By Professor Tri Giang Phan

Book Chapters

Brink R; Paus D; Bourne K; Hermes JR; Gardam S; Phan TG; Chan TD, 2015, 'The SWHEL system for high-resolution analysis of in vivo antigen-specific T-dependent B cell responses', in T Follicular Helper Cells: Methods and Protocols, pp. 103 - 123, http://dx.doi.org/10.1007/978-1-4939-2498-1_9

Journal articles

Phan TG; Weilbaecher KN; Aft R; Croucher PI; Chaffer CL, 2024, 'Chemotherapy and the Extra-Tumor Immune Microenvironment: EXTRA-TIME', Cancer discovery, 14, pp. 643 - 647, http://dx.doi.org/10.1158/2159-8290.CD-23-1543

Kyaw W; Chai RC; Khoo WH; Goldstein LD; Croucher PI; Murray JM; Phan TG, 2023, 'ENTRAIN: integrating trajectory inference and gene regulatory networks with spatial data to co-localize the receptor–ligand interactions that specify cell fate', Bioinformatics, 39, http://dx.doi.org/10.1093/bioinformatics/btad765

Bhattacharyya ND; Kyaw W; McDonald MM; Dhenni R; Grootveld AK; Xiao Y; Chai R; Khoo WH; Danserau LC; Sergio CM; Timpson P; Lee WM; Croucher PI; Phan TG, 2023, 'Minimally invasive longitudinal intravital imaging of cellular dynamics in intact long bone', Nature Protocols, 18, pp. 3856 - 3880, http://dx.doi.org/10.1038/s41596-023-00894-9

Pillay A; Yeola A; Tea F; Denkova M; Houston S; Burrell R; Merheb V; Lee FXZ; Lopez JA; Moran L; Jadhav A; Sterling K; Lai CL; Vitagliano TL; Aggarwal A; Catchpoole D; Wood N; Phan TG; Nanan R; Hsu P; Turville SG; Britton PN; Brilot F, 2023, 'Infection and Vaccine Induced Spike Antibody Responses Against SARS-CoV-2 Variants of Concern in COVID-19-Naïve Children and Adults', Journal of Clinical Immunology, 43, pp. 1706 - 1723, http://dx.doi.org/10.1007/s10875-023-01540-5

Conway JRW; Warren SC; Lee YK; McCulloch AT; Magenau A; Lee V; Metcalf XL; Stoehr J; Haigh K; Abdulkhalek L; Guaman CS; Reed DA; Murphy KJ; Pereira BA; Mélénec P; Chambers C; Latham SL; Lenthall H; Deenick EK; Ma Y; Phan T; Lim E; Joshua AM; Walters S; Grey ST; Shi YC; Zhang L; Herzog H; Croucher DR; Philp A; Scheele CLGJ; Herrmann D; Sansom OJ; Morton JP; Papa A; Haigh JJ; Nobis M; Timpson P, 2023, 'Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse', Science Advances, 9, http://dx.doi.org/10.1126/sciadv.adf9063

Thai LM; O'Reilly L; Reibe-Pal S; Sue N; Holliday H; Small L; Schmitz-Peiffer C; Dhenni R; Wang-Wei Tsai V; Norris N; Yau B; Zhang X; Lee K; Yan C; Shi YC; Kebede MA; Brink R; Cooney GJ; Irvine KM; Breit SN; Phan TG; Swarbrick A; Biden TJ, 2023, 'β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling', iScience, 26, http://dx.doi.org/10.1016/j.isci.2023.106477

Grootveld AK; Kyaw W; Panova V; Lau AWY; Ashwin E; Seuzaret G; Dhenni R; Bhattacharyya ND; Khoo WH; Biro M; Mitra T; Meyer-Hermann M; Bertolino P; Tanaka M; Hume DA; Croucher PI; Brink R; Nguyen A; Bannard O; Phan TG, 2023, 'Apoptotic cell fragments locally activate tingible body macrophages in the germinal center', Cell, 186, pp. 1144 - 1161.e18, http://dx.doi.org/10.1016/j.cell.2023.02.004

Phan TG, 2023, 'Epstein–Barr virus and multiple sclerosis: the dawn of a new age', Clinical and Translational Immunology, 12, http://dx.doi.org/10.1002/cti2.1457

Guo D; Jurek R; Beaumont KA; Sharp DS; Tan SY; Mariana A; Failes TW; Grootveld AK; Bhattacharyya ND; Phan TG; Arndt GM; Jain R; Weninger W; Tikoo S, 2023, 'Invasion-Block and S-MARVEL: A high-content screening and image analysis platform identifies ATM kinase as a modulator of melanoma invasion and metastasis', Proceedings of the National Academy of Sciences of the United States of America, 120, http://dx.doi.org/10.1073/pnas.2303978120

Khoo WH; Jackson K; Phetsouphanh C; Zaunders JJ; Alquicira-Hernandez J; Yazar S; Ruiz-Diaz S; Singh M; Dhenni R; Kyaw W; Tea F; Merheb V; Lee FXZ; Burrell R; Howard-Jones A; Koirala A; Zhou L; Yuksel A; Catchpoole DR; Lai CL; Vitagliano TL; Rouet R; Christ D; Tang B; West NP; George S; Gerrard J; Croucher PI; Kelleher AD; Goodnow CG; Sprent JD; Powell JE; Brilot F; Nanan R; Hsu PS; Deenick EK; Britton PN; Phan TG, 2023, 'Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19', Clinical Immunology, 246, http://dx.doi.org/10.1016/j.clim.2022.109209

Phetsouphanh C; Khoo WH; Jackson K; Klemm V; Howe A; Aggarwal A; Akerman A; Milogiannakis V; Stella AO; Rouet R; Schofield P; Faulks ML; Law H; Danwilai T; Starr M; Munier CML; Christ D; Singh M; Croucher PI; Brilot-Turville F; Turville S; Phan TG; Dore GJ; Darley D; Cunningham P; Matthews GV; Kelleher AD; Zaunders JJ, 2022, 'High titre neutralizing antibodies in response to SARS–CoV–2 infection require RBD–specific CD4 T cells that include proliferative memory cells', Frontiers in Immunology, 13, http://dx.doi.org/10.3389/fimmu.2022.1032911

Ren Q; Khoo WH; Corr AP; Phan TG; Croucher PI; Stewart SA, 2022, 'Gene expression predicts dormant metastatic breast cancer cell phenotype', Breast Cancer Research, 24, http://dx.doi.org/10.1186/s13058-022-01503-5

Dhenni R; Phan TG, 2022, 'EmBmem: will the real memory B cell please stand up?', Trends in Immunology, 43, pp. 595 - 597, http://dx.doi.org/10.1016/j.it.2022.05.001

Dai P; Honda A; Ewans L; McGaughran J; Burnett L; Law M; Phan TG, 2022, 'Recommendations for next generation sequencing data reanalysis of unsolved cases with suspected Mendelian disorders: A systematic review and meta-analysis', Genetics in Medicine, 24, pp. 1618 - 1629, http://dx.doi.org/10.1016/j.gim.2022.04.021

Law H; Mach M; Howe A; Obeid S; Milner B; Carey C; Elfis M; Fsadni B; Ognenovska K; Phan TG; Carey D; Xu Y; Venturi V; Zaunders J; Kelleher AD; Munier CML, 2022, 'Early expansion of CD38+ICOS+ GC Tfh in draining lymph nodes during influenza vaccination immune response', iScience, 25, pp. 103656, http://dx.doi.org/10.1016/j.isci.2021.103656

Youlten SE; Kemp JP; Logan JG; Ghirardello EJ; Sergio CM; Dack MRG; Guilfoyle SE; Leitch VD; Butterfield NC; Komla-Ebri D; Chai RC; Corr AP; Smith JT; Mohanty ST; Morris JA; McDonald MM; Quinn JMW; McGlade AR; Bartonicek N; Jansson M; Hatzikotoulas K; Irving MD; Beleza-Meireles A; Rivadeneira F; Duncan E; Richards JB; Adams DJ; Lelliott CJ; Brink R; Phan TG; Eisman JA; Evans DM; Zeggini E; Baldock PA; Bassett JHD; Williams GR; Croucher PI, 2021, 'Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease', Nature Communications, 12, pp. 2444, http://dx.doi.org/10.1038/s41467-021-22517-1

Yap JY; Moens L; Lin MW; Kane A; Kelleher A; Toong C; Wu KHC; Sewell WA; Phan TG; Hollway GE; Enthoven K; Gray PE; Casas-Martin J; Wouters C; De Somer L; Hershfield M; Bucciol G; Delafontaine S; Ma CS; Tangye SG; Meyts I, 2021, 'Intrinsic Defects in B Cell Development and Differentiation, T Cell Exhaustion and Altered Unconventional T Cell Generation Characterize Human Adenosine Deaminase Type 2 Deficiency', Journal of Clinical Immunology, 41, pp. 1915 - 1935, http://dx.doi.org/10.1007/s10875-021-01141-0

Mak G; Zaunders JJ; Bailey M; Seddiki N; Rogers G; Leong L; Phan TG; Kelleher AD; Koelsch KK; Boyd MA; Danta M, 2021, 'Preservation of Gastrointestinal Mucosal Barrier Function and Microbiome in Patients With Controlled HIV Infection', Frontiers in Immunology, 12, pp. 688886, http://dx.doi.org/10.3389/fimmu.2021.688886

McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Corr A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG, 2021, 'Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002))', Cell, 184, pp. 1940, http://dx.doi.org/10.1016/j.cell.2021.03.010

McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG; Corr A, 2021, 'Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption', Cell, 184, pp. 1330 - 1347.e13, http://dx.doi.org/10.1016/j.cell.2021.02.002

Alquicira-Hernandez J; Powell JE; Phan TG, 2021, 'No evidence that plasmablasts transdifferentiate into developing neutrophils in severe COVID-19 disease', Clinical and Translational Immunology, 10, http://dx.doi.org/10.1002/cti2.1308

Yap JY; Gloss B; Batten M; Hsu P; Berglund L; Cai F; Dai P; Parker A; Qiu M; Miley W; Roshan R; Marshall V; Whitby D; Wegman E; Garsia R; Wu KHC; Kirk E; Polizzotto M; Deenick EK; Tangye SG; Ma CS; CIRCA ; Phan TG, 2020, 'Everolimus-Induced Remission of Classic Kaposi’s Sarcoma Secondary to Cryptic Splicing Mediated CTLA4 Haploinsufficiency', Journal of Clinical Immunology, 40, pp. 774 - 779, http://dx.doi.org/10.1007/s10875-020-00804-8

Phan TG; Gray PE; Wong M; Macintosh R; Burnett L; Tangye SG, 2020, 'The Clinical Immunogenomics Research Consortium Australasia (CIRCA): a Distributed Network Model for Genomic Healthcare Delivery', Journal of Clinical Immunology, 40, pp. 763 - 766, http://dx.doi.org/10.1007/s10875-020-00787-6

Phan TG; Croucher PI, 2020, 'The dormant cancer cell life cycle', Nature Reviews Cancer, 20, pp. 398 - 411, http://dx.doi.org/10.1038/s41568-020-0263-0

Dhenni R; Phan TG, 2020, 'The geography of memory B cell reactivation in vaccine-induced immunity and in autoimmune disease relapses', Immunological Reviews, 296, pp. 62 - 86, http://dx.doi.org/10.1111/imr.12862

Owen KL; Gearing LJ; Zanker DJ; Brockwell NK; Khoo WH; Roden DL; Cmero M; Mangiola S; Hong MK; Spurling AJ; McDonald M; Chan CL; Pasam A; Lyons RJ; Duivenvoorden HM; Ryan A; Butler LM; Mariadason JM; Giang Phan T; Hayes VM; Sandhu S; Swarbrick A; Corcoran NM; Hertzog PJ; Croucher PI; Hovens C; Parker BS, 2020, 'Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone', EMBO Reports, 21, http://dx.doi.org/10.15252/embr.202050162

Singh M; Al-Eryani G; Carswell S; Ferguson JM; Blackburn J; Barton K; Roden D; Luciani F; Giang Phan T; Junankar S; Jackson K; Goodnow CC; Smith MA; Swarbrick A, 2019, 'High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-11049-4

Dai P; Furlong T; Gracie G; Huang ML; Yang T; Wu KHC; Danta M; Wong M; Williams A; March L; Hetherington M; Heyworth-Smith D; Phan TG, 2019, 'Autoinflammation Masquerading as Autoimmunity in an Adult with Heterozygous p.E250K PSTPIP1 Mutation', Journal of Clinical Immunology, 39, pp. 519 - 522, http://dx.doi.org/10.1007/s10875-019-00646-z

Khoo WH; Ledergor G; Weiner A; Roden DL; Terry RL; McDonald MM; Chai RC; De Veirman K; Owen KL; Opperman KS; Vandyke K; Clark JR; Seckinger A; Kovacic N; Nguyen A; Mohanty ST; Pettitt JA; Xiao Y; Corr AP; Seeliger C; Novotny M; Lasken RS; Nguyen TV; Oyajobi BO; Aftab D; Swarbrick A; Parker B; Hewett DR; Hose D; Vanderkerken K; Zannettino ACW; Amit I; Phan TG; Croucher PI, 2019, 'A niche-dependent myeloid transcriptome signature defines dormant myeloma cells', Blood, 134, pp. 30 - 43, http://dx.doi.org/10.1182/blood.2018880930

Pillay BA; Avery DT; Smart JM; Cole T; Choo S; Chan D; Gray PE; Frith K; Mitchell R; Phan TG; Wong M; Campbell DE; Hsu P; Ziegler JB; Peake J; Alvaro F; Picard C; Bustamante J; Neven B; Cant AJ; Uzel G; Arkwright PD; Casanova JL; Su HC; Freeman AF; Shah N; Hickstein DD; Tangye SG; Ma CS, 2019, 'Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK8-deficient patients', JCI Insight, 4, http://dx.doi.org/10.1172/jci.insight.127527

Moran I; Avery DT; Payne K; Lenthall H; Davies EG; Burns S; Ip W; Oleastro MM; Reisli I; Guner S; Keles S; Notarangelo L; Deenick EK; Goodnow CC; Zahra D; Brink R; Wong M; Tangye SG; Ma CS; Phan TG, 2019, 'B cell–intrinsic requirement for STK4 in humoral immunity in mice and human subjects', Journal of Allergy and Clinical Immunology, 143, pp. 2302 - 2305, http://dx.doi.org/10.1016/j.jaci.2019.02.010

Warren S; Magenau A; Nobis M; Mohammed Y; Melenec P; Phan T; Roberts M; Timpson P, 2019, 'Galene: correcting physiological motion blurring at the subcellular level in intravital FLIM data', eLife, 7, http://dx.doi.org/10.7554/eLife.35800

Moran I; Grootveld AK; Nguyen A; Phan TG, 2019, 'Subcapsular Sinus Macrophages: The Seat of Innate and Adaptive Memory in Murine Lymph Nodes', Trends in Immunology, 40, pp. 35 - 48, http://dx.doi.org/10.1016/j.it.2018.11.004

Moran I; Nguyen A; Khoo WH; Butt D; Bourne K; Young C; Hermes JR; Biro M; Gracie G; Ma CS; Munier CML; Luciani F; Zaunders J; Parker A; Kelleher AD; Tangye SG; Croucher PI; Brink R; Read MN; Phan TG, 2018, 'Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes', Nature Communications, 9, pp. 3372, http://dx.doi.org/10.1038/s41467-018-05772-7

Avery DT; Kane A; Nguyen T; Lau A; Nguyen A; Lenthall H; Payne K; Shi W; Brigden H; French E; Bier J; Hermes JR; Zahra D; Sewell WA; Butt D; Elliott M; Boztug K; Meyts I; Choo S; Hsu P; Wong M; Berglund LJ; Gray P; O’Sullivan M; Cole T; Holland SM; Ma CS; Burkhart C; Corcoran LM; Phan TG; Brink R; Uzel G; Deenick EK; Tangye SG, 2018, 'Germline-activating mutations in PIK3CD compromise B cell development and function', Journal of Experimental Medicine, 215, pp. 2073 - 2095, http://dx.doi.org/10.1084/jem.20180010

Phan TG; Tangye SG, 2018, 'B cells race the clock to get a second wind', Nature Immunology, 19, pp. 791 - 793, http://dx.doi.org/10.1038/s41590-018-0166-3

Warren SC; Nobis M; Magenau A; Mohammed YH; Herrmann D; Moran I; Vennin C; Conway JRW; Mélénec P; Cox TR; Wang Y; Morton JP; Welch HCE; Strathdee D; Anderson KI; Phan TG; Roberts MS; Timpson P, 2018, 'Removing physiological motion from Intravital and clinical functional imaging data', eLife, 7, http://dx.doi.org/10.7554/eLife.35800

Inoue T; Moran I; Shinnakasu R; Phan TG; Kurosaki T, 2018, 'Generation of memory B cells and their reactivation', Immunological Reviews, 283, pp. 138 - 149, http://dx.doi.org/10.1111/imr.12640

Brink R; Phan TG, 2018, 'Self-Reactive B Cells in the Germinal Center Reaction', Annual Review of Immunology, 36, pp. 339 - 357, http://dx.doi.org/10.1146/annurev-immunol-051116-052510

Deenick EK; Morey A; Danta M; Emmett L; Fay K; Gracie G; Ma CS; Macintosh R; Smith SABC; Sasson SC; Sewell WA; Cowley M; Tangye SG; Kelleher AD; Phan TG, 2018, 'Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency', Journal of Clinical Immunology, 38, pp. 159 - 162, http://dx.doi.org/10.1007/s10875-018-0477-z

Singh M; Al-Eryani G; Carswell S; Ferguson J; Blackburn J; Barton K; Roden D; Luciani F; Phan T; Junankar S; Jackson K; Goodnow C; Smith M; Swarbrick A, 2018, 'High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes', , http://dx.doi.org/10.1101/424945

Ma CS; Phan TG, 2017, 'Here, there and everywhere: T follicular helper cells on the move', Immunology, 152, pp. 382 - 387, http://dx.doi.org/10.1111/imm.12793

Munoz MA; Jurczyluk J; Mehr S; Chai RC; Arts RJW; Sheu A; McMahon C; Center JR; Singh-Grewal D; Chaitow J; Campbell DE; Quinn JMW; Alexandrov K; Tnimov Z; Tangye SG; Simon A; Phan TG; Rogers MJ, 2017, 'Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency', Journal of Allergy and Clinical Immunology, 140, pp. 873 - 875.e6, http://dx.doi.org/10.1016/j.jaci.2017.02.033

Chang J; Leong RW; Wasinger VC; Ip M; Yang M; Phan TG, 2017, 'Impaired Intestinal Permeability Contributes to Ongoing Bowel Symptoms in Patients With Inflammatory Bowel Disease and Mucosal Healing', Gastroenterology, 153, pp. 723 - 731.e1, http://dx.doi.org/10.1053/j.gastro.2017.05.056

McDonald MM; Reagan MR; Youlten SE; Mohanty ST; Seckinger A; Terry RL; Pettitt JA; Simic MK; Cheng TL; Morse A; Le LMT; Abi-Hanna D; Kramer I; Falank C; Fairfield H; Ghobrial IM; Baldock PA; Little DG; Kneissel M; Vanderkerken K; Bassett JHD; Williams GR; Oyajobi BO; Hose D; Phan TG; Croucher PI, 2017, 'Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma', Blood, 129, pp. 3452 - 3464, http://dx.doi.org/10.1182/blood-2017-03-773341

Vazquez-Lombardi R; Loetsch C; Zinkl D; Jackson J; Schofield P; Deenick EK; King C; Phan TG; Webster KE; Sprent J; Christ D; Vazquez Lombardi R, 2017, 'Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells', Nature Communications, 8, pp. 15373, http://dx.doi.org/10.1038/ncomms15373

Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JRW; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AAS; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NLE; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TRJ; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, 9, http://dx.doi.org/10.1126/scitranslmed.aai8504

Phan TG; Tangye SG, 2017, 'Memory B cells: total recall', Current Opinion in Immunology, 45, pp. 132 - 140, http://dx.doi.org/10.1016/j.coi.2017.03.005

Tangye SG; Pillay B; Randall KL; Avery DT; Tri GP; Gray P; Ziegler JB; Smart JM; Peake J; Arkwright PD; Hambleton S; Orange J; Goodnow CC; Uzel G; Casanova J-L; Lugo Reyes SO; Freeman AF; Su HC; Ma CS, 2017, 'Dedicator of cytokinesis 8-deficient CD4(+) T cells are biased to a T(H)2 effector fate at the expense of T(H)1 and T(H)17 cells', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139, pp. 933 - 949, http://dx.doi.org/10.1016/j.jaci.2016.07.016

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