By Professor Jake Baum

Journal articles

Del Rosario M; Periz J; Pavlou G; Lyth O; Latorre-Barragan F; Das S; Pall GS; Stortz JF; Lemgruber L; Whitelaw JA; Baum J; Tardieux I; Meissner M, 2019, 'Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion', EMBO Reports, 20, http://dx.doi.org/10.15252/embr.201948896

Satchwell TJ; Wright KE; Haydn-Smith KL; Sánchez-Román Terán F; Moura PL; Hawksworth J; Frayne J; Toye AM; Baum J, 2019, 'Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-11790-w

Robert-Paganin J; Robblee JP; Auguin D; Blake TCA; Bookwalter CS; Krementsova EB; Moussaoui D; Previs MJ; Jousset G; Baum J; Trybus KM; Houdusse A, 2019, 'Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-11120-0

Malpartida-Cardenas K; Miscourides N; Rodriguez-Manzano J; Yu LS; Moser N; Baum J; Georgiou P, 2019, 'Quantitative and rapid Plasmodium falciparum malaria diagnosis and artemisinin-resistance detection using a CMOS Lab-on-Chip platform', Biosensors and Bioelectronics, 145, http://dx.doi.org/10.1016/j.bios.2019.111678

Straschil U; Witmer K; Delves MJ; Marks SD; Baum J, 2019, 'Screen of traditional soup broths with reported antipyretic activity towards the discovery of potential antimalarials', Archives of Disease in Childhood, 104, pp. 1138 - 1142, http://dx.doi.org/10.1136/archdischild-2019-317590

Koch M; Cegla J; Jones B; Lu Y; Mallat Z; Blagborough AM; Angrisano F; Baum J, 2019, 'The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection', Malaria Journal, 18, http://dx.doi.org/10.1186/s12936-019-3016-3

Knuepfer E; Wright KE; Prajapati SK; Rawlinson TA; Mohring F; Koch M; Lyth OR; Howell SA; Villasis E; Snijders AP; Moon RW; Draper SJ; Rosanas-Urgell A; Higgins MK; Baum J; Holder AA, 2019, 'Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites', PLoS Pathogens, 15, http://dx.doi.org/10.1371/journal.ppat.1007809

Yahiya S; Rueda-Zubiaurre A; Delves MJ; Fuchter MJ; Baum J, 2019, 'The antimalarial screening landscape—looking beyond the asexual blood stage', Current Opinion in Chemical Biology, 50, pp. 1 - 9, http://dx.doi.org/10.1016/j.cbpa.2019.01.029

Baragaña B; Forte B; Choi R; Hewitt SN; Bueren-Calabuig JA; Pisco JP; Peet C; Dranow DM; Robinson DA; Jansen C; Norcross NR; Vinayak S; Anderson M; Brooks CF; Cooper CA; Damerow S; Delves M; Dowers K; Duffy J; Edwards TE; Hallyburton I; Horst BG; Hulverson MA; Ferguson L; Jiménez-Díaz MB; Jumani RS; Lorimer DD; Love MS; Maher S; Matthews H; McNamara CW; Miller P; O’Neill S; Ojo KK; Osuna-Cabello M; Pinto E; Post J; Riley J; Rottmann M; Sanz LM; Scullion P; Sharma A; Shepherd SM; Shishikura Y; Simeons FRC; Stebbins EE; Stojanovski L; Straschil U; Tamaki FK; Tamjar J; Torrie LS; Vantaux A; Witkowski B; Wittlin S; Yogavel M; Zuccotto F; Angulo-Barturen I; Sinden R; Baum J; Gamo FJ; Mäser P; Kyle DE; Winzeler EA; Myler PJ; Wyatt PG; Floyd D; Matthews D; Sharma A; Striepen B; Huston CD; Gray DW; Fairlamb AH; Pisliakov AV; Walpole C; Read KD; Van Voorhis WC; Gilbert IH, 2019, 'Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis', Proceedings of the National Academy of Sciences of the United States of America, 116, pp. 7015 - 7020, http://dx.doi.org/10.1073/pnas.1814685116

Delves MJ; Miguel-Blanco C; Matthews H; Molina I; Ruecker A; Yahiya S; Straschil U; Abraham M; León ML; Fischer OJ; Rueda-Zubiaurre A; Brandt JR; Cortés Á; Barnard A; Fuchter MJ; Calderón F; Winzeler EA; Sinden RE; Herreros E; Gamo FJ; Baum J, 2018, 'A high throughput screen for next-generation leads targeting malaria parasite transmission', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-05777-2

Lyth O; Vizcay-Barrena G; Wright KE; Haase S; Mohring F; Najer A; Henshall IG; Ashdown GW; Bannister LH; Drew DR; Beeson JG; Fleck RA; Moon RW; Wilson DW; Baum J, 2018, 'Cellular dissection of malaria parasite invasion of human erythrocytes using viable Plasmodium knowlesi merozoites', Scientific Reports, 8, http://dx.doi.org/10.1038/s41598-018-28457-z

Fang H; Gomes AR; Klages N; Pino P; Maco B; Walker EM; Zenonos ZA; Angrisano F; Baum J; Doerig C; Baker DA; Billker O; Brochet M, 2018, 'Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-06733-w

Malpartida-Cardenas K; Rodriguez-Manzano J; Yu LS; Delves MJ; Nguon C; Chotivanich K; Baum J; Georgiou P, 2018, 'Allele-Specific Isothermal Amplification Method Using Unmodified Self-Stabilizing Competitive Primers', Analytical Chemistry, 90, pp. 11972 - 11980, http://dx.doi.org/10.1021/acs.analchem.8b02416

Witmer K; Sherrard-Smith E; Straschil U; Tunnicliff M; Baum J; Delves M, 2018, 'An inexpensive open source 3D-printed membrane feeder for human malaria transmission studies', Malaria Journal, 17, http://dx.doi.org/10.1186/s12936-018-2436-9

Lubin AS; Rueda-Zubiaurre A; Matthews H; Baumann H; Fisher FR; Morales-Sanfrutos J; Hadavizadeh KS; Nardella F; Tate EW; Baum J; Scherf A; Fuchter MJ, 2018, 'Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum', ACS Infectious Diseases, 4, pp. 523 - 530, http://dx.doi.org/10.1021/acsinfecdis.7b00228

Bookwalter CS; Tay CL; McCrorie R; Previs MJ; Lu H; Krementsova EB; Fagnant PM; Baum J; Trybus KM, 2017, 'Reconstitution of the core of the malaria parasite glideosome with recombinant Plasmodium class XIV myosin A and Plasmodium actin', Journal of Biological Chemistry, 292, pp. 19290 - 19303, http://dx.doi.org/10.1074/jbc.M117.813972

Das S; Lemgruber L; Tay CL; Baum J; Meissner M, 2017, 'Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development', BMC Biology, 15, http://dx.doi.org/10.1186/s12915-017-0406-2

Miguel-Blanco C; Molina I; Bardera AI; Díaz B; De Las Heras L; Lozano S; González C; Rodrigues J; Delves MJ; Ruecker A; Colmenarejo G; Viera S; Martínez-Martínez MS; Fernández E; Baum J; Sinden RE; Herreros E, 2017, 'Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen', Nature Communications, 8, http://dx.doi.org/10.1038/ncomms15160

Koch M; Wright KE; Otto O; Herbig M; Salinas ND; Tolia NH; Satchwell TJ; Guck J; Brooks NJ; Baum J, 2017, 'Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion', Proceedings of the National Academy of Sciences of the United States of America, 114, pp. 4225 - 4230, http://dx.doi.org/10.1073/pnas.1620843114

Wong W; Bai XC; Sleebs BE; Triglia T; Brown A; Thompson JK; Jackson KE; Hanssen E; Marapana DS; Fernandez IS; Ralph SA; Cowman AF; Scheres SHW; Baum J, 2017, 'Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis', Nature Microbiology, 2, http://dx.doi.org/10.1038/nmicrobiol.2017.31

Baum J; Richard D; Riglar DT, 2017, 'Malaria Parasite Invasion: Achieving Superb Resolution', Cell Host and Microbe, 21, pp. 294 - 296, http://dx.doi.org/10.1016/j.chom.2017.02.006

Johnson S; Rahmani R; Drew DR; Williams MJ; Wilkinson M; Tan YH; Huang JX; Tonkin CJ; Beeson JG; Baum J; Smith BJ; Baell JB, 2016, 'Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion', Journal of Medicinal Chemistry, 59, pp. 10994 - 11005, http://dx.doi.org/10.1021/acs.jmedchem.6b01109

Bargieri DY; Thiberge S; Tay CL; Carey AF; Rantz A; Hischen F; Lorthiois A; Straschil U; Singh P; Singh S; Triglia T; Tsuboi T; Cowman A; Chitnis C; Alano P; Baum J; Pradel G; Lavazec C; Ménard R, 2016, 'Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes', Cell Host and Microbe, 20, pp. 618 - 630, http://dx.doi.org/10.1016/j.chom.2016.10.015

Delves MJ; Straschil U; Ruecker A; Miguel-Blanco C; Marques S; Dufour AC; Baum J; Sinden RE, 2016, 'Routine in vitro culture of P. Falciparum gametocytes to evaluate novel transmission-blocking interventions', Nature Protocols, 11, pp. 1668 - 1680, http://dx.doi.org/10.1038/nprot.2016.096

Bane KS; Lepper S; Kehrer J; Sattler JM; Singer M; Reinig M; Klug D; Heiss K; Baum J; Mueller AK; Frischknecht F, 2016, 'The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites', PLoS Pathogens, 12, http://dx.doi.org/10.1371/journal.ppat.1005710

Koch M; Baum J, 2016, 'The mechanics of malaria parasite invasion of the human erythrocyte - towards a reassessment of the host cell contribution', Cellular Microbiology, 18, pp. 319 - 329, http://dx.doi.org/10.1111/cmi.12557

Zuccala ES; Satchwell TJ; Angrisano F; Tan YH; Wilson MC; Heesom KJ; Baum J, 2016, 'Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton', Scientific Reports, 6, http://dx.doi.org/10.1038/srep19766

Riglar DT; Whitehead L; Cowman AF; Rogers KL; Baum J, 2016, 'Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion', Journal of Cell Science, 129, pp. 228 - 242, http://dx.doi.org/10.1242/jcs.177741

Olshina MA; Baumann H; Willison KR; Baum J, 2016, 'Plasmodium actin is incompletely folded by heterologous protein-folding machinery and likely requires the native Plasmodium chaperonin complex to enter a mature functional state', FASEB Journal, 30, pp. 405 - 416, http://dx.doi.org/10.1096/fj.15-276618

Tardieux I; Baum J, 2016, 'Reassessing the mechanics of parasite motility and host-cell invasion', Journal of Cell Biology, 214, pp. 507 - 515, http://dx.doi.org/10.1083/JCB.201605100

Baum J; Frischknecht F, 2015, 'Motorizing pathogens', Seminars in Cell and Developmental Biology, 46, pp. 78 - 81, http://dx.doi.org/10.1016/j.semcdb.2015.09.019

Haase S; Zimmermann D; Olshina MA; Wilkinson M; Fisher F; Tan YH; Stewart RJ; Tonkin CJ; Wong W; Kovar DR; Baum J, 2015, 'Disassembly activity of actin-depolymerizing factor (ADF) is associated with distinct cellular processes in apicomplexan parasites', Molecular Biology of the Cell, 26, pp. 3001 - 3012, http://dx.doi.org/10.1091/mbc.E14-10-1427

Wilson DW; Goodman CD; Sleebs BE; Weiss GE; de Jong NWM; Angrisano F; Langer C; Baum J; Crabb BS; Gilson PR; McFadden GI; Beeson JG, 2015, 'Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum', BMC Biology, 13, http://dx.doi.org/10.1186/s12915-015-0162-0

Olshina MA; Angrisano F; Marapana DS; Riglar DT; Bane K; Wong W; Catimel B; Yin MX; Holmes AB; Frischknecht F; Kovar DR; Baum J, 2015, 'Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites', Malaria Journal, 14, http://dx.doi.org/10.1186/s12936-015-0801-5

Dasgupta S; Auth T; Gov NS; Satchwell TJ; Hanssen E; Zuccala ES; Riglar DT; Toye AM; Betz T; Baum J; Gompper G, 2014, 'Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyte', Biophysical Journal, 107, pp. 43 - 54, http://dx.doi.org/10.1016/j.bpj.2014.05.024

Wong W; Bai XC; Brown A; Fernandez IS; Hanssen E; Condron M; Tan YH; Baum J; Scheres SHW, 2014, 'Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine', eLife, 2014, http://dx.doi.org/10.7554/eLife.03080

Wong W; Webb AI; Olshina MA; Infusini G; Tan YH; Hanssen E; Catimel B; Suarez C; Condron M; Angrisano F; Nebl T; Kovar DR; Baum J, 2014, 'A mechanism for actin filament severing by malaria parasite actin depolymerizing factor 1 via a low affinity binding interface', Journal of Biological Chemistry, 289, pp. 4043 - 4054, http://dx.doi.org/10.1074/jbc.M113.523365

Kan A; Tan YH; Angrisano F; Hanssen E; Rogers KL; Whitehead L; Mollard VP; Cozijnsen A; Delves MJ; Crawford S; Sinden RE; Mcfadden GI; Leckie C; Bailey J; Baum J, 2014, 'Quantitative analysis of Plasmodium ookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motility', Cellular Microbiology, 16, pp. 734 - 750, http://dx.doi.org/10.1111/cmi.12283

Zuccala E; Satchwell T; Angrisano F; Marapana D; Tan Y-H; Toye A; Baum J, 2014, 'Remodelling of the erythrocyte cytoskeleton during P. falciparum merozoite invasion', Malaria Journal, 13, http://dx.doi.org/10.1186/1475-2875-13-s1-p96

Riglar DT; Rogers KL; Hanssen E; Turnbull L; Bullen HE; Charnaud SC; Przyborski J; Gilson PR; Whitchurch CB; Crabb BS; Baum J; Cowman AF, 2013, 'Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes', Nature Communications, 4, http://dx.doi.org/10.1038/ncomms2449

Healer J; Thompson JK; Riglar DT; Wilson DW; Chiu YHC; Miura K; Chen L; Hodder AN; Long CA; Hansen DS; Baum J; Cowman AF, 2013, 'Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0072504

Hanssen E; Dekiwadia C; Riglar DT; Rug M; Lemgruber L; Cowman AF; Cyrklaff M; Kudryashev M; Frischknecht F; Baum J; Ralph SA, 2013, 'Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion', Cellular Microbiology, 15, pp. 1457 - 1472, http://dx.doi.org/10.1111/cmi.12132

Dahan-Pasternak N; Nasereddin A; Kolevzon N; Pe'er M; Wong W; Shinder V; Turnbull L; Whitchurch CB; Elbaum M; Gilberger TW; Yavin E; Baum J; Dzikowski R, 2013, 'Pfsec13 is an unusual chromatin-associated nucleoporin of plasmodium falciparum that is essential for parasite proliferation in human erythrocytes', Journal of Cell Science, 126, pp. 3055 - 3069, http://dx.doi.org/10.1242/jcs.122119

Regev-Rudzki N; Wilson DW; Carvalho TG; Sisquella X; Coleman BM; Rug M; Bursac D; Angrisano F; Gee M; Hill AF; Baum J; Cowman AF, 2013, 'Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles', Cell, 153, pp. 1120 - 1133, http://dx.doi.org/10.1016/j.cell.2013.04.029

Baum J, 2013, 'A complete molecular understanding of malaria parasite invasion of the human erythrocyte: Are we there yet?', Pathogens and Global Health, 107, pp. 107, http://dx.doi.org/10.1179/2047772413Z.000000000121

Lemgruber L; Kudryashev M; Dekiwadia C; Riglar DT; Baum J; Stahlberg H; Ralph SA; Frischknecht F, 2013, 'Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast', Malaria Journal, 12, http://dx.doi.org/10.1186/1475-2875-12-25

Makkonen M; Bertling E; Chebotareva NA; Baum J; Lappalainen P, 2013, 'Mammalian and Malaria Parasite Cyclase-associated Proteins Catalyze Nucleotide Exchange on G-actin through a Conserved Mechanism', JOURNAL OF BIOLOGICAL CHEMISTRY, 288, pp. 984 - 994, http://dx.doi.org/10.1074/jbc.M112.435719

Riglar DT; Baum J, 2013, 'Static and dynamic imaging of erythrocyte invasion and early intra-erythrocytic development in plasmodium falciparum', Methods in Molecular Biology, 923, pp. 269 - 280, http://dx.doi.org/10.1007/978-1-62703-26-7_18

Marapana DS; Wilson DW; Zuccala ES; Dekiwadia CD; Beeson JG; Ralph SA; Baum J, 2012, 'Malaria Parasite Signal Peptide Peptidase is an ER-Resident Protease Required for Growth but not for Invasion', Traffic, 13, pp. 1457 - 1465, http://dx.doi.org/10.1111/j.1600-0854.2012.01402.x

Zuccala ES; Gout AM; Dekiwadia C; Marapana DS; Angrisano F; Turnbull L; Riglar DT; Rogers KL; Whitchurch CB; Ralph SA; Speed TP; Baum J, 2012, 'Subcompartmentalisation of Proteins in the Rhoptries Correlates with Ordered Events of Erythrocyte Invasion by the Blood Stage Malaria Parasite', PLoS ONE, 7, http://dx.doi.org/10.1371/journal.pone.0046160

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