By Professor Levon Michael Khachigian

Journal articles

Khachigian LM, 2000, 'Catalytic DNAs as potential therapeutic agents and sequent-specific molecular tools to dissect biological function', Journal of Clinical Investigation, 106, pp. 1189 - 1195

Lowe HC; Costandi M; Chesterman CN; Khachigian LM, 2000, 'Human vascular injury triggers fibroblast growth factor 2 (FGF 2) release. Neointima formation in vitro is inhibited by novel catalytic DNA molecules targeting human EGR-1', Heart, Lung and Circulation, 9, pp. A95 - A95, http://dx.doi.org/10.1046/j.1443-9506.2000.0622x.x

Tapsall JW; Khachigian LM, 2000, 'Induction of platelet-derived growth factor B-chain expression by transforming growth factor-b involves transactivation by smads', The Journal of Biological Chemistry, pp. 16709 - 16716

Lowe HC; Murray BJ; Chong BH; Chesterman CN; Khachigian LM, 2000, 'Intracoronary blood sampling using the multifunction probing catheter does not cause platelet activation', Journal of Invasive Cardiology, 12, pp. 144 - 146

Khachigian LM; Takuwa Y; Collins TF, 2000, 'Mechanisms of angiotensin II-induced platelet-derived growth factor gene expression', Molecular and Cellular Biochemistry, pp. 183 - 186

Lowe HC; Chesterman CN; Khachigian LM, 2000, 'Neointimal formation following rat carotid angioplasty is inhibited by a novel catalytic DNA molecule targeting the transcription factor EGR-1', Heart, Lung and Circulation, 9, pp. A90 - A90, http://dx.doi.org/10.1046/j.1443-9506.2000.06012.x

Rafty LA; Khachigian LM, 2000, 'Novel negative regulatory element in the platelet-derived growth factor B chain promoter that mediates ERK-dependent transcriptional repression', The Journal of Biological Chemistry, pp. 11478 - 11483

Larkin L; Khachigian LM; Jessup W, 2000, 'Regulation of apolipoprotein E production in macrophages', International Journal of Molecular Medicine, pp. 253 - 258

Sungaran R; Chisholm OT; Markovic B; Khachigian LM; Tanaka Y; Chong BH, 2000, 'The role of platelet ?-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells.', Blood, pp. 3094 - 3101

Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker A; Atkins DG; Khachigian LM, 1999, 'New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury (vol 5, pg 1264, 1999)', NATURE MEDICINE, 5, pp. 1438 - 1438, http://dx.doi.org/10.1038/71020

Khachigian LM; Santiago FS; Rafty LA; Chan OLW; Delbridge GJ; Bobik A; Collins T; Johnson AC, 1999, 'GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury.', FASEB JOURNAL, 13, pp. A42 - A42, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082033300240&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker A; Atkins DG; Khachigian LM, 1999, 'Erratum: New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury (Nature Medicine (1999) 5 (1264-1269))', Nature Medicine, 5, pp. 1438, http://dx.doi.org/10.1038/71020

Day FL; Rafty LA; Chesterman CN; Khachigian LM, 1999, 'Angiotensin II (ATII)inducible plateletderived growth factor Achain gene expression is p42/44 extracellular signalregulated kinase1/2 and Egr1dependent and mediated via the ATII type 1 but not type 2 receptor. Induction by ATII a', The Journal of Biological Chemistry, pp. 23726 - 23733

Santiago FS; Lowe HC; Day FL; Chesterman CN; Khachigian LM, 1999, 'Early growth response factor1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor2.', American Journal of Pathology, 154, pp. 937 - 944

Khachigian LM; Santiago FS; Rafty LA; Onza CL; Delbridge G; Bobik A; Collins TF; Johnson AG, 1999, 'GC Factor 2 represses plateletderived growth factor Achain gene transcription and is itself induced by arterial injury', Circulation Research, pp. 1258 - 1267

Lowe HC; Chesterman CN; Khachigian LM, 1999, 'Left main coronary artery stenosis after percutaneous transluminal coronary angioplast: Importance of remaining `Minimally Invasive`', Catheterization and Cardiovascular Interventions, pp. 254 - 255

Santiago FS; Lowe HC; Kavurma MM; Chesterman CN; Baker AT; Atkins D; Khachigian LM, 1999, 'New DNA enzyme targeting Egr1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury', Nature Medicine, pp. 1264 - 1269

Khachigian LM, 1999, 'The imtimacies of blood vessel injury.', Today's Life Science, pp. 74 - 78

Santiago FS; Atkins D; Khachigian LM, 1999, 'Vascular smooth muscle cell proliferation and regrowth after mechanical injury in vitro are Egr1/NGFIAdependent.', American Journal of Pathology, 155, pp. 897 - 905

Silverman ES; Khachigian LM; Santiago FS; Williams A; Lindner V; Collins TF, 1999, 'Vascular smooth muscle cells express the transcriptional corepressor NAB2 in response to injury.', American Journal of Pathology, 155, pp. 1311 - 1317

Santiago FS; Atkins D; Khachigian LM, 1998, 'Antisense oligonucleotides directed against Egr-1 inhibit vascular smooth muscle cell proliferation.', FASEB JOURNAL, 12, pp. A189 - A189, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076006401100&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Santiago FS; Delbridge GJ; Chesterman CN, 1998, 'Endothelial injury triggers FGF-2 release and a signaling cascade involving MAPK and Egr-1.', FASEB JOURNAL, 12, pp. A467 - A467, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076006402706&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Collins TF, 1998, 'Early growth response factor-1: a pleiotropic mediator of inducible gene expression.', Journal of Molecular Medicine - Jmm, pp. 613 - 616

Sumpio RE; Du W; Galagher G; Wang H; Khachigian LM; Collins TF; Gimbrone MA; Resnick N, 1998, 'Regulation of PDGF-B in endothelial cells exposed to cyclic strain.', Arteriosclerosis, Thrombosis and Vascular Biology, 18, pp. 349 - 355

Rafty LA; Khachigian LM, 1998, 'Zinc finger transcription factors mediate high constitutive PDGF-B expression in smooth muscle cells derived from aortae of newborn rats.', The Journal of Biological Chemistry, pp. 5758 - 5764

Khachigian LM; Santiago FS; Delbridge GJ; Chesterman CN, 1997, 'Endothelial injury and transcriptional activation: bFGF induction of Egr-1 and PDGF-A', ATHEROSCLEROSIS, 134, pp. 265 - 265, http://dx.doi.org/10.1016/S0021-9150(97)89392-6

Resnick N; Yahav H; Khachigian LM; Collins T; Anderson KR; Dewey FC; Gimbrone MA, 1997, 'Endothelial gene regulation by laminar shear stress', Advances in Experimental Medicine and Biology, 430, pp. 155 - 164, http://dx.doi.org/10.1007/978-1-4615-5959-7_13

Gimbrone MA; Resnick N; Nagel T; Khachigian LM; Collins T; Topper JN, 1997, 'Hemodynamics, endothelial gene expression, and atherogenesis', Annals of the New York Academy of Sciences, 811, pp. 1 - 11, http://dx.doi.org/10.1111/j.1749-6632.1997.tb51983.x

Khachigian LM; Anderson KJ; Halnon NJ; Gimbrone MA; Resnick N; Collins TF, 1997, 'Egr-1 is activated in endothelial cells exposed to fluid shear stress and interacts with a novel shear-stress-response element in the PDGF A-chain promoter', Arteriosclerosis, Thrombosis and Vascular Biology, 17, pp. 2280 - 2286

Delbridge G; Khachigian LM, 1997, 'FGF-1-induced platelet-derived growth factor-A chain gene expression in endothelial cells involves transcriptional activation by early growth response factor-1', Circulation Research, pp. 282 - 288

Yang M; Khachigian LM; Hicks C; Chesterman CN; Chong BH, 1997, 'Identification of PDGF receptors on human megakaryocytes and megakarocytic cell lines', Thrombosis and Haemostasis, pp. 892 - 896

Khachigian LM; Collins TF, 1997, 'Inducible expression of Egr-1-dependent genes. A paradigm of transcriptional activation in vascular endothelium', Circulation Research, pp. 457 - 461

Silverman ES; Khachigian LM; Lindner V; Williams A; Collins TF, 1997, 'Inducible PDGF A-chain transcription in smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3', American Journal of Physiology - Cell Physiology, pp. H1415 - H1426

Khachigian LM; Dixon GJ; Huang XF; Catts SV; Hickie IB; Wakefield D, 1997, 'Molecular biology and the major psychoses', Australian and New Zealand Journal of Psychiatry, pp. 12 - 16

Khachigian LM; Collins TF; Fries JW, 1997, 'N-acetyl cysteine blocks mesangial VCAM-1 and NF-kappa B expression in vivo', American Journal of Pathology, 151, pp. 1225 - 1229

Khachigian LM; Anderson KR; Halnon NJ; Gimbrone MA; Resnick N; Collins T, 1996, 'Shear-induced endothelial pdgf-a chain gene expression involves EGR-1', FASEB Journal, 10

Khachigian LM; Lindner V; Williams A; Collins TF, 1996, 'Egr-1-induced endothelial gene expression: a common theme in vascular injury', Science, pp. 1427 - 1431

Field ST; Khachigian LM; Sleigh MJ; Yang G; Hogg PJ; Chesterman CN, 1996, 'Extracellular matrix as a source of mitogenically active platelet-derived growth factor', Journal of Cellular Physiology, 168, pp. 322 - 332

Khachigian LM; Williams AJ; Collins T, 1995, 'Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells', Journal of Biological Chemistry, 270, pp. 27679 - 27686, http://dx.doi.org/10.1074/jbc.270.46.27679

Khachigian LM; Williams AJ; Collins T, 1995, 'Interplay of Sp1 and Egr-1 in the PDGF A-chain proximal promoter in cultured vascular endothelial cells.', BLOOD, 86, pp. 1246 - 1246, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TH91001248&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

KHACHIGIAN LM; RESNICK N; GIMBRONE MA; COLLINS T, 1995, 'NUCLEAR FACTOR-KAPPA-B INTERACTS FUNCTIONALLY WITH THE SHEAR-STRESS-RESPONSE-ELEMENT IN THE PLATELET-DERIVED GROWTH-FACTOR B-CHAIN PROMOTER', FASEB JOURNAL, 9, pp. A412 - A412, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QL98702410&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Resnick N; Gimbrone MA; Collins T, 1995, 'Nuclear factor-κB interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress', Journal of Clinical Investigation, 96, pp. 1169 - 1175, http://dx.doi.org/10.1172/JCI118106

Khachigian LM; Collins T; Fries JWU, 1995, 'Nuclear factor-κB mediates induction of vascular cell adhesion molecule-1 in glomerular mesangial cells', Biochemical and Biophysical Research Communications, 206, pp. 462 - 467, http://dx.doi.org/10.1006/bbrc.1995.1065

Khachigian LM; Field SL; Crouch R; Chesterman CN, 1995, 'Platelet-derived growth factor A-chain synthetic peptide inhibits human glioma xenograft proliferation in nude mice', Anticancer Research, 15, pp. 337 - 341

Williams A; Khachigian LM; Shows T; Collins TF, 1995, 'Isolation and characterisation of a novel zinc-finger protein with transcriptional repressor activity', The Journal of Biological Chemistry, pp. 22143 - 22152

Neish AS; Khachigian LM; Baichwal VR; Park A; Collins TF, 1995, 'Sp1 is a component of the cytokine-inducible enhancer in the promoter of vascular cell adhesion molecule-1', The Journal of Biological Chemistry, pp. 28903 - 28908

Khachigian LM; Fries JWU; Benz MW; Bonthron DT; Collins T, 1994, 'Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells', Journal of Biological Chemistry, 269, pp. 22647 - 22656

KHACHIGIAN LM; BENZ MW; NEISH AS; BONTHRON DT; COLLINS T, 1994, 'NOVEL DNA-BINDING ELEMENTS IN THE PROMOTER OF HUMAN PLATELET-DERIVED GROWTH-FACTOR B-CHAIN GENE', FASEB JOURNAL, 8, pp. A392 - A392, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994ND19602268&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Chesterman CN, 1994, 'Structural basis for the extracellular retention of PDGF A-chain using a synthetic peptide corresponding to exon 6', Peptides, 15, pp. 133 - 137, http://dx.doi.org/10.1016/0196-9781(94)90181-3

KHACHIGIAN LM; SLEIGH MJ; CHESTERMAN CN, 1993, 'PLATELET-DERIVED GROWTH FACTOR-A-CHAIN EXON-6 PRODUCT ASSOCIATES WITH EXTRACELLULAR HEPARIN-LIKE GLYCOSAMINOGLYCANS', THROMBOSIS AND HAEMOSTASIS, 69, pp. 972 - 972, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993LT57701547&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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