Select Publications

Book Chapters

Cohen-Hallaleh RB; Rickard M; Lim E; Raymond WA; Segara D; Arnold L; Lee AHS; Schmitt FC; Field A, 2020, 'Clinical Management', in In The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology Atlas

Field AS; Raymond WA; Rickard MT; Arnold L; Brachtel EF; Chaiwun B; Chen L; Chong PY; Di Bonito L; Hoda RS; Kurtycz DFI; Lee AHS; Lim E; Ljung BM; Michelow P; Osamura RY; Pinamonti M; Sauer T; Segara D; Tse GM; Vielh P; Schmitt F, 2020, 'The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology: Introduction and Overview', in The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology, pp. 1 - 9,

Saunders C; Jassal S; Lim E, 2019, 'Breast Cancer: The facts', in Breast Cancer: The Facts, Oxford University Press

Lim E; Goel S; Winer EP, 2015, 'Adjuvant chemotherapy in breast cancer', in Breast disease: Comprehensive management, pp. 335 - 351,

Journal articles

Peters TJ; Meyer B; Ryan L; Achinger-Kawecka J; Song J; Campbell EM; Qu W; Nair S; Loi-Luu P; Stricker P; Lim E; Stirzaker C; Clark SJ; Pidsley R, 2024, 'Characterisation and reproducibility of the HumanMethylationEPIC v2.0 BeadChip for DNA methylation profiling', BMC Genomics, 25,

Hosseinzadeh L; Kikhtyak Z; Laven-Law G; Pederson SM; Puiu CG; D’Santos CS; Lim E; Carroll JS; Tilley WD; Dwyer AR; Hickey TE, 2024, 'The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer', Genome Biology, 25,

Guarducci C; Nardone A; Russo D; Nagy Z; Heraud C; Grinshpun A; Zhang Q; Freelander A; Leventhal MJ; Feit A; Cohen Feit G; Feiglin A; Liu W; Hermida-Prado F; Kesten N; Ma W; De Angelis C; Morlando A; O'Donnell M; Naumenko S; Huang S; Nguyen Q-D; Huang Y; Malorni L; Bergholz JS; Zhao JJ; Fraenkel E; Lim E; Schiff R; Shapiro GI; Jeselsohn R, 2024, 'Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor-positive Breast Cancer.', Clin Cancer Res, 30, pp. 1889 - 1905,

Palmieri C; Linden H; Birrell SN; Wheelwright S; Lim E; Schwartzberg LS; Dwyer AR; Hickey TE; Rugo HS; Cobb P; O'Shaughnessy JA; Johnston S; Brufsky A; Tilley WD; Overmoyer B, 2024, 'Activity and safety of enobosarm, a novel, oral, selective androgen receptor modulator, in androgen receptor-positive, oestrogen receptor-positive, and HER2-negative advanced breast cancer (Study G200802): a randomised, open-label, multicentre, multinational, parallel design, phase 2 trial', The Lancet Oncology, 25, pp. 317 - 325,

Achinger-Kawecka J; Stirzaker C; Portman N; Campbell E; Chia KM; Du Q; Laven-Law G; Nair SS; Yong A; Wilkinson A; Clifton S; Milioli HH; Alexandrou S; Caldon CE; Song J; Khoury A; Meyer B; Chen W; Pidsley R; Qu W; Gee JMW; Schmitt A; Wong ES; Hickey TE; Lim E; Clark SJ, 2024, 'The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer', Nature Structural and Molecular Biology, 31, pp. 498 - 512,

Jhaveri KL; Bellet M; Turner NC; Loi S; Bardia A; Boni V; Sohn J; Neilan TG; Villanueva-Vázquez R; Kabos P; García-Estévez L; López-Miranda E; Pérez-Fidalgo JA; Pérez-García JM; Yu J; Fredrickson J; Moore HM; Chang CW; Bond JW; Eng-Wong J; Gates MR; Lim E, 2024, 'Phase Ia/b Study of Giredestrant ± Palbociclib and ± Luteinizing Hormone-Releasing Hormone Agonists in Estrogen Receptor-Positive, HER2-Negative, Locally Advanced/Metastatic Breast Cancer', Clinical Cancer Research, 30, pp. 754 - 766,

Thompson EJ; Escarbe S; Tvorogov D; Farshid G; Gregory PA; Khew-Goodall Y; Madden S; Ingman WV; Lindeman GJ; Lim E; Lopez AF; Bonder CS, 2024, 'Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis', Growth Factors,

Park KH; Loibl S; Sohn J; Park YH; Jiang Z; Tadjoedin H; Nag S; Saji S; Md. Yusof M; Villegas EMB; Lim EH; Lu YS; Ithimakin S; Tseng LM; Dejthevaporn T; Chen TWW; Lee SC; Galvez C; Malwinder S; Kogawa T; Bajpai J; Brahma B; Wang S; Curigliano G; Yoshino T; Kim SB; Pentheroudakis G; Im SA; Andre F; Ahn JB; Harbeck N, 2024, 'Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with early breast cancer', ESMO Open,

Filipe EC; Velayuthar S; Philp A; Nobis M; Latham SL; Parker AL; Murphy KJ; Wyllie K; Major GS; Contreras O; Mok ETY; Enriquez RF; McGowan S; Feher K; Quek LE; Hancock SE; Yam M; Tran E; Setargew YFI; Skhinas JN; Chitty JL; Phimmachanh M; Han JZR; Cadell AL; Papanicolaou M; Mahmodi H; Kiedik B; Junankar S; Ross SE; Lam N; Coulson R; Yang J; Zaratzian A; Da Silva AM; Tayao M; Chin IL; Cazet A; Kansara M; Segara D; Parker A; Hoy AJ; Harvey RP; Bogdanovic O; Timpson P; Croucher DR; Lim E; Swarbrick A; Holst J; Turner N; Choi YS; Kabakova IV; Philp A; Cox TR, 2024, 'Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism', Advanced Science,

Chiu JWY; Lee SC; Ho JCM; Park YH; Chao TC; Kim SB; Lim E; Lin CH; Loi S; Low SY; Teo LLS; Yeo W; Dent R, 2023, 'Clinical Guidance on the Monitoring and Management of Trastuzumab Deruxtecan (T-DXd)-Related Adverse Events: Insights from an Asia-Pacific Multidisciplinary Panel', Drug Safety, 46, pp. 927 - 949,

Chowdary P; Hastie R; Lino T; Middleton A; Capes G; Humphries A; Abed-Ali A; Anderson M; Mol BWJ; Horne A; Lim E; Andrew P; Brownfoot F; Tong S, 2023, 'Oral vinorelbine to treat women with ectopic pregnancy: a phase 1 clinical safety and tolerability study', Fertility and Sterility, 120, pp. 695 - 696,

Hurwitz J; Haggstrom LR; Lim E, 2023, 'Antibody–Drug Conjugates: Ushering in a New Era of Cancer Therapy', Pharmaceutics, 15,

Collier A; Chavez Mac Gregor M; Hilz S; Bardia A; Sohn J; Martin M; Lim E; Martinalbo J; Pérez-Moreno PD; Moore HM, 2023, 'Exploratory biomarker analysis of acelERA breast cancer (BC): Phase II study of giredestrant vs. physician’s choice of endocrine therapy (PCET) for previously treated, estrogen receptor-positive, HER2-negative advanced BC (ER+, HER2– aBC).', Journal of Clinical Oncology, 41, pp. 1069 - 1069,

Karimi L; Alves CL; Terp MG; Tuttolomondo M; Portman N; Ehmsen S; Johansen LE; Bak M; Lim E; Ditzel HJ, 2023, 'Triple combination targeting PI3K, ER, and CDK4/6 inhibits growth of ER-positive breast cancer resistant to fulvestrant and CDK4/6 or PI3K inhibitor', Cancer Communications, 43, pp. 720 - 725,

André F; Hee Park Y; Kim SB; Takano T; Im SA; Borges G; Lima JP; Aksoy S; Gavila Gregori J; De Laurentiis M; Bianchini G; Roylance R; Miyoshi Y; Armstrong A; Sinha R; Ruiz Borrego M; Lim E; Ettl J; Yerushalmi R; Zagouri F; Duhoux FP; Fehm T; Gambhire D; Cathcart J; Wu C; Chu C; Egorov A; Krop I, 2023, 'Trastuzumab deruxtecan versus treatment of physician's choice in patients with HER2-positive metastatic breast cancer (DESTINY-Breast02): a randomised, open-label, multicentre, phase 3 trial', The Lancet, 401, pp. 1773 - 1785,

Conway JRW; Warren SC; Lee YK; McCulloch AT; Magenau A; Lee V; Metcalf XL; Stoehr J; Haigh K; Abdulkhalek L; Guaman CS; Reed DA; Murphy KJ; Pereira BA; Mélénec P; Chambers C; Latham SL; Lenthall H; Deenick EK; Ma Y; Phan T; Lim E; Joshua AM; Walters S; Grey ST; Shi YC; Zhang L; Herzog H; Croucher DR; Philp A; Scheele CLGJ; Herrmann D; Sansom OJ; Morton JP; Papa A; Haigh JJ; Nobis M; Timpson P, 2023, 'Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse', Science Advances, 9,

Krop I; Park YH; Kim S-B; Borges G; Aksoy S; Gregori JG; Roylance R; Lim E; Yerushalmi R; Zagouri F; Duhoux FP; Fehm T; Takano T; Egorov A; Wu I; Cathcart J; Chu C; Andre F, 2023, 'Abstract GS2-01: GS2-01 Trastuzumab deruxtecan vs physician’s choice in patients with HER2+ unresectable and/or metastatic breast cancer previously treated with trastuzumab emtansine: primary results of the randomized, phase 3 study DESTINY-Breast02', Cancer Research, 83,

Lim E; Hamilton E; Palmieri C; Arkenau H-T; Brook S; Fisher G; Mazur A, 2023, 'Abstract OT1-02-02: A phase 1/2 study to evaluate the safety and efficacy of EP0062, an oral Selective Androgen Receptor Modulator (SARM), for the treatment of AR+/HER2-/ER+ advanced breast cancer', Cancer Research, 83,

Downton T; Segara D; Ong A; Bingham J; Carson E-K; Chen J; Middleton K; Lindeman G; Parker A; Lim E, 2023, 'Abstract OT2-01-10: WinPro: A window of opportunity study of endocrine therapy with and without prometrium in postmenopausal women with early-stage hormone receptor-positive breast cancer', Cancer Research, 83,

Downton T; Karlsen E; Cuff K; Walpole E; Simpson F; Lim E, 2023, 'Abstract OT2-10-05: HER2Pro: A Phase 1b dose de-escalation study of high dose prochlorperazine added to paclitaxel, trastuzumab and pertuzumab in patients with previously untreated HER2-positive metastatic breast cancer', Cancer Research, 83,

Lim E; Chavez M; Bardia A; Sohn JH; Moore HM; Shivhare M; Martinalbo J; Roncoroni L; Perez-Moreno PD; Martín M, 2023, 'Abstract PD13-04: PD13-04 Exploratory subgroup and biomarker analyses of acelERA Breast Cancer: Phase II study of giredestrant (GDC-9545) vs physician’s choice of endocrine therapy for previously treated, estrogen receptor+, HER2– advanced breast cancer', Cancer Research, 83,

Jhaveri K; Wang H-C; Ma C; Lim E; Tao JJ; Manso L; Pierga J-Y; Parajuli R; Gilarranz YJ; Lu Y-S; Beeram M; Larson T; Dhakal A; Ismail-Khan R; Karacsonyi C; Cao S; Osborne C; Estrem ST; Nguyen B; Li Y; Yuen E, 2023, 'Abstract PD13-12: PD13-12 Imlunestrant, an oral selective estrogen receptor degrader, in combination with abemaciclib with or without an aromatase inhibitor, in estrogen receptor-positive advanced breast cancer: Results from the phase 1a/b EMBER study', Cancer Research, 83,

Chen J; Wu S; Ruan T; Slapetova I; Millar E; Lim E; Swarbrick A, 2023, 'Abstract PD9-01: Stromal mediators of lymphocyte exclusion and dysfunction in triple negative breast cancer', Cancer Research, 83,

Zhou FH; Downton T; Freelander A; Hurwitz J; Caldon CE; Lim E, 2023, 'CDK4/6 inhibitor resistance in estrogen receptor positive breast cancer, a 2023 perspective', Frontiers in Cell and Developmental Biology, 11,

Jhaveri K; Jeselsohn R; Ma CX; Lim E; Yonemori K; Hamilton EP; Harnden K; Im S-A; Beck T; Sammons S; Bhave M; Kaufman PA; Manich CS; Meniawy T; Bacchion F; Ismail-Khan R; Li Y; Estrem ST; Nguyen B; Beeram M, 2023, '383MO Imlunestrant with or without everolimus or alpelisib, in ER+, HER2- advanced breast cancer (aBC): Results from the phase Ia/b EMBER study', Annals of Oncology, 34, pp. S338 - S339,

Martin Jimenez M; Hilz S; Collier A; Chibly A; Sohn J; Bardia A; Lim E; Chavez Mac Gregor M; Martinalbo J; Pérez-Moreno PD; Moore HM, 2023, '413P Characteristics of patients (pts) with previously treated, oestrogen receptor-positive, HER2-negative advanced breast cancer (ER+, HER2– aBC) who had rapid progression (RP) in acelERA BC', Annals of Oncology, 34, pp. S356 - S357,

Wong V; de Boer R; Baron-Hay S; Blum R; Boyle F; Chua S; Clarke K; Cuff K; Green M; Lim E; Mok K; Nott L; Nottage M; Tafreshi A; Tsoi D; Uccellini A; Hong W; Gibbs P; Lok SW, 2022, 'Real-World Outcomes of Ribociclib and Aromatase Inhibitor Use in First Line Hormone Receptor Positive, HER2-Negative Metastatic Breast Cancer', Clinical Breast Cancer, 22, pp. 792 - 800,

Papanicolaou M; Parker AL; Yam M; Filipe EC; Wu SZ; Chitty JL; Wyllie K; Tran E; Mok E; Nadalini A; Skhinas JN; Lucas MC; Herrmann D; Nobis M; Pereira BA; Law AMK; Castillo L; Murphy KJ; Zaratzian A; Hastings JF; Croucher DR; Lim E; Oliver BG; Mora FV; Parker BL; Gallego-Ortega D; Swarbrick A; O’Toole S; Timpson P; Cox TR, 2022, 'Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis', Nature Communications, 13,

Lim E; Boyle F; Okera M; Loi S; Goksu SS; van Hal G; Chapman SC; Gable JC; Chen Y; Price GL; Hossain AM; Gainford MC; Ezquerra MB, 2022, 'An open label, randomized phase 2 trial assessing the impact of food on the tolerability of abemaciclib in patients with advanced breast cancer', Breast Cancer Research and Treatment, 195, pp. 275 - 287,

Nguyen A; Fullard K; Sheehan-Dare G; Tang R; Chan L; Ho B; Dear R; Keane J; Hickey A; Nandurkar R; Chen J; Chen A; Lim E; Emmett L, 2022, 'Diagnostic value of 68Ga-DOTATATE PET-CT imaging for staging of ER+/PR+ HER2- breast cancer patients with metastatic disease: Comparison with conventional imaging with bone scan, diagnostic CT and 18F-FDG PET-CT in a prospective pilot trial', Journal of Medical Imaging and Radiation Oncology, 66, pp. 731 - 737,

Wong K; Sheehan-Dare G; Nguyen A; Ho B; Liu V; Lee J; Brown L; Dear R; Chan L; Sharma S; Malaroda A; Smith I; Lim E; Emmett L, 2022, '64Cu-SAR-Bombesin PET-CT Imaging in the Staging of Estrogen/Progesterone Receptor Positive, HER2 Negative Metastatic Breast Cancer Patients: Safety, Dosimetry and Feasibility in a Phase I Trial', Pharmaceuticals, 15,

Berthelet J; Foroutan M; Bhuva DD; Whitfield HJ; El-Saafin F; Cursons J; Serrano A; Merdas M; Lim E; Charafe-Jauffret E; Ginestier C; Ernst M; Hollande F; Anderson RL; Pal B; Yeo B; Davis MJ; Merino D, 2022, 'Computational Screening of Anti-Cancer Drugs Identifies a New BRCA Independent Gene Expression Signature to Predict Breast Cancer Sensitivity to Cisplatin', Cancers, 14,

Morrow RJ; Allam AH; Yeo B; Deb S; Murone C; Lim E; Johnstone CN; Ernst M, 2022, 'Paracrine IL-6 Signaling Confers Proliferation between Heterogeneous Inflammatory Breast Cancer Sub-Clones', Cancers, 14,

Portman N; Lim E, 2022, 'A new sophistication for breast cancer PDXs', Nature Cancer, 3, pp. 138 - 140,

Haggstrom LR; Vardy JL; Carson EK; Segara D; Lim E; Kiely BE, 2022, 'Effects of Endocrine Therapy on Cognitive Function in Patients with Breast Cancer: A Comprehensive Review', Cancers, 14,

Brown LJ; Achinger-Kawecka J; Portman N; Clark S; Stirzaker C; Lim E, 2022, 'Epigenetic Therapies and Biomarkers in Breast Cancer', Cancers, 14,

Dinh P; Graham JD; Elder EN; Kabir M; Doan TB; French J; Meybodi F; Hui R; Wilcken NR; Harnett PR; Hsu J; Stuart KE; Wang T; Ahern V; Brennan M; Fox SB; Dear RF; Lim E; White M; Mann GB; Pathmanathan N, 2022, 'Impact of the EndoPredict genomic assay on treatment decisions for oestrogen receptor-positive early breast cancer patients: benefits of physician selective testing', Breast Cancer Research and Treatment, 191, pp. 501 - 511,

Downton T; Zhou F; Segara D; Jeselsohn R; Lim E, 2022, 'Oral Selective Estrogen Receptor Degraders (SERDs) in Breast Cancer: Advances, Challenges, and Current Status', Drug Design, Development and Therapy, 16, pp. 2933 - 2948,

Martin Jimenez M; Lim E; Chavez Mac Gregor M; Bardia A; Wu J; Zhang Q; Nowecki Z; Cruz F; Safin R; Kim S-B; Schem C; Montero A; Khan S; Bandyopadhyay R; Shivhare M; Patre M; Martinalbo J; Roncoroni L; Pérez-Moreno PD; Sohn J, 2022, '211MO Giredestrant (GDC-9545) vs physician choice of endocrine monotherapy (PCET) in patients (pts) with ER+, HER2– locally advanced/metastatic breast cancer (LA/mBC): Primary analysis of the phase II, randomised, open-label acelERA BC study', Annals of Oncology, 33, pp. S633 - S634,

Harbeck N; Rastogi P; Martin M; Tolaney SM; Shao ZM; Fasching PA; Huang CS; Jaliffe GG; Tryakin A; Goetz MP; Rugo HS; Senkus E; Testa L; Andersson M; Tamura K; Del Mastro L; Steger GG; Kreipe H; Hegg R; Sohn J; Guarneri V; Cortés J; Hamilton E; André V; Wei R; Barriga S; Sherwood S; Forrester T; Munoz M; Shahir A; San Antonio B; Nabinger SC; Toi M; Johnston SRD; O'Shaughnessy J; Jimenez MM; Johnston S; Boyle F; Neven P; Jiang Z; Campone M; Huober J; Shimizu C; Cicin I; Wardley A; Abuin GG; Zarba J; Lim E; Sant P; Liao N; Christiansen B; Eigeliene N; Martin-Babau J; Ettl J; Mavroudis D; Chiu J; Boer K; Nagarkar R; Paluch-Shimon S; Moscetti L; Sagara Y; Kim SB; Maciel MM; Tjan-Heijnen V; Broom R; Lacko A; Schenker M; Volkov N; Sim Yap Y; Coccia-Portugal M; Ángel García Sáenz J; Andersson A; Chao TY; Gokmen E; Harputluoglu H; Berzoy O; Patt D; McArthur H; Chew H; Chalasani P; Kaufman P; Tedesco K; Graff SL, 2021, 'Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study', Annals of Oncology, 32, pp. 1571 - 1581,

Alves CL; Ehmsen S; Terp MG; Portman N; Tuttolomondo M; Gammelgaard OL; Hundebøl MF; Kaminska K; Johansen LE; Bak M; Honeth G; Bosch A; Lim E; Ditzel HJ, 2021, 'Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer', Nature Communications, 12,

Wu SZ; Roden DL; Al-Eryani G; Bartonicek N; Harvey K; Cazet AS; Chan CL; Junankar S; Hui MN; Millar EA; Beretov J; Horvath L; Joshua AM; Stricker P; Wilmott JS; Quek C; Long GV; Scolyer RA; Yeung BZ; Segara D; Mak C; Warrier S; Powell JE; O’Toole S; Lim E; Swarbrick A, 2021, 'Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis', Genome Medicine, 13,

Chew NJ; Lim Kam Sian TCC; Nguyen EV; Shin SY; Yang J; Hui MN; Deng N; McLean CA; Welm AL; Lim E; Gregory P; Nottle T; Lang T; Vereker M; Richardson G; Kerr G; Micati D; Jardé T; Abud HE; Lee RS; Swarbrick A; Daly RJ, 2021, 'Evaluation of FGFR targeting in breast cancer through interrogation of patient-derived models', Breast Cancer Research, 23,

Alves CL; Ehmsen S; Terp MG; Portman N; Tuttolomondo M; Gammelgaard OL; Hundebøl MF; Kaminska K; Johansen LE; Bak M; Honeth G; Bosch A; Lim E; Ditzel HJ, 2021, 'Publisher Correction: Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer (Nature Communications, (2021), 12, 1, (5112), 10.1038/s41467-021-25422-9)', Nature Communications, 12,

Aziz D; Portman N; Fernandez KJ; Lee C; Alexandrou S; Llop-Guevara A; Phan Z; Yong A; Wilkinson A; Sergio CM; Ferraro D; Etemadmoghadam D; Bowtell DD; Serra V; Waring P; Lim E; Caldon CE, 2021, 'Synergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition', npj Breast Cancer, 7,

Portman N; Chen J; Lim E, 2021, 'MDM2 as a Rational Target for Intervention in CDK4/6 Inhibitor Resistant, Hormone Receptor Positive Breast Cancer', Frontiers in Oncology, 11,

Back to profile page