By Professor Richard Bryan Lock

Journal articles

Lock RB; Carol H, 2012, 'Initial testing of the MDM2 inhibitor RG7112 by the Pediatric Preclinical Testing Program', Pediatric Blood and Cancer, 60, pp. 633 - 641, http://dx.doi.org/10.1002/pbc.24235

Szymanska B; Wilczynska-Kalak U; Kang M; Liem N; Carol H; Boehm I; Groepper D; Reynolds CP; Stewart C; Lock RB; Ingrid , 2012, 'Pharmacokinetic modeling of an induction regimen for in vivo combined testing of novel drugs against pediatric acute lymphoblastic leukemia xenografts', PLoS One, 7, pp. Article number e33894, http://dx.doi.org/10.1371/journal.pone.0033894

Frolova O; Samudio I; Benito J; Jacamo R; Kornblau SM; Markovic A; Schober W; Lu H; Qiu YH; Buglio D; Mcqueen T; Pierce S; Shpall E; Konoplev S; Thomas D; Kantarjian H; Lock RB; Andreeff M; Konopleva M, 2012, 'Regulation of HIF-1 alpha signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment', Cancer Biology and Therapy, 13, pp. 858 - 870, http://dx.doi.org/10.4161/cbt.20838

Gorlick R; Maris JM; Houghton PJ; Lock RB; Carol H; Kurmasheva RT; Kolb EA; Reynolds CP; Kang MH; Billups CA; Smith MA, 2012, 'Testing of the Akt/PKB inhibitor MK-2206 by the pediatric preclinical testing program', Pediatric Blood and Cancer, 59, pp. 518 - 524, http://dx.doi.org/10.1002/pbc.23412

Houghton PJ; Lock RB; Carol H; Morton CL; Gorlick R; Kolb EA; Keir ST; Reynolds CP; Kang MH; Maris JM; Billups C; Zhang MX; Madden SL; Teicher BA; Smith MA, 2012, 'Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program', Pediatric Blood and Cancer, 58, pp. 200 - 209, http://dx.doi.org/10.1002/pbc.23016

Lu H; Battula VL; Shi Y; Lock RB; Spong S; Andreeff M; Konopleva M, 2011, 'Role of Connective Tissue Growth Factor (CTGF) in Survival and Chemosensitivity of Acute Lymphoblastic Leukemia', Blood, 118, pp. 2593 - 2593, http://dx.doi.org/10.1182/blood.v118.21.2593.2593

Pimanda J; Thoms J; Birger Y; Foster S; Knezevic K; Kirschenbaum Y; Chandrakanthan V; Lock R; MacKenzie K; Gottgens B; Izraeli S, 2011, 'ERG PROMOTES T-ACUTE LYMPHOBLASTIC LEUKEMIA AND IS TRANSCRIPTIONALLY REGULATED IN LEUKEMIC CELLS BY A STEM CELL ENHANCER', EXPERIMENTAL HEMATOLOGY, 39, pp. S108 - S108, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293801700179&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Smith MPW; Wood SL; Zougman A; Ho JTC; Peng J; Jackson D; Cairns DA; Lewington AJP; Selby PJ; Banks RE, 2011, 'A systematic analysis of the effects of increasing degrees of serum immunodepletion in terms of depth of coverage and other key aspects in top-down and bottom-up proteomic analyses.', Proteomics, 11, pp. 2222 - 2235, http://dx.doi.org/10.1002/pmic.201100005

Carol H; Boehm I; Reynolds CP; Kang MH; Maris JM; Morton CL; Gorlick R; Kolb EA; Keir ST; Wu J; Wozniak AE; Yang Y; Manfredi M; Ecsedy J; Wang J; Neale G; Houghton PJ; Smith MA; Lock RB, 2011, 'Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer', Cancer Chemotherapy and Pharmacology, 68, pp. 1291 - 1304, http://dx.doi.org/10.1007/s00280-011-1618-8

Thoms JAI; Birger Y; Foster S; Knezevic K; Kirshenbaum Y; Chandrakanthan V; Jonquieres G; Spensberger D; Wong JW; Oram SH; Kinston SJ; Groner Y; Lock RB; MacKenzie KL; Gottgens B; Izraeli S; Pimanda JE, 2011, 'ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer', Blood, 117, pp. 7079 - 7089, http://dx.doi.org/10.1182/blood-2010-12-317990

Bhadri V; Cowley MJ; Kaplan W; Trahair TN; Lock RB, 2011, 'Evaluation of the NOD/SCID xenograft model for glucocorticoid-regulated gene expression in childhood B-cell precursor acute lymphoblastic leukemia', BMC Genomics, 12, pp. 1 - 13, http://dx.doi.org/10.1186/1471-2164-12-565

Kolb AE; Gorlick R; Lock RB; Carol H; Morton CL; Keir ST; Reynolds CP; Kang MH; Mans JM; Billups C; Smith MA; Houghton PJ, 2011, 'Initial Testing (Stage 1) of the IGF-1 Receptor Inhibitor BMS-754807 by the Pediatric Preclinical Testing Program', Pediatric Blood and Cancer, 56, pp. 595 - 603, http://dx.doi.org/10.1002/pbc.22741

Smith MA; Maris JM; Lock RB; Kolb EA; Gorlick R; Keir ST; Carol H; Morton CL; Reynolds CP; Kang MH; Houghton PJ, 2011, 'Initial Testing (Stage 1) of the Polyamine Analog PG11047 by the Pediatric Preclinical Testing Program', Pediatric Blood and Cancer, 57, pp. 268 - 274, http://dx.doi.org/10.1002/pmic.201100005

Reynolds CP; Kang MH; Keir ST; Gorlick R; Kolb EA; Lock RB; Maris JM; Carol H; Morton CL; Billups CA; Smith MA; Houghton PJ, 2011, 'Initial Testing of Lenalidomide by the Pediatric Preclinical Testing Program', Pediatric Blood and Cancer, 57, pp. 606 - 611, http://dx.doi.org/10.1002/pbc.22877

Houghton PJ; Lock RB; Carol H; Morton CL; Phelps D; Gorlick R; Kolb EA; Keir ST; Reynolds CP; Kang MH; Maris JM; Wozniak AW; Gu Y; Wilson WR; Smith MA, 2011, 'Initial Testing of the Hypoxia-Activated Prodrug PR-104 by the Pediatric Preclinical Testing Program', Pediatric Blood and Cancer, 57, pp. 443 - 453, http://dx.doi.org/10.1002/pbc.22921

Davies C; Hogarth L; Dietrich PA; Bachmann PS; Mackenzie KL; Hall AG; Lock RB, 2011, 'p53-independent epigenetic repression of the p21WAF1 gene in T-cell acute lymphoblastic leukemia', The Journal of Biological Chemistry, 286, pp. 37639 - 37650, http://dx.doi.org/10.1074/jbc.M111.272336

Benito J; Shi Y; Szymanska B; Carol H; Boehm I; Lu H; Konoplev S; Fang W; Zweidler-McKay PA; Campana D; Borthakur G; Bueso-ramos C; Shpall E; Thomas DA; Jordan CT; Kantarjian H; Wilson WR; Lock RB; Andreeff M; Konopleva M; Ingrid , 2011, 'Pronounced Hypoxia in Models of Murine and Human Leukemia: High Efficacy of Hypoxia-Activated Prodrug PR-104', PLoS ONE, 6, pp. e23108, http://dx.doi.org/10.1371/journal.pone.0023108

Barry JB; Lock RB, 2011, 'Small ubiquitin-related modifier-1: Wrestling with protein regulation', International Journal of Biochemistry and Cell Biology, 43, pp. 37 - 40, http://dx.doi.org/10.1016/j.biocel.2010.09.022

Lu H; Battula VL; Korchin B; Spong S; Canizales M; Lock RB; Andreeff M; Konopleva M, 2010, 'Targeting Connective Tissue Growth Factor (CTGF) In Acute Lymphoblastic Leukemia Pre-Clinical Models: Anti-CTGF Monoclonal Antibody Attenuates Tumor Growth In Mouse Models of ALL', Blood, 116, pp. 3257 - 3257, http://dx.doi.org/10.1182/blood.v116.21.3257.3257

Benito J; Shi Y; Szymanska B; Carol H; Bohem I; Lu H; Konoplev S; Fang W; Kornblau SM; Zweidler-McKay P; Wilson W; Campana D; Borthakur G; Bueso-Ramos CE; Kantarjian HM; Shpall EJ; Thomas DA; Jordan CT; Lock RB; Andreeff M; Konopleva M, 2010, 'Targeting the Leukemia-Associated Hypoxic Microenvironment with Hypoxia-Activated Prodrug PR-104', Blood, 116, pp. 868 - 868, http://dx.doi.org/10.1182/blood.v116.21.868.868

Bhadri VA; Cowley MJ; Kaplan W; Lock RB, 2010, 'The NOD/SCID Xenograft Model Provides Clinically-Relevant Insights Into Glucocorticoid-Induced Gene Expression In Childhood B-Cell Precursor Acute Lymphoblastic Leukemia (ALL)', Blood, 116, pp. 2493 - 2493, http://dx.doi.org/10.1182/blood.v116.21.2493.2493

Oram SH; Thoms JAI; Pridans C; Janes ME; Kinston SJ; Anand S; Landry JR; Lock RB; Jayaraman PS; Huntly BJ; Pimanda JE; Gottgens B, 2010, 'A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients', Oncogene, 29, pp. 5796 - 5808, http://dx.doi.org/10.1038/onc.2010.320

Bachmann PS; Piazza RG; Janes M; Wong NC; Davies C; Mogavero A; Bhadri V; Szymanska B; Geninson G; Magistroni V; Cazaniga G; Biondi A; Miranda-saavedra D; Gottgens B; Saffery R; Craig JM; Marshall GM; Gambacorti-passerini C; Pimanda JE; Lock RB, 2010, 'Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition', Blood, 116, pp. 3013 - 3022, http://dx.doi.org/10.1182/blood-2010-05-284968

Kolb EA; Gorlick R; Houghton PJ; Morton CL; Keir ST; Carol H; Lock RB; Phelps D; Kang MH; Reynolds CP; Maris JM; Billups C; Smith MA, 2010, 'Initial Testing (Stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program', Pediatric Blood and Cancer, 55, pp. 668 - 677, http://dx.doi.org/10.1002/pbc.22576

Smith MA; Morton CL; Kolb EA; Gorlick R; Keir ST; Carol H; Lock RB; Kang MH; Reynolds CP; Maris JM; Watkins AE; Houghton PJ, 2010, 'Initial Testing (Stage 1) of Mapatumumab (HGS-ETR1) by the Pediatric Preclinical Testing Program', Pediatric Blood and Cancer, 54, pp. 307 - 310, http://dx.doi.org/10.1002/pbc.22188

Carol H; Morton CL; Gorlick R; Kolb EA; Keir ST; Reynolds CP; Kang MH; Maris JM; Billups C; Smith MA; Houghton PJ; Lock RB, 2010, 'Initial Testing (Stage 1) of the Akt Inhibitor GSK690693 by the Pediatric Preclinical Testing Program', Pediatric Blood and Cancer, 55, pp. 1329 - 1337, http://dx.doi.org/10.1002/pbc.22710

Keir ST; Maris JM; Lock RB; Kolb EA; Gorlick R; Carol H; Morton CL; Reynolds CP; Kang MH; Watkins A; Houghton PJ; Smith MA, 2010, 'Initial Testing (Stage 1) of the Multi-Targeted Kinase Inhibitor Sorafenib by the Pediatric Preclinical Testing Program', Pediatric Blood and Cancer, 55, pp. 1126 - 1133, http://dx.doi.org/10.1002/pbc.22712

Maris JM; Morton CL; Gorlick R; Kolb EA; Lock RB; Carol H; Keir ST; Reynolds CP; Kang MH; Wu J; Smith MA; Houghton PJ, 2010, 'Initial Testing of the Aurora Kinase A Inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP)', Pediatric Blood and Cancer, 55, pp. 26 - 34, http://dx.doi.org/10.1002/pbc.22430

Carol H; Houghton PJ; Morton CL; Kolb EA; Gorlick R; Reynolds CP; Kang MH; Maris JM; Keir ST; Watkins A; Smith MA; Lock RB, 2010, 'Initial Testing of Topotecan by the Pediatric Preclinical Testing Program', Pediatric Blood and Cancer, 54, pp. 707 - 715, http://dx.doi.org/10.1002/pbc.22352

Napier CE; Veas LA; Kan C; Taylor LM; Yuan J; Wen VW; James A; O'Brien TA; Lock RB; Mackenzie K, 2010, 'Mild hyperoxia limits hTR levels, telomerase activity, and telomere length maintenance in hTERT-transduced bone marrow endothelial cells', Biochimica et Biophysica ACTA - Molecular Cell Research, 1803, pp. 1142 - 1153, http://dx.doi.org/10.1016/j.bbamcr.2010.06.010

Houghton PJ; Morton CL; Gorlick R; Lock RB; Carol H; Reynolds CP; Kang MH; Maris JM; Keir ST; Kolb EA; Wu J; Wozniak AW; Billups CA; Rubinstein L; Smith MA, 2010, 'Stage 2 Combination Testing of Rapamycin with Cytotoxic Agents by the Pediatric Preclinical Testing Program', Molecular Cancer Therapeutics, 9, pp. 101 - 112, http://dx.doi.org/10.1158/1535-7163.MCT-09-0952

High L; Szymanska B; Wilczynska-kalak U; Barber N; O'Brien R; Khaw SL; Vikstrom IB; Roberts AW; Lock RB; High L, 2010, 'The Bcl-2 Homology Domain 3 Mimetic ABT-737 Targets the Apoptotic Machinery in Acute Lymphoblastic Leukemia Resulting in Synergistic in Vitro and in Vivo Interactions with Established Drugs', Molecular Pharmacology, 77, pp. 483 - 494, http://dx.doi.org/10.1124/mol.109.060780

Samuels AL; Peeva VK; Papa R; Firth MJ; Francis RW; Beesley AH; Lock RB; Kees UR, 2010, 'Validation of a mouse xenograft model system for gene expression analysis of human acute lymphoblastic leukaemia', BMC Genomics, 11, pp. 256, http://dx.doi.org/10.1186/1471-2164-11-256

Lock RB; Bachmann PS; Piazza RG; Davies C; James M; Wong NC; Bhadri VA; Mogavero A; Magistroni V; Gambacorti-Passerini C; Saffery R; Craig JM; Pimanda JE; Marshall GM, 2009, 'Epigenetic Silencing of the Pro-Apoptotic Bim Gene in Glucocorticoid Poor-Responsive Pediatric Acute Lymphoblastic Leukemia, and Its Reversal by Histone Deacetylase Inhibition.', Blood, 114, pp. 939 - 939, http://dx.doi.org/10.1182/blood.v114.22.939.939

Gorlick R; Kolb EA; Houghton PJ; Morton CL; Phelps D; Schaiquevich P; Stewart C; Keir ST; Lock RB; Reynolds CP; Maris JM; Wu J; Smith MA, 2009, 'Initial Testing (Stage 1) of Lapatinib by the Pediatric Preclinical Testing Program', Pediatric Blood and Cancer, 53, pp. 594 - 598, http://dx.doi.org/10.1002/pbc.21989

Carol H; Lock RB; Houghton PJ; Morton CL; Kolb EA; Gorlick R; Reynolds CP; Maris JM; Keir ST; Billups CA; Smith MA, 2009, 'Initial Testing (Stage 1) of the Kinesin Spindle Protein Inhibitor Ispinesib by the Pediatric Preclinical Testing Program', Pediatric Blood and Cancer, 53, pp. 1255 - 1263, http://dx.doi.org/10.1002/pbc.22056

Keshelava N; Houghton PJ; Morton CL; Lock RB; Carol H; Keir ST; Maris JM; Reynolds CP; Gorlick R; Kolb EA; Wu J; Smith MA, 2009, 'Initial Testing (Stage 1) of Vorinostat (SAHA) by the Pediatric Preclinical Testing Program', Pediatric Blood and Cancer, 53, pp. 505 - 508, http://dx.doi.org/10.1002/pbc.21988

Morton CL; Houghton PJ; Gorlick R; Kolb EA; Lock RB; Carol H; Keir ST; Reynolds CP; Kang MH; Maris JM; Billups C; Smith MA, 2009, 'Initial Testing of Aplidin by the Pediatric Pre-Clinical Testing Program', Pediatric Blood and Cancer, 53, pp. 509 - 512, http://dx.doi.org/10.1002/pbc.21976

Kang MH; Harutyunyan N; Hall CP; Papa R; Lock RB, 2009, 'Methotrexate and aminopterin exhibit similar in vitro and in vivo preclinical activity against acute lymphoblastic leukaemia and lymphoma', British Journal of Haematology, 145, pp. 389 - 393, http://dx.doi.org/10.1111/j.1365-2141.2009.07631.x

Jin L; Lee EM; Ramshaw HS; Busfield SJ; Peoppl AG; Wilkinson L; Guthridge M; Thomas D; Barry EF; Boyd A; Gearing DP; Vairo G; Lopez AF; Dick J; Lock RB, 2009, 'Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor alpha Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells', Cell Stem Cell, 5, pp. 31 - 42, http://dx.doi.org/10.1016/j.stem.2009.04.018

Lee EM; Lock RB, 2009, 'Targeting of AML-leukemic stem cells with monoclonal antibodies', Future Oncology, 5, pp. 1327 - 1330, http://dx.doi.org/10.2217/FON.09.115

Yuan J; Yang BMP; Zhong Z; Shats I; Milyavsky M; Rotter V; Lock RB; Reddel R; Mackenzie K, 2009, 'Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase', Oncogene, 28, pp. 2678 - 2689, http://dx.doi.org/10.1038/onc.2009.136

Tuch B; Wu W; Brands K; Colvin E; Sung J; Williams L; Lock R; Wang R, 2008, 'EARLY HUMAN FETAL PANCREAS AS A THERAPY FOR DIABETES', Transplantation, 86, pp. 561 - 561, http://dx.doi.org/10.1097/01.tp.0000331028.21911.80

Ong V; Liem N; Schmid M; Verrills NM; Papa R; Marshall GM; Mackenzie K; Kavallaris M; Lock RB, 2008, 'A role for altered microtubule polymer levels in vincristine resistance of childhood acute lymphoblastic leukemia xenografts', Journal of Pharmacology and Experimental Therapeutics, 324, pp. 434 - 442, http://dx.doi.org/10.1124/jpet.107.128926

Henderson M; Choi S; Beesley A; Baker DL; Wright DC; Papa R; Murch A; Campbell L; Lock RB; Norris MD; Haber M; Kees UR, 2008, 'A xenograft model of infant leukaemia reveals a complex MLL translocation', British Journal of Haematology, 140, pp. 716 - 719, http://dx.doi.org/10.1111/j.1365-2141.2007.06966.x

Kolb EA; Gorlick R; Houghton P; Morton C; Lock RB; Carol H; Reynolds CP; Maris JM; Keir ST; Billups CA; Smith MA, 2008, 'Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the Pediatric Preclinical Testing Program.', Pediatric Blood and Cancer, 50, pp. 1190 - 1197

Maris JM; Courtright J; Houghton P; Morton C; Kolb EA; Lock RB; Tajbakhsh M; Reynolds CP; Keir ST; Wu J; Smith MA, 2008, 'Initial testing (stage 1) of sunitinib by the pediatric preclinical testing program.', Pediatric Blood and Cancer, 51, pp. 42 - 48, http://dx.doi.org/10.1002/pbc.21535

Lock RB; Carol H; Houghton P; Morton CR; Kolb EA; Gorlick R; Reynolds CP; Maris JM; Keir ST; Wu JJ; Smith MS, 2008, 'Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program', Pediatric Blood and Cancer, 50, pp. 1181 - 1189, http://dx.doi.org/10.1002/pbc.21433

Houghton P; Morton C; Kolb EA; Gorlick R; Lock RB; Carol H; Reynolds CP; Maris JM; Keir ST; Billups CA; Smith MA, 2008, 'Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program.', Pediatric Blood and Cancer, 50, pp. 799 - 805

Houghton P; Morton C; Kolb EA; Lock RB; Carol H; Reynolds CP; Keshelava N; Maris JM; Keir ST; Wu J; Smith MA, 2008, 'Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program', Pediatric Blood and Cancer, 50, pp. 37 - 45

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