By Professor Levon Michael Khachigian

Journal articles

Chan CWS; Kaplan W; Parish CR; Khachigian LM, 2012, 'Reduced retinal microvascular density, improved forepaw reach, comparative microarray and gene set enrichment analysis with c-jun targeting DNA enzyme', PLoS One, 7, pp. e39160, http://dx.doi.org/10.1371/journal.pone.0039160

Zhang N; Chan CWS; Sanchez-Guerrero E; Khachigian LM, 2012, 'Repression of PDGF-R-á after cellular injury involves TNF-á, formation of a c-Fos-YY1 complex, and negative regulation by HDAC', American Journal of Physiology - Cell Physiology, 302, pp. 1590 - 1598, http://dx.doi.org/10.1152/ajpcell.00429.2011

Midwinter R; Maghzal GJ; Dennis JM; Wu BJ; Cai H; Kapralov AA; Natalia A; Belikova NA; Tyurina YY; Dong LF; Khachigian LM; Neuzil J; Kagan VE; Stocker R, 2012, 'Succinobucol induces apoptosis in vascular smooth muscle cells', Free Radical Biology and Medicine, 52, pp. 871 - 879, http://dx.doi.org/10.1016/j.freeradbiomed.2011.11.029

Rayner B; Figtree G; Lay W; Sabaretnam T; Mazar J; Weaver J; Grieve S; Hunyor S; Khachigian L; Bhindi R, 2012, 'The Intracoronary Delivery of DNAzymes Targeting Egr-1 Upon Restoration of Blood Flow Reduces Inflammation and Subsequent Tissue Damage Following Acute Myocardial Ischemia Reperfusion', Heart, Lung and Circulation, 21, pp. S179 - S179, http://dx.doi.org/10.1016/j.hlc.2012.05.446

Ishii H; Hulett M; Li J; Santiago FS; Parish CR; Khachigian LM, 2012, 'Yin Yang-1 inhibits tumor cell growth and inhibits p21 WAF1/Cip1complex formation with cdk4 and cyclin D1', International Journal of Oncology, 40, pp. 1575 - 1580, http://dx.doi.org/10.3892/ijo.2012.1362

Truong A; Wong TY; Khachigian LM, 2011, 'Emerging therapeutic approaches in the management of retinal angiogenesis and edema', Journal of Molecular Medicine, 89, pp. 343 - 361, http://dx.doi.org/10.1007/s00109-010-0709-z

Khachigian LM, 2011, 'Catalytic DNA as new drugs for vascular disease and cancer', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 28, pp. S70 - S70, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295422700266&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM; Nath A; Malabanan KP, 2011, 'Regulation of cell migration by activation transcription factor-4', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 28, pp. S71 - S71, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295422700267&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Liang S; Khachigian LM; Ahmadi Z; Yang ; Liu S; Chong BH, 2011, 'In vitro and in vivo proliferation, differentiation and migration of cardiac endothelial progenitor cells (SCA1(+) /CD31(+) side-population cells).', Journal of Thrombosis and Haemostasis, 9, pp. 1628 - 1637, http://dx.doi.org/10.1111/j.1538-7836.2011.04375.x

Chen J; Liu M; Parish CR; Chong BH; Khachigian LM, 2011, 'Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine', International Journal of Biochemistry and Cell Biology, 43, pp. 905 - 912, http://dx.doi.org/10.1016/j.biocel.2011.03.004

Cheng Q; McKeown SJ; Santos L; Santiago FS; Khachigian LM; Morand EF; Hickey MJ, 2010, 'Erratum: Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules (Journal of Immunology (2010) 185 (1238-1247))', Journal of Immunology, 185, pp. 4959, http://dx.doi.org/10.4049/jimmunol.1090092

Zhang N; Khachigian LM, 2010, 'Erratum: Injury-induced platelet-derived growth factor receptor-α expression mediated by interleukin-1β (IL-1β) release and cooperative transactivation by NF-κB and ATF-4. IL-1β FACILITATES HDAC-1/2 DISSOCIATION FROM PROMOTER. ((****) ** (***–***), (), (10.1074/jbc.m109.025742))', Journal of Biological Chemistry, 285, pp. 21902, http://dx.doi.org/10.1074/jbc.A109.025742

Kavurma MM; Bobryshev Y; Khachigian LM, 2010, 'Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1 (Retraction of vol 277, pg 36244, 2002)', JOURNAL OF BIOLOGICAL CHEMISTRY, 285, pp. 21902 - 21902, http://dx.doi.org/10.1074/jbc.A110.200463

Ni J; Waldman A; Khachigian LM, 2010, 'Erratum: C-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins(Journal of Biological Chemistry (2018) 293(20307) DOI: 10.1074/jbc.M109.078345)', Journal of Biological Chemistry, 293, pp. 20307, http://dx.doi.org/10.1074/jbc.W118.007069

Liu MY; Khachigian LM, 2010, 'Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1 beta and forms a cytokine-inducible gene-silencing complex with NF-kappa B p65 and interferon regulatory factor-1 (vol 284, pg 35101, 2009)', JOURNAL OF BIOLOGICAL CHEMISTRY, 285, pp. 4263 - 4263, http://dx.doi.org/10.1074/jbc.A109.061903

Liu MY; Khachigian LM, 2010, 'Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1β and forms a cytokine-inducible gene-silencing complex with NF-κB p65 and interferon regulatory factor-1 (Journal of Biological Chemistry (2009) 284, (35101-35112)) DOI: 10.1074/jbc.A109.061903', Journal of Biological Chemistry, 285, pp. 4363

Perdomo JS; Fock E; Kaur G; Yan F; Khachigian LM; Jans D; Chong BH, 2010, 'A monopartite sequence is essential for p45 NF-E2 nuclear translocation, transciptional activity and platelet production', Journal of Thrombosis and Haemostasis, 8, pp. 2542 - 2553, http://dx.doi.org/10.1111/j.1538-7836.2010.04058.x

Malabanan KP; Khachigian LM, 2010, 'Activation transcription factor-4 and the acute vascular response to injury.', Journal of Molecular Medicine - Jmm, 88, pp. 545 - 552

Pourgholami MH; Khachigian LM; Fahmy R; Badar S; Wang L; Chu SW; Morris DL, 2010, 'Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis', Biochemical and Biophysical Research Communications, 397, pp. 729 - 734, http://dx.doi.org/10.1016/j.bbrc.2010.06.019

Ni J; Waldman A; Khachigian LM, 2010, 'c-Jun regulates shear-and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins.', The Journal of Biological Chemistry, 285, pp. 4038 - 4048, http://dx.doi.org/10.1074/jbc.M109.078345

Liang SX; Pinkevych M; Khachigian LM; Parish CR; Davenport MP; Chong BH, 2010, 'Drug-induced thrombocytopenia (DITP): development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG', Blood, 116, pp. 1958 - 1960

Liu MY; Khachigian LM, 2010, 'Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1β and forms a cytokine-inducible gene-silencing complex with NF-κB p65 and interferon regulatory factor-1.', Journal of Biological Chemistry, 285, pp. 21902, http://dx.doi.org/10.1074/jbc.a209.061903

Cheng Q; Mckeown S; Santos L; Santiago FS; Khachigian LM; Morand E; Hickey M, 2010, 'Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules.', Journal of Immunology, 185, pp. 1238 - 1247

Getachew R; Ballinger M; Burch M; Reid J; Khachigian LM, 2010, 'PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminologycan elongationon biglycan and increases binding to LDL.', Endocrinology, 151, pp. 4356 - 4367

Wang B; Chen J; Santiago FS; Janes ME; Kavurma MM; Chong BH; Pimanda JE; Khachigian LM, 2010, 'Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.', Arteriosclerosis, Thrombosis and Vascular Biology, 30, pp. 536 - 545, http://dx.doi.org/10.1161/ATVBAHA.109.193821

Ye ; Chan G; Qiao ; Meng ; Luo ; Khachigian LM; Ma ; Deng R; Chen ; Chong BH; Yang , 2010, 'Platelet-derived growth factor enhances platelet recovery in a murine model of radiation-induced thrombocytopenia and reduces apoptosis in megakaryocytes via its receptors and the PI3-k/Akt pathway', Haematologica, 95, pp. 1745 - 1753

Kavurma MM, 2010, 'TRAIL promotes VSMC proliferation and neointima formation in a FGF-2-, Sp1 phosphorylation-, and NFkappaB-dependent manner', Circulation Research, 106, pp. 1061 - 1071

Zhang C; Song QH; Khachigian LM; Lubenec I; Shie J-L; Yang B; Li J; Tian Y, 2009, 'Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells (Retraction of vol 380, pg 689, 2009)', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 388, pp. 464 - 464, http://dx.doi.org/10.1016/j.bbrc.2009.08.011

Dass CR; Khachigian LM; Choong PFM, 2009, 'C-Jun is critical for the progression of osteosarcoma: Proof in an orthotopic spontaneously metastasizing model (Molecular Cancer Research (2008) 6, (1289-1292))', Molecular Cancer Research, 7, pp. 1594, http://dx.doi.org/10.1158/1541-7786.MCR-07-9-COR2

Ni J; Waldman A; Khachigian L, 2009, 'DNA enzyme targeting transcription factor c-Jun reduces intimal hyperplasia in human saphenous vein explants and inhibits Vein Graft stenosis in rabbits', EUROPEAN HEART JOURNAL, 30, pp. 322 - 322, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208702603073&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian L, 2009, 'DNAZYME TARGETING TRANSCRIPTION FACTOR C-JUN INHIBITS MYOCARDIAL INFLAMMATION, ROS GENERATION AND INFARCT SIZE AFTER ISCHEMIA-REPERFUSION INJURY', ATHEROSCLEROSIS SUPPLEMENTS, 10, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207957101541&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Li C; Wu B; Midwinter R; Beck K; Collinson E; Maghzal G; Cassano C; Santiago F; Khachigian L; Gamble J; Stocker R, 2009, 'PROTECTION AGAINST ATHEROSCLEROSIS BY HEME OXYGENASE-1', ATHEROSCLEROSIS SUPPLEMENTS, 10, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207957100820&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Khachigian LM, 2009, 'Immediate-early genes as master regulators in cancer and other vascular disease', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 24, pp. S77 - S77, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000270497500292&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wang B; Khachigian LM; Esau L; Birrer M; Zhao X; Parker M; Hendricks D, 2009, 'A Key Role for Early Growth Response-1 and Nuclear Factor-kappa B in Mediating and Maintaining GRO/CXCR2 Proliferative Signaling in Esophageal Cancer', Molecular Cancer Research, 7, pp. 755 - 764

Li C; Wu B; Midwinter R; Beck K; Collinson E; Maghzal G; Cassano C; Santiago F; Khachigian L; Gamble J; Stocker R, 2009, 'Abstract: 81 PROTECTION AGAINST ATHEROSCLEROSIS BY HEME OXYGENASE', Atherosclerosis Supplements, 10, pp. e220 - e220, http://dx.doi.org/10.1016/s1567-5688(09)70224-7

Khachigian L, 2009, 'Abstract: P668 DNAZYME TARGETING TRANSCRIPTION FACTOR C-JUN INHIBITS MYOCARDIAL INFLAMMATION, ROS GENERATION AND INFARCT SIZE AFTER ISCHEMIA-REPERFUSION INJURY', Atherosclerosis Supplements, 10, pp. e854 - e854, http://dx.doi.org/10.1016/s1567-5688(09)70836-0

Tan N; Li J; Stocker R; Khachigian LM, 2009, 'Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and fasl-fas engagement', Circulation Research, 105, pp. 422 - 430, http://circres.ahajournals.org/cgi/content/full/105/5/422

Luo X; Cai H; Ni J; Bhindi R; Lowe HC; Chesterman CN; Khachigian LM, 2009, 'c-Jun DNAzymes Inhibit Myocardial Inflammation, ROS Generation, Infarct Size, and Improve Cardiac Function After Ischemia-Reperfusion Injury', Arteriosclerosis, Thrombosis and Vascular Biology, 29, pp. 1836 - U282

Ni J; Waldman A; Khachigian LM, 2009, 'c-Jun Induces Intimal Hyperplasia in a Rabbit End-to-Side Autologous Veno-Arterial Transplantation Model', Heart, Lung and Circulation, 18, pp. S110 - S111, http://dx.doi.org/10.1016/j.hlc.2009.05.250

Chan C; Khachigian LM, 2009, 'DNAzymes and their therapeutic possibilities', Internal Medicine Journal, 39, pp. 249 - 251

Abdel-Malak N; Mofarrahi M; Mayaki D; Khachigian LM; Hussain S, 2009, 'Early growth response-1 regulates angiopoietin-1-induced endothelial cell proliferation, migration, and differentiation', Arteriosclerosis, Thrombosis and Vascular Biology, 29, pp. 209 - 216

Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2009, 'Prolonged Diabetes in Rats is Associated With Increased Myocardial Fibrosis and Profound Sensitivity to Ischaemia', Heart, Lung and Circulation, 18, pp. S314 - S314, http://dx.doi.org/10.1016/j.hlc.2009.05.484

Khachigian LM; Peter K; Berndt MC, 2009, 'Recent advances in vascular biology: Selected highlights from IVBM 2008', Thrombosis and Haemostasis, 101, pp. 997 - 998

Zhang C; Song Q; Khachigian LM; Lubenec I; Shie J; Yang B; Li J; Tian Y, 2009, 'Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells', Biochemical and Biophysical Research Communications, 380, pp. 689 - 694

Zhang C; Song Q; Khachigian LM; Lubenec I; Shie J; Yang B; Li J; Tian Y, 2009, 'Retraction notice to `Related transcriptional enhancer factor-1 induces fibroblast growth factor receptor-1 expression in endothelial cells` [Biophys. Res. Commun. 380 (3) (2009) 689-694] (DOI:10.1016/j.bbrc.2009.01.151)', Biochemical and Biophysical Research Communications, 388, pp. 464

Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2009, 'Selected Egr-1-dependent molecules are increased acutely with acute myocardial infarction', Heart, Lung and Circulation, 18, pp. S253 - S254, http://dx.doi.org/10.1016/j.hlc.2009.05.625

Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2009, 'Selective Egr-1 Inhibition Reduces Infarct Size in the Diabetic Rat Heart with Myocardial Ischaemia–Reperfusion Injury', Heart, Lung and Circulation, 18, pp. S315 - S315, http://dx.doi.org/10.1016/j.hlc.2009.05.485

Tan N; Khachigian LM, 2009, 'Sp1 phosphorylation and its regulation of gene transcription', Molecular and Cellular Biology, 29, pp. 2483 - 2488

Khachigian LM; Bobik A; Kanellakis P; Malabanan K, 2008, 'Response to abcouwer and roybal', Circulation Research, 103, pp. e119, http://dx.doi.org/10.1161/CIRCRESAHA.108.187559

Dass CR; Friedhuber AM; Khachigian LM; Dunstan DM; Choong PFM, 2008, 'Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity', Journal of Microencapsulation, 25, pp. 421 - 425, http://dx.doi.org/10.1080/02652040802033673

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