By Professor Levon Michael Khachigian

Journal articles

Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2007, 'The transcription factor Egr-1 is implicated in myocardial ischaemic reperfusion injury in an in vivo model of diabetes', Journal of Molecular and Cellular Cardiology, 42, pp. S194 - S194

Benson VL; McMahon AC; Khachigian LM; Lowe HC, 2007, 'The Transcription Factor Egr-1 is Upregulated by Myocardial Ischaemia Reperfusion Injury in an In Vivo Rat Model Of Diabetes', Heart, Lung and Circulation, 16, pp. S23 - S24, http://dx.doi.org/10.1016/j.hlc.2007.06.062

Khachigian LM; Santiago FS; Ishii H; Shafi S; Khurana R; Kanellakis P; Bhindi R; Ramirez M; Bobik A; Martin JL; Chesterman CN; Zachary I, 2007, 'Yin yang-1 inhibits intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-Cyclin D1 assembly', Federation of American Societies for Experimantal Biology Journal, 21, pp. A69 - A69

Santiago FS; Ishii H; Shafi S; Khurana R; Kanellakis P; Bhindi R; Ramirez M; Bobik A; Martin J; Chesterman CN; Zachary I; Khachigian LM, 2007, 'Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21(WAF1/Cip1) transcription and p21(WAF1/Cip1)-Cdk4-cyclin D1 assembly', Circulation Research, 101, pp. 146 - 155

Lowe HC; Khachigian LM, 2006, 'The endothelium and cardiovascular disease: New developments, new challenges', Endothelium: Journal of Endothelial Cell Research, 13, pp. 365, http://dx.doi.org/10.1080/10623320601125303

Khachigian L, 2006, 'Molecular assassin targets master regulator gene', Australian Life Scientist, 3, pp. 15

Khachigian LM, 2006, 'Collagen antibody-induced arthritis', Nature Protocols, 1, pp. 2512 - 2516

Khachigian LM; Lowe HC; Bhindi R, 2006, 'DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats', Journal of Thrombosis and Haemostasis, 4, pp. 1479 - 1483

Khachigian LM, 2006, 'Early growth response-1 in Cardiovascular Pathobiology', Circulation Research, 98, pp. 186 - 191

Kingwell B; Anderson GP; Duckett S; Hoole E; Jackson Pulver L; Khachigian LM; Morris ME; Roder D; Rothwell-Short J; Wilson A, 2006, 'Evaluation of NHMRC funded research completed in 1992, 1997 and 2003: gains in knowledge, health and wealth', Medical Journal of Australia, 184, pp. 282 - 286

Khachigian LM, 2006, 'Health and medical research funding: an investment in Australia`s future', Medical Journal of Australia, 185, pp. 348 - 350

Liu M; Eyries MM; Zhang C; Santiago FS; Khachigian LM, 2006, 'Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1', Blood, 107, pp. 2322 - 2329

Santiago FS; Ishii H; Hulett MD; Bobik A; Martin JF; Chesterman CN; Zachary IC; Khachigian LM, 2006, 'Injury-inducible yin yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing P21WAF1/CIP1 transcription and perturbing cyclin D1-CDK4-P21WAF1/CIP1 assembly', Vascular Pharmacology, 45, pp. e46 - e47, http://dx.doi.org/10.1016/j.vph.2006.08.160

Khachigian LM; Fahmy R; Di Girolamo N; Zhang GS, 2006, 'JUN siRNA regulates matrix metalloproteinase-2 expression, microvascular endothelial growth and retinal neovascularisation', Journal of Cell Science, 119, pp. 3219 - 3226

Khachigian LM; Witting PK; McMahon AC; Lowe HC; Bhindi R, 2006, 'Rat models of myocardial infarction', Thrombosis and Haemostasis, 96, pp. 602 - 610

Khachigian LM; Luo X; Sumithran E; Pua VS; Barnetson R; Halliday GM; Zhang GS, 2006, 'Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression', Oncogene, 25, pp. 7260 - 7266

Fahmy R; Waldman A; Zhang GS; Mitchell A; Tedla NT; Cai H; Geczy C; Chesterman CN; Perry MA; Khachigian LM, 2006, 'Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun', Nature Biotechnology, 24, pp. 856 - 863, http://dx.doi.org/10.1038/nbt1225

Murrell MJ; Khachigian L; Ward MR, 2006, 'The role of c-jun in flow dependent and flow independent restenosis after angioplasty and stenting', Vascular Pharmacology, 45, pp. e59 - e59, http://dx.doi.org/10.1016/j.vph.2006.08.155

Khachigian LM; Waldman A; Fahmy R; Perry M; Geczy C; Zhang G, 2005, 'Novel Insights into Functions of Immediate-Early Genes In Vascular Permeability and Inflammation using Catalytic DNA', INFLAMMATION RESEARCH, 54, pp. S89 - S89, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000205501600014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Bonello MR; Khachigian LM, 2005, 'Erratum: Fibroblast growth factor-2 represses platelet-derived growth factor receptor-α (PDGFR-α) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-α promoter (Journal of Biological Chemistry (2004) 279 (2377-2382))', Journal of Biological Chemistry, 280, pp. 1704

Bonello MR; Khachigian LM, 2005, 'Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter (vol 279, pg 2377, 2004)', JOURNAL OF BIOLOGICAL CHEMISTRY, 280, pp. 1704 - 1704, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000226195200102&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lowe HC; James B; Khachigian LM, 2005, 'A novel model of in-stent restenosis: rat aortic stenting', Heart, 91, pp. 393 - 395

Waldman A; Fahmy R; Khachigian LM, 2005, 'DNAzymes targeting c-Jun inhibit inflammation and downregulate endothelial ICAM-1, VCAM-1 and E-selectin expression', Circulation, 112, pp. U319 - U319

Bhindi R; Khachigian LM; Lowe HC, 2005, 'DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats', Circulation, 112, pp. U239 - U239

de Mestre A; Rao S; Hornby J; Soe-Htwe T; Khachigian LM; Hulett M, 2005, 'Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells', The Journal of Biological Chemistry, 280, pp. 35136 - 35147

Bhindi R; Brieger D; Ishii H; Di Girolamo N; Kumar RK; Khachigian LM; Lowe HC, 2005, 'Fibroblast growth factor 2 and the transcription factor Egr-l localiseto endothelial cell microvascular channels in human coronary artery occlusion', Thrombosis and Haemostasis, 93, pp. 172 - 174

Fisher C; Sanchez-Ruderisch H; Welzel M; Wiedenmann B; Sakai T; Andre S; Gabius H; Khachigian LM; Detjen K; Rosewicz S, 2005, 'Galectin-1 Interacts with the alpha 5 Beta 1 Fibronectin Receptor to Restrict Carcinoma Cell growth via Induction of p21 and p27', The Journal of Biological Chemistry, 280, pp. 37266 - 37277

Bonello M; Bobryshev YV; Khachigian LM, 2005, 'Peroxide-inducible Ets-1 mediates platelet-derived growth factor receptor-alpha gene transcription in vascular smooth muscle cells', American Journal of Pathology, 167, pp. 1149 - 1159

Khachigian LM, 2005, 'Suppressing a sick heart', Nature Medicine, 11, pp. 828 - 829

Kavurma MM; Bhindi R; Lowe HC; Chesterman CN; Khachigian LM, 2005, 'Vessel wall apoptosis and atherosclerotic plaque instability', Journal of Thrombosis and Haemostasis, 3, pp. 465 - 472

Eisbacher M; Holmes ML; Newton A; Hogg PJ; Khachigian LM; Crossley M; Chong BH, 2004, 'Erratum: Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding (Molecular and Cellular Biology (2003) 23, 10 (3427-3441))', Molecular and Cellular Biology, 24, pp. 5088, http://dx.doi.org/10.1128/MCB.24.11.5088.2004

Khachigian LM, 2004, 'Deoxyribozymes as inhibitors of vascular smooth muscle cell growth', Current Pharmaceutical Biotechnology, 5, pp. 337 - 339

Khachigian LM, 2004, 'DNAzymes as molecular agents that manipulate Egr-1 gene expression', Biochemical Pharmacology, 68, pp. 1023 - 1025

Zhang GS; Dass CR; Sun L; Khachigian LM, 2004, 'DNAZYMES TARGETING C-JUN BLOCK ENDOTHELIAL PROLIFERATION, MIGRATION, TUBULE FORMATION, ANGIOGENESIS AND SOLID TUMOR GROWTH', Cardiovascular Pathology, 13, pp. 131 - 131, http://www.sciencedirect.com/science/article/B6T13-4C88SSS-FR/2/5289ac8546a33c5e6f75f4effe492cdc

Khachigian LM, 2004, 'Early growth response-1: blocking angiogenesis by shooting the messenger', Cell Cycle, 3, pp. 10 - 11

Zhang GS; Dass CR; Sumithran E; Di Girolamo N; Sun L; Khachigian LM, 2004, 'Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents', Journal of the National Cancer Institute, 96, pp. 683 - 696

Santiago FS; Khachigian LM, 2004, 'Ets-1 Stimulates Platelet-Derived Growth Factor A-Chain Gene Transcription and Vascular Smooth Muscle Cell Growth via Cooperative Interactions With Sp1', Circulation Research, 95, pp. 479 - 487

Midgley VC; Khachigian LM, 2004, 'Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1', The Journal of Biological Chemistry, 279, pp. 40289 - 40295

Bonello M; Khachigian LM, 2004, 'Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter', The Journal of Biological Chemistry, 279, pp. 2377 - 2382

Mitchell A; Dass CR; Sun L; Khachigian LM, 2004, 'Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumour growth by DNAzymes targeting the zinc finger transcription factor EGR-1', Nucleic Acids Research, 32, pp. 3065 - 3069

Fahmy R; Khachigian LM, 2004, 'Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth', Nucleic Acids Research, 32, pp. 2281 - 2285

Hanratty C; Murrell MJ; Khachigian LM; Tsao P; Ward M, 2004, 'Low flow promotes instent intimal hyperplasia: Comparison with lumen loss in balloon-injured and uninjured vessels and the effects of the antioxidant pyrrolidine dithiocarbamate', Atherosclerosis, 177, pp. 269 - 274, http://www.sciencedirect.com/science/article/B6T12-4D991WV-1/2/92716c5740e514de9583a3122e2a7710

Eyries MM; Collins TF; Khachigian LM, 2004, 'Modulation of growth factor gene expression in vascular cells by oxidative stress', Endothelium - Journal of Endothelial Cell Research, 11, pp. 133 - 139

Khachigian LM, 2004, 'Oxidative stress and endothelial dysfunction', Endothelium - Journal of Endothelial Cell Research, 11, pp. 77 - 78

Khachigian LM; Parish CR, 2004, 'Phosphomannopentaose sulfate (PI-88): heparan sulfate mimetic with clinical potential in multiple vascular pathologies', Cardiovascular Drug Reviews, 22, pp. 1 - 6

Sharma L; Melis E; Hickey M; Clyne C; Erlich JH; Khachigian LM; Morand E; Carmeliet P; Tipping P; Davenport P, 2004, 'The cytoplasmic domain of tissue factor contributes to leukocyterecruitment and death in endotoxemia', American Journal of Pathology, 165, pp. 331 - 340

Kavurma MM; Khachigian LM, 2004, 'Vascular smooth muscle cell-specific regulation of cyclin-dependent kinase inhibitor p21(WAF1/Cip1) transcription by Sp1 is mediated via distinct cis-acting positive and negative regulatory elements in the proximal p21(WAF1/Cip1) promoter', Journal of Cellular Biochemistry, 93, pp. 904 - 916, http://www.sciencedirect.com/science/article/B6WVB-4DPTTDJ-2JG/2/67c285e89191727f56c2098219b8da14

De Mestre AM; Khachigian LM; Santiago FS; Staykova MA; Hulett MD, 2003, 'Regulation of Inducible Heparanase Gene Transcription in Activated T Cells by Early Growth Response 1', Journal of Biological Chemistry, 278, pp. 50377 - 50385, http://dx.doi.org/10.1074/jbc.M310154200

Kavurma MM; Khachigian LM, 2003, 'Sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21^WAF1/Cip1 transcription and cyclin D1-Cdk4-p21^WAF1/Cip1 complex formation', Journal of Biological Chemistry, 278, pp. 32537 - 32543, http://dx.doi.org/10.1074/jbc.M305650200

Zhang C; Kavurma MM; Lai A; Khachigian LM, 2003, 'Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21^WAF1/Cip1: ETS-1 regulates basal and inducible p21^WAF1/Cip1 transcription via distinct cis-acting elements in the p21^WAF1/Cip1 promoter', Journal of Biological Chemistry, 278, pp. 27903 - 27909, http://dx.doi.org/10.1074/jbc.M304328200

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