By Professor Steven Krilis

Book Chapters

McNeil HP; Krilis SA; Chesterman CN, 2020, 'Arterial Thrombosis—Diagnosis and Management', in Phospholipid-Binding Antibodies, CRC Press, pp. 191 - 203, http://dx.doi.org/10.1201/9780429278129-15

Qi M; Weaver JC; Rahgozar S; Giannakopoulos B; Krilis SA, 2019, 'Quantitation of total and free thiol angiotensinogen as a prognostic marker for preeclampsia', in Functional Disulphide Bonds : Methods and Protocols, pp. 285 - 293, http://dx.doi.org/10.1007/978-1-4939-9187-7_18

Qi M; Weaver JC; Krilis SA; Giannakopoulos B, 2019, 'Quantitation of total and free Thiol β2-Glycoprotein I levels for diagnostic and prognostic purposes in the antiphospholipid syndrome', in Functional Disulphide Bonds : Methods and Protocols, pp. 275 - 283, http://dx.doi.org/10.1007/978-1-4939-9187-7_17

Willis R; Cohen H; Giles I; Knight JS; Krilis SA; Rahman A; de Groot PG, 2017, 'Mechanisms of Antiphospholipid Antibody-Mediated Thrombosis', in Antiphospholipid Syndrome, Springer International Publishing, pp. 77 - 116, http://dx.doi.org/10.1007/978-3-319-55442-6_5

de Groot PG; de Laat B; Rand J; Vlachoyiannopoulos PG; El-Assaad F; Krilis SA; Giannakopoulos B, 2017, 'Natural Proteins Involved in Antiphospholipid Syndrome', in Antiphospholipid Syndrome, Springer International Publishing, pp. 15 - 27, http://dx.doi.org/10.1007/978-3-319-55442-6_2

Ioannou Y; Krilis SA, 2011, 'CHAPTER 52 Laboratory Testing for Antiphospholipid Syndrome', in Systemic Lupus Erythematosus, Elsevier, pp. 985 - 1000, http://dx.doi.org/10.1016/b978-0-12-374994-9.10052-x

Ioannou Y; Krilis SA, 2010, 'Laboratory Testing for Antiphospholipid Syndrome', in Systemic Lupus Erythematosus, Fifth Edition, pp. 985 - 1000, http://dx.doi.org/10.1016/B978-0-12-374994-9.10052-X

Giannakopoulos B; Yan XK; Krilis S, 2007, 'Antibodies and their antigenic targets in the antiphospholipid syndrome', in Murphy K; Ray M (ed.), A Companion to Rheumatology: Systemic Lupus Erythematosus, Mosby Elsevier, USA, pp. 233 - 240

Giannakopoulos B; Yan X; Krilis SA, 2007, 'Chapter 22B Antibodies and their Antigenic Targets in the Antiphospholipid Syndrome', in Systemic Lupus Erythematosus, Elsevier, pp. 233 - 240, http://dx.doi.org/10.1016/b978-0-323-04434-9.50028-2

Reddel SW; Krilis S, 2002, 'The Anti-Phospholipid Syndrome', in Theofilopoulos CA; Bona AN (ed.), The Molecular Pathology of Autoimmune Diseases, Taylor & Francis, USA, pp. 325 - 352

Reddel SW; Krilis S, 2001, 'Antiphospholipid syndrome', in Austen ; Frank ; Atkinson ; Cantor (ed.), Sampter`s Immunologic Diseases, Lippincott Williams OEM_sqlplus_input_finished, Philadelphia, USA, pp. 571 - 579

Li L; Reddel SW; Krilis S, 2000, 'Phenotypic similarities and differences between human basophils and mast cells', in Mast cells adn Basophils in Physiology, Pathology and Host Defence, Academic Press, San Diego, California

Li L; Reddel SW; Krilis SA, 2000, 'The Phenotypic Similarities and Differences Between Human Basophils and Mast Cells', in Mast Cells and Basophils, Elsevier, pp. 97 - 116, http://dx.doi.org/10.1016/b978-012473335-0/50009-x

Li L; Zhang X; Krilis S, 1999, 'Factors that affect humkan mast cell and basophil growth', in Signal transduction in mast cells and basophils, Springer Publishing Company, Berlin, pp. 54 - 65

Li Y; Li L; Krilis S, 1997, 'Growth factors modulating human mast cell growth and function', in Seminars in Clinical Immunology, Edizioni Grafiche Mazzucchelli S.B.L., Italy, pp. 17 - 24

Kandiah DA; Krilis S, 1996, 'Immunology and methods of detection of antiphospholipid antibodies', in The antiphospholipid syndrome, CRC Press, Boca Raton, pp. 29 - 48

Hunt J; Krilis , 1994, 'Immunology of Antiphospholipid Antibodies', in Panayi GS (ed.), Immunology of the Connective Tissue Diseases, Kluwer Academic Pub

Krilis S; Lewis RA; Corey EJ; Austen KF, 1983, 'Determinants for an Integrated Tissue Response to the Sulphidopeptide Leukotrienes', in Proceedings of Invited Symposia, Palgrave Macmillan UK, pp. 3 - 9, http://dx.doi.org/10.1007/978-1-349-17072-2_1

Journal articles

Giannakopoulos B; Krilis SA, 2024, 'Domain 5 of Beta 2 glycoprotein I: Friend or foe in health? Context matters', Clinical Immunology, 265, http://dx.doi.org/10.1016/j.clim.2024.110282

Barbhaiya M; Zuily S; Amigo MC; Andrade D; Avcin T; Bertolaccini ML; Branch DW; Costedoat-Chalumeau N; Crowther M; Ramires de Jesus G; Devreese KMJ; Frances C; Garcia D; Gómez-Puerta JA; Guillemin F; Levine SR; Levy RA; Lockshin MD; Ortel TL; Petri M; Sanna G; Sciascia S; Seshan SV; Tektonidou MG; Wahl D; Willis R; Yelnik C; Hendry A; Naden R; Costenbader K; Erkan D; Agmon-Levin N; Aguilar C; Alba P; Alpan O; Ambrozic A; Andrade L; Appenzeller S; Berkun Y; Cabral A; Canaud G; Chen P; Chighizola C; Cimaz R; Cuadrado MJ; de Groot PG; de Moerloose P; Derksen R; Dörner T; Fortin P; Giannakopoulos B; Gonzalez EB; Inanc M; Kenet G; Khamashta M; Kriegel M; Krilis S; Ladha D; Manneville F; Massicotte P; McCarty G; Mikdashi J; Myones B; Sammaritano L; Signorelli F; Soybilgic A; Woller S; Zuo R, 2024, 'Development of the 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria, Phase III-D Report: Multicriteria Decision Analysis', Arthritis Care and Research, http://dx.doi.org/10.1002/acr.25415

Zuo Y; Navaz S; Tsodikov A; Kmetova K; Kluge L; Ambati A; Hoy CK; Yalavarthi S; de Andrade D; Tektonidou MG; Sciascia S; Pengo V; Ruiz-Irastorza G; Belmont HM; Gerosa M; Fortin PR; de Jesus GR; Branch DW; Andreoli L; Rodriguez-Almaraz E; Petri M; Cervera R; Willis R; Karp DR; Li QZ; Cohen H; Bertolaccini ML; Erkan D; Knight JS; Pons-Estel G; Giannakopoulos B; Krilis S; Levy R; Signorelli F; Andrade D; Balbi G; Clarke AE; Skeith L; Ji L; Zhang Z; Yang C; Shi H; Zuily S; Wahl D; Nalli C; Tincani A; Chighizola CB; Meroni P; Cheng C; Pazzola G; Foddai S; Radin M; Davis S; Amengual O; Atsumi T; Uthman I; Limper M; de Groot P; Ugarte A; Rodriguez-Pinto I; Ríos-Garcés R; Barilaro G; Pardos-Gea J; Almaraz ER; Cuadrado MJ; Zamorano MAA; Lopez-Pedrera C; Artim-Esen B; Inanc M; Efthymiou M; Khamashta M; Mackie I; Sanna G; Knight J; Zuo Y; Petri M; Leaf RK; Roubey R; Ortel T; Gonzalez E; Kello N; Belmont M; Levine S; Rand J; Barbhaiya M; Salmon J; Lockshin M; Duarte Garcia AA, 2023, 'Anti–Neutrophil Extracellular Trap Antibodies in Antiphospholipid Antibody–Positive Patients: Results From the Antiphospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking Clinical Database and Repository', Arthritis and Rheumatology, 75, pp. 1407 - 1414, http://dx.doi.org/10.1002/art.42489

Gkrouzman E; Willis R; Andrade D; Tektonidou MG; Pengo V; Ruiz-Irastorza G; Belmont HM; Fortin PR; Gerosa M; Signorelli F; Atsumi T; Branch DW; Nalli C; Rodriguez-Almaraz E; Petri MA; Cervera R; Knight JS; Efthymiou M; Cohen H; Bertolaccini ML; Erkan D; Roubey R; Pons-Estel G; Giannakopoulos B; Krilis S; de Jesus G; Levy R; Balbi G; Clarke AE; Skeith L; Ji L; Zhang Z; Yang C; Shi H; Zuily S; Wahl D; Andreoli L; Tincani A; Chighizola CB; Meroni P; Cheng C; Pazzola G; Sciascia S; Foddai S; Radin M; Davis S; Amengual O; Uthman I; Limper M; Groot PD; Ruiz—Irastorza G; Ugarte A; Rodriguez-Pinto I; Pardos-Gea J; Cuadrado MJ; Aguirre Zamorano MA; Lopez-Pedrera C; Artim-Esen B; Inanc M; Khamashta M; Mackie I; Sanna G; Knight J; Zuo Y; Petri M; Leaf RK; Ortel T; Gonzalez E; Kello N; Belmont M; Levine S; Rand J; Barbhaiya M; Salmon J; Lockshin M; Duarte Garcia AA, 2023, 'Associations Among Antiphospholipid Antibody Types, Isotypes, and Titers: An AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Study', Laboratory Investigation, 103, http://dx.doi.org/10.1016/j.labinv.2023.100147

Chighizola CB; Pregnolato F; Andrade D; Tektonidou M; Pengo V; Ruiz-Irastorza G; Belmont HM; Gerosa M; Fortin P; Branch DW; Andreoli L; Petri MA; Cervera R; Knight JS; Willis R; Efthymiou M; Cohen H; Erkan D; Bertolaccini ML; Pons-Estel G; Giannakopoulos B; Krilis S; de Jesus G; Levy R; Signorelli F; Balbi G; Clarke AE; Skeith L; Ji L; Zhang Z; Yang C; Shi H; Zuily S; Wahl D; Nalli C; Tincani A; Meroni PL; Cheng C; Pazzola G; Sciascia S; Foddai S; Radin M; Davis S; Amengual O; Atsumi T; Uthman I; Limper M; de Groot P; Ugarte A; Rodriguez-Pinto I; Barilaro G; Ríos-Garcés R; Pardos-Gea J; Almaraz ER; Cuadrado MJ; Zamorano MAA; Lopez-Pedrera C; Artim-Esen B; Inanc M; Khamashta M; Mackie I; Sanna G; Knight J; Zuo Y; Petri M; Leaf RK; Roubey R; Ortel T; Gonzalez E; Kello N; Belmont M; Levine S; Rand J; Barbhaiya M; Salmon J; Lockshin M; Duarte Garcia AA, 2023, 'Fluctuation of Anti–Domain 1 and Anti–β2-Glycoprotein I Antibody Titers Over Time in Patients With Persistently Positive Antiphospholipid Antibodies', Arthritis and Rheumatology, 75, pp. 984 - 995, http://dx.doi.org/10.1002/art.42459

Passam FH; Chen G; Chen VM; Qi M; Krilis SA; Giannakopoulos B, 2022, 'Βeta-2-glycoprotein I exerts antithrombotic function through its domain V in mice', Journal of Autoimmunity, 126, http://dx.doi.org/10.1016/j.jaut.2021.102747

Barbhaiya M; Zuily S; Ahmadzadeh Y; Amigo MC; Avcin T; Bertolaccini M; Branch DW; de Jesus G; Devreese KMJ; Frances C; Garcia D; Guillemin F; Levine SR; Levy RA; Lockshin MD; Ortel T; Seshan SV; Tektonidou M; Wahl D; Willis R; Naden R; Costenbader K; Erkan D; Agmon-Levin N; Aguilar C; Alba P; Alpan O; Ambrozic A; Amoura Z; Andrade D; Andrade L; Appenzeller S; Esen BA; Atsumi T; Berkun Y; Cabral A; Canaud G; Cervera R; Chen P; Chighizola C; Cimaz R; Cohen H; Costedoat-Chalumeau N; Crowther M; Cuadrado MJ; de Groot PG; de Moerloose P; Derksen R; Diz-Kucukkaya R; Dörner T; Fortin P; Giannakopoulos B; Gómez-Puerta JA; Gonzalez EB; Inanc M; Kenet G; Khamashta M; Kriegel M; Krilis S; Laskin C; Massicotte P; McCarty G; Meroni PL; Mikdashi J; Myones B; Pengo V; Petri M; Roubey R; Sammaritano L; Sanna G; Sciascia S; Signorelli F; Soybilgic A; Tincani A; Woller S; Yelnik C, 2021, 'Development of a New International Antiphospholipid Syndrome Classification Criteria Phase I/II Report: Generation and Reduction of Candidate Criteria', Arthritis Care and Research, 73, pp. 1490 - 1501, http://dx.doi.org/10.1002/acr.24520

Krilis M; Qi M; Ioannou Y; Zhang JY; Ahmadi Z; Wong JWH; Vlachoyiannopoulos PG; Moutsopoulos HM; Koike T; Sturgess AD; Chong BH; Krilis SA; Giannakopoulos B, 2021, 'Clinical relevance of nitrated beta 2-glycoprotein I in antiphospholipid syndrome: Implications for thrombosis risk', Journal of Autoimmunity, 122, http://dx.doi.org/10.1016/j.jaut.2021.102675

Weaver JC; Ullah I; Qi M; Giannakopoulos B; Rye KA; Kockx M; Kritharides L; Krilis SA, 2020, 'Free Thiol β2-GPI (β-2-Glycoprotein-I) Provides a Link Between Inflammation and Oxidative Stress in Atherosclerotic Coronary Artery Disease', Arteriosclerosis, Thrombosis, and Vascular Biology, 40, pp. 2794 - 2804, http://dx.doi.org/10.1161/ATVBAHA.120.315156

Zuily S; Clerc-Urmès I; Bauman C; Andrade D; Sciascia S; Pengo V; Tektonidou MG; Ugarte A; Gerosa M; Michael Belmont H; Zamorano MAA; Fortin P; Ji L; Efthymiou M; Cohen H; Branch DW; Jesus GRD; Nalli C; Petri M; Rodriguez E; Cervera R; Knight JS; Atsumi T; Willis R; Bertolaccini ML; Vega J; Wahl D; Erkan D; Pons-Estel G; Giannakopoulos B; Krilis S; de Jesus G; Levy R; Fortin PF; Zhang Z; Andreoli L; Tincani A; Chighizola CB; Meroni P; Banzato A; Davis S; Amengual O; Uthman I; Limper M; de Groot P; Irastorza GR; Rodríguez-Pintó I; Cuadrado MJ; Lopez-Pedrera R; Artim-Esen B; Inanc M; Khamashta M; Mackie I; Sanna G; Knight J; Roubey R; Ortel T; Gonzalez E; Belmont M; Levine S; Rand J; Barbhaiya M; Salmon J; Lockshin M, 2020, 'Cluster analysis for the identification of clinical phenotypes among antiphospholipid antibody-positive patients from the APS ACTION Registry', Lupus, 29, pp. 1353 - 1363, http://dx.doi.org/10.1177/0961203320940776

Sciascia S; Willis R; Pengo V; Krilis S; Andrade D; Tektonidou MG; Ugarte A; Chighizola C; Branch DW; Levy RA; Nalli C; Fortin PR; Petri M; Rodriguez E; Rodriguez-Pinto I; Atsumi T; Nascimento I; Rosa R; Banzato A; Erkan D; Cohen H; Efthymiou M; Mackie I; Bertolaccini ML, 2019, 'The comparison of real world and core laboratory antiphospholipid antibody ELISA results from antiphospholipid syndrome alliance for clinical trials & international networking (APS ACTION) clinical database and repository analysis', Thrombosis Research, 175, pp. 32 - 36, http://dx.doi.org/10.1016/j.thromres.2019.01.010

Krilis M; Qi M; Qi J; Wong JWH; Guymer R; Liew G; Hunyor AP; Madigan M; McCluskey P; Weaver J; Krilis SA; Giannakopoulos B, 2018, 'Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration', Free Radical Biology and Medicine, 129, pp. 237 - 246, http://dx.doi.org/10.1016/j.freeradbiomed.2018.09.034

Weaver JC; Krilis SA; Giannakopoulos B, 2018, 'Oxidative post-translational modification of βeta 2-glycoprotein I in the pathophysiology of the anti-phospholipid syndrome', Free Radical Biology and Medicine, 125, pp. 98 - 103, http://dx.doi.org/10.1016/j.freeradbiomed.2018.03.048

El-Assaad F; Qi M; Gordon AK; Qi J; Dong S; Passam F; Weaver JC; Giannakopoulos B; Krilis SA, 2017, 'Βeta 2-glycoprotein i protects mice against gram-negative septicaemia in a sexually dimorphic manner', Scientific Reports, 7, pp. 8201, http://dx.doi.org/10.1038/s41598-017-07945-8

Stevens RL; McNeil HP; Wensing LA; Shin K; Wong GW; Hansbro PM; Krilis SA, 2017, 'Experimental arthritis is dependent on mouse mast cell protease-5', Journal of Biological Chemistry, 292, pp. 5392 - 5404, http://dx.doi.org/10.1074/jbc.M116.773416

Krilis M; Qi M; Madigan MC; Wong JWH; Abdelatti M; Guymer RH; Whitelock J; McCluskey P; Zhang P; Qi J; Hunyor AP; Krilis SA; Giannakopoulos B, 2017, 'Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration', Oncotarget, 8, pp. 49016 - 49032, http://dx.doi.org/10.18632/oncotarget.14940

Dong S; Qi M; Wang Y; Chen L; Weaver JC; Krilis SA; Giannakopoulos B, 2017, 'β2GPI exerts an anti-obesity effect in female mice by inhibiting lipogenesis and promoting lipolysis', Oncotarget, 8, pp. 92652 - 92666, http://dx.doi.org/10.18632/oncotarget.21536

Ullah I; Qi M; Qi J; Giannakopoulos B; Weaver J; Krilis S, 2017, 'Development of Novel Assays for Quantitation of Total and Free Thiol Beta 2 Glycoprotein I', Heart, Lung and Circulation, 26, pp. S55 - S55, http://dx.doi.org/10.1016/j.hlc.2017.06.027

El-Assaad F; Krilis SA; Giannakopoulos B, 2016, 'Posttranslational forms of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome', Thrombosis Journal, 14, pp. 20, http://dx.doi.org/10.1186/s12959-016-0115-z

Zhou S; Chen G; Qi M; El-Assaad F; Wang Y; Dong S; Chen L; Yu D; Weaver JC; Beretov J; Krilis SA; Giannakopoulos B, 2016, 'Gram negative bacterial inflammation ameliorated by the plasma protein beta 2-Glycoprotein I', Scientific Reports, 6, pp. 33656, http://dx.doi.org/10.1038/srep33656

Zhou S; Tanaka K; O'Keeffe M; Qi M; El-Assaad F; Weaver JC; Chen G; Weatherall C; Wang Y; Giannakopoulos B; Chen L; Yu DM; Hamilton MJ; Wensing LA; Stevens RL; Krilis SA, 2016, 'CD117⁺ dendritic and mast cells are dependent on RasGRP4 to function as accessory cells for optimal natural killer cell-mediated responses to lipopolysaccharide', PLoS ONE, 11, pp. e0151638, http://dx.doi.org/10.1371/journal.pone.0151638

Zhang P; Weaver JC; Chen G; Beretov J; Atsumi T; Qi M; Bhindi R; Qi JC; Madigan MC; Giannakopoulos B; Krilis SA, 2016, 'The fifth domain of beta 2 glycoprotein I protects from natural IgM mediated cardiac ischaemia reperfusion injury', PLoS ONE, 11, pp. e0152681, http://dx.doi.org/10.1371/journal.pone.0152681

Qi M; Abdelatti M; Krilis M; Madigan MC; Weaver J; Guymer RH; McCluskey P; Wang Y; Zhou S; Krilis SA; Giannakopoulos B, 2016, 'Do Beta 2-Glycoprotein i Disulfide Bonds Protect the Human Retina in the Setting of Age-Related Macular Degeneration?', Antioxidants and Redox Signaling, 24, pp. 32 - 38, http://dx.doi.org/10.1089/ars.2014.6052

Rahgozar S; Amirian T; Qi M; Shahshahan Z; Entezar-E-Ghaem M; Tehrani HG; Miroliaei M; Krilis SA; Giannakopoulos B, 2015, 'Improved assay for quantifying a redox form of angiotensinogen as a biomarker for pre-eclampsia: A case-control study', PLoS ONE, 10, pp. e0135905, http://dx.doi.org/10.1371/journal.pone.0135905

Krilis SA; Giannakopoulos B, 2014, 'Laboratory methods to detect antiphospholipid antibodies', Hematology (United States), 2014, pp. 321 - 328, http://dx.doi.org/10.1182/asheducation-2014.1.321

Hansbro PM; Hamilton MJ; Fricker M; Gellatly SL; Jarnicki AG; Zheng D; Frei SM; Wong GW; Hamadi S; Zhou S; Foster PS; Krilis SA; Stevens RL, 2014, 'Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis', Journal of Biological Chemistry, 289, pp. 18214 - 18227, http://dx.doi.org/10.1074/jbc.M114.548594

Giannakopoulos B; Krilis S, 2014, 'In APS, two A1's are better than one!', Blood, 123, pp. 955 - 956, http://dx.doi.org/10.1182/blood-2013-12-542506

Giannakopoulos B; Mirarabshahi P; Qi M; Weatherall C; Qi JC; Tanaka K; Millar E; Vonthethoff L; Gatto D; Spielman D; Krilis SA, 2014, 'Deletion of the antiphospholipid syndrome autoantigen β2- glycoprotein i potentiates the lupus autoimmune phenotype in a toll-like receptor 7-mediated murine model', Arthritis and Rheumatology, 66, pp. 2270 - 2280, http://dx.doi.org/10.1002/art.38646

Douaiher J; Succar J; Lancerotto L; Gurish MF; Orgill DP; Hamilton MJ; Krilis SA; Stevens RL, 2014, 'Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing', , 122, pp. 211 - 252, http://dx.doi.org/10.1016/B978-0-12-800267-4.00006-7

Krilis M; Mao Q; Madigan M; Wong J; Abulatti M; Guymer R; McCluskey P; Zhang P; Qi J; Krilis S; Giannakopoulos B, 2013, 'POST TRANSLATIONALLY MODIFIED COMPLEMENT FACTOR H IN AGE RELATED MACULAR DEGENERATION', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 41, pp. 17 - 17, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000329507100022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Yong A; Pennings G; Wong C; Javadzadegan A; Brieger D; Lowe H; Qi M; Behnia M; Krilis S; Kritharides L, 2013, 'Intracoronary upregulation of platelet extracellular matrix metalloproteinase inducer (CD147) in coronary disease', International Journal of Cardiology, 166, pp. 716 - 721, http://dx.doi.org/10.1016/j.ijcard.2011.11.093

Giannakopoulos B; Krilis S, 2013, 'The Pathogenesis of the Antiphospholipid Syndrome', New England Journal of Medicine, 368, pp. 1033 - 1044

Back to profile page