By Professor Richard Bryan Lock

Conference Presentations

Shahbazi J; Scarlett CJ; Norris M; Liu B; Haber M; Tee AE; Carrier A; Biankin AV; London WB; Marshall GM; Lock R; Liu T, 2014, 'Abstract 5138: Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1', http://dx.doi.org/10.1158/1538-7445.am2014-5138

Maude SL; Dolai S; Delagdo-Martin C; Vincent T; Robbins A; Selvanathan A; Ryan T; Hunger SP; Loh ML; Mullighan CG; Wood BL; Hermiston ML; Grupp SA; Lock RB; Teachey DT, 2014, 'Abstract 997: Targeting the Jak/Stat signaling pathway is highly effective in xenograft models of early T cell precursor (ETP) acute lymphoblastic leukemia (ALL)', http://dx.doi.org/10.1158/1538-7445.am2014-997

Conference Abstracts

Lock RB; Evans K; Watts B; Agoncillo M; Smith CM; Neuhauser S; Stearns TM; Jocoy EL; Kwon JY; Chuang JH; Levin-Furtney S; Teicher BA; Kung C; Bult CJ; Smith MA, 2026, 'Abstract 4030: Targeting MYB with REM-422 for the treatment of pediatric T-cell acute lymphoblastic leukemia - A report from the Pediatric Preclinical Testing Consortium (PIVOT)', in Cancer Research, American Association for Cancer Research (AACR), Vol. 86, pp. 4030 - 4030, http://dx.doi.org/10.1158/1538-7445.am2026-4030

Mayoh C; Ajuyah P; Altekoester A; Alvaro F; Barahona P; Fuentes-Bolanos N; Corley S; Cui L; Curran B; Dias K; Eisenstat DD; Ekert PG; Endersby R; Fares C; Fletcher J; Fleuren ED; Gifford A; Gottardo NG; Hansford J; Jessop S; El-Kamand S; Khaw S-L; Kotecha RS; Lau L; Lin A; Lock RB; Manoharan N; Marshall GM; Mateos M; McCowage G; Moore AS; Nagabushan S; Nicholls W; Omer N; Pozza LD; Priestley P; Khuong Quang D-A; Rumford M; Senapati A; Shale C; Sullivan A; Sullivan P; Taouk K; Trahair TN; Wong-Erasmus M; Wood PJ; Ziegler DS; Tyrrell V; Haber M; Cowley MJ, 2025, 'Abstract A002-PR011: Precision Diagnosis in High-Risk Pediatric Oncology through Integrated Whole Genome, Transcriptome, and Epigenome Profiling', in Cancer Research, American Association for Cancer Research (AACR), Vol. 85, pp. a002-pr011-a002-pr011, http://dx.doi.org/10.1158/1538-7445.pediatric25-a002-pr011

Houghton PJ; Ghilu S; Robles A; Kurmasheva RT; Lock RB, 2025, 'Abstract IA017: Single mouse testing (SMT): An alternative approach to encompass clinical heterogeneity of pediatric cancers', in Cancer Research, American Association for Cancer Research (AACR), Vol. 85, pp. ia017 - ia017, http://dx.doi.org/10.1158/1538-7445.genfunc25-ia017

McKay C; Power P; Staunton J; Sriharan S; Jessop S; Zhukova N; Trinder S; Govender D; Barahona P; Gifford AJ; Mignone C; Xie A; Tax G; Tsoli M; Dolman E; Mayoh C; Wong M; Cowley M; Marshall G; Trahair T; Lock RB; Ekert P; Haber M; Tyrell V; Lau L; Manoharan* N; Ziegler* DS; Khuong-Quang* D-A, 2024, 'DIPG-48. PRECISION GUIDED THERAPY PROVIDES CLINICAL BENEFIT IN H3K27-ALTERED DIFFUSE MIDLINE GLIOMA', in Neuro-Oncology, Oxford University Press (OUP), Vol. 26, http://dx.doi.org/10.1093/neuonc/noae064.101

, 2024, 'DIPG-48. PRECISION GUIDED THERAPY PROVIDES CLINICAL BENEFIT IN H3K27-ALTERED DIFFUSE MIDLINE GLIOMA', in Neuro-oncology, Vol. 26

Lock RB; Mohamed SMA; Schofield P; Friedrich K-H; Christ D; Kavallaris M; Bayat N, 2023, 'Abstract B134: Targeting Philadelphia chromosome-like acute lymphoblastic leukemia with a novel CRLF2 antibody fragment-drug conjugate', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), Vol. 22, pp. b134 - b134, http://dx.doi.org/10.1158/1535-7163.targ-23-b134

Lock RB; Evans K; Gawan-Taylor S; Watts B; Stearns T; Earley EJ; Jocoy EL; Bult CJ; Teicher BA; McGeehan GM; Smith MA, 2023, 'Abstract C095: The menin inhibitor VTP-50469 enhances the  in vivo  efficacy of established drugs against preclinical models of aggressive infant MLL-r acute lymphoblastic leukemia', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), Vol. 22, pp. c095 - c095, http://dx.doi.org/10.1158/1535-7163.targ-23-c095

Lock RB; Toscan CE; McCalmont H; Evans K; Doculara L; Kosasih HJ; Gifford AJ; Ashoorzadeh A; Lin X; Trahair TN; De Bock CE; Patterson AV; Smaill JB, 2023, 'The AKR1C3-Activated Prodrug, Achm-025, Eradicates Disease in Preclinical Models of Aggressive T-Cell Acute Lymphoblastic Leukemia', in Blood, American Society of Hematology, Vol. 142, pp. 4251, http://dx.doi.org/10.1182/blood-2023-181298

Truong P; Shen S; Joshi S; Afrasiabi A; Zhong L; Raftery MJ; Larsson J; Lock RB; Walkley CR; Rokny HA; Thoms JAI; Jolly CJ; Pimanda JE, 2022, 'Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and Sumoylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia', in Blood, American Society of Hematology, Vol. 140, pp. 220 - 221, http://dx.doi.org/10.1182/blood-2022-165713

Lock RB; Evans K; El-Zein N; Lannutti BJ; Jessen KA; Earley EJ; Erickson SW; Smith MA; Kurmasheva R; Houghton PJ, 2021, 'Evaluation of ROR1-targeted antibody-drug conjugates against ROR1-expressing pediatric preclinical models - a report from the pediatric preclinical testing consortium (PPTC).', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, Vol. 81, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 10 April 2021 - 21 May 2021

Lock RB; Evans K; El-Zein N; Earley EJ; Erickson SW; Teicher BA; Smith MA, 2021, 'Pediatric preclinical testing consortium evaluation of the dual SYK/FLT3 inhibitor TAK-659 in xenograft models of pediatric acute lymphoblastic leukemia.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, Vol. 81, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 10 April 2021 - 21 May 2021

Lock RB; Evans K; El-Zein N; Earley EJ; Erickson SW; Teicher BA; Sung V; Smith MA, 2021, 'The differentiated CD47 monoclonal antibody AO-176 exhibits significant in vivo activity against xenograft models of pediatric acute lymphoblastic leukemia (ALL).', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, Vol. 81, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 10 April 2021 - 21 May 2021

Khuong-Quang D-A; Nagabushan S; Manoharan N; Arndt G; Barahona P; Cowley MJ; Ekert PG; Failes T; Bolanos NF; Gauthier M; Gifford AJ; Haber M; Kumar A; Lock RB; Marshall GM; Mayoh C; Mould E; Norris MD; Gopalakrishnan A; Omer N; Trebilcock P; Trahair TN; Tsoli M; Tucker K; Wong M; Tyrrell V; Lau L; S ZD, 2020, 'DIPG-75. PRECISION MEDICINE FOR PAEDIATRIC HIGH-GRADE DIFFUSE MIDLINE GLIOMAS - RESULTS FROM THE ZERO CHILDHOOD CANCER COMPREHENSIVE PRECISION MEDICINE PROGRAM', in Neuro-Oncology, Oxford University Press (OUP), Vol. 22, pp. iii302 - iii302, http://dx.doi.org/10.1093/neuonc/noaa222.117

Mohamed SMA; Sia K; Friedrich K-H; Wohlmann A; Savvides S; Schofield P; Christ D; Kavallaris M; Lock RB; Bayat N, 2020, 'A Novel Engineered Single-Chain Antibody Fragment for Targeting Pediatric Philadelphia Chromosome-like Acute Lymphoblastic Leukemia', in Blood, American Society of Hematology, Vol. 136, pp. 36, http://dx.doi.org/10.1182/blood-2020-138421

Haber M; Cowley MJ; Ekert P; Lau L; Mould E; Core ZPO; Core ZPDT; Gifford A; Lock RB; Marshall GM; Norris MD; O'Brien T; Quang DAK; Thomas D; Trahair T; Tucker K; Ziegler DS; Tyrrell V, 2020, 'Abstract SY09-02: Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer in Australia', in Cancer Research, American Association for Cancer Research (AACR), Vol. 80, pp. sy09-02-sy09-02, http://dx.doi.org/10.1158/1538-7445.am2020-sy09-02

Atkinson C; Tactacan C; Kamili A; Saletta F; Gana C; Eden G; Mayoh C; Lock R; Norris M; Haber M; Gifford A; Trahair T; Fletcher J, 2020, 'Abstract A35: P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma', in Cancer Research, American Association for Cancer Research (AACR), Vol. 80, pp. a35 - a35, http://dx.doi.org/10.1158/1538-7445.pedca19-a35

Barahona P; Fletcher J; Fuentes-Bolanos N; Gauthier M-E; Haber M; Lock RB; Marshall GM; Mayoh C; Mould E; Nagabushan S; Norris M; O’Brien T; Sherstyuk A; Thomas D; Trahair T; Tucker K; Warby M; Wong M; Ziegler DS; Tyrrell VJ; Ekert P; Cowley MJ; Lau L; Quang D-AK, 2020, 'Abstract A52: Zero Childhood Cancer (ZERO): A comprehensive precision medicine platform for children with high-risk cancer', in Cancer Research, American Association for Cancer Research (AACR), Vol. 80, pp. a52 - a52, http://dx.doi.org/10.1158/1538-7445.pedca19-a52

Khuong-Quang D-A; Nagabushan S; Manoharan N; Arndt G; Barahona P; Cowley MJ; Ekert PG; Failes T; Bolanos NF; Gauthier M; Gifford AJ; Haber M; Kumar A; Lock RB; Marshall GM; Mayoh C; Mould E; Norris MD; Gopalakrishnan A; Omer N; Trebilcock P; Trahair TN; Tsoli M; Tucker K; Wong M; Tyrrell V; Lau L; S, Ziegler D, 2020, 'DIPG-75. PRECISION MEDICINE FOR PAEDIATRIC HIGH-GRADE DIFFUSE MIDLINE GLIOMAS - RESULTS FROM THE ZERO CHILDHOOD CANCER COMPREHENSIVE PRECISION MEDICINE PROGRAM', in Neuro-oncology, Vol. 22, pp. iii302 - iii302

Quang DAK; Lau L; Cowley MJ; Ekert PG; Gifford AJ; Haber M; Lock R; Marshall G; Mayoh C; Mould E; Norris M; O'Brien T; Trahair T; Tyrrell V; Ziegler DS, 2019, 'Zero Childhood Cancer: A Comprehensive Precision Medicine Platform for Children and Adolescents with High-Risk Cancer', in PEDIATRIC BLOOD & CANCER, WILEY, Vol. 66, pp. S504 - S505, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000488458005162&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Haber M; Gamble L; Xiao L; Pandher R; Somers K; Murray J; Khan A; Yu D; Franshaw L; Burns MR; Tsoli M; Ehteda A; Cesare A; O'Connor A; Mussai F; de Santo C; Cheng P; Korotchkina L; Gurova K; Tyrrell V; Mould E; Lau L; Dong AKQ; Mayoh C; Arndt G; Barahona P; Failes T; Fletcher J; Fuentes-Bolanos N; Gauthier M-E; Gifford A; Grebert-Wade D; Kamili A; Kumar A; Nagabushan S; O'Brien T; Strong P; Sherstyuk A; Thomas D; Trahair T; Tucker K; Warby M; Wong M; Xie J; Evans K; Lock R; Chernova OB; Henderson M; Gudkov AV; Ekert P; Cowley MJ; Marshall GM; Ziegler DS; Norris MD, 2019, 'Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Montreal, Vol. 80, pp. 23 - 24, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, CANADA, Montreal, 17 September 2019 - 20 September 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Atkinson C; Tactacan C; Kamili A; Saletta F; Gana C; Eden G; Mayoh C; Lock R; Norris M; Haber M; Gifford A; Trahair T; Fletcher J, 2019, 'P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Montreal, Vol. 80, pp. 61 - 61, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, CANADA, Montreal, 17 September 2019 - 20 September 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400079&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Barahona P; Fletcher J; Fuentes-Bolanos N; Gauthier M-E; Haber M; Lock RB; Marshall GM; Mayoh C; Mould E; Nagabushan S; Norris M; O'Brien T; Sherstyuk A; Thomas D; Trahair T; Tucker K; Warby M; Wong M; Ziegler DS; Tyrrell VJ; Ekert P; Cowley MJ; Lau L; Quang D-AK, 2019, 'Zero Childhood Cancer (ZERO): A comprehensive precision medicine platform for children with highrisk cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Montreal, Vol. 80, pp. 70 - 71, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, CANADA, Montreal, 17 September 2019 - 20 September 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400096&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Teicher BA; Lock RB; Evans K; Houghton PJ; Kurmasheva RT; Gorlicki R; Erickson S; Wishka D; Morris J; Difilippantonio M; Collins JE; Smith MA; Doroshow JH, 2019, 'Abstract 3839: Comparison of thio-deoxy-cytidine (TdCyd) and aza-thio-deoxy-cytidine (Aza-TdCyd) in solid and liquid tumor cell lines and PPTC pediatric xenografts', American Association for Cancer Research (AACR), pp. 3839 - 3839, presented at Experimental and Molecular Therapeutics, http://dx.doi.org/10.1158/1538-7445.sabcs18-3839

Atkinson C; Tactacan CM; Kamili A; Saletta F; Gana C; Eden GL; Mayoh C; Lock RB; Norris MD; Haber M; Gifford AJ; Trahair TN; Fletcher JI, 2019, 'Abstract 4741: Re-evaluating the role of P-glycoprotein in the resistance of high-risk neuroblastoma to standard-of-care chemotherapies', American Association for Cancer Research (AACR), pp. 4741 - 4741, presented at Experimental and Molecular Therapeutics, http://dx.doi.org/10.1158/1538-7445.sabcs18-4741

Atkinson C; Tactacan CM; Kamili A; Saletta F; Gana C; Eden GL; Mayoh C; Lock RB; Norris MD; Haber M; Gifford AJ; Trahair TN; Fletcher JI, 2019, 'Abstract 4741: Re-evaluating the role of P-glycoprotein in the resistance of high-risk neuroblastoma to standard-of-care chemotherapies', in Cancer Research, American Association for Cancer Research (AACR), Vol. 79, pp. 4741 - 4741, http://dx.doi.org/10.1158/1538-7445.am2019-4741

Evans K; El-Zein N; Jones C; Erickson SW; Guo Y; Teicher BA; Adams S; Zweidler-McKay PA; Smith MA; Lock RB, 2019, 'Abstract 4820: Pediatric preclinical testing consortium evaluation of the CD123 antibody drug conjugate, IMGN632, against xenograft models of pediatric acute lymphoblastic leukemia', in Cancer Research, American Association for Cancer Research (AACR), Vol. 79, pp. 4820 - 4820, http://dx.doi.org/10.1158/1538-7445.am2019-4820

Evans K; El-Zein N; Jones C; Erickson SW; Guo Y; Teicher BA; Adams S; Zweidler-McKay PA; Smith MA; Lock RB, 2019, 'Abstract 4820: Pediatric preclinical testing consortium evaluation of the CD123 antibody drug conjugate, IMGN632, against xenograft models of pediatric acute lymphoblastic leukemia', American Association for Cancer Research (AACR), pp. 4820 - 4820, presented at Experimental and Molecular Therapeutics, http://dx.doi.org/10.1158/1538-7445.sabcs18-4820

Tsoli M; Lau L; Barahona P; Mayoh C; Failes T; Wong M; Sherstyuk A; Gifford AJ; Kumar A; Mould E; Ung C; Tolhurst O; Gopalakrishnan A; Grebert-Wade D; Strong P; Trebilcock P; Lock R; Tyrrell V; Trahair T; Tucker K; Warby M; Arndt G; Norris M; Haber M; Marshall G; O'Brien T; Dong AKQ; Cowley M; Ekert P; Ziegler DS, 2019, 'RESULTS OF THE ZERO CHILDHOOD CANCER INTEGRA-TM PRECISION MEDICINE PLATFORM FOR PAEDIATRIC HIGH-RISK BRAIN TUMOURS', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, CA, San Francisco, Vol. 21, pp. 118 - 118, presented at 5th Biennial Conference of the Society-for-Neuro-Oncology on Pediatric Neuro-Oncology Basic and Translational Research, CA, San Francisco, 03 May 2019 - 04 May 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000473243700229&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mould EV; Lau L; Arndt G; Barahona P; Cowley MJ; Ekert P; Failes T; Fletcher J; Gifford A; Grebert-Wade D; Haber M; Kamili A; Kumar A; Lock RB; Marshall GM; Mayoh C; Norris M; O'Brien T; Quang DAK; Strong P; Sherstyuk A; Trahair T; Tsoli M; Tucker K; Warby M; Wong M; Xie J; Ziegler DS; Tyrrell V, 2019, 'Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Atlanta, GA, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Atlanta, GA, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.AM2019-3111

Tsoli M; Wadham C; Pinese M; Failes T; Joshi S; Mould E; Yin J; Gayevski V; Kumar A; Kaplan W; Ekert P; Franshaw L; Gifford A; Weber M; Rodriguez M; Mayoh C; Cohn R; Arndt G; Lock R; Tyrrell V; Norris M; Haber M; Lau L; Quang DAK; Wong M; Trahair T; Marshall GM; Cowley MJ; Ziegler DS, 2018, 'Abstract LB-137: Integrated genomics: drug screening and personalized xenograft development approach to identify precision treatments for aggressive pediatric brain tumors', in Cancer Research, American Association for Cancer Research (AACR), Vol. 78, pp. lb-137-lb-137, http://dx.doi.org/10.1158/1538-7445.am2018-lb-137

Mould E; Lau L; Arndt G; Barahona P; Cowley M; Ekert P; Failes T; Fletcher J; Gifford A; Haber M; Kamili A; Kumar A; Lock R; Marshall G; Mayoh C; Mead S; Norris M; O'Brien T; Pinese M; Quang DAK; Trahair T; Tsoli M; Tucker K; Warby M; Wong M; Xie J; Ziegler D; Tyrrell V, 2018, 'Abstract LB-138: Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer', in Cancer Research, American Association for Cancer Research (AACR), Vol. 78, pp. lb-138-lb-138, http://dx.doi.org/10.1158/1538-7445.am2018-lb-138

Somers K; Evans K; Cheung L; Korotchkina L; Chernova O; Gudkov A; Norris M; Haber M; Lock R; Henderson M, 2018, 'PO-028 Effective targeting of NAD+biosynthesis in patient-derived xenograft models of high-risk paediatric acute lymphoblastic leukaemia', in ESMO Open, Elsevier, Vol. 3, pp. a238, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.563

Tyrrell V; Lau L; Arndt G; Barahona P; Cowley M; Ekert P; Failes T; Fletcher J; Gifford A; Haber M; Kamili A; Kumar A; Lock R; Marshall G; Mayoh C; Mead S; Mould E; O'Brien T; Pinese M; Khuong-Quang DA; Thomas D; Trahair T; Tsoli M; Tucker K; Wharby M; Wong M; Xie J; Ziegler D, 2018, 'Zero childhood cancer – Accelerating translation of experimental oncology: Better matching drug to target', in Pathology, Elsevier, Vol. 50, pp. s31, http://dx.doi.org/10.1016/j.pathol.2017.12.072

Karsa M; Somers K; Mariana A; Failes T; Arndt GM; Kees UR; Haber M; Norris MD; Sutton R; Lock RB; Henderson MJ, 2017, 'REPOSITIONING EXISTING DRUGS AS NOVEL THERAPEUTICS: OXIDATIVE STRESS AS A TARGET FOR HIGH-RISK LEUKAEMIA IN CHILDREN', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, SPAIN, Madrid, Vol. 102, pp. 27 - 27, presented at 22nd Congress of the European-Hematology-Association, SPAIN, Madrid, 22 June 2017 - 25 June 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000404127001055&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lau L; Byrne J; Ekert PG; Failes T; Fellowes A; Fletcher J; Gifford A; Haber M; Kumar A; Lock R; Marshall G; McCowage GB; Mould E; Norris M; Trahair T; Tsoli M; Tyrrell V; Wadham C; Xie J; Ziegler DS, 2017, 'Pilot study of a comprehensive precision medicine platform for children with high-risk cancer.', in Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 35, pp. 10539 - 10539, http://dx.doi.org/10.1200/jco.2017.35.15_suppl.10539

Nilsson S; Cao B; Leung Y; Williams B; Hatwell-Humble J; Domingues M; Jones L; Bendall L; Lock R, 2017, 'Therapeutic targeting of a9b1 and a4b1 integrins for chemosensitization of drug resistant acute leukaemia', in Experimental Hematology, Elsevier, Vol. 53, pp. s75, http://dx.doi.org/10.1016/j.exphem.2017.06.158

Sutton R; Law T; Venn NC; Wadham C; Mould EV; Norris MD; Kotecha RS; Marschalek R; Meyer C; Dalla-Pozza L; Marshall GM; Lock RB; Trahair TN, 2016, 'Comparison of MRD Levels and Gene Expression Patterns in MLL-R Versus Non-MLL Infant ALL', in Blood, American Society of Hematology, Vol. 128, pp. 1740, http://dx.doi.org/10.1182/blood.v128.22.1740.1740

Churchman ML; Jones L; Evans K; Richmond J; Shapiro IM; Pachter JA; Weaver DT; Houghton PJ; Smith MA; Lock RB; Mullighan CG, 2015, 'Efficacy of Focal Adhesion Kinase Inhibition in Combination with Dasatinib in BCR-ABL1 Acute Lymphoblastic Leukemia', in Blood, American Society of Hematology, Vol. 126, pp. 3766, http://dx.doi.org/10.1182/blood.v126.23.3766.3766

Alruwetei AM; Carol H; Sutton R; Marshall GM; Lock RB, 2015, 'Evaluation of Patient-Derived Xenografts for Modeling Outcome of Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia', in Blood, American Society of Hematology, Vol. 126, pp. 3759, http://dx.doi.org/10.1182/blood.v126.23.3759.3759

Lock R; Houghton P; Smith M, 2015, 'A REVIEW OF NEW AGENTS TESTED BY THE PEDIATRIC PRECLINICAL TESTING PROGRAM AGAINST ACUTE LYMPHOBLASTIC LEUKEMIA XENOGRAFTS', in PEDIATRIC BLOOD & CANCER, WILEY-BLACKWELL, Vol. 62, pp. S211 - S211, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361247200258&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Haber M; Murray J; Gamble L; Carnegie-Clark A; Webber H; Ruhle M; Henderson MJ; Middlemass S; Carter D; Tsoli M; Ehteda A; Simon S; Oberthuer A; Fischer M; Gurova K; Burkhart C; Purmal A; Lock RB; Ziegler D; Marshall GM; Gudkov AV; Norris MD, 2015, 'Abstract 1611: The FACT histone chaperone complex is highly expressed in aggressive drug refractory childhood cancers and the anti-FACT compound CBL0137 represents a highly promising therapeutic approach in this setting', in Cancer Research, American Association for Cancer Research (AACR), Vol. 75, pp. 1611 - 1611, http://dx.doi.org/10.1158/1538-7445.am2015-1611

Suryani S; Evans K; Richmond J; Robbins A; Bracken L; Kurmasheva R; Houghton PJ; Smith MA; Lock RB, 2015, 'Abstract 3276: Evaluation of the Bcl-2 inhibitor ABT-199 in xenograft models of acute lymphoblastic leukemia by the pediatric preclinical testing program', in Cancer Research, American Association for Cancer Research (AACR), Vol. 75, pp. 3276 - 3276, http://dx.doi.org/10.1158/1538-7445.am2015-3276

Dolnikov A; Klamer G; Chitranjan A; Xu N; Shen S; Micklethwaite KP; Lock RB; O’Brien T, 2014, 'Identifying the Factors Modulating the Efficacy of CAR-T Cell Therapy', in Blood, American Society of Hematology, Vol. 124, pp. 5813, http://dx.doi.org/10.1182/blood.v124.21.5813.5813

Bruedigam C; Bagger FO; Heidel FH; Kuhn C; Guignes S; Song A; Austin R; Vu T; Lee EM; Moore AS; Lock RB; Bullinger L; Hill GR; Lane SW, 2014, 'Inhibition of Telomerase with Imetelstat Is Detrimental to Leukemia Stem Cells in Acute Myeloid Leukemia (AML)', in Blood, American Society of Hematology, Vol. 124, pp. 2322, http://dx.doi.org/10.1182/blood.v124.21.2322.2322

Dolai S; Sia KC; Robbins AK; Zhong L; Heatley S; Vincent T; Hochgräfe F; Kurmasheva RT; White DL; Houghton PJ; Smith MA; Teachey DT; Daly RJ; Raftery MJ; Lock RB, 2014, 'Targeted Cancer Therapy in High-Risk Pediatric Leukemia Using Global Phosphotyrosine Profiling', in Blood, American Society of Hematology, Vol. 124, pp. 969, http://dx.doi.org/10.1182/blood.v124.21.969.969

Dolnikov A; Klamer G; Shen S; Chitranjan A; Carol H; Lock R; O'Brien T, 2014, 'Identifying the factors modulating the efficacy of car-t cell therapy', in Cytotherapy, Elsevier, Vol. 16, pp. s7, http://dx.doi.org/10.1016/j.jcyt.2014.01.015

Smith M; Kang M; Reynolds P; Gorlick R; Kolb A; Maris J; Lock R; Carol H; Keir S; Billups C; Kurmasheva R; Houghton P, 2013, 'Abstract C206: Pediatric Preclinical Testing Program (PPTP) evaluation of BMN 673, an inhibitor of Poly-ADP Ribose Polymerase (PARP), alone and with Temozolomide (TMZ).', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), Vol. 12, pp. c206 - c206, http://dx.doi.org/10.1158/1535-7163.targ-13-c206

Lu H; Battula VL; Shi Y; Lock RB; Spong S; Andreeff M; Konopleva M, 2011, 'Role of Connective Tissue Growth Factor (CTGF) in Survival and Chemosensitivity of Acute Lymphoblastic Leukemia', in Blood, American Society of Hematology, Vol. 118, pp. 2593, http://dx.doi.org/10.1182/blood.v118.21.2593.2593

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