By Professor Levon Michael Khachigian

Journal articles

Billah M; Ridiandries A; Khachigian L; Dona A; Bhindi R, 2017, 'Abstract 445: Autophagy is Essential for Remote Preconditioning Induced Cardioprotection and May Involve JAK-STAT Pathway for Autophagy Activation', Circulation Research, 121, http://dx.doi.org/10.1161/res.121.suppl_1.445

Murrell M; Khachigian L; Ward MR, 2017, 'Corrigendum to “The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting” [Atherosclerosis 194 (2) (2007) 364–371] (S0021915006006836) (10.1016/j.atherosclerosis.2006.11.016)', Atherosclerosis, 261, pp. 172, http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.011

Li Y; McRobb LS; Khachigian LM, 2016, 'Inhibition of intimal thickening after vascular injury with a cocktail of vascular endothelial growth factor and cyclic Arg-Gly-Asp peptide', International Journal of Cardiology, 220, pp. 185 - 191, http://dx.doi.org/10.1016/j.ijcard.2016.06.300

Khachigian LM, 2016, 'Early growth response-1 in the pathogenesis of cardiovascular disease', Journal of Molecular Medicine, 94, pp. 747 - 753, http://dx.doi.org/10.1007/s00109-016-1428-x

Li Y; McRobb LS; Khachigian LM, 2016, 'MicroRNA miR-191 targets the zinc finger transcription factor Egr-1 and suppresses intimal thickening after carotid injury', International Journal of Cardiology, 212, pp. 299 - 302, http://dx.doi.org/10.1016/j.ijcard.2016.03.037

Tan NY; Li J-M; Stocker R; Khachigian LM, 2016, 'Angiotensin II-Inducible Smooth Muscle Cell Apoptosis Involves the Angiotensin II Type 2 Receptor, GATA-6 Activation, and FasL-Fas Engagement (Retraction of vol 105, pg 422, 2009)', CIRCULATION RESEARCH, 118, pp. E31 - E31, http://dx.doi.org/10.1161/RES.0000000000000090

Hurst LD; Ghanbarian AT; Forrest ARR; Huminiecki L; Rehli M; Kenneth Baillie J; de Hoon MJL; Haberle V; Lassmann T; Kulakovskiy IV; Lizio M; Itoh M; Andersson R; Mungall CJ; Meehan TF; Schmeier S; Bertin N; Jørgensen M; Dimont E; Arner E; Schmidl C; Schaefer U; Medvedeva YA; Plessy C; Vitezic M; Severin J; Semple CA; Ishizu Y; Young RS; Francescatto M; Alam I; Albanese D; Altschuler GM; Arakawa T; Archer JAC; Arner P; Babina M; Baker S; Balwierz PJ; Beckhouse AG; Pradhan SB; Blake JA; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Maxwell Burroughs A; Califano A; Cannistraci CV; Carbajo D; Chen Y; Chierici M; Ciani Y; Clevers HC; Dalla E; Davis CA; Detmar M; Diehl AD; Dohi T; Drabløs F; Edge ASB; Edinger M; Ekwall K; Endoh M; Enomoto H; Fagiolini M; Fairbairn L; Fang H; Farach-Carson MC; Faulkner GJ; Favorov AV; Fisher ME; Frith MC; Fujita R; Fukuda S; Furlanello C; Furuno M; Furusawa JI; Geijtenbeek TB; Gibson A; Gingeras T; Goldowitz D; Gough J; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Harbers M; Harshbarger J; Hasegawa A; Hasegawa Y; Hashimoto T; Herlyn M; Hitchens KJ; Ho Sui SJ; Hofmann OM, 2015, 'The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome', PLoS Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002315

Fahmy RG; Waldman A; Zhang G; Mitchell A; Tedla N; Cai H; Geczy CR; Chesterman CN; Perry M; Khachigian LM, 2015, 'Erratum: Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun(Nat.Biotechnol.(2006) 24(856-863))', Nature Biotechnology, 33, pp. 882, http://dx.doi.org/10.1038/nbt0815-882c

Aitken S; Magi S; Alhendi AMN; Itoh M; Kawaji H; Lassmann T; Daub CO; Arner E; Carninci P; Forrest ARR; Hayashizaki Y; Khachigian LM; Okada-Hatakeyama M; Semple CA; Sandelin A; Wells C; Hume DA; Summers KM; Vitting-Seerup K; Andersson R; Yumoto MN, 2015, 'Transcriptional Dynamics Reveal Critical Roles for Non-coding RNAs in the Immediate-Early Response', PLoS Computational Biology, 11, http://dx.doi.org/10.1371/journal.pcbi.1004217

Arner E; Daub CO; Vitting-Seerup K; Andersson R; Lilje B; Drabløs F; Lennartsson A; Rönnerblad M; Hrydziuszko O; Vitezic M; Freeman TC; Alhendi AMN; Arner P; Axton R; Baillie JK; Beckhouse A; Bodega B; Briggs J; Brombacher F; Davis M; Detmar M; Ehrlund A; Endoh M; Eslami A; Fagiolini M; Fairbairn L; Faulkner GJ; Ferrai C; Fisher ME; Forrester L; Goldowitz D; Guler R; Ha T; Hara M; Herlyn M; Ikawa T; Kai C; Kawamoto H; Khachigian LM; Klinken SP; Kojima S; Koseki H; Klein S; Mejhert N; Miyaguchi K; Mizuno Y; Morimoto M; Morris KJ; Mummery C; Nakachi Y; Ogishima S; Okada-Hatakeyama M; Okazaki Y; Orlando V; Ovchinnikov D; Passier R; Patrikakis M; Pombo A; Qin XY; Roy S; Sato H; Savvi S; Saxena A; Schwegmann A; Sugiyama D; Swoboda R; Tanaka H; Tomoiu A; Winteringham LN; Wolvetang E; Yanagi-Mizuochi C; Yoneda M; Zabierowski S; Zhang P; Abugessaisa I; Bertin N; Diehl AD; Fukuda S; Furuno M; Harshbarger J; Hasegawa A; Hori F; Ishikawa-Kato S; Ishizu Y; Itoh M; Kawashima T; Kojima M; Kondo N; Lizio M; Meehan TF; Mungall CJ; Murata M; Nishiyori-Sueki H; Sahin S; Nagao-Sato S; Severin J; De Hoon MJL; Kawai J; Kasukawa T; Lassmann T, 2015, 'Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells', Science, 347, pp. 1010 - 1014, http://dx.doi.org/10.1126/science.1259418

Xie J; Zhang S; Hu Y; Li D; Cui J; Xue J; Zhang G; Khachigian LM; Wong J; Sun L; Wang M, 2014, 'Regulatory roles of c-jun in H5N1 influenza virus replication and host inflammation', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1842, pp. 2479 - 2488, http://dx.doi.org/10.1016/j.bbadis.2014.04.017

Young JA; Ting KK; Li J; Moller T; Dunn L; Lu Y; Lay AJ; Moses J; Prado-Lourenço L; Khachigian LM; Ng M; Gregory PA; Goodall GJ; Tsykin A; Lichtenstein I; Hahn CN; Tran N; Shackel N; Kench JG; McCaughan G; Vadas MA; Gamble JR, 2014, 'Erratum: Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted mirna antagonists of mir-27 (Blood (2012) 122:16 (2911-2919))', Blood, 124, pp. 3034, http://dx.doi.org/10.1182/blood-2014-09-604066

Chaabane SC; De Brachéne AC; Essaghir A; Velghe A; Re SL; Stockis J; Lucas S; Khachigian LM; Huaux F; Demoulin JB, 2014, 'PDGF-D expression is down-regulated by TGFβ in fibroblasts', PLoS ONE, 9, http://dx.doi.org/10.1371/journal.pone.0108656

Morikawa H; Ohkura N; Vandenbon A; Itoh M; Nagao-Sato S; Kawaji H; Lassmann T; Carninci P; Hayashizaki Y; Forrest ARR; Standley DM; Date H; Sakaguchi S; FANTOM Consortium , 2014, 'Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation.', Proc Natl Acad Sci U S A, 111, pp. 5289 - 5294, http://dx.doi.org/10.1073/pnas.1312717110

Forrest ARR; Kawaji H; Rehli M; Baillie JK; De Hoon MJL; Haberle V; Lassmann T; Kulakovskiy IV; Lizio M; Itoh M; Andersson R; Mungall CJ; Meehan TF; Schmeier S; Bertin N; Jørgensen M; Dimont E; Arner E; Schmidl C; Schaefer U; Medvedeva YA; Plessy C; Vitezic M; Severin J; Semple CA; Ishizu Y; Young RS; Francescatto M; Altschuler IA; Albanese D; Altschule GM; Arakawa T; Archer JAC; Arner P; Babina M; Rennie S; Balwierz PJ; Beckhouse AG; Pradhan-Bhatt S; Blake JA; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Burroughs AM; Califano A; Cannistraci CV; Carbajo D; Chen Y; Chierici M; Ciani Y; Clevers HC; Dalla E; Davis CA; Detmar M; Diehl AD; Dohi T; Drabløs F; Edge ASB; Edinger M; Ekwall K; Endoh M; Enomoto H; Fagiolini M; Fairbairn L; Fang H; Farach-Carson MC; Faulkner GJ; Favorov AV; Fisher ME; Frith MC; Fujita R; Fukuda S; Furlanello C; Furuno M; Furusawa JI; Geijtenbeek TB; Gibson AP; Gingeras T; Goldowitz D; Gough J; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Harbers M; Harshbarger J; Hasegawa A; Hasegawa Y; Hashimoto T; Herlyn M; Hitchens KJ; Sui SJH; Hofmann OM; Hoof I; Hori F; Huminiecki L, 2014, 'A promoter-level mammalian expression atlas', Nature, 507, pp. 462 - 470, http://dx.doi.org/10.1038/nature13182

Charni Chaabane S; Coomans de Brachène A; Essaghir A; Velghe A; Lo Re S; Stockis J; Lucas S; Khachigian LM; Huaux F; Demoulin JB, 2014, 'PDGF-D expression is down-regulated by TGFβ in fibroblasts', PloS one, 9, pp. e108656, http://dx.doi.org/10.1371/journal.pone.0108656

Sanchez-Guerrero E; Chen E; Kockx M; An S-W; Chong BH; Khachigian LM, 2013, 'Correction: IL-1beta Signals through the EGF Receptor and Activates Egr-1 through MMP-ADAM', PLoS ONE, 8, http://dx.doi.org/10.1371/annotation/a0bc2cbb-0390-4476-833d-30ce4f829794

Ni J; Waldman A; Khachigian LM, 2013, 'Erratum: C-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins (The Journal of Biological Chemistry (2010) 285 (4038-4048))', Journal of Biological Chemistry, 288, pp. 31918, http://dx.doi.org/10.1074/jbc.A109.078345

Li Y; Bhindi R; Deng ZJ; Morton SW; Hammond PT; Khachigian LM, 2013, 'Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)', International Journal of Cardiology, 168, pp. 3659 - 3664, http://dx.doi.org/10.1016/j.ijcard.2013.05.092

Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2013, 'Acute local elevation in monocyte chemoattractant protein-1 (MCP-1), distal to the culprit lesion in acute ST elevation myocardial infarction', International Journal of Cardiology, 168, pp. 1679 - 1680, http://dx.doi.org/10.1016/j.ijcard.2013.03.078

Chan CWS; Khachigian LM, 2013, 'DNAzyme delivery approaches in biological settings', Current Medicinal Chemistry, 20, pp. 3448 - 3455, http://dx.doi.org/10.2174/09298673113209990033

Sheahan AV; Phillips PA; Khachigian LM, 2013, 'Therapeutic perspectives on pancreatic cancer', Current Cancer Drug Targets, 13, pp. 400 - 410, http://dx.doi.org/10.2174/1568009611313040004

Yee GPC; De Souza PL; Khachigian LM, 2013, 'Reducing invasion potential of cervical cancer cells via targeted knockdown of c-Jun.', Journal of Clinical Oncology, 31, pp. e22005 - e22005, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e22005

Perdomo J; Jiang XM; Carter DR; Khachigian LM; Chong BH, 2013, 'Correction: SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4 (PLoS ONE)', PLoS ONE, 8, http://dx.doi.org/10.1371/annotation/3d7a31cd-09e7-47d1-af57-c58c7082058d

Sheahan AV; Phillips PA; Khachigian LM, 2013, 'Therapeutic Perspectives on Pancreatic Cancer', Current Cancer Drug Targets, 888, pp. 1 - 6, http://dx.doi.org/10.2174/15680096113138880007

Rayner B; Figtree G; Lay W; Sabaretnam T; Shang P; Mazhar J; Weaver J; Grieve S; Hunyor S; Khachigian L; Bhindi R, 2013, 'SELECTIVE INHIBITION OF THE MASTER REGULATOR TRANSCRIPTION FACTOR EGR-1 USING CATALYTIC OLIGONUCLEOTIDES REDUCES MYOCARDIAL INJURY AND IMPROVES LV SYSTOLIC FUNCTION IN A PRECLINICAL MODEL OF MYOCARDIAL INFARCTION', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61, pp. E213 - E213, http://dx.doi.org/10.1016/S0735-1097(13)60214-4

Li D; Ilnytskyy Y; Kovalchuk A; Khachigian LM; Bronson RT; Wang B; Kovalchuk O, 2013, 'Crucial role for early growth response-1 in the transcriptional regulation of miR-20b in breast cancer', Oncotarget, 4, pp. 1373 - 1387, http://dx.doi.org/10.18632/oncotarget.1165

Sanchez-Guerrero E; Jo SR; Chong BH; Khachigian LM, 2013, 'EGFR and the complexity of receptor crosstalk in the cardiovascular system', Current Molecular Medicine, 13, pp. 3 - 12, http://dx.doi.org/10.2174/156652413804486313

Khachigian LM, 2013, 'Inhibition of intimal thickening and acceleration of reendothelialization after vascular injury using a cocktail approach', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 32, pp. S64 - S64, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324507400238&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM, 2013, 'Nephron regeneration after acute kidney injury in the zebrafish', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 32, pp. S63 - S63, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324507400237&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Young JA; Ting KK; Li J; Moller T; Dunn L; Lu Y; Lay AJ; Moses J; Prado-Lourenço L; Khachigian LM; Ng M; Gregory PA; Goodall GJ; Tsykin A; Lichtenstein I; Hahn CN; Tran N; Shackel N; Kench JG; McCaughan G; Vadas MA; Gamble JR, 2013, 'Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27', Blood, 122, pp. 2911 - 2919, http://dx.doi.org/10.1182/blood-2012-12-473017

Rayner BS; Figtree GA; Sabaretnam T; Shang P; Mazhar J; Weaver JC; Lay WN; Witting PK; Hunyor SN; Grieve SM; Khachigian LM; Bhindi R, 2013, 'Selective inhibition of the master regulator transcription factor Egr-1 with catalytic oligonucleotides reduces myocardial injury and improves left ventricular systolic function in a preclinical model of myocardial infarction.', Journal of the American Heart Association, 2, http://dx.doi.org/10.1161/JAHA.113.000023

Chong BH; Choi PY; Khachigian LM; Perdomo JS, 2013, 'Drug-induced immune thrombocytopenia', Hematology - Oncology Clinics of North America, 27, pp. 521 - 540, http://dx.doi.org/10.1016/j.hoc.2013.02.003

Perdomo J; Jiang X-M; Carter DR; Khachigian LM; Chong BH, 2012, 'SUMOylation Regulates the Transcriptional Repression Activity of FOG-2 and Its Association with GATA-4', PLoS ONE, 7, pp. e50637 - e50637, http://dx.doi.org/10.1371/journal.pone.0050637

2012, '', , 3, http://dx.doi.org/10.18632/oncotarget.v3i6

Little PJ; Getachew R; Rezaei HB; Sanchez-Guerrero E; Khachigian LM; Wang H; Liao S; Zheng W; Ballinger ML; Osman N, 2012, 'Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFâ receptor phosphorylation', Archives of Biochemistry and Biophysics, 525, pp. 25 - 31, http://dx.doi.org/10.1016/j.abb.2012.05.025

Bhindi R; Fahmy RG; McMahon AC; Khachigian LM; Lowe HC, 2012, 'Intracoronary delivery of DNAzymes targeting human Egr-1 reduces infarct size following myocardial ischaemia reperfusion', Journal of Pathology, 227, pp. 157 - 164, http://dx.doi.org/10.1002/path.2991

Malabanan KP; Sheahan A; Khachigian LM, 2012, 'Platelet-derived growth factor-BB mediates cell migration through induction of activating transcription factor 4 and tenascin-C', American Journal of Pathology, 180, pp. 2590 - 2597, http://dx.doi.org/10.1016/j.ajpath.2012.02.009

Chan CWS; Kaplan W; Parish CR; Khachigian LM, 2012, 'Reduced retinal microvascular density, improved forepaw reach, comparative microarray and gene set enrichment analysis with c-jun targeting DNA enzyme', PLoS One, 7, pp. e39160, http://dx.doi.org/10.1371/journal.pone.0039160

Zhang N; Chan CWS; Sanchez-Guerrero E; Khachigian LM, 2012, 'Repression of PDGF-R-á after cellular injury involves TNF-á, formation of a c-Fos-YY1 complex, and negative regulation by HDAC', American Journal of Physiology - Cell Physiology, 302, pp. 1590 - 1598, http://dx.doi.org/10.1152/ajpcell.00429.2011

Midwinter R; Maghzal GJ; Dennis JM; Wu BJ; Cai H; Kapralov AA; Natalia A; Belikova NA; Tyurina YY; Dong LF; Khachigian LM; Neuzil J; Kagan VE; Stocker R, 2012, 'Succinobucol induces apoptosis in vascular smooth muscle cells', Free Radical Biology and Medicine, 52, pp. 871 - 879, http://dx.doi.org/10.1016/j.freeradbiomed.2011.11.029

Rayner B; Figtree G; Lay W; Sabaretnam T; Mazar J; Weaver J; Grieve S; Hunyor S; Khachigian L; Bhindi R, 2012, 'The Intracoronary Delivery of DNAzymes Targeting Egr-1 Upon Restoration of Blood Flow Reduces Inflammation and Subsequent Tissue Damage Following Acute Myocardial Ischemia Reperfusion', Heart, Lung and Circulation, 21, pp. S179 - S179, http://dx.doi.org/10.1016/j.hlc.2012.05.446

Ishii H; Hulett M; Li J; Santiago FS; Parish CR; Khachigian LM, 2012, 'Yin Yang-1 inhibits tumor cell growth and inhibits p21 WAF1/Cip1complex formation with cdk4 and cyclin D1', International Journal of Oncology, 40, pp. 1575 - 1580, http://dx.doi.org/10.3892/ijo.2012.1362

Truong A; Wong TY; Khachigian LM, 2011, 'Emerging therapeutic approaches in the management of retinal angiogenesis and edema', Journal of Molecular Medicine, 89, pp. 343 - 361, http://dx.doi.org/10.1007/s00109-010-0709-z

Khachigian LM, 2011, 'Catalytic DNA as new drugs for vascular disease and cancer', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 28, pp. S70 - S70, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295422700266&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Nath A; Malabanan KP, 2011, 'Regulation of cell migration by activation transcription factor-4', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 28, pp. S71 - S71, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295422700267&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Liang S; Khachigian LM; Ahmadi Z; Yang ; Liu S; Chong BH, 2011, 'In vitro and in vivo proliferation, differentiation and migration of cardiac endothelial progenitor cells (SCA1(+) /CD31(+) side-population cells).', Journal of Thrombosis and Haemostasis, 9, pp. 1628 - 1637, http://dx.doi.org/10.1111/j.1538-7836.2011.04375.x

Chen J; Liu M; Parish CR; Chong BH; Khachigian LM, 2011, 'Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine', International Journal of Biochemistry and Cell Biology, 43, pp. 905 - 912, http://dx.doi.org/10.1016/j.biocel.2011.03.004

Cheng Q; McKeown SJ; Santos L; Santiago FS; Khachigian LM; Morand EF; Hickey MJ, 2010, 'Erratum: Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules (Journal of Immunology (2010) 185 (1238-1247))', Journal of Immunology, 185, pp. 4959, http://dx.doi.org/10.4049/jimmunol.1090092

Kavurma MM; Bobryshev Y; Khachigian LM, 2010, 'Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1 (Retraction of vol 277, pg 36244, 2002)', JOURNAL OF BIOLOGICAL CHEMISTRY, 285, pp. 21902 - 21902, http://dx.doi.org/10.1074/jbc.A110.200463

Back to profile page