By Professor Andrew John Brown

Journal articles

Dong J; Du X; Wang H; Wang J; Lu C; Chen X; Zhu Z; Luo Z; Yu L; Brown AJ; Yang H; Wu JW, 2019, 'Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-08791-0

Brown AJ; Chua NK; Yan N, 2019, 'The shape of human squalene epoxidase expands the arsenal against cancer', Nat Commun, 10, pp. 888 - 888, http://dx.doi.org/10.1038/s41467-019-08866-y

Coates HW; Chua NK; Brown AJ, 2019, 'Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene', Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids, 1864, pp. 1656 - 1668, http://dx.doi.org/10.1016/j.bbalip.2019.08.006

Chua NK; Scott NA; Brown AJ, 2019, 'Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron', Biochemical Journal, 476, pp. 2545 - 2560, http://dx.doi.org/10.1042/BCJ20190418

Brown A; Sharpe L, 2019, 'Oxysterols', Encyclopedia of Molecular Pharmacology, 3rd Edition, pp. 1 - 6, http://dx.doi.org/10.1007/978-3-030-21573-6_10016-1

Alrosan A; Aleidi SM; Yang A; Brown AJ; Gelissen IC, 2019, 'The adaptor protein alix is involved in the interaction between the ubiquitin ligase NEDD4-1 and its targets, ABCG1 and ABCG4', International Journal of Molecular Sciences, 20, http://dx.doi.org/10.3390/ijms20112714

Chua NK; Hart-Smith G; Brown AJ, 2019, 'Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase', Journal of Biological Chemistry, 294, pp. 8134 - 8147, http://dx.doi.org/10.1074/jbc.RA119.007798

Sharpe LJ; Howe V; Scott NA; Luu W; Phan L; Berk JM; Hochstrasser M; Brown AJ, 2019, 'Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation', Journal of Biological Chemistry, 294, pp. 2436 - 2448, http://dx.doi.org/10.1074/jbc.RA118.005069

Wang H; Ma Q; Qi Y; Dong J; Du X; Rae J; Wang J; Wu WF; Brown AJ; Parton RG; Wu JW; Yang H, 2019, 'ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P 2 )', Molecular Cell, 73, pp. 458 - 473.e7, http://dx.doi.org/10.1016/j.molcel.2018.11.014

Baker MAB; Brown AJ, 2019, 'A detour to sterol synthesis', Nature Microbiology, 4, pp. 214 - 215, http://dx.doi.org/10.1038/s41564-018-0347-8

Coates HW; Brown AJ, 2019, 'A Wolf in sheep’s clothing: Unmasking the lanosterol-induced degradation of HMG-CoA reductase1', Journal of Lipid Research, 60, pp. 1643 - 1645, http://dx.doi.org/10.1194/jlr.C119000358

Chua NK; Brown AJ, 2018, 'Correction: Mallostery: Filling a niche between quality and metabolic control.', Journal of Biological Chemistry, 293, pp. 16176, http://dx.doi.org/10.1074/jbc.AAC118.006017

Chua NK; Brown AJ, 2018, 'Mallostery: Filling a niche between quality and metabolic control', Journal of Biological Chemistry, 293, pp. 14951 - 14952, http://dx.doi.org/10.1074/jbc.H118.005031

Chua NK; Coates HW; Brown AJ, 2018, 'Cholesterol, cancer, and rebooting a treatment for athlete’s foot', Science Translational Medicine, 10, http://dx.doi.org/10.1126/scitranslmed.aat3741

Aleidi SM; Yang A; Sharpe LJ; Rao G; Cochran BJ; Rye KA; Kockx M; Brown AJ; Gelissen IC, 2018, 'The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages', Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids, 1863, pp. 359 - 368, http://dx.doi.org/10.1016/j.bbalip.2017.12.011

Du X; Zadoorian A; Lukmantara IE; Qi Y; Brown AJ; Yang H, 2018, 'Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of MTORC1 signaling', Journal of Biological Chemistry, 293, pp. 3806 - 3818, http://dx.doi.org/10.1074/jbc.RA117.001558

Brown AJ; Gelissen IC, 2018, 'Cholesterol and desmosterol dancing to the beat of a different drug', Journal of Internal Medicine, 283, pp. 102 - 105, http://dx.doi.org/10.1111/joim.12710

Meerman R; Brown A, 2018, 'Why diets fail: Eating more, moving less', Postgraduate Medical Journal, 94, pp. 65, http://dx.doi.org/10.1136/postgradmedj-2017-135153

Chua NK; Howe V; Jatana N; Thukral L; Brown AJ, 2018, 'A Conserved Degron Containing an Amphipathic Helix Regulates the Cholesterol‐Mediated Turnover of Human Squalene Monooxygenase, a Rate‐Limiting Enzyme in Cholesterol Synthesis', The FASEB Journal, 32, http://dx.doi.org/10.1096/fasebj.2018.32.1_supplement.539.4

Chua NK; Howe V; Jatana N; Thukral L; Brown AJ, 2017, 'A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis', Journal of Biological Chemistry, 292, pp. 19959 - 19973, http://dx.doi.org/10.1074/jbc.M117.794230

Ghai R; Du X; Wang H; Dong J; Ferguson C; Brown AJ; Parton RG; Wu JW; Yang H, 2017, 'ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane', Nature Communications, 8, http://dx.doi.org/10.1038/s41467-017-00861-5

Caruana BT; Skoric A; Brown AJ; Lutze-Mann LH, 2017, 'Site-1 protease, a novel metabolic target for glioblastoma', Biochemical and Biophysical Research Communications, 490, pp. 760 - 766, http://dx.doi.org/10.1016/j.bbrc.2017.06.114

Saratzis A; Dattani N; Brown A; Shalhoub J; Bosanquet D; Sidloff D; Stather P, 2017, 'Multi-Centre Study on Cardiovascular Risk Management on Patients Undergoing AAA Surveillance', European Journal of Vascular and Endovascular Surgery, 54, pp. 116 - 122, http://dx.doi.org/10.1016/j.ejvs.2017.04.009

Howe V; Sharpe LJ; Prabhu AV; Brown AJ, 2017, 'New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis', Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids, 1862, pp. 647 - 657, http://dx.doi.org/10.1016/j.bbalip.2017.03.009

Gelissen IC; Brown AJ, 2017, 'An overview of cholesterol homeostasis', , 1583, pp. 1 - 6, http://dx.doi.org/10.1007/978-1-4939-6875-6_1

Howe V; Brown AJ, 2017, 'Determining the topology of membrane-bound proteins using PEGylation', , 1583, pp. 201 - 210, http://dx.doi.org/10.1007/978-1-4939-6875-6_15

Sharpe LJ; Brown AJ, 2017, 'Identifying sterol response elements within promoters of genes', , 1583, pp. 185 - 191, http://dx.doi.org/10.1007/978-1-4939-6875-6_13

Luu W; Gelissen IC; Brown AJ, 2017, 'Manipulating cholesterol status within cells', , 1583, pp. 41 - 52, http://dx.doi.org/10.1007/978-1-4939-6875-6_4

Prabhu AV; Luu W; Brown AJ, 2017, 'Measuring activity of cholesterol synthesis enzymes using gas chromatography/mass spectrometry', , 1583, pp. 211 - 219, http://dx.doi.org/10.1007/978-1-4939-6875-6_16

Prabhu AV; Luu W; Sharpe LJ; Brown AJ, 2017, 'Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis', Journal of Steroid Biochemistry and Molecular Biology, 165, pp. 363 - 368, http://dx.doi.org/10.1016/j.jsbmb.2016.08.003

Jurczyluk J; Munoz MA; Skinner OP; Chai RC; Ali N; Palendira U; Quinn JMW; Preston A; Tangye SG; Brown AJ; Argent E; Ziegler JB; Mehr S; Rogers MJ, 2016, 'Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases', Immunology and Cell Biology, 94, pp. 994 - 999, http://dx.doi.org/10.1038/icb.2016.58

Prabhu AV; Luu W; Li D; Sharpe LJ; Brown AJ, 2016, 'DHCR7: A vital enzyme switch between cholesterol and vitamin D production', Progress in Lipid Research, 64, pp. 138 - 151, http://dx.doi.org/10.1016/j.plipres.2016.09.003

Howe V; Sharpe LJ; Alexopoulos SJ; Kunze SV; Chua NK; Li D; Brown AJ, 2016, 'Cholesterol homeostasis: How do cells sense sterol excess?', Chemistry and Physics of Lipids, 199, pp. 170 - 178, http://dx.doi.org/10.1016/j.chemphyslip.2016.02.011

Brown A; Saggu GK; Bown MJ; Sayers RD; Sidloff DA, 2016, 'Type II endoleaks: Challenges and solutions', Vascular Health and Risk Management, 12, pp. 53 - 63, http://dx.doi.org/10.2147/VHRM.S81275

Luu W; Sharpe LJ; Capell-Hattam I; Gelissen IC; Brown AJ, 2016, 'Oxysterols: Old Tale, New Twists', Annual Review of Pharmacology and Toxicology, 56, pp. 447 - 467, http://dx.doi.org/10.1146/annurev-pharmtox-010715-103233

Loregger A; Cook ECL; Nelson JK; Moeton M; Sharpe LJ; Engberg S; Karimova M; Lambert G; Brown AJ; Zelcer N, 2016, 'A MARCH6 and IDOL E3 ubiquitin ligase circuit uncouples cholesterol synthesis from lipoprotein uptake in hepatocytes', Molecular and Cellular Biology, 36, pp. 285 - 294, http://dx.doi.org/10.1128/MCB.00890-15

Brown AJ; Hsieh J, 2016, 'Foiling IDOL to help control cholesterol', Circulation Research, 118, pp. 371 - 373, http://dx.doi.org/10.1161/CIRCRESAHA.116.308191

Prabhu AV; Luu W; Sharpe LJ; Brown AJ, 2016, 'Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis', Journal of Biological Chemistry, http://dx.doi.org/10.1074/jbc.M115.699546

Rye KA; Barter PJ; Brown AJ, 2015, 'Speed kills in more ways than one: Methamphetamine and atherosclerosis', Atherosclerosis, 243, pp. 654 - 655, http://dx.doi.org/10.1016/j.atherosclerosis.2015.09.034

Sharpe LJ; Howe V; Prabhu AV; Luu W; Brown AJ, 2015, 'Navigating the shallows and rapids of cholesterol synthesis downstream of HMGCR', Journal of Nutritional Science and Vitaminology, 61, pp. S154 - S156, http://dx.doi.org/10.3177/jnsv.61.S154

Howe V; Chua NK; Stevenson J; Brown AJ, 2015, 'The regulatory domain of squalene monooxygenase contains a re-entrant loop and senses cholesterol via a conformational change', Journal of Biological Chemistry, 290, pp. 27533 - 27544, http://dx.doi.org/10.1074/jbc.M115.675181

Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602

Aleidi SM; Howe V; Sharpe LJ; Yang A; Rao G; Brown AJ; Gelissen IC, 2015, 'The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters', Journal of Biological Chemistry, 290, pp. 24604 - 24613, http://dx.doi.org/10.1074/jbc.M115.675579

Sharpe LJ; Rao G; Jones PM; Glancey E; Aleidi SM; George AM; Brown AJ; Gelissen IC, 2015, 'Cholesterol sensing by the ABCG1 lipid transporter: Requirement of a CRAC motif in the final transmembrane domain', Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids, 1851, pp. 956 - 964, http://dx.doi.org/10.1016/j.bbalip.2015.02.016

Luu W; Hart-Smith G; Sharpe LJ; Brown AJ, 2015, 'The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally', Journal of Lipid Research, 56, pp. 888 - 897, http://dx.doi.org/10.1194/jlr.M056986

Stevenson J; Brown AJ, 2015, 'Universal CG cloning of polymerase chain reaction products', Analytical Biochemistry, 471, pp. 80 - 82, http://dx.doi.org/10.1016/j.ab.2014.10.018

Moon H; Ruelcke JE; Choi E; Sharpe LJ; Nassar ZD; Bielefeldt-Ohmann H; Parat MO; Shah A; Francois M; Inder KL; Brown AJ; Russell PJ; Parton RG; Hill MM, 2015, 'Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1', Oncotarget, 6, pp. 7438 - 7453, http://dx.doi.org/10.18632/oncotarget.3476

Du X; Brown AJ; Yang H, 2015, 'Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites.', Curr Opin Cell Biol, 35, pp. 37 - 42, http://dx.doi.org/10.1016/j.ceb.2015.04.002

Meerman R; Brown A, 2014, 'When somebody loses weight, where does the fat go? (vol 349, pg g7257, 2014)', BMJ-BRITISH MEDICAL JOURNAL, 349, http://dx.doi.org/10.1136/bmj.g7782

Meerman R; Brown AJ, 2014, 'When somebody loses weight, where does the fat go?', BMJ Online, 349, http://dx.doi.org/10.1136/bmj.g7257

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