By Associate Professor Thomas Robert Cox

Journal articles

Baker AM; Bird D; Lang G; Cox TR; Erler JT, 2013, 'Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK', Oncogene, 32, pp. 1863 - 1868, http://dx.doi.org/10.1038/onc.2012.202

Cox TR; Bird D; Baker AM; Barker HE; Ho MWY; Lang G; Erler JT, 2013, 'LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis', Cancer Research, 73, pp. 1721 - 1732, http://dx.doi.org/10.1158/0008-5472.CAN-12-2233

Baker AM; Bird D; Welti JC; Gourlaouen M; Lang G; Murray GI; Reynolds AR; Cox TR; Erler JT, 2013, 'Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis', Cancer Research, 73, pp. 583 - 594, http://dx.doi.org/10.1158/0008-5472.CAN-12-2447

R Cox T, 2013, 'The Importance of LOX Family Members on Modulating Cell-ECM Interactions in Carcinogenesis', Journal of Carcinogenesis & Mutagenesis, S13, http://dx.doi.org/10.4172/2157-2518.s13-001

Barker HE; Cox TR; Erler JT, 2012, 'The rationale for targeting the LOX family in cancer', Nature Reviews Cancer, 12, pp. 540 - 552, http://dx.doi.org/10.1038/nrc3319

Cox TR; Erler JT, 2012, 'Network biology and the 3-Dimensional tumor microenvironment: personalizing medicine for the future', Tumor Microenvironment and Therapy, 1, http://dx.doi.org/10.2478/tumor-2012-0002

Cox TR; Gartland A; Erler JT, 2012, 'The pre-metastatic niche: is metastasis random?', Bonekey Rep, 1, pp. 80, http://dx.doi.org/10.1038/bonekey.2012.80

Baker AM; Cox TR; Bird D; Lang G; Murray GI; Sun XF; Southall SM; Wilson JR; Erler JT, 2011, 'The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer', Journal of the National Cancer Institute, 103, pp. 407 - 424, http://dx.doi.org/10.1093/jnci/djq569

Barker HE; Chang J; Cox TR; Lang G; Bird D; Nicolau M; Evans HR; Gartland A; Erler JT, 2011, 'LOXL2-mediated matrix remodeling in metastasis and mammary gland involution', Cancer Research, 71, pp. 1561 - 1572, http://dx.doi.org/10.1158/0008-5472.CAN-10-2868

Cox TR; Erler JT, 2011, 'Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer', DMM Disease Models and Mechanisms, 4, pp. 165 - 178, http://dx.doi.org/10.1242/dmm.004077

Evans HR; Ab Latif N; Cox TR; Bird D; Lang G; Erler JT; Gartland* A, 2011, 'Tumour-secreted lox mediates osteolytic bone metastases prior to metastatic tumour cell colonisation', Bone, 48, pp. S21 - S21, http://dx.doi.org/10.1016/j.bone.2010.10.054

Graham HK; Hodson NW; Hoyland JA; Millward-Sadler SJ; Garrod D; Scothern A; Griffiths CEM; Watson REB; Cox TR; Erler JT; Trafford AW; Sherratt MJ, 2010, 'Tissue section AFM: In situ ultrastructural imaging of native biomolecules', Matrix Biology, 29, pp. 254 - 260, http://dx.doi.org/10.1016/j.matbio.2010.01.008

Erler JT; Bennewith KL; Cox TR; Lang G; Bird D; Koong A; Le QT; Giaccia AJ, 2009, 'Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche', Cancer Cell, 15, pp. 35 - 44, http://dx.doi.org/10.1016/j.ccr.2008.11.012

Conference Papers

Høye AM; Tolstrup S; Cox TR; Mauldin JP; Frankel AE; Erler JT, 2016, 'Abstract B17: Disrupting tumor growth through targeting TEM8', in Cancer Research, American Association for Cancer Research (AACR), pp. B17 - B17, http://dx.doi.org/10.1158/1538-7445.tme16-b17

Liu N; Cox TR; Cui W; Adell G; Holmlund B; Erler JT; Sun X, 2016, 'Abstract 5012: Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients', in Cancer Research, American Association for Cancer Research (AACR), pp. 5012 - 5012, http://dx.doi.org/10.1158/1538-7445.am2016-5012

Conference Abstracts

Hui MN; Cazet A; Elsworth B; Roden D; Cox T; Yang J; McFarland A; Deng N; Chan C-L; O'Toole S; Swarbrick A, 2018, 'Targeting the Hedgehog signalling pathway in triple negative breast cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Vol. 36, http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.e24216

Preprints

Perryman L; Høye AM; Cox TR; Baker A-M; Strøbech J; Leonte L; Singh LB; Popov S; Lorentzen LG; Reuten R; Skovgaard Poulsen H; Davies MJ; Jones C; Erler JT, 2024, Cleavage of the vascular matrix attracts glioblastoma cells to infiltrate the brain parenchyma, http://dx.doi.org/10.1101/2024.08.02.606279

Widodo S; Dinevska M; Cuzcano L; Papanicolaou M; Cox T; Stylli S; Mantamadiotis T, 2022, Spatial analysis of the metastatic brain tumor immune and extracellular matrix microenvironment, http://dx.doi.org/10.1101/2022.08.30.505945

Rad MA; Mahmodi H; Filipe EC; Cox TR; Kabakova I; Tipper JL, 2021, Micromechanical Characterisation of 3D Bioprinted neural cell models using Brillouin Microscopy, http://dx.doi.org/10.1101/2021.08.17.456575

Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey S; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill A; Gonzales-Aloy E; Kokkinos J; Gebski V; Turner N; Apte M; Davis TP; Morton JP; Haghighi K; Phillips PA, 2020, Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition, http://dx.doi.org/10.1101/2020.07.12.199638

Cazet A; Hui M; Elsworth B; Wu S; Roden D; Chan C-L; Skhinas J; Collot R; Yang J; Harvey K; Johan Z; Cooper C; Nair R; Herrmann D; McFarland A; Deng N-T; Ruiz-Borrego M; Rojo F; Trigo J; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins N; Cox T; Samuel M; Martín M; Swarbrick A, 2017, Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer, http://dx.doi.org/10.1101/215954

Wullkopf L; Jensen LE; Horton ER; Mayorca Guiliani AE; Madsen CD; Cox TR; Reuten R; Erler JT, Breast Cancer-Secreted Laminin γ2 Promotes Metastatic Progression Through Attraction of Blood Vessels, http://dx.doi.org/10.2139/ssrn.3631394

Es HA; Aref AR; Kulasinghe A; Cox TR; Thiery JP; Ebrahimi Warkiani M, Epithelial-Mesenchymal Transition Inversely Associates With Immune Activity in Breast Cancer Tumour Immune Microenvironment, http://dx.doi.org/10.2139/ssrn.3811836

Valdes-Mora F; Salomon R; Gloss B; Law AMK; Castillo L; Murphy K; Venhuizen J; Magenau A; Papanicolau M; Rodriguez de la Fuente L; Roden DL; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Oakes SR; Sikta N; O'Donoghue SI; Cox TR; Timpson P; Ormandy CJ; Gallego Ortega D, Single Cell Transcriptomics Reveals Involution Mimicry During the Specification of the Basal Breast Cancer Subtype, http://dx.doi.org/10.2139/ssrn.3634808

Mantamadiotis T; Widodo SS; Dinevska M; Cuzcano L; Papanicolaou M; Cox TR; Stylli SS, Spatial Analysis of the Metastatic Brain Tumor Immune and Extracellular Matrix Microenvironment, http://dx.doi.org/10.2139/ssrn.4214030

Other

Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2023, Data from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition, http://dx.doi.org/10.1158/0008-5472.c.6512931

Back to profile page