By Professor Georgina Hold

Journal articles

Mahalhal A; Burkitt M; Duckworth C; Hold G; Campbell B; Pritchard M; Probert C, 2019, 'Long-term iron deficiency and iron supplementation exacerbate acute DSS-induced colitis and are associated with significant dysbiosis', , http://dx.doi.org/10.1101/585174

Hansen R; Gibson S; De Paiva Alves E; Goddard M; MacLaren A; Karcher AM; Berry S; Collie-Duguid ESR; El-Omar E; Munro M; Hold GL, 2018, 'Adaptive response of neonatal sepsis-derived Group B Streptococcus to bilirubin', Scientific Reports, 8, pp. 6470, http://dx.doi.org/10.1038/s41598-018-24811-3

Gemmell MR; Berry S; Mukhopadhya I; Hansen R; Nielsen HL; Bajaj-Elliott M; Nielsen H; Hold GL, 2018, 'Comparative genomics of Campylobacter concisus: Analysis of clinical strains reveals genome diversity and pathogenic potential', Emerging Microbes and Infections, 7, http://dx.doi.org/10.1038/s41426-018-0118-x

Ianiro G; Maida M; Burisch J; Simonelli C; Hold G; Ventimiglia M; Gasbarrini A; Cammarota G, 2018, 'Efficacy of different faecal microbiota transplantation protocols for Clostridium difficile infection: A systematic review and meta-analysis', United European Gastroenterology Journal, 6, pp. 1232 - 1244, http://dx.doi.org/10.1177/2050640618780762

McIlroy JR; Nalagatla N; Hansen R; Hart A; Hold GL, 2018, 'Faecal microbiota transplantation as a treatment for inflammatory bowel disease: A national survey of adult and paediatric gastroenterologists in the UK', Frontline Gastroenterology, 9, pp. 250 - 255, http://dx.doi.org/10.1136/flgastro-2017-100936

Mahalhal A; Williams JM; Johnson S; Ellaby N; Duckworth CA; Burkitt MD; Liu X; Hold GL; Campbell BJ; Mark Pritchard D; Probert CS, 2018, 'Oral iron exacerbates colitis and influences the intestinal microbiome', PLoS ONE, 13, http://dx.doi.org/10.1371/journal.pone.0202460

Kupcinskas J; Hold GL, 2018, 'Other Helicobacters and the gastric microbiome', Helicobacter, 23, http://dx.doi.org/10.1111/hel.12521

Garg M; Hendy P; Ding JN; Shaw S; Hold G; Hart A, 2018, 'The effect of Vitamin D on intestinal inflammation and faecal microbiota in patients with ulcerative colitis', Journal of Crohn's and Colitis, 12, pp. 963 - 972, http://dx.doi.org/10.1093/ecco-jcc/jjy052

Kennedy NA; Lamb CA; Berry SH; Walker AW; Mansfield J; Parkes M; Simpkins R; Tremelling M; Nutland S; Parkhill J; Probert C; Hold GL; Lees CW, 2018, 'The impact of NOD2 variants on fecal microbiota in Crohn's disease and controls without gastrointestinal disease', Inflammatory Bowel Diseases, 24, pp. 583 - 592, http://dx.doi.org/10.1093/ibd/izx061

Segal JP; Oke S; Hold GL; Clark SK; Faiz OD; Hart AL, 2018, 'Systematic review: ileoanal pouch microbiota in health and disease', Alimentary Pharmacology and Therapeutics, 47, pp. 466 - 477, http://dx.doi.org/10.1111/apt.14454

McIlroy J; Nalagatla N; Hansen R; Hart A; Hold G, 2018, 'P659 FMT as a treatment for IBD: A national survey of gastroenterologists in the UK', Journal of Crohn's and Colitis, 12, pp. S443 - S444, http://dx.doi.org/10.1093/ecco-jcc/jjx180.786

Douglas GM; Hansen R; Jones CMA; Dunn KA; Comeau AM; Bielawski JP; Tayler R; El-Omar EM; Russell RK; Hold GL; Langille MGI; Limbergen JV, 2018, 'Multi-omics differentially classify disease state and treatment outcome in pediatric Crohn's disease', Microbiome, 6, pp. 13, http://dx.doi.org/10.1186/s40168-018-0398-3

Brunner K; John CM; Phillips NJ; Alber DG; Gemmell MR; Hansen R; Nielsen HL; Hold GL; Bajaj-Elliott M; Jarvis GA, 2018, 'Novel Campylobacter concisus lipooligosaccharide is a determinant of inflammatory potential and virulence', Journal of Lipid Research, 59, pp. 1893 - 1905, http://dx.doi.org/10.1194/jlr.M085860

McIlroy J; Ianiro G; Mukhopadhya I; Hansen R; Hold GL, 2018, 'Review article: the gut microbiome in inflammatory bowel disease—avenues for microbial management', Alimentary Pharmacology and Therapeutics, 47, pp. 26 - 42, http://dx.doi.org/10.1111/apt.14384

Mahalhal A; Williams J; Johnson S; Ellaby N; Duckworth C; Burkitt M; Liu X; Hold G; Campbell B; Pritchard M; Probert C, 2018, 'Oral iron exacerbates colitis and influences the intestinal microbiome', , http://dx.doi.org/10.1101/385997

Boyle SE; Cotton SC; Myint PK; Hold GL, 2017, 'The influence of early research experience in medical school on the decision to intercalate and future career in clinical academia: A questionnaire study', BMC Medical Education, 17, pp. 245, http://dx.doi.org/10.1186/s12909-017-1066-1

Maida M; Macaluso FS; Ianiro G; Mangiola F; Sinagra E; Hold G; Maida C; Cammarota G; Gasbarrini A; Scarpulla G, 2017, 'Screening of colorectal cancer: present and future', Expert Review of Anticancer Therapy, 17, pp. 1131 - 1146, http://dx.doi.org/10.1080/14737140.2017.1392243

Berry SH; El-Omar EM; Hold GL; Mukhopadhya A, 2017, 'THE EFFECT OF LACTULOSE ON THE FAECAL MICROBIOTA OF PATIENTS WITH MINIMAL HEPATIC ENCEPHALOPATHY', GASTROENTEROLOGY, 152, pp. S1049 - S1049, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000403140304299&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mukhopadhya I; Murdoch H; Berry S; Hunt A; Iturriza-Gomara M; Smith-Palmer A; Cameron JC; Hold GL, 2017, 'Changing molecular epidemiology of rotavirus infection after introduction of monovalent rotavirus vaccination in Scotland', Vaccine, 35, pp. 156 - 163, http://dx.doi.org/10.1016/j.vaccine.2016.11.028

Watt E; Gemmell MR; Berry S; Glaire M; Farquharson F; Louis P; Murray GI; El-Omar E; Hold GL, 2016, 'Extending colonic mucosal microbiome analysis-assessment of colonic lavage as a proxy for endoscopic colonic biopsies', Microbiome, 4, pp. 61, http://dx.doi.org/10.1186/s40168-016-0207-9

Mukhopadhya I; Murray GI; Duncan L; Yuecel R; Shattock R; Kelly C; Iannelli F; Pozzi G; El-Omar EM; Hold GL; Hijazi K, 2016, 'Transporters for antiretroviral drugs in colorectal CD4+ T cells and circulating α4β7 integrin CD4+ T cells: Implications for HIV microbicides', Molecular Pharmaceutics, 13, pp. 3334 - 3340, http://dx.doi.org/10.1021/acs.molpharmaceut.6b00351

Hold GL, 2016, 'Gastrointestinal Microbiota and Colon Cancer', Digestive Diseases, 34, pp. 244 - 250, http://dx.doi.org/10.1159/000443358

Mukhopadhya I; Murray GI; Berry S; Thomson J; Frank B; Gwozdz G; Ekeruche-Makinde J; Shattock R; Kelly C; Iannelli F; Pozzi G; El-Omar EM; Hold GL; Hijazi K, 2016, 'Drug transporter gene expression in human colorectal tissue and cell lines: Modulation with antiretrovirals for microbicide optimization', Journal of Antimicrobial Chemotherapy, 71, pp. 372 - 386, http://dx.doi.org/10.1093/jac/dkv335

Marchesi JR; Adams DH; Fava F; Hermes GDA; Hirschfield GM; Hold G; Quraishi MN; Kinross J; Smidt H; Tuohy KM; Thomas LV; Zoetendal EG; Hart A, 2016, 'The gut microbiota and host health: A new clinical frontier', Gut, 65, pp. 330 - 339, http://dx.doi.org/10.1136/gutjnl-2015-309990

Porter R; Murray R; Petty R; El-Omar EM; Hold GL; McLean MH, 2016, 'PTU-154 HMGB1 As a Prognostic Biomarker in The Progression of Barrett’s Oesophagus', Gut, 65, pp. A133.1 - A133, http://dx.doi.org/10.1136/gutjnl-2016-312388.239

Hansen R; Scott KP; Khan S; Martin JC; Berry SH; Stevenson M; Okpapi A; Munro MJ; Hold GL, 2015, 'First-Pass Meconium Samples from Healthy Term Vaginally-Delivered Neonates: An Analysis of the Microbiota', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0133320

Hijazi K; Cuppone AM; Smith K; Stincarelli MA; Ekeruche-Makinde J; De Falco G; Hold GL; Shattock R; Kelly CG; Pozzi G; Iannelli F, 2015, 'Expression of genes for drug transporters in the human female genital tract and modulatory effect of antiretroviral drugs', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0131405

Basavaraju U; Shebl FM; Palmer AJ; Berry S; Hold GL; El-Omar EM; Rabkin CS, 2015, 'Cytokine gene polymorphisms, cytokine levels and the risk of colorectal neoplasia in a screened population of Northeast Scotland', European Journal of Cancer Prevention, 24, pp. 296 - 304, http://dx.doi.org/10.1097/CEJ.0000000000000087

Mukhopadhya I; Hansen R; Meharg C; Thomson JM; Russell RK; Berry SH; El-Omar EM; Hold GL, 2015, 'The fungal microbiota of de-novo paediatric inflammatory bowel disease', Microbes and Infection, 17, pp. 304 - 310, http://dx.doi.org/10.1016/j.micinf.2014.12.001

Hijazi K; Lowe T; Meharg C; Berry SH; Foley J; Hold GL, 2015, 'Mucosal microbiome in patients with recurrent aphthous stomatitis', Journal of Dental Research, 94, pp. 87S - 94S, http://dx.doi.org/10.1177/0022034514565458

Hold GL; Garrett WS, 2015, 'Gut microbiota: Microbiota organization-a key to understanding CRC development', Nature Reviews Gastroenterology and Hepatology, 12, pp. 128 - 129, http://dx.doi.org/10.1038/nrgastro.2015.25

Connors J; Hansen R; Dunn KA; Langille MG; Russell RK; Otley AR; MacIntyre B; El-Omar E; Bielawski JP; Hold GL; Van Limbergen J, 2015, '169 Assessment of Community Structure and Predictive Functional Profiling of the Mucosa-Associated Microbiome Implicates Alterations in Benzoate Metabolism in ‘de novo’ IBD After Pouch-Surgery and in Treatment-Naïve Pediatric IBD', Gastroenterology, 148, pp. S - 45, http://dx.doi.org/10.1016/s0016-5085(15)30158-x

Khan S; Hansen R; Scott KP; Martin JC; Berry SH; Stevenson M; Okapapi A; Hold GL; Munro M, 2015, 'G116(P) The human gut is probably sterile at birth', Archives of Disease in Childhood, 100, pp. A50.3 - A51, http://dx.doi.org/10.1136/archdischild-2015-308599.115

Kennedy NA; Walker AW; Berry SH; Lamb CA; Lewis S; Mansfield JC; Parkes M; Parkhill J; Probert C; Read D; Satsangi J; Simpkins RL; Tomlinson D; Tremelling M; Nutland SL; Hold GL; Lees CW, 2015, 'Mo1816 The Impact of NOD2 Variants on Gut Microbiota in Crohn's Disease and Healthy Controls', Gastroenterology, 148, pp. S - 718, http://dx.doi.org/10.1016/s0016-5085(15)32446-x

Hold GL, 2014, 'The gut microbiota, dietary extremes and exercise', Gut, 63, pp. 1838 - 1839, http://dx.doi.org/10.1136/gutjnl-2014-307305

Hold GL; Berry S; Saunders KA; Drew J; Mayer C; Brookes H; Gay NJ; El-Omar EM; Bryant CE, 2014, 'The TLR4 D299G and T399I SNPs are constitutively active to up-regulate expression of Trif-dependent genes', PLoS ONE, 9, pp. e111460, http://dx.doi.org/10.1371/journal.pone.0111460

Mactier KE; Glaire MA; Basavaraju U; El-Omar EM; Hold GL, 2014, 'MicroRNAs in gastrointestinal malignancy: A tool in cancer prevention?', European Journal of Cancer Prevention, 23, pp. 540 - 549, http://dx.doi.org/10.1097/CEJ.0000000000000014

Louis P; Hold GL; Flint HJ, 2014, 'The gut microbiota, bacterial metabolites and colorectal cancer', Nature Reviews Microbiology, 12, pp. 661 - 672, http://dx.doi.org/10.1038/nrmicro3344

Adams AT; Kennedy NA; Hansen R; Ventham NT; O'Leary KR; Drummond HE; Noble CL; El-Omar E; Russell RK; Wilson DC; Nimmo ER; Hold GL; Satsangi J, 2014, 'Two-stage genome-wide methylation profiling in childhood-onset Crohn's disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci', Inflammatory Bowel Diseases, 20, pp. 1784 - 1793, http://dx.doi.org/10.1097/MIB.0000000000000179

Kennedy NA; Walker AW; Berry SH; Duncan SH; Farquarson FM; Louis P; Thomson JM; Satsangi J; Flint HJ; Parkhill J; Lees CW; Hold GL, 2014, 'The impact of different DNA extraction kits and laboratories upon the assessment of human gut microbiota composition by 16S rRNA gene sequencing', PLoS ONE, 9, http://dx.doi.org/10.1371/journal.pone.0088982

Hold GL; Smith M; Grange C; Watt ER; El-Omar EM; Mukhopadhya I, 2014, 'Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?', World Journal of Gastroenterology, 20, pp. 1192 - 1210, http://dx.doi.org/10.3748/wjg.v20.i5.1192

Kennedy NA; Adams AT; Hansen R; Ventham NT; O'Leary KR; Drummond H; Noble CL; El-Omar E; Russell RK; Wilson DC; Nimmo ER; Hold GL; Satsangi J, 2014, 'Epigenome-wide analysis in childhood-onset Crohn's disease implicates MIR21 in pathogenesis and identifies multiple methylation-based diagnostic biomarkers', JOURNAL OF CROHNS & COLITIS, 8, pp. S19 - S19, http://dx.doi.org/10.1016/S1873-9946(14)60035-0

Folmer F; Basavaraju U; Jaspars M; Hold G; El-Omar E; Dicato M; Diederich M, 2014, 'Anticancer effects of bioactive berry compounds', Phytochemistry Reviews, 13, pp. 295 - 322, http://dx.doi.org/10.1007/s11101-013-9319-z

Hold GL; Mukhopadhya I; Hansen R, 2014, 'Diet, the microbiome, and IBD', Inflammatory Bowel Disease Monitor, 14, pp. 39 - 43

Hold GL, 2014, 'Western lifestyle: A 'master' manipulator of the intestinal microbiota?', Gut, 63, pp. 5 - 6, http://dx.doi.org/10.1136/gutjnl-2013-304969

Lochhead PJ; Mayer C-D; Hold GL; El-Omar E, 2014, '946 Genome-Wide Analysis of DNA Methylation in Low-Grade Colorectal Adenomas and Normal Colonic Mucosa', Gastroenterology, 146, pp. S - 165, http://dx.doi.org/10.1016/s0016-5085(14)60588-6

Kostic AD; Chun E; Robertson L; Glickman JN; Gallini CA; Michaud M; Clancy TE; Chung DC; Lochhead P; Hold GL; El-Omar EM; Brenner D; Fuchs CS; Meyerson M; Garrett WS, 2013, 'Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment', Cell Host and Microbe, 14, pp. 207 - 215, http://dx.doi.org/10.1016/j.chom.2013.07.007

McLean MH; Thomson AJ; Murray GI; Fyfe N; Hold GL; El-Omar EM, 2013, 'Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression: A marker of malignant potential?', British Journal of Cancer, 108, pp. 2537 - 2541, http://dx.doi.org/10.1038/bjc.2013.264

Hansen R; Berry SH; Mukhopadhya I; Thomson JM; Saunders KA; Nicholl CE; Bisset WM; Loganathan S; Mahdi G; Kastner-Cole D; Barclay AR; Bishop J; Flynn DM; McGrogan P; Russell RK; El-Omar EM; Hold GL, 2013, 'The Microaerophilic Microbiota of De-Novo Paediatric Inflammatory Bowel Disease: The BISCUIT Study', PLoS ONE, 8, pp. e58825, http://dx.doi.org/10.1371/journal.pone.0058825

Kennedy NA; Walker AW; Berry SH; Duncan SH; Farquarson F; Louis P; Satsangi J; Flint HJ; Lees CW; Hold GL, 2013, 'P705 Evaluation of the impact of different commercially available DNA extraction kits and laboratories for assessing bacterial community structure in fecal samples – implications for IBD research', Journal of Crohn's and Colitis, 7, pp. S294 - S294, http://dx.doi.org/10.1016/s1873-9946(13)60726-6

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