Smart bio-mimetic self-assembled gels for biomedical applications
Self-assembled gels are a new class of materials that have been shown to have applications in tissue engineering and drug delivery.
The role of proinflammatory interleukin-17 in neuropathic pain
Peripheral nerve injury often results in persistent and debilitating neuropathic pain. My overall objective is to understand the immunological mechanisms responsible for such pain.
A controlled study of bilateral electroconvulsive therapy
Electroconvulsive therapy (ECT) is a highly effective treatment for depression, used in Australia and throughout the world to treat severe depression that has not responded to other treatments.
Neurobiological causes of overeating in a rodent model - hedonic versus homeostatic control
Unlimited access to palatable high fat foods, in conjunction with a sedentary life style, has led to increased obesity. Exactly what mechanisms drive over consumption of energy rich foods and override mechanisms that normally regulate body weight?
Targeting NPY mechanisms in rodent models of generalised epilepsy
This project will provide important information regarding the pharmacological mechanisms by which NPY acts to suppress seizures in animal models of epilepsy. It will provide strategies regarding potential new treatments of absence epilepsy.
Mobility and Location Information providing Social Equality for Blind and Vision Impaired persons
This project will produce an easy-to-use prototype system for guiding blind and visually impaired (BVI) people both indoors and outdoors and delivering location based information.
Plantwide Control of Modern Chemical Processes from a Network Perspective
To achieve high economical efficiency, modern chemical plants are becoming increasingly complex, to an extent that cannot be effectively managed by existing process modelling and control techniques.
Immunomodulation of neuropathic pain due to peripheral nerve injury or spinal cord injury
The aims of this research are to assess the effects of immune modulation by inducing immune tolerance and manipulating regulatory T cells on pain behaviours following nervous system injury.
Regulation of cell proliferation by the actin cytoskeleton
The actin cytoskeleton has long been known to be a key regulator of cell proliferation linking biochemical sensing of the environment with cell cycle progression.
Feedback destabilizing control of electro-osmotic flow for reducing fouling and enhancing productivity of membrane systems
Fouling reduces throughput and productivity of membrane systems and as such increases operating costs and reduces profitability of water treatment industries. This work aims to reduce fouling by reducing the amount of solute at a membrane surface by destabilizing flow control.
The role and regulation of protein methylation: a study using the recently developed methylation network of yeast
We have recently built the first protein 'methylation network' for any species. This project will study the dynamics of this network during the cell cycle and will identify protein complexes which have methylation-associated interactions.
The stabilization of lifted jet flames in hot oxidiser
The aim of the project is to reveal the mechanisms of the stabilisation of lifted jet flames in hot oxidiser. Such flames occur in several important combustion devices, notably diesel engines.
Maximum entropy methods for Bayesian analysis in chemistry
The project will develop a robust approach to use maximum entropy methods to model likelihood functions for a Bayesian analysis of chemical data.
Fuel stratification to enable higher load operation in homogeneous charge compression ignition engines
The project will contribute fundamental knowledge towards the development of the clean and highly efficient homogeneous charge compression ignition engine concept.
Development of anti-tropomyosin drugs, anti-cancer drugs
A potential target for anti-cancer drugs is the actin cytoskeleton; however, it has been unattainable because the toxicity associated with disabling this target has been unacceptable.
Accelerating clean automotive innovation: Fundamental insights into alternative fuel combustion
Alternative fuels such as renewable ethanol have much potential for a sustainable transportation future, yet engines are not optimised for these fuels, and engine design is hindered by the lack of understanding of key governing phenomena.
NEU-HORIZONS: The neuroprotection and therapeutic use of riluzole for the prevention of oxaliplatin neurotoxicity study.
Colorectal cancer is the second most commonly diagnosed cancer in Australia, with more than 13500 cases recorded annually. Oxaliplatin is an effective chemotherapy for the treatment of colorectal cancer.