By Professor Jake Baum

Book Chapters

Riglar DT; Baum J, 2012, 'Static and Dynamic Imaging of Erythrocyte Invasion and Early Intra-erythrocytic Development in Plasmodium falciparum', in Methods in Molecular Biology, Humana Press, pp. 269 - 280, http://dx.doi.org/10.1007/978-1-62703-026-7_18

Journal articles

Awalt JK; Su W; Nguyen W; Loi K; Jarman KE; Penington JS; Ramesh S; Fairhurst KJ; Yeo T; Park H; Uhlemann AC; Chandra Maity B; De N; Mukherjee P; Chakraborty A; Churchyard A; Famodimu MT; Delves MJ; Baum J; Mittal N; Winzeler EA; Papenfuss AT; Chowdury M; de Koning-Ward TF; Maier AG; van Dooren GG; Baud D; Brand S; Fidock DA; Jackson PF; Cowman AF; Dans MG; Sleebs BE, 2024, 'Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b', European Journal of Medicinal Chemistry, 280, http://dx.doi.org/10.1016/j.ejmech.2024.116921

Najer A; Kim J; Saunders C; Che J; Baum J; Stevens MM, 2024, 'Enhanced Antimalarial and Antisequestration Activity of Methoxybenzenesulfonate-Modified Biopolymers and Nanoparticles for Tackling Severe Malaria', ACS Infectious Diseases, 10, pp. 732 - 745, http://dx.doi.org/10.1021/acsinfecdis.3c00564

Andradi-Brown C; Wichers-Misterek JS; von Thien H; Höppner YD; Scholz JAM; Hansson H; Filtenborg Hocke E; Gilberger TW; Duffy MF; Lavstsen T; Baum J; Otto TD; Cunnington AJ; Bachmann A, 2024, 'A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture', eLife, 12, http://dx.doi.org/10.7554/eLife.87726

Andradi-Brown C; Wichers-Misterek JS; von Thien H; Höppner YD; Scholz JAM; Hansson H; Filtenborg Hocke E; Gilberger TW; Duffy MF; Lavstsen T; Baum J; Otto TD; Cunnington AJ; Bachmann A, 2024, 'A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture', eLife, 12, http://dx.doi.org/10.7554/elife.87726.3

Robert-Paganin J; Moussaoui D; Robblee JP; Auguin D; Baum J; Trybus KM; Houdusse AM, 2024, 'Dissecting the plasmodium actomyosin system, a new perspective against malaria', Biophysical Journal, 123, pp. 2a - 3a, http://dx.doi.org/10.1016/j.bpj.2023.11.148

Andrews M; Baum J; Gilson PR; Wilson DW, 2023, 'Bottoms up! Malaria parasite invasion the right way around', Trends in Parasitology, 39, pp. 1004 - 1013, http://dx.doi.org/10.1016/j.pt.2023.09.010

Moussaoui D; Robblee JP; Robert-Paganin J; Auguin D; Fisher F; Fagnant PM; Macfarlane JE; Schaletzky J; Wehri E; Mueller-Dieckmann C; Baum J; Trybus KM; Houdusse A, 2023, 'Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-38976-7

Murdoch J; Baum J, 2023, 'A sting in the tail—are antibodies against the C-terminus of Plasmodium falciparum circumsporozoite protein protective?', EMBO Molecular Medicine, 15, http://dx.doi.org/10.15252/emmm.202317556

Malpartida-Cardenas K; Baum J; Cunnington A; Georgiou P; Rodriguez-Manzano J, 2023, 'A dual paper-based nucleic acid extraction method from blood in under ten minutes for point-of-care diagnostics', Analyst, 148, pp. 3036 - 3044, http://dx.doi.org/10.1039/d3an00296a

Ramakrishnan C; Fort C; Marques SR; Ferguson DJP; Gransagne M; Baum J; Chaouch S; Mouray E; Kohl L; Wheeler RJ; Sinden RE, 2023, 'Radial spoke protein 9 is necessary for axoneme assembly in Plasmodium but not in trypanosomatid parasites', Journal of cell science, 136, http://dx.doi.org/10.1242/jcs.260655

Malpartida-Cardenas K; Moser N; Ansah F; Pennisi I; Prah DA; Amoah LE; Awandare G; Hafalla JCR; Cunnington A; Baum J; Rodriguez-Manzano J; Georgiou P, 2023, 'Sensitive Detection of Asymptomatic and Symptomatic Malaria with Seven Novel Parasite-Specific LAMP Assays and Translation for Use at Point-of-Care', Microbiology Spectrum, 11, http://dx.doi.org/10.1128/spectrum.05222-22

Nguyen W; Dans MG; Currie I; Awalt JK; Bailey BL; Lumb C; Ngo A; Favuzza P; Palandri J; Ramesh S; Penington J; Jarman KE; Mukherjee P; Chakraborty A; Maier AG; van Dooren GG; Papenfuss T; Wittlin S; Churchyard A; Baum J; Winzeler EA; Baud D; Brand S; Jackson PF; Cowman AF; Sleebs BE, 2023, '7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex', ACS Infectious Diseases, 9, pp. 668 - 691, http://dx.doi.org/10.1021/acsinfecdis.2c00607

Imlay LS; Lawong AK; Gahalawat S; Kumar A; Xing C; Mittal N; Wittlin S; Churchyard A; Niederstrasser H; Crespo-Fernandez B; Posner BA; Gamo FJ; Baum J; Winzeler EA; Laleu B; Ready JM; Phillips MA, 2023, 'Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (PfCARL)', ACS Infectious Diseases, 9, pp. 527 - 539, http://dx.doi.org/10.1021/acsinfecdis.2c00527

Ashton TD; Dans MG; Favuzza P; Ngo A; Lehane AM; Zhang X; Qiu D; Chandra Maity B; De N; Schindler KA; Yeo T; Park H; Uhlemann AC; Churchyard A; Baum J; Fidock DA; Jarman KE; Lowes KN; Baud D; Brand S; Jackson PF; Cowman AF; Sleebs BE, 2023, 'Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4', Journal of Medicinal Chemistry, 66, pp. 3540 - 3565, http://dx.doi.org/10.1021/acs.jmedchem.2c02092

Yahiya S; Saunders CN; Hassan S; Straschil U; Fischer OJ; Rueda-Zubiaurre A; Haase S; Vizcay-Barrena G; Famodimu MT; Jordan S; Delves MJ; Tate EW; Barnard A; Fuchter MJ; Baum J, 2023, 'A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein', DMM Disease Models and Mechanisms, 16, pp. dmm049950, http://dx.doi.org/10.1242/dmm.049950

Malpartida-Cardenas K; Moser N; Ansah F; Prah DA; Awandare G; Cunnington A; Baum J; Rodriguez-Manzano J; Georgiou P, 2023, 'EVALUATION OF SYMPTOMATIC AND ASYMPTOMATIC P. FALCIPARUM WITH SPECIES-SPECIFIC LAMP ASSAY AND TRANSLATION TO THE POINT- OF-CARE', International Journal of Infectious Diseases, 130, pp. S133 - S133, http://dx.doi.org/10.1016/j.ijid.2023.04.328

Wilkinson MD; Ferreira JL; Beeby M; Baum J; Willison KR, 2022, 'The malaria parasite chaperonin containing TCP-1 (CCT) complex: Data integration with other CCT proteomes', Frontiers in Molecular Biosciences, 9, http://dx.doi.org/10.3389/fmolb.2022.1057232

de Vries LE; Jansen PAM; Barcelo C; Munro J; Verhoef JMJ; Pasaje CFA; Rubiano K; Striepen J; Abla N; Berning L; Bolscher JM; Demarta-Gatsi C; Henderson RWM; Huijs T; Koolen KMJ; Tumwebaze PK; Yeo T; Aguiar ACC; Angulo-Barturen I; Churchyard A; Baum J; Fernández BC; Fuchs A; Gamo FJ; Guido RVC; Jiménez-Diaz MB; Pereira DB; Rochford R; Roesch C; Sanz LM; Trevitt G; Witkowski B; Wittlin S; Cooper RA; Rosenthal PJ; Sauerwein RW; Schalkwijk J; Hermkens PHH; Bonnert RV; Campo B; Fidock DA; Llinás M; Niles JC; Kooij TWA; Dechering KJ, 2022, 'Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-29688-5

Benns HJ; Storch M; Falco JA; Fisher FR; Tamaki F; Alves E; Wincott CJ; Milne R; Wiedemar N; Craven G; Baragaña B; Wyllie S; Baum J; Baldwin GS; Weerapana E; Tate EW; Child MA, 2022, 'CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery', Nature Microbiology, 7, pp. 1891 - 1905, http://dx.doi.org/10.1038/s41564-022-01249-y

Najer A; Blight J; Ducker CB; Gasbarri M; Brown JC; Che J; Høgset H; Saunders C; Ojansivu M; Lu Z; Lin Y; Yeow J; Rifaie-Graham O; Potter M; Tonkin R; Penders J; Doutch JJ; Georgiadou A; Barriga HMG; Holme MN; Cunnington AJ; Bugeon L; Dallman MJ; Barclay WS; Stellacci F; Baum J; Stevens MM, 2022, 'Potent Virustatic Polymer-Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites in Vivo', ACS Central Science, 8, pp. 1238 - 1257, http://dx.doi.org/10.1021/acscentsci.1c01368

Xie SC; Metcalfe RD; Dunn E; Morton CJ; Huang SC; Puhalovich T; Du Y; Wittlin S; Nie S; Luth MR; Ma L; Kim MS; Pasaje CFA; Kumpornsin K; Giannangelo C; Houghton FJ; Churchyard A; Famodimu MT; Barry DC; Gillett DL; Dey S; Kosasih CC; Newman W; Niles JC; Lee MCS; Baum J; Ottilie S; Winzeler EA; Creek DJ; Williamson N; Parker MW; Brand S; Langston SP; Dick LR; Griffin MDW; Gould AE; Tilley L, 2022, 'Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy', Science, 376, pp. 1074 - 1079, http://dx.doi.org/10.1126/science.abn0611

Tamaki F; Fisher F; Milne R; Terán FSR; Wiedemar N; Wrobel K; Edwards D; Baumann H; Gilbert IH; Baragana B; Baum J; Wyllie S, 2022, 'High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria', Antimicrobial Agents and Chemotherapy, 66, http://dx.doi.org/10.1128/aac.00237-22

Bullen HE; Sanders PR; Dans MG; Jonsdottir TK; Riglar DT; Looker O; Palmer CS; Kouskousis B; Charnaud SC; Triglia T; Gabriela M; Parkyn Schneider M; Chan JA; de Koning-Ward TF; Baum J; Kazura JW; Beeson J; Cowman AF; Gilson PR; Crabb BS, 2022, 'The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture', Molecular Microbiology, 117, pp. 1245 - 1262, http://dx.doi.org/10.1111/mmi.14904

Yahiya S; Jordan S; Smith HX; Gaboriau DCA; Famodimu MT; Dahalan FA; Churchyard A; Ashdown GW; Baum J, 2022, 'Live-cell fluorescence imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum', PLoS Pathogens, 18, http://dx.doi.org/10.1371/journal.ppat.1010276

Real E; Howick VM; Dahalan FA; Witmer K; Cudini J; Andradi-Brown C; Blight J; Davidson MS; Dogga SK; Reid AJ; Baum J; Lawniczak MKN, 2021, 'A single-cell atlas of Plasmodium falciparum transmission through the mosquito', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-23434-z

Miguel-Blanco C; Murithi JM; Benavente ED; Angrisano F; Sala KA; van Schalkwyk DA; Vanaerschot M; Schwach F; Fuchter MJ; Billker O; Sutherland CJ; Campino SG; Clark TG; Blagborough AM; Fidock DA; Herreros E; Gamo FJ; Baum J; Delves MJ, 2021, 'The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957', Scientific Reports, 11, http://dx.doi.org/10.1038/s41598-021-81343-z

Ellis KM; Lucantoni L; Chavchich M; Abraham M; De Paoli A; Luth MR; Zeeman AM; Delves MJ; Terán FSR; Straschil U; Baum J; Kocken CHM; Ralph SA; Winzeler EA; Avery VM; Edstein MD; Baell JB; Creek DJ, 2021, 'The novel bis-1,2,4-Triazine MIPS-0004373 demonstrates rapid and potent activity against all blood stages of the malaria parasite', Antimicrobial Agents and Chemotherapy, 65, http://dx.doi.org/10.1128/AAC.00311-21

Xie SC; Metcalfe RD; Mizutani H; Puhalovich T; Hanssen E; Morton CJ; Du Y; Dogovski C; Huang SC; Ciavarri J; Hales P; Griffin RJ; Cohen LH; Chuang BC; Wittlin S; Deni I; Yeo T; Ward KE; Barry DC; Liu B; Gillett DL; Crespo-Fernandez BF; Ottilie S; Mittal N; Churchyard A; Ferguson D; Aguiar ACC; Guido RVC; Baum J; Hanson KK; Winzeler EA; Gamo FJ; Fidock DA; Baud D; Parker MW; Brand S; Dick LR; Griffin MDW; Gould AE; Tilley L, 2021, 'Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/pnas.2107213118

Blight J; Sala KA; Atcheson E; Kramer H; Turabi AE; Real E; Dahalan FA; Bettencourt P; Dickinson-Craig E; Alves E; Salman AM; Janse CJ; Ashcroft FM; Hill AV; Reyes-Sandoval A; Blagborough AM; Baum J, 2021, 'Dissection-independent production of Plasmodium sporozoites from whole mosquitoes', Life Science Alliance, 4, http://dx.doi.org/10.26508/lsa.202101094

Okaniwa M; Shibata A; Ochida A; Akao Y; White KL; Shackleford DM; Duffy S; Lucantoni L; Dey S; Striepen J; Yeo T; Mok S; Aguiar ACC; Sturm A; Crespo B; Sanz LM; Churchyard A; Baum J; Pereira DB; Guido RVC; Dechering KJ; Wittlin S; Uhlemann AC; Fidock DA; Niles JC; Avery VM; Charman SA; Laleu B, 2021, 'Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors', ACS Infectious Diseases, 7, pp. 1680 - 1689, http://dx.doi.org/10.1021/acsinfecdis.1c00020

Haase S; Condron M; Miller D; Cherkaoui D; Jordan S; Gulbis JM; Baum J, 2021, 'Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum', Molecular and Biochemical Parasitology, 243, http://dx.doi.org/10.1016/j.molbiopara.2021.111374

Lawong A; Gahalawat S; Okombo J; Striepen J; Yeo T; Mok S; Deni I; Bridgford JL; Niederstrasser H; Zhou A; Posner B; Wittlin S; Gamo FJ; Crespo B; Churchyard A; Baum J; Mittal N; Winzeler E; Laleu B; Palmer MJ; Charman SA; Fidock DA; Ready JM; Phillips MA, 2021, 'Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum', Journal of Medicinal Chemistry, 64, pp. 2739 - 2761, http://dx.doi.org/10.1021/acs.jmedchem.0c02022

Varghese S; Rahmani R; Drew DR; Beeson JG; Baum J; Smith BJ; Baell JB, 2021, 'Structure-Activity Studies of Truncated Latrunculin Analogues with Antimalarial Activity', ChemMedChem, 16, pp. 679 - 693, http://dx.doi.org/10.1002/cmdc.202000399

Witmer K; Dahalan FA; Delves MJ; Yahiya S; Watson OJ; Straschil U; Chiwcharoen D; Sornboon B; Pukrittayakamee S; Pearson RD; Howick VM; Lawniczak MKN; White NJ; Dondorp AM; Okell LC; Chotivanich K; Ruecker A; Baum J, 2021, 'Transmission of artemisinin-resistant malaria parasites to mosquitoes under antimalarial drug pressure', Antimicrobial Agents and Chemotherapy, 65, http://dx.doi.org/10.1128/AAC.00898-20

Davidson MS; Andradi-Brown C; Yahiya S; Chmielewski J; O'Donnell AJ; Gurung P; Jeninga MD; Prommana P; Andrew DW; Petter M; Uthaipibull C; Boyle MJ; Ashdown GW; Dvorin JD; Reece SE; Wilson DW; Cunningham KA; Ando DM; Dimon M; Baum J, 2021, 'Automated detection and staging of malaria parasites from cytological smears using convolutional neural networks.', Biol Imaging, 1, pp. e2, http://dx.doi.org/10.1017/S2633903X21000015

Robert-Paganin J; Moussaoui D; Robblee JP; Auguin D; Blake TCA; Krementsova E; Baum J; Trybus KM; Houdusse A, 2021, 'Deciphering the Function and the Regulation of Plasmodium falciparum Myosin A', Biophysical Journal, 120, pp. 344a - 344a, http://dx.doi.org/10.1016/j.bpj.2020.11.2143

Qian WW; Xia C; Venugopalan S; Narayanaswamy A; Dimon M; Ashdown GW; Baum J; Peng J; Michael Ando D, 2020, 'Batch equalization with a generative adversarial network', Bioinformatics, 36, pp. I875 - I883, http://dx.doi.org/10.1093/bioinformatics/btaa819

Blake TCA; Haase S; Baum J, 2020, 'Actomyosin forces and the energetics of red blood cell invasion by the malaria parasite Plasmodium falciparum', PLoS Pathogens, 16, http://dx.doi.org/10.1371/journal.ppat.1009007

Eagon S; Hammill JT; Sigal M; Ahn KJ; Tryhorn JE; Koch G; Belanger B; Chaplan CA; Loop L; Kashtanova AS; Yniguez K; Lazaro H; Wilkinson SP; Rice AL; Falade MO; Takahashi R; Kim K; Cheung A; Dibernardo C; Kimball JJ; Winzeler EA; Eribez K; Mittal N; Gamo FJ; Crespo B; Churchyard A; García-Barbazán I; Baum J; Anderson MO; Laleu B; Guy RK, 2020, 'Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4- b]pyridines', Journal of Medicinal Chemistry, 63, pp. 11902 - 11919, http://dx.doi.org/10.1021/acs.jmedchem.0c01152

Moussaoui D; Robblee JP; Auguin D; Krementsova EB; Haase S; Blake TCA; Baum J; Robert-Paganin J; Trybus KM; Houdusse A, 2020, 'Full-length plasmodium falciparum myosin a and essential light chain pfelc structures provide new anti-malarial targets', eLife, 9, pp. 1 - 24, http://dx.doi.org/10.7554/eLife.60581

Ashdown GW; Dimon M; Fan M; Terán FSR; Witmer K; Gaboriau DCA; Armstrong Z; Ando DM; Baum J, 2020, 'A machine learning approach to define antimalarial drug action from heterogeneous cell-based screens', Science Advances, 6, http://dx.doi.org/10.1126/sciadv.aba9338

Wang X; Wilkinson MD; Lin X; Ren R; Willison KR; Ivanov AP; Baum J; Edel JB, 2020, 'Erratum: Single-molecule nanopore sensing of actin dynamics and drug binding (Chemical Science (2020) 11 (970-979) DOI: 10.1039/C9SC05710B)', Chemical Science, 11, pp. 8036 - 8038, http://dx.doi.org/10.1039/d0sc90132f

Saunders CN; Cota E; Baum J; Tate EW, 2020, 'Peptide Probes for Plasmodium falciparum MyoA Tail Interacting Protein (MTIP): Exploring the Druggability of the Malaria Parasite Motor Complex', ACS Chemical Biology, 15, pp. 1313 - 1320, http://dx.doi.org/10.1021/acschembio.0c00328

Llorà-Batlle O; Michel-Todó L; Witmer K; Toda H; Fernández-Becerra C; Baum J; Cortés A, 2020, 'Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum', Science Advances, 6, http://dx.doi.org/10.1126/sciadv.aaz5057

Baum J; Pasvol G; Carter R, 2020, 'The R0 journey: from 1950s malaria to COVID-19', Nature, 582, pp. 488, http://dx.doi.org/10.1038/d41586-020-01882-9

Wilkinson MD; Lai HE; Freemont PS; Baum J, 2020, 'A biosynthetic platform for antimalarial drug discovery', Antimicrobial Agents and Chemotherapy, 64, http://dx.doi.org/10.1128/AAC.02129-19

Rueda-Zubiaurre A; Yahiya S; Fischer OJ; Hu X; Saunders CN; Sharma S; Straschil U; Shen J; Tate EW; Delves MJ; Baum J; Barnard A; Fuchter MJ, 2020, 'Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes', Journal of Medicinal Chemistry, 63, pp. 2240 - 2262, http://dx.doi.org/10.1021/acs.jmedchem.9b00898

Warszawski S; Dekel E; Campeotto I; Marshall JM; Wright KE; Lyth O; Knop O; Regev-Rudzki N; Higgins MK; Draper SJ; Baum J; Fleishman SJ, 2020, 'Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5', Proteins: Structure, Function and Bioinformatics, 88, pp. 187 - 195, http://dx.doi.org/10.1002/prot.25786

Wang X; Wilkinson MD; Lin X; Ren R; Willison KR; Ivanov AP; Baum J; Edel JB, 2020, 'Single-molecule nanopore sensing of actin dynamics and drug binding', Chemical Science, 11, pp. 970 - 979, http://dx.doi.org/10.1039/c9sc05710b

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