By Professor Steven Krilis

Journal articles

Giannakopoulos B; Gao L; Qi M; Wong JW; Yu D; Vlachoyiannopoulos P; Moutsopoulos HM; Atsumi T; Koike T; Hogg PJ; Qi JC; Krilis S, 2012, 'Factor XI is a substrate for oxidoreductases: Enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis.', Journal of Autoimmunity, 39, pp. 121 - 129, http://dx.doi.org/10.1016/j.jaut.2012.05.005

Mirarabshahii P; Abdelatti A; Krilis S, 2012, 'Post-translational oxidative modification of â2-glycoprotein I and its role in the pathophysiology of the antiphospholipid syndrome.', Autoimmunity Reviews, 11, pp. 779 - 780, http://dx.doi.org/10.1016/j.autrev.2011.12.007

Adachi R; Krilis S; Nigrovic P; Hamilton MJ; Chung K; Thakurdas SM; Boyce JA; Anderson P; Stevens RL, 2012, 'Ras guanine nucleotide releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis.', The Journal of Biological Chemistry, 287, pp. 20047 - 20055, http://dx.doi.org/10.1074/jbc.M112.360388

Ioannou Y; Krilis SA, 2011, 'Laboratory Testing for Antiphospholipid Syndrome', , pp. 985 - 1000, http://dx.doi.org/10.1016/B978-0-12-374994-9.10052-X

Krilis S; Passam F; Giannakopoulos B; Mirarabshahi P, 2011, 'Molecular pathophysiology of the antiphospholipid syndrome: the role of oxidative posttranslational modification of beta 2 glycoprotein I', JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 9, pp. 715 - 715, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208992803015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hamilton MJ; Sinnamon MJ; Lyng GD; Glickman JN; Wang X; Xing W; Krilis S; Blumberg RS; Adachi R; Lee DM; Stevens RL, 2011, 'Essential role for mast cell tryptase in acute experimental colitis.', Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 290 - 295, http://dx.doi.org/10.1073/pnas.1005758108

Ruiz-irastorza G; Cuadrado MJ; Brey R; Crowther M; Derksen R; Erkan D; Krilis S; Machin S; Pengo V; Pierangeli S; Tektonidou M; Khamashta MA, 2011, 'Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task force at the 13th International Congress on antiphospholipid antibodies.', Lupus, 20, pp. 206 - 218, http://dx.doi.org/10.1177/0961203310395803

Yong A; Pennings GJ; Chang M; Hamzah A; Chung T; Qi M; Brieger D; Behnia M; Krilis S; Ng MK; Lowe HC; Kritharides L, 2011, 'Intracoronary shear-related up-regulation of platelet P-selectin and platelet monocyte aggregation despite the use of aspirin and clopidogral', Blood, 117, pp. 11 - 20, http://dx.doi.org/10.1182/blood-2010-04-278812

Giannakopoulos B; Mirarabshahi P; Krilis S, 2011, 'New insights into the biology and pathobiology of beta2-glycoprotein I.', Current Rheumatology Reports, 13, pp. 90 - 95, http://dx.doi.org/10.1007/s11926-010-0151-9

Passam F; Rahgozar S; Qi M; Raftery MJ; Wong JWH; Tanaka K; Ioannou Y; Zhang JY; Gemmell R; Qi JC; Giannakopoulos B; Hughes WE; Hogg PJ; Krilis S; Qi J, 2011, 'Redox control of â2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1.', Journal of Thrombosis and Haemostasis, 8, pp. 1754 - 1762, http://dx.doi.org/10.1111/j.1538-7836.2010.03944.x

Ioannou Y; Zhang JY; Passam FH; Rahgozar S; Qi JC; Giannakopoulos B; Qi M; Yu P; Yu DM; Hogg PJ; Krilis SA, 2010, 'Naturally occurring free thiols within β2-glycoprotein I in vivo: Nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress-induced cell injury', Blood, 116, pp. 1961 - 1970, http://dx.doi.org/10.1182/blood-2009-04-215335

Passam F; Rahgozar S; Qi M; Raftery MJ; Wong J; Tanaka K; Ioannou Y; Zhang JY; Gemmell R; Qi JC; Giannakopoulos B; Hughes WE; Hogg PJ; Krilis S, 2010, 'Beta 2 glycoprotein I is a substrate of thiol oxidoreductases', Blood, 116, pp. 1995 - 1997, http://bloodjournal.hematologylibrary.org/cgi/content/citation/116/11/1995

Passam F; Qi JC; Tanaka K; Matthaei K; Krilis S, 2010, 'In vivo modulation of angiogenesis by beta 2 glycoprotein I.', Journal of Autoimmunity, 35, pp. 232 - 240

Figtree M; Miyakis S; Stenos J; Graves S; Botham S; Ferson MJ; Krilis S, 2010, 'Q fever cholecystitis in an unvaccinated butcher diagnosed by gallbladder plymerase chain reaction', Vector - Borne and Zoonotic Diseases, 10, pp. 421 - 423, http://dx.doi.org/10.1089/vbz.2008.0209

Figtree M; Konecny P; Jennings Z; Goh C; Krilis S; Miyakis S, 2010, 'Risk Stratification and outcome of Cellulitis admitted to hospital', Journal of Infection, 60, pp. 431 - 439

Figtree MC; Miyakis S; Tanaka K; Martin L; Konecny P; Krilis S, 2009, 'Dapsone hypersensitivity syndrome causing disseminated intravascular coagulation', BMJ Case Reports, http://dx.doi.org/10.1136/bcr.11.2008.1257

Giannakopoulos B; Krilis S, 2009, 'How I treat the antiphospholipid syndrome', Blood, 114, pp. 2020 - 2030

Krilis S; Giannakopoulos B; Passam F; Ioannou Y, 2009, 'How we diagnose the antiphospholipid syndrome', Blood, 113, pp. 985 - 994

Reed J; Giannakopoulos B; Jackson M; Krilis S; Gordon T, 2009, 'Ro 60 functions as a receptor for β2-glycoprotein I on apoptotic cells', Arthritis Care & Research, 60, pp. 860 - 869

Krilis S; Reed J; Giannakopoulos B; Jackson M; Gordon T, 2009, 'Ro60 Functions as a receptor for B2-glycoprotein I on apoptotic cells', Arthritis Care & Research, 60, pp. 985 - 994

Figtree M; Miyakis S; Jennings Z; Goh C; Konecny P; Krilis S, 2008, 'Factors Influencing Outcome in Cellulitis Admitted to Hospital and the Role of the Infectious Disease Physician', INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 12, pp. E240 - E240, http://dx.doi.org/10.1016/j.ijid.2008.05.599

Rahgozar S; Giannakopoulos B; Yan X; Wei J; Jian CQ; Gemmell R; Krilis SA, 2008, 'Beta2-glycoprotein I protects thrombin from inhibition by heparin cofactor II: Potentiation of this effect in the presence of anti-β2-glycoprotein I autoantibodies', Arthritis and Rheumatism, 58, pp. 1146 - 1155, http://dx.doi.org/10.1002/art.23387

Yu P; Passam F; Yu D; Denyer GS; Krilis S, 2008, 'beta 2-glycoprotein I inhibits vascular endothelial growth factor and basic fibroblast growth factor induced angiogenesis through its amino terminal domain', Journal of Thrombosis and Haemostasis, 6, pp. 1215 - 1223, http://dx.doi.org/10.1111/j.1538-7836.2008.03000.x

Krilis S; Rahgozar S; Giannakopoulos B; Qi JC; Gemmell R; Yan X; Wei J, 2008, 'Beta2- Glycoprotein I Protects Thrombin from Inhibition by Heparin Cofactor II', Arthritis Care & Research, 58, pp. 1146 - 1155

Krilis S, 2008, 'The antiphospholipid syndrome: molecular and diagnostic aspects', INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 30, pp. 18 - 19

Katsoulotos GP; Qi M; Qi JC; Tanaka K; Hughes WE; Molloy T; Adachi R; Stevens RL; Krilis S, 2008, 'The Diacylglcerol-dependent translocation of ras guanine nucleotide -releasing protein 4 inside a human mast cell line results in substantional phenotypic changes ,including expressions of interluken 13 recepter a2', The Journal of Biological Chemistry, 283, pp. 1610 - 1621

Rahgozar S; Yang Q; Giannakopoulos B; Yan X; Miyakis S; Krilis SA, 2007, 'Beta2-glycoprotein I binds thrombin via exosite I and exosite II: Anti-β2-glycoprotein I antibodies potentiate the inhibitory effect of β2-glycoprotein I on thrombin-mediated factor XIa generation', Arthritis and Rheumatism, 56, pp. 605 - 613, http://dx.doi.org/10.1002/art.22367

Giannakopoulos B; Shi T; Yan XK; Yu P; Berndt MC; Andrew R; Rivera J; Iverson GM; Cockerill KA; Linnik MD; Krilis S, 2007, 'Anti-beta(2)-glycoprotein I antibodies in complex with beta(2)-glycoprotein I can activate platelets via glycoprotein Ib-IX-V', Clinical and Experimental Rheumatology, 25, pp. 159 - 160

Krilis S, 2007, 'APL targets and mediated effects: PL-binding proteins B2GPI', Clinical and Experimental Rheumatology, 25, pp. 123 - 123

Rahgozar S; Yang Q; Giannakopoulos B; Yan XK; Miyakis S; Krilis S, 2007, 'Beta(2)-glycoprotein I binds thrombin via exosite I and exosite II Anti-beta(2)-glycoprotein I antibodies potentiate the inhibitory effect of beta(2)-glycoprotein I on thrombin-mediated factor XIa generation', Arthritis Care & Research, 56, pp. 605 - 613

Giannakopoulos B; Passam F; Rahgozar S; Krilis S, 2007, 'Current concepts on the pathogenesis of the antiphospholipid syndrome', Blood, 109, pp. 422 - 430

Katsoulotos GP; Tanaka K; Molloy TJ; Stevens RL; Krilis S, 2007, 'Ras guanine nucleotide releasing protein 4 (RasGRP4) dependent pathways and genes that reversibly control the development, phenotype, and function of human mast cells (MCs)', Journal of Allergy and Clinical Immunology, 119, pp. S50 - S50

Shi T; Giannakopoulos B; Yan X; Yu P; Berndt MC; Andrews RK; Rivera J; Iverson GM; Cockerill KA; Linnik MD; Krilis SA, 2006, 'Anti-β2-glycoprotein I antibodies in complex with β2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V', Arthritis and Rheumatism, 54, pp. 2558 - 2567, http://dx.doi.org/10.1002/art.21968

Shi T; Giannakopoulos B; Yan XK; Yu P; Berndt MC; Andrews RK; Rivera J; Iverson M; Cockerill KA; Linnik MD; Krilis S, 2006, 'Anti-Beta2-Glycoprotein I Antibodies in Complex With Beta2-Glycoprotein I Can Activate Platelets in a Dysregulated Manner Via Glycoprotein Ib-IX-V', Arthritis Care & Research, 54, pp. 2558 - 2567

Qi J; Wang JQ; Mandadi S; Tanaka K; Roufogalis BD; Madigan MC; Lai K; Yan F; Chong BH; Stevens RL; Krilis S, 2006, 'Human and mouse mast cells use the Tetraspanin CD9 as an alternate Interleukin 16 receptor', Blood, 107, pp. 135 - 142

Miyakis S; Lockshin M; Atsumi T; Branch D; Brey R; Cervera R; Derksen R; Tincani A; Vlachoyiannopoulos P; Krilis S, 2006, 'International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)', Journal of Thrombosis and Haemostasis, 4, pp. 295 - 306

Miyakis S; Lockshin M; Atsumi T; Branch D; Brey R; Cervera R; Derksen R; De Groot P; Koike T; Meroni PL; Reber G; Shoenfeld Y; Tincani A; Vlachoyiannopoulos P; Krilis S, 2006, 'International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)', Journal of Thrombosis and Haemostasis, 4, pp. 295 - 306

Kordjian N; Donaldson A; Murrell DF; Krilis S, 2005, 'A case of desquamating rash associated with methadone use', Medical Journal of Australia, 182, pp. 76 - 77

Shi T; Giannakopoulos B; Iverson M; Cockerill KA; Linnik MD; Krilis S, 2005, 'Domain V of B2-Glycoprotein I Binds Factor XI/XIa and Is Cleaved of Lys317-Thr318', The Journal of Biological Chemistry, 280, pp. 907 - 912

Cai H; Song C; Lim IG; Krilis S; Geczy C; McNeil HP, 2005, 'Importance of C-Reactive Protein in Regulating Monocyte Tissue Factor Expresion in Patients with Inflammatory Rhumatic Diseases', The Journal of Rheumatology, 32, pp. 1224 - 1231

Andreson D; Donaldson A; Choo L; Knox A; Klaassen M; Ursic CM; Vonthethoff LW; Krilis S; Konecny P, 2005, 'Multifocal cutaneous mucormycosis complicating polymicrobial wound infections in a tsunami survivor from Sri Lanka', Lancet, 365, pp. 876 - 878

Di Simone N; Raschi E; Testoni C; Castellani R; D Asta M; Shi T; Krilis S; Caruso A; Luigi MP, 2005, 'Pathogenic role of anTi-beta 2-glycoprotein I in antiphospholipid-associated with fetal loss: characterisation of beta 2-glycoprotein I binding to trophoblast cells and functional effects of anti-beta 2-gylprotein I antiobodies in vitro', Annals of the Rheumatic Diseases, 64, pp. 462 - 467

Yasuda S; Morokawa N; Wong GW; Rossi A; Madhusudhan MS; Sali A; Askew YS; Adachi R; Silverman GA; Krilis S; Stevens RL, 2005, 'Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase /PRSS22', Blood, 105, pp. 3893 - 3901

Ho LH; Ruffin RE; Murgia C; Li LX; Krilis SA; Zalewski PD, 2004, 'Labile zinc and zinc transporter ZnT4 in mast cell granules: Role in regulation NF-KB translocation', JOURNAL OF IMMUNOLOGY, 172, pp. 7750 - 7760, http://dx.doi.org/10.4049/jimmunol.172.12.7750

Shi T; Iverson GM; Qi JC; Cockerill KA; Linnik MD; Konecny P; Krilis SA, 2004, 'β2-Glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIa: Loss of inhibition by clipped β2-glycoprotein I', Proceedings of the National Academy of Sciences of the United States of America, 101, pp. 3939 - 3944, http://dx.doi.org/10.1073/pnas.0400281101

Passam FH; Krilis SA, 2004, 'Laboratory tests for the antiphospholipid syndrome: Current concepts', Pathology, 36, pp. 129 - 138, http://dx.doi.org/10.1080/00313020410001671966

Yang Q; Shi T; Cheyne B; Giannakopoulos B; Krilis S, 2004, 'Anti-beta(2) glycoprotein I antibodies potentiate the inhibitory effects of beta(2)glycoprotein I on the activation of FXI by FIIa: Effect of clipped beta(2) glycoprotein I', Thrombosis Research, 114, pp. 608 - 608

Bester C; Shi T; Iverson GM; Cockerill KA; Linnik MD; Konecny P; Krilis S, 2004, 'B-2-glycoprotein I binds factor XI by its C-terminal domain and inhibits its activation by thrombin and factor XIIA. Plasmin cleavage of B-2-glycoprotein I abolishes its inhibition of factor XIIA activation of factor XI', Thrombosis Research, 114, pp. 608 - 609

Shi T; Iverson M; Qi JC; Cockerill KA; Linnik MD; Konecny P; Krilis S, 2004, 'B2Glycoprotein I binds Factor XI and inhibits its activation by thrombin and Factor XIIa. Loss of Inhibition by Clipped B2Glycoprotein I.', Proceedings of the National Academy of Sciences of the United States of America, 101, pp. 3939 - 3944

Miyakis S; Giannakopoulos B; Krilis S, 2004, 'Beta 2-Glycoprotein I-function in health and disease', Thrombosis Research, 114, pp. 335 - 346

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