'Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis', Genome Medicine, vol. 13, pp. 81, http://dx.doi.org/10.1186/s13073-021-00885-z

Chew NJ; Lim Kam Sian TCC; Nguyen EV; Shin SY; Yang J; Hui MN; Deng N; McLean CA; Welm AL; Lim E; Gregory P; Nottle T; Lang T; Vereker M; Richardson G; Kerr G; Micati D; Jardé T; Abud HE; Lee RS; Swarbrick A; Daly RJ, 2021, 'Evaluation of FGFR targeting in breast cancer through interrogation of patient-derived models', Breast Cancer Research, vol. 23, pp. 82, http://dx.doi.org/10.1186/s13058-021-01461-4

Alves CL; Ehmsen S; Terp MG; Portman N; Tuttolomondo M; Gammelgaard OL; Hundebøl MF; Kaminska K; Johansen LE; Bak M; Honeth G; Bosch A; Lim E; Ditzel HJ, 2021, 'Publisher Correction: Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer (Nature Communications, (2021), 12, 1, (5112), 10.1038/s41467-021-25422-9)', Nature Communications, vol. 12, pp. 5588, http://dx.doi.org/10.1038/s41467-021-25901-z

Aziz D; Portman N; Fernandez KJ; Lee C; Alexandrou S; Llop-Guevara A; Phan Z; Yong A; Wilkinson A; Sergio CM; Ferraro D; Etemadmoghadam D; Bowtell DD; Serra V; Waring P; Lim E; Caldon CE, 2021, 'Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition', npj Breast Cancer, vol. 7, http://dx.doi.org/10.1038/s41523-021-00312-x

Portman N; Chen J; Lim E, 2021, 'MDM2 as a Rational Target for Intervention in CDK4/6 Inhibitor Resistant, Hormone Receptor Positive Breast Cancer', Frontiers in Oncology, vol. 11, http://dx.doi.org/10.3389/fonc.2021.777867

Brown LJ; Meredith T; Yu J; Patel A; Neal B; Arnott C; Lim E, 2021, 'Heart failure therapies for the prevention of her2-monoclonal antibody-mediated cardiotoxicity: A systematic review and meta-analysis of randomized trials', Cancers, vol. 13, http://dx.doi.org/10.3390/cancers13215527

Kumar S; Freelander A; Lim E, 2021, 'Type 1 nuclear receptor activity in breast cancer: Translating preclinical insights to the clinic', Cancers, vol. 13, pp. 4972 - 4972, http://dx.doi.org/10.3390/cancers13194972

Du Q; Smith GC; Luu PL; Ferguson JM; Armstrong NJ; Caldon CE; Campbell EM; Nair SS; Zotenko E; Gould CM; Buckley M; Chia KM; Portman N; Lim E; Kaczorowski D; Chan CL; Barton K; Deveson IW; Smith MA; Powell JE; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark SJ, 2021, 'DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity', Cell Reports, vol. 36, http://dx.doi.org/10.1016/j.celrep.2021.109722

Wu SZ; Al-Eryani G; Roden DL; Junankar S; Harvey K; Andersson A; Thennavan A; Wang C; Torpy JR; Bartonicek N; Wang T; Larsson L; Kaczorowski D; Weisenfeld NI; Uytingco CR; Chew JG; Bent ZW; Chan CL; Gnanasambandapillai V; Dutertre CA; Gluch L; Hui MN; Beith J; Parker A; Robbins E; Segara D; Cooper C; Mak C; Chan B; Warrier S; Ginhoux F; Millar E; Powell JE; Williams SR; Liu XS; O’Toole S; Lim E; Lundeberg J; Perou CM; Swarbrick A, 2021, 'A single-cell and spatially resolved atlas of human breast cancers', Nature Genetics, vol. 53, pp. 1334 - 1347, http://dx.doi.org/10.1038/s41588-021-00911-1

Chen J; Colosimo M; Lim E, 2021, 'The management of HER2-positive early breast cancer: Current and future therapies', Asia-Pacific Journal of Clinical Oncology, vol. 17, pp. 3 - 12, http://dx.doi.org/10.1111/ajco.13655

Ardolino L; Lau B; Wilson I; Chen J; Borella L; Stone E; Lim E, 2021, 'Case Report: Paclitaxel-Induced Pneumonitis in Early Breast Cancer: A Single Institution Experience and Review', Frontiers in Oncology, vol. 11, http://dx.doi.org/10.3389/fonc.2021.701424

Achinger-Kawecka J; Stirzaker C; Portman N; Campbell E; Chia K-M; Du Q; Laven-Law G; Nair SS; Yong A; Wilkinson A; Clifton S; Milioli HH; Alexandrou S; Caldon CE; Song J; Khoury A; Meyer B; Gee JMW; Schmitt A; Wong ES; Hickey TE; Lim E; Clark SJ, 2021, 'Epigenetic therapy targets the 3D epigenome in endocrine-resistant breast cancer', , http://dx.doi.org/10.1101/2021.06.21.449340

Jhaveri KL; Lim E; Hamilton EP; Saura C; Meniawy T; Jeselsohn R; Beck JT; Kaufman PA; Sammons S; Banda K; Okera M; Yonemori K; Harnden KK; Kim S-B; Sohn J; Ma CX; Aftimos PG; Wang XA; Young SRL; Beeram M, 2021, 'A first-in-human phase 1a/b trial of LY3484356, an oral selective estrogen receptor (ER) degrader (SERD) in ER plus advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC): Results from the EMBER study.', JOURNAL OF CLINICAL ONCOLOGY, vol. 39, http://dx.doi.org/10.1200/JCO.2021.39.15_suppl.1050

Martin M; Lim E; Mac Gregor MC; Shivhare M; Ross G; Patre M; Roncoroni L; Louka M; Sohn J, 2021, 'acelERA Breast Cancer (BC): Phase II study evaluating efficacy and safety of giredestrant (GDC-9545) versus physician's choice of endocrine monotherapy in patients (pts) with estrogen receptor-positive, HER2-negative (ER+/HER2-) locally advanced or metastatic breast cancer (LA/mBC).', JOURNAL OF CLINICAL ONCOLOGY, vol. 39, http://dx.doi.org/10.1200/JCO.2021.39.15_suppl.TPS1100

Wong V; de Boer R; Baron-Hay SE; Blum RH; Forster BC; Chua SLL; Cuff K; Green M; Lim E; Mok K; Nott LM; Nottage MK; Tafreshi A; Tsoi DTF; Yeo B; Gibbs P; Lok SW, 2021, 'Australian real-world outcomes of ribociclib and aromatase inhibitor in hormone receptor (HR) positive, HER2 negative metastatic breast cancer (MBC): Results from Kisqali Access Registry for Metastatic breast cancer in Australia (KARMA) collected alongside a medicine access program.', Journal of Clinical Oncology, vol. 39, pp. e13018 - e13018, http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e13018

Palmieri C; Linden HM; Birrell S; Lim E; Schwartzberg LS; Rugo HS; Cobb PW; Jain K; Vogel CL; O'Shaughnessy J; Johnston SRD; Getzenberg RH; Barnette KG; Steiner MS; Brufsky A; Overmoyer B, 2021, 'Efficacy of enobosarm, a selective androgen receptor (AR) targeting agent, correlates with the degree of AR positivity in advanced AR+/estrogen receptor (ER)+ breast cancer in an international phase 2 clinical study.', Journal of Clinical Oncology, vol. 39, pp. 1020 - 1020, http://dx.doi.org/10.1200/jco.2021.39.15_suppl.1020

Moore HM; Boni V; Bellet M; De Las Heras BB; Cortes MG; Oakman C; Schmid P; Trinh XB; Wheatley D; Jhaveri KL; Kabos P; Lim E; Velu T; Metcalfe C; Gates MR; Chang C-W; Bond J; Goldstein LD; Lauchle JO; Bardia A, 2021, 'Evaluation of pharmacodynamic (PD) and biologic activity in a preoperative window-of-opportunity (WOO) study of giredestrant (GDC-9545) in postmenopausal patients (pts) with estrogen receptor-positive, HER2-negative (ER+/HER2-) operable breast cancer (BC).', JOURNAL OF CLINICAL ONCOLOGY, vol. 39, http://dx.doi.org/10.1200/JCO.2021.39.15_suppl.577

Jhaveri KL; Boni V; Sohn J; Villanueva-Vasquez R; Bardia A; Schmid P; Lim E; Patel JM; Alejandro Perez-Fidalgo J; Loi S; Im S-A; Kshirsagar S; Gates MR; Bond J; Eng-Wong J; Chang C-W; Turner NC; Lopez Miranda E; Garcia-Estevez L; Bellet M, 2021, 'Safety and activity of single-agent giredestrant (GDC-9545) from a phase Ia/b study in patients (pts) with estrogen receptor-positive (ER+), HER2-negative locally advanced/metastatic breast cancer (LA/mBC).', JOURNAL OF CLINICAL ONCOLOGY, vol. 39, http://dx.doi.org/10.1200/JCO.2021.39.15_suppl.1017

Freelander A; Brown LJ; Parker A; Segara D; Portman N; Lau B; Lim E, 2021, 'Molecular biomarkers for contemporary therapies in hormone receptor‐positive breast cancer', Genes, vol. 12, pp. 1 - 24, http://dx.doi.org/10.3390/genes12020285

Hickey TE; Selth LA; Chia KM; Laven-Law G; Milioli HH; Roden D; Jindal S; Hui M; Finlay-Schultz J; Ebrahimie E; Birrell SN; Stelloo S; Iggo R; Alexandrou S; Caldon CE; Abdel-Fatah TM; Ellis IO; Zwart W; Palmieri C; Sartorius CA; Swarbrick A; Lim E; Carroll JS; Tilley WD, 2021, 'The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer', Nature Medicine, vol. 27, pp. 310 - 320, http://dx.doi.org/10.1038/s41591-020-01168-7

Hui R; de Boer R; Lim E; Yeo B; Lynch J, 2021, 'CDK4/6 inhibitor plus endocrine therapy for hormone receptor-positive, HER2-negative metastatic breast cancer: The new standard of care', Asia-Pacific Journal of Clinical Oncology, vol. 17, pp. 3 - 14, http://dx.doi.org/10.1111/ajco.13555

Chia KM; Freelander A; Kumar S; Parker A; Segara D; Portman N; Lim E, 2020, 'Estrogen receptor positive breast cancer patient–derived xenograft models in translational research', Current Opinion in Endocrine and Metabolic Research, vol. 15, pp. 31 - 36, http://dx.doi.org/10.1016/j.coemr.2020.10.004

de Boer R; Hui R; Lim E; Yeo B; Zdenkowski N, 2020, 'Optimizing care for younger women with hormone receptor-positive, HER2-negative metastatic breast cancer', Asia-Pacific Journal of Clinical Oncology, vol. 16, pp. 3 - 14, http://dx.doi.org/10.1111/ajco.13461

Wu SZ; Roden DL; Wang C; Holliday H; Harvey K; Cazet AS; Murphy KJ; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy JR; Junankar S; Chan CL; Lam CE; Hui MN; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O'Toole S; Cox TR; Timpson P; Lim E; Liu XS; Swarbrick A, 2020, 'Stromal cell diversity associated with immune evasion in human triple-negative breast cancer', EMBO Journal, vol. 39, http://dx.doi.org/10.15252/embj.2019104063

Light M; McFarlane T; Ives A; Shah B; Lim E; Grossmann M; Zajac JD; Cheung AS, 2020, 'Testosterone therapy considerations in oestrogen, progesterone and androgen receptor–positive breast cancer in a transgender man', Clinical Endocrinology, vol. 93, pp. 355 - 357, http://dx.doi.org/10.1111/cen.14263

Portman N; Milioli HH; Alexandrou S; Coulson R; Yong A; Fernandez KJ; Chia KM; Halilovic E; Segara D; Parker A; Haupt S; Haupt Y; Tilley WD; Swarbrick A; Caldon CE; Lim E, 2020, 'MDM2 inhibition in combination with endocrine therapy and CDK4/6 inhibition for the treatment of ER-positive breast cancer', Breast Cancer Research, vol. 22, pp. 87, http://dx.doi.org/10.1186/s13058-020-01318-2

Portman N; Milioli HH; Alexandrou S; Coulson R; Yong A; Fernandez KJ; Chia KM; Segara D; Parker A; Haupt S; Haupt Y; Tilley WD; Swarbrick A; Caldon CE; Lim E, 2020, 'MDM2 Inhibition in Combination with Endocrine Therapy and CDK4/6 Inhibition for the Treatment of ER-Positive Breast Cancer', , http://dx.doi.org/10.1101/2020.06.09.140921

Baker LA; Holliday H; Roden D; Krisp C; Wu SZ; Junankar S; Serandour AA; Mohammed H; Nair R; Sankaranarayanan G; Law AMK; McFarland A; Simpson PT; Lakhani S; Dodson E; Selinger C; Anderson L; Anderson L; Samimi G; Hacker NF; Lim E; Ormandy CJ; Naylor MJ; Simpson K; Nikolic I; O'Toole S; Kaplan W; Cowley MJ; Carroll JS; Molloy M; Swarbrick A, 2020, 'Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer', Breast Cancer Research, vol. 22, pp. 63, http://dx.doi.org/10.1186/s13058-020-01306-6

Wu S; Roden D; Al-Eryani G; Bartonicek N; Harvey K; Cazet A; Chan C-L; Junankar S; Hui M; Millar E; Beretov J; Horvath L; Joshua A; Stricker P; Wilmott J; Quek C; Long G; Scolyer R; Yeung B; Segara D; Mak C; Warrier S; Powell J; O'Toole S; Lim E; Swarbrick A, 2020, 'Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis', bioRxiv, http://dx.doi.org/10.1101/2020.06.04.135277

Wu S; Roden D; Wang C; Holliday H; Harvey K; Cazet A; Murphy K; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy J; Junankar S; Chan C-L; Lam E; Hui M; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O’Toole S; Cox T; Timpson P; Lim E; Liu S; Swarbrick A, 2020, 'Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer', bioRxiv, http://dx.doi.org/10.1101/2020.06.04.135327

Lim E; Jhaveri KL; Perez-Fidalgo JA; Bellet M; Boni V; Perez Garcia JM; Estevez L; Bardia A; Turner NC; Villanueva R; Lopez-Tarruella Cobo S; Im S-A; Kim S-B; Gates MR; Monemi S; Chen Y-C; Moore H; Loi S; Sohn J, 2020, 'A phase Ib study to evaluate the oral selective estrogen receptor degrader GDC-9545 alone or combined with palbociclib in metastatic ER-positive HER2-negative breast cancer.', Journal of Clinical Oncology, vol. 38, pp. 1023 - 1023, http://dx.doi.org/10.1200/jco.2020.38.15_suppl.1023

Tadesse S; Anshabo AT; Portman N; Lim E; Tilley W; Caldon CE; Wang S, 2020, 'Targeting CDK2 in cancer: challenges and opportunities for therapy', Drug Discovery Today, vol. 25, pp. 406 - 413, http://dx.doi.org/10.1016/j.drudis.2019.12.001


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