By Professor Jake Baum

Journal articles

Cowman AF; Berry D; Baum J, 2012, 'The cellular and molecular basis for malaria parasite invasion of the human red blood cell', Journal of Cell Biology, 198, pp. 961 - 971, http://dx.doi.org/10.1083/jcb.201206112

de Azevedo MF; Gilson PR; Gabriel HB; Simões RF; Angrisano F; Baum J; Crabb BS; Wunderlich G, 2012, 'Systematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparum', PLoS ONE, 7, http://dx.doi.org/10.1371/journal.pone.0040981

Baum J; Saliba KJ; Cooke BM, 2012, 'Editorial - Molecular Approaches to Malaria 2012 (MAM 2012)', International Journal for Parasitology, 42, pp. 517, http://dx.doi.org/10.1016/j.ijpara.2012.05.001

Angrisano F; Tan YH; Sturm A; McFadden GI; Baum J, 2012, 'Malaria parasite colonisation of the mosquito midgut - Placing the Plasmodium ookinete centre stage', International Journal for Parasitology, 42, pp. 519 - 527, http://dx.doi.org/10.1016/j.ijpara.2012.02.004

Olshina MA; Wong W; Baum J, 2012, 'Holding back the microfilament - Structural insights into actin and the actin-monomer-binding proteins of apicomplexan parasites', IUBMB Life, 64, pp. 370 - 377, http://dx.doi.org/10.1002/iub.1014

Zhang JG; Czabotar PE; Policheni AN; Caminschi I; San Wan S; Kitsoulis S; Tullett KM; Robin AY; Brammananth R; van Delft MF; Lu J; O'Reilly LA; Josefsson EC; Kile BT; Chin WJ; Mintern JD; Olshina MA; Wong W; Baum J; Wright MD; Huang DCS; Mohandas N; Coppel RL; Colman PM; Nicola NA; Shortman K; Lahoud MH, 2012, 'The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments', Immunity, 36, pp. 646 - 657, http://dx.doi.org/10.1016/j.immuni.2012.03.009

Bullen HE; Charnaud SC; Kalanon M; Riglar DT; Dekiwadia C; Kangwanrangsan N; Torii M; Tsuboi T; Baum J; Ralph SA; Cowman AF; De Koning-Ward TF; Crabb BS; Gilsona PR, 2012, 'Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX)', Journal of Biological Chemistry, 287, pp. 7871 - 7884, http://dx.doi.org/10.1074/jbc.M111.328591

Angrisano F; Delves MJ; Sturm A; Mollard V; McFadden GI; Sinden RE; Baum J, 2012, 'A GFP-Actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle', Molecular and Biochemical Parasitology, 182, pp. 93 - 96, http://dx.doi.org/10.1016/j.molbiopara.2011.11.008

Volz JC; Bártfai R; Petter M; Langer C; Josling GA; Tsuboi T; Schwach F; Baum J; Rayner JC; Stunnenberg HG; Duffy MF; Cowman AF, 2012, 'PfSET10, a Plasmodium falciparum Methyltransferase, Maintains the Active var Gene in a Poised State during Parasite Division', Cell Host and Microbe, 11, pp. 7 - 18, http://dx.doi.org/10.1016/j.chom.2011.11.011

Wong W; Zhang J-G; Baum J; Lahoud M; Shortman K, 2012, 'Co-sedimentation Assay for the Detection of Direct Binding to F-actin', BIO-PROTOCOL, 2, http://dx.doi.org/10.21769/bioprotoc.270

Angrisano F; Riglar D; Sturm A; Volz J; Delves MJ; Zuccala E; Turnbull L; Dekiwadia C; Olshina MA; Marapana DS; Wong W; Mollard V; Bradin CH; Tonkin CJ; Gunning P; Ralph SA; Whitchurch CB; Sinden RE; Cowman AF; McFadden GI; Baum J, 2012, 'Spatial localisation of actin filaments across developmental stages of the malaria parasite', PLoS ONE, 7, pp. Article number e32188, http://dx.doi.org/10.1371/journal.pone.0032188

Chen L; Lopaticki S; Riglar DT; Dekiwadia C; Uboldi AD; Tham WH; O'Neill MT; Richard D; Baum J; Ralph SA; Cowman AF, 2011, 'An egf-like protein forms a complex with pfrh5 and is required for invasion of human erythrocytes by plasmodium falciparum', PLoS Pathogens, 7, http://dx.doi.org/10.1371/journal.ppat.1002199

Zuccala ES; Baum J, 2011, 'Cytoskeletal and membrane remodelling during malaria parasite invasion of the human erythrocyte', British Journal of Haematology, 154, pp. 680 - 689, http://dx.doi.org/10.1111/j.1365-2141.2011.08766.x

Baum J; Cowman AF, 2011, 'Revealing a parasite's invasive trick', Science, 333, pp. 410 - 411, http://dx.doi.org/10.1126/science.1209875

Wong W; Skau CT; Marapana DS; Hanssen E; Taylord NL; Riglar DT; Zuccala ES; Angrisano F; Lewis H; Catimel B; Clarke OB; Kershaw NJ; Perugini MA; Kovar DR; Gulbis JM; Baum J, 2011, 'Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1', Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 9869 - 9874, http://dx.doi.org/10.1073/pnas.1018927108

Triglia T; Chen L; Lopaticki S; Dekiwadia C; Riglar DT; Hodder AN; Ralph SA; Baum J; Cowman AF, 2011, 'Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRH2a and b binding domains', PLoS Pathogens, 7, http://dx.doi.org/10.1371/journal.ppat.1002075

Yeoman JA; Hanssen E; Maier AG; Klonis N; Maco B; Baum J; Turnbull L; Whitchurch CB; Dixon MWA; Tilley L, 2011, 'Tracking glideosome-associated protein 50 reveals the development and organization of the inner membrane complex of Plasmodium falciparum', Eukaryotic Cell, 10, pp. 556 - 564, http://dx.doi.org/10.1128/EC.00244-10

Riglar DT; Richard D; Wilson DW; Boyle MJ; Dekiwadia C; Turnbull L; Angrisano F; Marapana DS; Rogers KL; Whitchurch CB; Beeson JG; Cowman AF; Ralph SA; Baum J, 2011, 'Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte', Cell Host and Microbe, 9, pp. 9 - 20, http://dx.doi.org/10.1016/j.chom.2010.12.003

Baum J; Billker O; Bousema T; Dinglasan R; McGovern V; Mota MM; Mueller I; Sinden R, 2011, 'A Research Agenda for Malaria Eradication: Basic Science and Enabling Technologies', PLOS MEDICINE, 8, http://dx.doi.org/10.1371/journal.pmed.1000399

Boyle MJ; Wilson DW; Richards JS; Riglar DT; Tetteh KKA; Conway DJ; Ralph SA; Baum J; Beeson JG, 2010, 'Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development', Proceedings of the National Academy of Sciences of the United States of America, 107, pp. 14378 - 14383, http://dx.doi.org/10.1073/pnas.1009198107

Richard D; MacRaild CA; Riglar DT; Chan JA; Foley M; Baum J; Ralph SA; Norton RS; Cowman AF, 2010, 'Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites', Journal of Biological Chemistry, 285, pp. 14815 - 14822, http://dx.doi.org/10.1074/jbc.M109.080770

Riglar D; Richard D; Boyle M; Wilson D; Angrisano F; Turnbull L; Whitchurch C; Cowman A; Beeson J; Ralph S; Baum J, 2010, 'Stepwise dissection of Plasmodium falciparum merozoite invasion of the human erythrocyte', Malaria Journal, 9, http://dx.doi.org/10.1186/1475-2875-9-s2-o25

Riglar D; Richard D; Boyle M; Wilson D; Angrisano F; Turnbull L; Whitchurch C; Cowman A; Beeson J; Ralph S; Baum J, 2010, 'Stepwise dissection of Plasmodium falciparum merozoite invasion of the human erythrocyte', Malaria Journal, 9, http://dx.doi.org/10.1186/1475-2875-9-s2-p42

Baum J; Papenfuss AT; Mair GR; Janse CJ; Vlachou D; Waters AP; Cowman AF; Crabb BS; De Koning-Ward TF, 2009, 'Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites', Nucleic Acids Research, 37, pp. 3788 - 3798, http://dx.doi.org/10.1093/nar/gkp239

Maier AG; Baum J; Smith B; Conway DJ; Cowman AF, 2009, 'Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum', Infection and Immunity, 77, pp. 1689 - 1699, http://dx.doi.org/10.1128/IAI.01331-08

Baum J; Chen L; Healer J; Lopaticki S; Boyle M; Triglia T; Ehlgen F; Ralph SA; Beeson JG; Cowman AF, 2009, 'Reticulocyte-binding protein homologue 5 - An essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum', International Journal for Parasitology, 39, pp. 371 - 380, http://dx.doi.org/10.1016/j.ijpara.2008.10.006

Baum J; Gilberger TW; Frischknecht F; Meissner M, 2008, 'Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma', Trends in Parasitology, 24, pp. 557 - 563, http://dx.doi.org/10.1016/j.pt.2008.08.006

Baum J; Tonkin CJ; Paul AS; Rug M; Smith BJ; Gould SB; Richard D; Pollard TD; Cowman AF, 2008, 'A Malaria Parasite Formin Regulates Actin Polymerization and Localizes to the Parasite-Erythrocyte Moving Junction during Invasion', Cell Host and Microbe, 3, pp. 188 - 198, http://dx.doi.org/10.1016/j.chom.2008.02.006

Baum J; Papenfuss AT; Baum B; Speed TP; Cowman AF, 2006, 'Regulation of apicomplexan actin-based motility', Nature Reviews Microbiology, 4, pp. 621 - 628, http://dx.doi.org/10.1038/nrmicro1465

Baum J; Richard D; Healer J; Rug M; Krnajski Z; Gilberger TW; Green JL; Holder AA; Cowman AF, 2006, 'A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites', Journal of Biological Chemistry, 281, pp. 5197 - 5208, http://dx.doi.org/10.1074/jbc.M509807200

Baum J; Maier AG; Good RT; Simpson KM; Cowman AF, 2005, 'Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions', PLoS Pathogens, 1, pp. 0299 - 0309, http://dx.doi.org/10.1371/journal.ppat.0010037

Marti M; Baum J; Rug M; Tilley L; Cowman AF, 2005, 'Signal-mediated export of proteins from the malaria parasite to the host erythrocyte', Journal of Cell Biology, 171, pp. 587 - 592, http://dx.doi.org/10.1083/jcb.200508051

Simpson KM; Baum J; Good RT; Winzeler EA; Cowman AF; Speed TP, 2005, 'A comparison of match-only algorithms for the analysis of Plasmodium falciparum oligonucleotide arrays', International Journal for Parasitology, 35, pp. 523 - 531, http://dx.doi.org/10.1016/j.ijpara.2005.02.010

Greenblatt CL; Baum J; Klein BY; Nachshon S; Koltunov V; Cano RJ, 2004, 'Micrococcus luteus - Survival in amber', Microbial Ecology, 48, pp. 120 - 127, http://dx.doi.org/10.1007/s00248-003-2016-5

Baum J; Pinder M; Conway DJ, 2003, 'Erythrocyte invasion phenotypes of Plasmodium falciparum in the Gambia', Infection and Immunity, 71, pp. 1856 - 1863, http://dx.doi.org/10.1128/IAI.71.4.1856-1863.2003

Baum J; Thomas AW; Conway DJ, 2003, 'Evidence for diversifying selection on erythrocyte-binding antigens of Plasmodium falciparum and P. vivax', Genetics, 163, pp. 1327 - 1336

Conway DJ; Baum J, 2002, 'In the blood - The remarkable ancestry of Plasmodium falciparum', Trends in Parasitology, 18, pp. 351 - 355, http://dx.doi.org/10.1016/S1471-4922(02)02330-9

Baum J; Ward RH; Conway DJ, 2002, 'Natural selection on the erythrocyte surface', Molecular Biology and Evolution, 19, pp. 223 - 229, http://dx.doi.org/10.1093/oxfordjournals.molbev.a004075

Binks RH; Baum J; Oduola AMJ; Arnot DE; Babiker HA; Kremsner PG; Roper C; Greenwood BM; Conway DJ, 2001, 'Population genetic analysis of the Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene', Molecular and Biochemical Parasitology, 114, pp. 63 - 70, http://dx.doi.org/10.1016/S0166-6851(01)00240-7

Conference Papers

Malpartida-Cardenas K; Miscourides N; Yu LS; Baum J; Rodriguez-Manzano J; Georgiou P, 2018, 'A CMOS-based diagnostic system for detection of artemisinin-resistant malaria', in 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, pp. 871 - 873

Working Papers

Andradi-Brown C; Wichers-Misterek JS; von Thien H; Höppner YD; Scholz JAM; Hansson HS; Hocke EF; Gilberger TW; Duffy MF; Lavstsen T; Baum J; Otto TD; Cunnington AJ; Bachmann A, 2023, A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture, http://dx.doi.org10.7554/eLife.87726.1

Preprints

Andradi-Brown C; Wichers-Misterek JS; von Thien H; Höppner YD; Scholz JAM; Hansson H; Hocke EF; Gilberger T-W; Duffy MF; Lavstsen T; Baum J; Otto TD; Cunnington AJ; Bachmann A, 2023, A novel computational pipeline forvargene expression augments the discovery of changes in thePlasmodium falciparumtranscriptome during transition fromin vivoto short-termin vitroculture, http://dx.doi.org/10.1101/2023.03.21.533599

Imlay LS; Lawong AK; Gahalawat S; Kumar A; Xing C; Mittal N; Wittlin S; Churchyard A; Niederstrasser H; Crespo-Fernandez B; Posner B; Gamo FJ; Baum J; Winzeler EA; Laleu B; Ready JM; Phillips MA, 2022, A fast-killing tyrosine amide ((S)-SW228703) with blood and liver-stage antimalarial activity associated with the Cyclic Amine Resistance Locus (PfCARL), http://dx.doi.org/10.1101/2022.10.16.512381

Moussaoui D; Robblee JP; Auguin D; Fisher F; Fagnant PM; Macfarlane JE; Schaletzky J; Wehri E; Mueller-Dieckmann C; Baum J; Robert-Paganin J; Trybus KM; Houdusse A, 2022, Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design, http://dx.doi.org/10.1101/2022.09.09.507123

Malpartida-Cardenas K; Baum J; Cunnington A; Georgiou P; Rodriguez-Manzano J, 2022, Electricity-free nucleic acid extraction method from dried blood spots on filter paper for point-of-care diagnostics, http://dx.doi.org/10.1101/2022.07.28.501845

Yahiya S; Jordan S; Smith HX; Gaboriau DCA; Famodimu MT; Dahalan FA; Churchyard A; Ashdown GW; Baum J, 2021, 4D live-cell imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum, http://dx.doi.org/10.1101/2021.07.28.454129

Yahiya S; Saunders CN; Straschil U; Fischer OJ; Rueda-Zubiaurre A; Haase S; Vizcay-Barrena G; Jordan S; Hassan S; Delves MJ; Tate EW; Barnard A; Fuchter MJ; Baum J, 2021, Plasmodium falciparumprotein Pfs16 is a target for transmission-blocking antimalarial drug development, http://dx.doi.org/10.1101/2021.06.14.448287

de Vries LE; Jansen PAM; Barcelo C; Munro J; Verhoef JMJ; Pasaje CFA; Rubiano K; Striepen J; Bolscher JM; Henderson R; Huijs T; Koolen KMJ; Tumwebaze PK; Yeo T; Aguiar ACC; Angulo-Barturen I; Churchyard A; Baum J; Fernández BC; Gamo F-J; Guido RVC; Jiménez-Diaz MB; Pereira DB; Rochford R; Sanz LM; Trevitt G; Wittlin S; Cooper RA; Rosenthal PJ; Sauerwein RW; Schalkwijk J; Hermkens PHH; Bonnert R; Campo B; Fidock DA; Llinás M; Niles JC; Kooij TWA; Dechering KJ, 2021, Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183, http://dx.doi.org/10.1101/2021.05.12.443866

Davidson MS; Yahiya S; Chmielewski J; O’Donnell AJ; Gurung P; Jeninga M; Prommana P; Andrew D; Petter M; Uthaipibull C; Boyle M; Ashdown GW; Dvorin JD; Reece SE; Wilson DW; Ando DM; Dimon M; Baum J, 2021, Automated detection and staging of malaria parasites from cytological smears using convolutional neural networks, http://dx.doi.org/10.1101/2021.01.26.21250284

Benns HJ; Storch M; Falco J; Fisher FR; Alves E; Wincott CJ; Baum J; Baldwin GS; Weerapana E; Tate EW; Child MA, 2021, Prioritization of antimicrobial targets by CRISPR-based oligo recombineering, http://dx.doi.org/10.1101/2021.02.04.429737

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