By Associate Professor Andrew Moorhouse

Book Chapters

Moorhouse AJ, 2022, 'Membrane Potential: Concepts', in Encyclopedia of Cell Biology: Volume 1-6, Second Edition, pp. 284 - 305, http://dx.doi.org/10.1016/B978-0-12-821618-7.00200-5

Kato D; Ikegami A; Horiuchi H; Moorhouse AJ; Nabekura J; Wake H, 2019, 'In Vivo Two-Photon Imaging of Microglial Synapse Contacts', in Methods in Molecular Biology, pp. 281 - 286, http://dx.doi.org/10.1007/978-1-4939-9658-2_20

Wake H; Horiuchi H; Kato D; Moorhouse AJ; Nabekura J, 2019, 'Physiological Implications of Microglia–Synapse Interactions', in Methods in Molecular Biology, pp. 69 - 80, http://dx.doi.org/10.1007/978-1-4939-9658-2_6

Moorhouse AJ, 2016, 'Membrane Potential: Concepts', in Encyclopedia of Cell Biology, pp. 218 - 236, http://dx.doi.org/10.1016/B978-0-12-394447-4.10027-6

Moorhouse AJ; Lewis TM; Barry PH, 2015, 'Analyzing Ion Permeation in Channels and Pumps Using Patch-Clamp Recording', in Clarke RJ; Khalid MAA (ed.), Pumps, Channels and Transporters Methods of Functional Analysis, John Wiley & Sons, Hoboken, New Jersey, pp. 51 - 88

Ishibashi H; Moorhouse AJ; Nabekura J, 2012, 'Perforated Whole-Cell Patch-Clamp Technique: A User’s Guide', in Okada Y (ed.), Patch Clamp Techniques: From Beginning to Advanced Protocols, Springer, Tokyo, pp. 71 - 83, http://dx.doi.org/10.1007/978-4-431-53993-3

Ishibashi H; Moorhouse AJ; Nabekura J, 2012, 'Perforated Whole-Cell Patch-Clamp Technique: A User’s Guide', in Springer Protocols Handbooks, Springer Japan, pp. 71 - 83, http://dx.doi.org/10.1007/978-4-431-53993-3_4

Moorhouse AJ; Nabekura J, 2011, 'Cellular Mechanisms of neuronal Homeostasis and its Modulation by Neuronal Injury', in Woodin MA; Maffei A (ed.), Inhibitory Synaptic Plasticity, Springer, New York, pp. 123 - 134, http://dx.doi.org/10.1007/978-1-4419-6978-1_9

Barry PH; Qu W; Moorhouse AJ, 2008, 'Biophysics of CNG Ion Channels', in Martinac B (ed.), Sensing with Ion Channels, Springer, Berlin Heidelberg, pp. 175 - 200

Journal articles

Cheung DL; Toda T; Narushima M; Eto K; Takayama C; Ooba T; Wake H; Moorhouse AJ; Nabekura J, 2023, 'KCC2 downregulation after sciatic nerve injury enhances motor function recovery', Scientific Reports, 13, http://dx.doi.org/10.1038/s41598-023-34701-y

Kato D; Aoyama Y; Nishida K; Takahashi Y; Sakamoto T; Takeda I; Tatematsu T; Go S; Saito Y; Kunishima S; Cheng J; Hou L; Tachibana Y; Sugio S; Kondo R; Eto F; Sato S; Moorhouse AJ; Yao I; Kadomatsu K; Setou M; Wake H, 2023, 'Regulation of lipid synthesis in myelin modulates neural activity and is required for motor learning', GLIA, 71, pp. 2591 - 2608, http://dx.doi.org/10.1002/glia.24441

Hashimoto A; Kawamura N; Tarusawa E; Takeda I; Aoyama Y; Ohno N; Inoue M; Kagamiuchi M; Kato D; Matsumoto M; Hasegawa Y; Nabekura J; Schaefer A; Moorhouse AJ; Yagi T; Wake H, 2023, 'Microglia enable cross-modal plasticity by removing inhibitory synapses', Cell Reports, 42, http://dx.doi.org/10.1016/j.celrep.2023.112383

Tangalakis K; Lexis L; Hryciw DH; Towstoless M; Bakker AJ; Beckett E; Brown D; Cameron M; Choate J; Chopin L; Cooke MB; Douglas T; Estaphan S; Etherington S; Gaganis V; Moorhouse A; Moro C; Paravicini T; Perry B; Phillips R; Scott C; Todd G; Uebergang T; Wadley G; Watt M; Hayes A, 2023, 'Establishing consensus for the core concepts of physiology in the Australian higher education context using the Delphi method', Advances in Physiology Education, 47, pp. 419 - 426, http://dx.doi.org/10.1152/ADVAN.00140.2022

Parmar J; von Jonquieres G; Gorlamandala N; Chung B; Craig AJ; Pinyon JL; Birnbaumer L; Klugmann M; Moorhouse AJ; Power JM; Housley GD, 2023, 'TRPC Channels Activated by G Protein-Coupled Receptors Drive Ca²⁺ Dysregulation Leading to Secondary Brain Injury in the Mouse Model', Translational Stroke Research, http://dx.doi.org/10.1007/s12975-023-01173-1

Etherington SJ; Moorhouse AJ; Paravicini TM; Towstoless M; Hayes A; Hryciw DH; Lexis L; Tangalakis K, 2023, 'Unpacking and validating the “cell membrane” core concept of physiology by an Australian team', Advances in Physiology Education, 47, pp. 575 - 581, http://dx.doi.org/10.1152/ADVAN.00143.2022

Chopin LK; Choate J; Rathner JA; Towstoless M; Hayes A; Hryciw DH; Lexis L; Tangalakis K; Bakker A; Beckett E; Cameron M; Cooke M; Douglas T; Estaphan S; Etherington S; Gaganis V; Masters N; Moorhouse A; Moro C; Paravicini T; Perry B; Phillips R; Scott C; Todd G; Uebergang T; Wadley G, 2023, 'Unpacking and validating the “cell-cell communication” core concept of physiology by an Australian team', Advances in Physiology Education, 47, pp. 443 - 452, http://dx.doi.org/10.1152/ADVAN.00145.2022

Moro C; Douglas T; Phillips R; Towstoless M; Hayes A; Hryciw DH; Lexis L; Tangalakis K; Etherington S; Gaganis V; Todd G; Scott C; Estaphan S; Paravicini T; Moorhouse A; Wadley G; Masters N; Choate J; Chopin L; Beckett E; Bakker A; Cameron M; Uebergang T; Cooke M; Perry B, 2023, 'Unpacking and validating the “integration” core concept of physiology by an Australian team', Advances in Physiology Education, 47, pp. 436 - 442, http://dx.doi.org/10.1152/ADVAN.00144.2022

Brown D; Uebergang T; Masters N; Towstoless M; Hayes A; Hryciw DH; Lexis L; Tangalakis K; Bakker A; Beckett E; Cameron M; Choate J; Chopin L; Cooke M; Douglas T; Estaphan S; Etherington S; Gaganis V; Moorhouse A; Moro C; Paravicini T; Phillips R; Todd G; Wadley G; Douglas T, 2023, 'Unpacking the “movement of substances” core concept of physiology by an Australian team', Advances in Physiology Education, 47, pp. 514 - 520, http://dx.doi.org/10.1152/ADVAN.00149.2022

Beckett EAH; Gaganis V; Bakker AJ; Towstoless M; Hayes A; Hryciw DH; Lexis L; Tangalakis K; Brown D; Cameron M; Choate J; Chopin L; Cooke M; Douglas T; Estaphan S; Etherington S; Masters N; Moorhouse A; Moro C; Paravicini T; Perry B; Phillips R; Scott C; Todd G; Uebergang T; Wadley G, 2023, 'Unpacking the homeostasis core concept in physiology: an Australian perspective', Advances in Physiology Education, 47, pp. 427 - 435, http://dx.doi.org/10.1152/ADVAN.00141.2022

Perry BD; Cameron MS; Cooke MB; Towstoless M; Hryciw DH; Hayes A; Lexis L; Tangalakis K; Etherington S; Gaganis V; Todd G; Scott C; Estaphan S; Moro C; Phillips R; Paravicini T; Douglas T; Moorhouse A; Chopin L; Beckett E; Brown D; Bakker A, 2023, 'Unpacking the renal system component of the “structure and function” core concept of physiology by an Australian team', Advances in Physiology Education, 47, pp. 453 - 460, http://dx.doi.org/10.1152/ADVAN.00150.2022

Takeda I; Yoshihara K; Cheung DL; Kobayashi T; Agetsuma M; Tsuda M; Eto K; Koizumi S; Wake H; Moorhouse AJ; Nabekura J, 2022, 'Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-31773-8

Cheung DL; Cooke MJ; Goulton CS; Chaichim C; Cheung LF; Khoshaba A; Nabekura J; Moorhouse AJ, 2022, 'Global transgenic upregulation of KCC2 confers enhanced diazepam efficacy in treating sustained seizures', Epilepsia, 63, pp. e15 - e22, http://dx.doi.org/10.1111/epi.17097

Okada T; Kato D; Nomura Y; Obata N; Quan X; Morinaga A; Yano H; Guo Z; Aoyama Y; Tachibana Y; Moorhouse AJ; Matoba O; Takiguchi T; Mizobuchi S; Wake H, 2021, 'Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target', Science Advances, 7, http://dx.doi.org/10.1126/sciadv.abd8261

Takeda I; Yoshihara K; Cheung D; Agetsuma M; Tsuda M; Eto K; Moorhouse A; Nabekura J, 2021, 'Controlled activation of cortical astrocytes can reverse neuropathic chronic pain', , http://dx.doi.org/10.21203/rs.3.rs-150434/v1

Ozaki K; Kato D; Ikegami A; Hashimoto A; Sugio S; Guo Z; Shibushita M; Tatematsu T; Haruwaka K; Moorhouse AJ; Yamada H; Wake H, 2020, 'Maternal immune activation induces sustained changes in fetal microglia motility', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-78294-2

Karunanithi S; Lin YQ; Lorenzo Odierna G; Menon H; Gonzalez JM; Gregory Neely G; Noakes PG; Lavidis NA; Moorhouse AJ; van Swinderen B, 2020, 'Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila', Journal of Neuroscience, 40, pp. 8025 - 8041, http://dx.doi.org/10.1523/JNEUROSCI.0349-20.2020

Kato D; Wake H; Lee PR; Tachibana Y; Ono R; Sugio S; Tsuji Y; Tanaka YH; Tanaka YR; Masamizu Y; Hira R; Moorhouse AJ; Tamamaki N; Ikenaka K; Matsukawa N; Fields RD; Nabekura J; Matsuzaki M, 2020, 'Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity', GLIA, 68, pp. 193 - 210, http://dx.doi.org/10.1002/glia.23713

Haruwaka K; Ikegami A; Tachibana Y; Ohno N; Konishi H; Hashimoto A; Matsumoto M; Kato D; Ono R; Kiyama H; Moorhouse AJ; Nabekura J; Wake H, 2019, 'Dual microglia effects on blood brain barrier permeability induced by systemic inflammation', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-13812-z

Nakamura K; Moorhouse AJ; Cheung DL; Eto K; Takeda I; Rozenbroek PW; Nabekura J, 2019, 'Overexpression of neuronal K ⁺ –Cl ⁻ co-transporter enhances dendritic spine plasticity and motor learning', Journal of Physiological Sciences, 69, pp. 453 - 463, http://dx.doi.org/10.1007/s12576-018-00654-5

Moorhouse AJ; Power JM, 2019, 'Making light work of fine-tuning channelrhodopsins', Journal of Biological Chemistry, 294, pp. 3822 - 3823, http://dx.doi.org/10.1074/jbc.H119.007749

Gorlamandala N; Parmar J; Craig AJ; Power JM; Moorhouse AJ; Krishnan AV; Housley GD, 2018, 'Focal Ischaemic Infarcts Expand Faster in Cerebellar Cortex than Cerebral Cortex in a Mouse Photothrombotic Stroke Model', Translational Stroke Research, 9, pp. 643 - 653, http://dx.doi.org/10.1007/s12975-018-0615-1

Akiyoshi R; Wake H; Kato D; Horiuchi H; Ono R; Ikegami A; Haruwaka K; Omori T; Tachibana Y; Moorhouse AJ; Nabekura J, 2018, 'Microglia enhance synapse activity to promote local network synchronization', eNeuro, 5, http://dx.doi.org/10.1523/ENEURO.0088-18.2018

Ishikawa T; Eto K; Kim SK; Wake H; Takeda I; Horiuchi H; Moorhouse AJ; Ishibashi H; Nabekura J, 2018, 'Cortical astrocytes prime the induction of spine plasticity and mirror image pain', Pain, 159, pp. 1592 - 1606, http://dx.doi.org/10.1097/j.pain.0000000000001248

Goulton CS; Watanabe M; Cheung DL; Wang KW; Oba T; Khoshaba A; Lai D; Inada H; Eto K; Nakamura K; Power JM; Lewis TM; Housley GD; Wake H; Nabekura J; Moorhouse AJ, 2018, 'Conditional Upregulation of KCC2 selectively enhances neuronal inhibition during seizures', , http://dx.doi.org/10.1101/253831

Nakahata Y; Eto K; Murakoshi H; Watanabe M; Kuriu T; Hirata H; Moorhouse AJ; Ishibashi H; Nabekura J, 2017, 'Activation-dependent rapid postsynaptic clustering of glycine receptors in mature spinal cord neurons', eNeuro, 4, http://dx.doi.org/10.1523/ENEURO.0194-16.2017

Miyamoto A; Wake H; Ishikawa AW; Eto K; Shibata K; Murakoshi H; Koizumi S; Moorhouse AJ; Yoshimura Y; Nabekura J, 2016, 'Microglia contact induces synapse formation in developing somatosensory cortex', Nature Communications, 7, http://dx.doi.org/10.1038/ncomms12540

Kim SK; Hayashi H; Ishikawa T; Shibata K; Shigetomi E; Shinozaki Y; Inada H; Roh SE; Kim SJ; Lee G; Bae H; Moorhouse AJ; Mikoshiba K; Fukazawa Y; Koizumi S; Nabekura J, 2016, 'Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain', Journal of Clinical Investigation, 126, pp. 1983 - 1997, http://dx.doi.org/10.1172/JCI82859

Kato G; Inada H; Wake H; Akiyoshi R; Miyamoto A; Eto K; Ishikawa T; Moorhouse AJ; Strassman AM; Nabekura J, 2016, 'Microglial contact prevents excess depolarization and rescues neurons from excitotoxicity', eNeuro, 3, pp. 9133 - 9144, http://dx.doi.org/10.1523/ENEURO.0004-16.2016

Alexander SPH; Benson HE; Faccenda E; Pawson AJ; Sharman JL; McGrath JC; Catterall WA; Spedding M; Peters JA; Harmar AJ, 2013, 'THE CONCISE GUIDE TO PHARMACOLOGY 2013/14: OVERVIEW', BRITISH JOURNAL OF PHARMACOLOGY, 170, pp. 1449 - 1458, http://dx.doi.org/10.1111/bph.12444

Barry PH; Lewis TM; Moorhouse AJ, 2013, 'An optimised 3 M KCl salt-bridge technique used to measure and validate theoretical liquid junction potential values in patch-clamping and electrophysiology', European Biophysics Journal, 42, pp. 631 - 646, http://dx.doi.org/10.1007/s00249-013-0911-3

Miyamoto A; Wake H; Moorhouse AJ; Nabekura J, 2013, 'Microglia and synapse interactions: Fine tuning neural circuits and candidate molecules', Frontiers in Cellular Neuroscience, 7, http://dx.doi.org/10.3389/fncel.2013.00070

Wake H; Moorhouse AJ; Miyamoto A; Nabekura J, 2013, 'Microglia: Actively surveying and shaping neuronal circuit structure and function', Trends in Neurosciences, 36, pp. 209 - 217, http://dx.doi.org/10.1016/j.tins.2012.11.007

Kim YS; Wong AC; Power J; Tadros SF; Klugmann M; Moorhouse AJ; Bertrand PP; Housley GD, 2012, 'Alternative Splicing of the TRPC3 Ion Channel Calmodulin/ IP3 Receptor-Binding Domain in the Hindbrain Enhances Cation Flux', The Journal of Neuroscience, 32, pp. 11414 - 11423, http://dx.doi.org/10.1523/JNEUROSCI.6446-11.2012

Eto K; Ishibashi H; Yoshimura T; Watanabe M; Miyamoto A; Ikenaka K; Moorhouse AJ; Nabekura J, 2012, 'Enhanced GABAergic activity in the mouse primary somatosensory cortex is insufficient to alleviate chronic pain behavior with reduced expression of neuronal potassium-chloride cotransporter', Journal of Neuroscience, 32, pp. 16552 - 16559, http://dx.doi.org/10.1523/JNEUROSCI.2104-12.2012

Wake H; Moorhouse AJ; Nabekura J, 2012, 'Functions of microglia in the central nervous system-beyond the immune response', Neuron Glia Biology, 7, pp. 47 - 53, http://dx.doi.org/10.1017/S1740925X12000063

Nakahata Y; Miyamoto A; Watanabe M; Moorhouse AJ; Nabekura J; Ishibashi H, 2010, 'Depolarizing shift in the GABA-induced current reversal potential by lidocaine hydrochloride', Brain Research, 1345, pp. 19 - 27, http://dx.doi.org/10.1016/j.brainres.2010.05.052

Sugiharto S; Carland JE; Lewis TM; Moorhouse AJ; Barry PH, 2010, 'External divalent cations increase anion-cation permeability ratio in glycine receptor channels', Pflugers Archiv - European Journal of Physiology, 460, pp. 131 - 152, http://dx.doi.org/10.1007/s00424-010-0792-6

Barry PH; Sugiharto S; Lewis TM; Moorhouse AJ, 2010, 'Further analysis of counterion permeation through anion-selective glycine receptor channels.', Channels, 4, pp. 142 - 149, http://www.landesbioscience.com/journals/channels/article/11020

Carland JE; cooper MA; Sugiharto S; Jeong H; Lewis TM; Barry PH; Peters JA; Lambert J; Moorhouse AJ, 2009, 'Characterization of the effects of charged residues in the intracellular loop on ion permeation in α1 glycine receptor channels', The Journal of Biological Chemistry, 284, pp. 2023 - 2030, http://dx.doi.org/10.1074/jbc.M806618200

Watanabe M; Wake H; Moorhouse AJ; Nabekura J, 2009, 'Clustering of Neuronal K+-Cl- Cotransporters in Lipid Raftsby Tyrosine Phosphorylation', The Journal of Biological Chemistry, 284, pp. 27980 - 27988

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