By Associate Professor Thomas Robert Cox

Journal articles

Elgundi Z; Papanicolaou M; Major G; Cox TR; Melrose J; Whitelock JM; Farrugia BL, 2020, 'Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan', Frontiers in Oncology, 9, pp. 1482, http://dx.doi.org/10.3389/fonc.2019.01482

Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C; Christ D; Cox T; Timpson P; Phillips P; Whitelock J; Pajic M; Gill A; Croucher D, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6

Chitty JL; Setargew YFI; Cox TR, 2019, 'Targeting the lysyl oxidases in tumour desmoplasia', Biochemical Society Transactions, 47, pp. 1661 - 1678, http://dx.doi.org/10.1042/BST20190098

Pereira BA; Vennin C; Papanicolaou M; Chambers CR; Herrmann D; Morton JP; Cox TR; Timpson P, 2019, 'CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer', Trends in Cancer, 5, pp. 724 - 741, http://dx.doi.org/10.1016/j.trecan.2019.09.010

Zijlstra A; Von Lersner A; Yu D; Borrello L; Oudin M; Kang Y; Sahai E; Fingleton B; Stein U; Cox TR; Price JT; Kato Y; Welm AL; Aguirre-Ghiso JA, 2019, 'The importance of developing therapies targeting the biological spectrum of metastatic disease', Clinical and Experimental Metastasis, 36, pp. 305 - 309, http://dx.doi.org/10.1007/s10585-019-09972-3

Zeltz C; Pasko E; Cox TR; Navab R; Tsao MS, 2019, 'LOXL1 is regulated by integrin α11 and promotes non-small cell lung cancer tumorigenicity', Cancers, 11, http://dx.doi.org/10.3390/cancers11050705

Beadnell T; Borriello L; Christenson J; Fornetti J; Guldner I; Hanna A; Kyjacova L; Marinak-Whately K; de Melo Martins PC; Rotinen M; te Boekhorst V; Cox TR, 2019, 'Meeting report: Metastasis Research Society (MRS) 17th Biennial conference and associated Young Investigator Satellite Meeting (YISM) on cancer metastasis', Clinical and Experimental Metastasis, 36, pp. 119 - 137, http://dx.doi.org/10.1007/s10585-018-09953-y

Kennedy SP; Han JZR; Portman N; Nobis M; Hastings JF; Murphy KJ; Latham SL; Cadell AL; Miladinovic D; Marriott GR; O'Donnell YEI; Shearer RF; Williams JT; Munoz AG; Cox TR; Watkins DN; Saunders DN; Timpson P; Lim E; Kolch W; Croucher DR, 2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, 21, http://dx.doi.org/10.1186/s13058-019-1127-y

Nguyen EV; Pereira BA; Lawrence MG; Ma X; Rebello RJ; Chan H; Niranjan B; Wu Y; Ellem S; Guan X; Wu J; Skhinas JN; Cox TR; Risbridger GP; Taylor RA; Lister NL; Daly RJ, 2019, 'Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment', Molecular and Cellular Proteomics, 18, pp. 1410 - 1427, http://dx.doi.org/10.1074/mcp.RA119.001496

Hastings JF; Skhinas JN; Fey D; Croucher DR; Cox TR, 2019, 'The extracellular matrix as a key regulator of intracellular signalling networks', British Journal of Pharmacology, 176, pp. 82 - 92, http://dx.doi.org/10.1111/bph.14195

Weerakoon AT; Meyers IA; Roy S; Cooper C; Cox TR; Condon ND; Sexton C; Thomson DH; Ford PJ; Symons AL, 2019, 'Dentin changes associated with patient age and cavity site', Dental Materials, 35, pp. e41 - e41, http://dx.doi.org/10.1016/j.dental.2019.08.083

Nguyen EV; Pereira BA; Lawrence MG; Ma X; Rebello RJ; Chan H; Niranjan B; Wu Y; Ellem S; Guan X; Wu J; Skhinas JN; Cox TR; Risbridger GP; Taylor RA; Lister NL; Daly RJ, 2019, 'Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment.', Mol Cell Proteomics, 18, pp. 1410 - 1427, http://dx.doi.org/10.1074/mcp.RA119.001496

Chou A; Froio D; Nagrial AM; Parkin A; Murphy KJ; Chin VT; Wohl D; Steinmann A; Stark R; Drury A; Walters SN; Vennin C; Burgess A; Pinese M; Chantrill LA; Cowley MJ; Molloy TJ; Waddell N; Johns A; Grimmond SM; Chang DK; Biankin AV; Sansom OJ; Morton JP; Grey ST; Cox TR; Turchini J; Samra J; Clarke SJ; Timpson P; Gill AJ; Pajic M, 2018, 'Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer', Gut, 67, pp. 2142 - 2155, http://dx.doi.org/10.1136/gutjnl-2017-315144

Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan CL; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel MS; Martín M; Swarbrick A; O'Toole S, 2018, 'Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer', Nature Communications, 9, pp. 2897, http://dx.doi.org/10.1038/s41467-018-05220-6

Skhinas JN; Cox TR, 2018, 'The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis', Cell Adhesion and Migration, 12, pp. 529 - 537, http://dx.doi.org/10.1080/19336918.2017.1405208

Wullkopf L; West AKV; Leijnse N; Cox TR; Madsen CD; Oddershede LB; Erler JT, 2018, 'Cancer cells' ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential', Molecular Biology of the Cell, 29, pp. 2378 - 2385, http://dx.doi.org/10.1091/mbc.E18-05-0319

Høye AM; Tolstrup SD; Horton ER; Nicolau M; Frost H; Woo JH; Mauldin JP; Frankel AE; Cox TR; Erler JT, 2018, 'Tumor endothelial marker 8 promotes cancer progression and metastasis', Oncotarget, 9, pp. 30173 - 30188, http://dx.doi.org/10.18632/oncotarget.25734

Warren SC; Nobis M; Magenau A; Mohammed YH; Herrmann D; Moran I; Vennin C; Conway JRW; Mélénec P; Cox TR; Wang Y; Morton JP; Welch HCE; Strathdee D; Anderson KI; Phan TG; Roberts MS; Timpson P, 2018, 'Removing physiological motion from Intravital and clinical functional imaging data', eLife, 7, http://dx.doi.org/10.7554/eLife.35800

Filipe EC; Chitty JL; Cox TR, 2018, 'Charting the unexplored extracellular matrix in cancer', International Journal of Experimental Pathology, 99, pp. 58 - 76, http://dx.doi.org/10.1111/iep.12269

Vennin C; Murphy KJ; Morton JP; Cox TR; Pajic M; Timpson P, 2018, 'Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer', Gastroenterology, 154, pp. 820 - 838, http://dx.doi.org/10.1053/j.gastro.2017.11.280

Cox TR; Erler JT; Rumney RMH, 2018, 'Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease', Calcified Tissue International, 102, pp. 163 - 173, http://dx.doi.org/10.1007/s00223-017-0352-6

Xia T; Horton ER; Salcini AE; Pocock R; Cox TR; Erler JT, 2018, 'Proteomic Characterization of Caenorhabditis elegans Larval Development', Proteomics, 18, http://dx.doi.org/10.1002/pmic.201700238

Chitty JL; Filipe EC; Lucas MC; Herrmann D; Cox TR; Timpson P, 2018, 'Recent advances in understanding the complexities of metastasis', F1000Research, 7, http://dx.doi.org/10.12688/f1000research.15064.2

Murphy K; Vennin C; Cox T; Wang Y; Morton J; Sansom O; Pajic M; Herrmann D; Timpson P, 2018, 'PO-229 Transient tissue ‘priming’ via FAK inhibition to impair pancreatic ductal adenocarcinoma (PDAC) progression to improve sensitivity to gemcitabine/abraxane', ESMO Open, 3, pp. A316 - A317, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.746

Fingleton B; Lange K; Caldwell B; Bankaitis KV; Kang Y; Yu D; Aguirre-Ghiso J; Cox TR; Erler JT; Gelman IH; Hurst DR; Kato Y; Lynch CC; Price JT; Samant RS; Sleeman J; Stein U; Zijlstra A, 2017, 'Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example', Clinical and Experimental Metastasis, 34, pp. 443 - 447, http://dx.doi.org/10.1007/s10585-017-9872-8

Conway JRW; Vennin C; Cazet AS; Herrmann D; Murphy KJ; Warren SC; Wullkopf L; Boulghourjian A; Zaratzian A; Da Silva AM; Pajic M; Morton JP; Cox TR; Timpson P, 2017, 'Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology', Scientific Reports, 7, pp. 16887, http://dx.doi.org/10.1038/s41598-017-17177-5

Vennin C; Cox TR; Pajic M; Timpson P, 2017, 'Transient targeting of the pancreatic cancer stroma as a 'finetuned' anti-tumor and anti-metastatic therapy', Oncotarget, 8, pp. 84635 - 84636, http://dx.doi.org/10.18632/oncotarget.21468

Koplev S; Longden J; Ferkinghoff-Borg J; Blicher Bjerregård M; Cox TR; Erler JT; Pedersen JT; Voellmy F; Sommer MOA; Linding R, 2017, 'Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments', Cell Reports, 20, pp. 2784 - 2791, http://dx.doi.org/10.1016/j.celrep.2017.08.095

Liu N; Cox TR; Cui W; Adell G; Holmlund B; Ping J; Jarlsfelt I; Erler JT; Sun X-F, 2017, 'Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.', Oncotarget, 8, pp. 60015 - 60024, http://dx.doi.org/10.18632/oncotarget.9623

Mayorca-Guiliani AE; Madsen CD; Cox TR; Horton ER; Venning FA; Erler JT, 2017, 'ISDoT: In situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix', Nature Medicine, 23, pp. 890 - 898, http://dx.doi.org/10.1038/nm.4352

Madsen CD; Cox TR, 2017, 'Relative Stiffness Measurements of Tumour Tissues by Shear Rheology', BIO-PROTOCOL, 7, http://dx.doi.org/10.21769/BioProtoc.2265

Peinado H; Zhang H; Matei IR; Costa-Silva B; Hoshino A; Rodrigues G; Psaila B; Kaplan RN; Bromberg JF; Kang Y; Bissell MJ; Cox TR; Giaccia AJ; Erler JT; Hiratsuka S; Ghajar CM; Lyden D, 2017, 'Pre-metastatic niches: Organ-specific homes for metastases', Nature Reviews Cancer, 17, pp. 302 - 317, http://dx.doi.org/10.1038/nrc.2017.6

Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JRW; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AAS; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NLE; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TRJ; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, 9, http://dx.doi.org/10.1126/scitranslmed.aai8504

Bankaitis K; Borriello L; Cox T; Lynch C; Zijlstra A; Fingleton B; Gužvić M; Anderson R; Neman J, 2017, 'Meeting report: Metastasis Research Society–Chinese Tumor Metastasis Society joint conference on metastasis', Clinical and Experimental Metastasis, 34, pp. 203 - 213, http://dx.doi.org/10.1007/s10585-017-9842-1

Cox TR; Madsen CD, 2017, 'Relative Stiffness Measurements of Cell-embedded Hydrogels by Shear Rheology in vitro.', Bio Protoc, 7, pp. e2101, http://dx.doi.org/10.21769/BioProtoc.2101

Elyas E; Papaevangelou E; Alles EJ; Erler JT; Cox TR; Robinson SP; Bamber JC, 2017, 'Correlation of ultrasound shear wave elastography with pathological analysis in a xenografic tumour model', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-00144-5

Elyas E; Grimwood A; Erler JT; Robinson SP; Cox TR; Woods D; Clowes P; De Luca R; Marinozzi F; Fromageau J; Bamber JC, 2017, 'Multi-channel optical coherence elastography using relative and absolute shear-wave time of flight', PLoS ONE, 12, http://dx.doi.org/10.1371/journal.pone.0169664

Liu N; Cox TR; Cui W; Adell G; Holmlund B; Ping J; Jarlsfelt I; Erler JT; Sun XF, 2017, 'Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients', Oncotarget, 8, pp. 60015 - 60024, http://dx.doi.org/10.18632/oncotarget.9623

Chang J; Lucas MC; Leonte LE; Garcia-Montolio M; Singh LB; Findlay AD; Deodhar M; Foot JS; Jarolimek W; Timpson P; Erler JT; Cox TR, 2017, 'Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer', Oncotarget, 8, pp. 26066 - 26078, http://dx.doi.org/10.18632/oncotarget.15257

Gartland A; Erler JT; Cox TR, 2016, 'The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis', Journal of Bone Oncology, 5, pp. 100 - 103, http://dx.doi.org/10.1016/j.jbo.2016.04.001

Cox TR; Erler JT, 2016, 'Fibrosis and Cancer: Partners in Crime or Opposing Forces?', Trends in Cancer, 2, pp. 279 - 282, http://dx.doi.org/10.1016/j.trecan.2016.05.004

Cox TR; Gartland A; Erler JT, 2016, 'Lysyl oxidase, a targetable secreted molecule involved in cancer metastasis', Cancer Research, 76, pp. 188 - 192, http://dx.doi.org/10.1158/0008-5472.CAN-15-2306

Cox TR; Schoof EM; Gartland A; Erler JT; Linding R, 2015, 'Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism', Data in Brief, 5, pp. 621 - 625, http://dx.doi.org/10.1016/j.dib.2015.09.039

Madsen CD; Pedersen JT; Venning FA; Singh LB; Moeendarbary E; Charras G; Cox TR; Sahai E; Erler JT, 2015, 'Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis', EMBO Reports, 16, pp. 1394 - 1408, http://dx.doi.org/10.15252/embr.201540107

Creixell P; Schoof EM; Simpson CD; Longden J; Miller CJ; Lou HJ; Perryman L; Cox TR; Zivanovic N; Palmeri A; Wesolowska-Andersen A; Helmer-Citterich M; Ferkinghoff-Borg J; Itamochi H; Bodenmiller B; Erler JT; Turk BE; Linding R, 2015, 'Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling', Cell, 163, pp. 202 - 217, http://dx.doi.org/10.1016/j.cell.2015.08.056

Rodriguez-Teja M; Gronau JH; Breit C; Zhang YZ; Minamidate A; Caley MP; McCarthy A; Cox TR; Erler JT; Gaughan L; Darby S; Robson C; Mauri F; Waxman J; Sturge J, 2015, 'AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival', Journal of Pathology, 235, pp. 581 - 592, http://dx.doi.org/10.1002/path.4485

Cox TR; Erler JT, 2014, 'Molecular pathways: Connecting fibrosis and solid tumor metastasis', Clinical Cancer Research, 20, pp. 3637 - 3643, http://dx.doi.org/10.1158/1078-0432.CCR-13-1059

Cox TR; Erler JT, 2014, 'Fibrosis, Cancer and the Premetastatic Niche', Breast Cancer Management, 3, pp. 453 - 455, http://dx.doi.org/10.2217/bmt.14.36

Cox TR; Erler JT, 2013, 'Lysyl oxidase in colorectal cancer', American Journal of Physiology - Gastrointestinal and Liver Physiology, 305, http://dx.doi.org/10.1152/ajpgi.00425.2012

Chang J; Nicolau MM; Cox TR; Wetterskog D; Martens JWM; E Barker H; Erler JT, 2013, 'LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling', Breast Cancer Research, 15, http://dx.doi.org/10.1186/bcr3461

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