By Professor Andrew John Brown

Journal articles

Wiklund ED; Catts VS; Catts SV; Ng TF; Whitaker NJ; Brown AJ; Lutze-Mann L, 2010, 'Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic target.', International Journal of Cancer, 126, pp. 28 - 40

Brown AJ, 2010, 'Does upsizing statins have a downside?', Drug Safety, 33, pp. 435 - 436

Gelissen I; Cartland SP; Brown AJ; Sandoval C; Lee Y; Dinnes DL; Hsieh V; Kritharides L; Jessup W; Gaus K, 2010, 'Expression and stability of two isoforms of ABCG1 in human vascular cells.', Atherosclerosis, 208, pp. 75 - 82

Appelqvist H; Nilsson C; Garner B; Brown A; Kågedal K; Karin Öllinger , 2010, 'P2‐211: Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation', Alzheimer's & Dementia, 6, http://dx.doi.org/10.1016/j.jalz.2010.05.1260

Krycer JR; Sharpe LJ; Luu W; Brown AJ, 2010, 'The Akt-SREBP nexus: cell signaling meets lipid metabolism.', Trends in Endocrinology and Metabolism, 21, pp. 268 - 278

Brown AJ, 2009, '24(S),25-Epoxycholesterol: A messenger for cholesterol homeostasis', International Journal of Biochemistry and Cell Biology, 41, pp. 744 - 747

Brown AJ; Kristiana I; Krycer JR, 2009, 'Cholesterol homeostasis in two commonly used human prostate cancer cell-lines, LNCap and PC-3.', PLoS One, 4, pp. e8496

Stevenson J; Brown AJ, 2009, 'How essential is cholesterol?', Biochemical Journal, 420

Brown AJ; Jessup W, 2009, 'Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis', Molecular Aspects of Medicine, 30, pp. 111 - 122

Krycer JR; Brown AJ, 2009, 'Putative Fat Fighter Hits the Middle Man', Chemistry and biology, 16, pp. 798 - 800

Galea AM; Brown AJ, 2009, 'Special relationship between sterols and oxygen: Were sterols an adaptation to aerobic life?', Free Radical Biology and Medicine, 47, pp. 880 - 889

Fei W; Shui G; Gaeta B; Du X; Kuerschner L; Li P; Brown AJ; Wenk MR; Parton RG; Yang H, 2008, 'Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast.', J Cell Biol, 180, pp. 473 - 482, http://dx.doi.org/10.1083/jcb.200711136

Sharpe LJ; Du X; Brown AJ, 2008, 'Approaches to investigate the role of signaling in ER-to-golgi transport', Methods in Molecular Biology, 457, pp. 215 - 225, http://dx.doi.org/10.1007/978-1-59745-261-8_16

McCarthy F; Brown AJ, 2008, 'Autonomous Hedgehog signalling is undetectable in PC-3 prostate cancer cells', Biochemical and Biophysical Research Communications, 373, pp. 109 - 112

Kristiana I; Yang H; Brown AJ, 2008, 'Different kinetics of cholesterol delivery to components of the cholesterol homeostatic machinery: Implications for cholesterol trafficking to the endoplasmic reticulum', Biochimica et Biophysica ACTA - Molecular and Cell Biology of Lipids, 1781, pp. 724 - 730

Wong J; Quinn CM; Gelissen I; Brown AJ, 2008, 'Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis', The Journal of Biological Chemistry, 283, pp. 700 - 707, http://dx.doi.org/10.1074/jbc.M706416200

Yan DB; Mayranpaa M; Wong J; Perttila J; Lehto M; Jauhiainen M; Kovanen P; Ehnholm C; Brown AJ; Olkkonen V, 2008, 'OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages', The Journal of Biological Chemistry, 283, pp. 332 - 340, http://dx.doi.org/10.1074/jbc.M705313200

Sharpe LJ; Brown AJ, 2008, 'Rapamycin down-regulates LDL-receptor expression independently of SREBP-2', Biochemical and Biophysical Research Communications, 373, pp. 670 - 674

Gill S; Chow R; Brown AJ, 2008, 'Sterol regulators of cholesterol homeostasis and beyond: The oxysterol hypothesis revisited and revised', Progress in Lipid Research, 47, pp. 391 - 404

Wong J; Quinn CM; Gelissen I; Jessup W; Brown AJ, 2008, 'The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation', Atherosclerosis, 196, pp. 180 - 189, http://dx.doi.org/10.1016/j.atherosclerosis.2007.03.030

Brown AJ, 2008, 'Viral hepatitis and fatty liver disease: how an unwelcome guest makes pate of the host', Biochemical Journal, 416, pp. e15 - e17

Brown AJ, 2007, 'Cholesterol, statins and cancer.', Clin Exp Pharmacol Physiol, 34, pp. 135 - 141, http://dx.doi.org/10.1111/j.1440-1681.2007.04565.x

Brown AJ, 2007, 'Low-carb diets, fasting and euphoria: Is there a link between ketosis and y-hydroxybutyrate (GHB)?', Journal of Medical Hypotheses, 68, pp. 268 - 271

Yan DB; Mayranpaa M; Wong J; Perttila J; Lehto M; Jauhiainen M; Kovanen P; Ehnholm C; Brown AJ; Olkkonen V, 2007, 'OSBP-related protein 8 (ORP8) regulates ABCA1 expression and cholesterol efflux to apolipoprotein A-I', Chemistry and Physics of Lipids, 149, pp. S73 - S73

Wong J; Quinn CM; Guillemin GJ; Brown AJ, 2007, 'Primary human astrocytes product 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis', Journal of Neurochemistry, 103, pp. 1764 - 1773

Wong J; Quinn CM; Brown AJ, 2007, 'Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol', Lipids in Health and Disease, 6

Jessup W; Gelissen I; Kritharides L; Quinn CM; Kockx M; Brown AJ; Rye K; Harris M; Packianathan M; Cartland SP, 2006, 'ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I', Arteriosclerosis, Thrombosis and Vascular Biology, 26, pp. 534 - 540

Gelissen I; Rye K-A; Quinn C; Brown A; Kockx M; Cartland S; Kritharides L; Jessup W, 2006, 'Concerted action of ABCA1 and ABCG1 in cell cholesterol export', Vascular Pharmacology, 45, pp. e23 - e23, http://dx.doi.org/10.1016/j.vph.2006.08.107

Du X; Kristiana I; Wong J; Brown AJ, 2006, 'Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: a link between a key cell proliferative pathway and membrane synthesis.', Mol Biol Cell, 17, pp. 2735 - 2745, http://dx.doi.org/10.1091/mbc.e05-11-1094

Jessup W; Brown AJ; van Reyk DM; Mattsson Hult en L; Dean RT, 2006, 'Oxysterols in biological systems: sources, metabolism and pathophysiological relevance', Redox Report, 11, pp. 255 - 262

Wong J; Quinn CM; Brown AJ, 2006, 'SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR', Biochemical Journal, 400, pp. 485 - 491

Quinn CM; Jessup W; Wong J; Kritharides L; Brown AJ, 2005, 'Expression and regulation of sterol 27-hydroxylase (CYP27A1) in humanmacrophages: a role for RXR and PPAR gamma ligands', Biochemical Journal, 385, pp. 823 - 830

Brown AJ; Wong J; Quinn CM, 2005, 'Human macrophages can synthesise de novo an oxysterol ligand for the liver X receptor: Effects of statins and consequences for cholesterol efflux', Atherosclerosis Supplements, 6, pp. 96 - 96

Jessup W; Brown AJ, 2005, 'Novel Routes for Metabolism of 7-Ketocholesterol', Rejuvenation Research, 8, pp. 9 - 12, http://dx.doi.org/10.1089/rej.2005.8.9

Du X; Pham YH; Brown AJ, 2004, 'Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in the endoplasmic reticulum.', J Biol Chem, 279, pp. 47010 - 47016, http://dx.doi.org/10.1074/jbc.M408690200

Brown AJ, 2004, 'Of cholesterol-free mice and men', Current Opinion in Lipidology, 15, pp. 373 - 375

Wong J; Quinn CM; Brown AJ, 2004, 'Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux', Arteriosclerosis, Thrombosis and Vascular Biology, 24, pp. 2365 - 2371, http://www.sciencedirect.com/science/article/B6WVB-4DYM7R6-1F1/2/3c81550ef6b4b3f41c3b52d70fee5c03

Jessup W; Quinn CM; Brown AJ; Kritharides L, 2003, 'Expression and regulation of sterol 27-hydroxylase (CYP27A1) in humanmacrophages', Atherosclerosis Supplements, 4, pp. 219 - 219

Lyons MA; Maeda N; Brown AJ, 2002, 'Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice', Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids, 1581, pp. 119 - 126, http://dx.doi.org/10.1016/S1388-1981(02)00156-7

Brown AJ; Sun L; Feramisco JD; Brown MS; Goldstein JL, 2002, 'Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism', Molecular Cell, 10, pp. 237 - 245, http://dx.doi.org/10.1016/S1097-2765(02)00591-9

Upston JM; Niu X; Brown AJ; Mashima R; Wang H; Senthilmohan R; Kettle AJ; Dean RT; Stocker R, 2002, 'Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis', American Journal of Pathology, 160, pp. 701 - 710, http://dx.doi.org/10.1016/S0002-9440(10)64890-0

Gatto LM; Lyons MA; Brown AJ; Samman S, 2002, 'Trans fatty acids affect lipoprotein metabolism in rats', Journal of Nutrition, 132, pp. 1242 - 1248, http://dx.doi.org/10.1093/jn/132.6.1242

Brown AJ, 2002, 'Atherosclerosis: cell biology and lipoproteins: cholesterol absorption inhibitors: gateway therapy for hypercholesterolaemia', Current Opinions in Lipidology, 13, pp. 701 - 703

Brown AJ, 2001, 'Atherosclerosis: Cell biology and lipoproteins', Current Opinion in Lipidology, 12, pp. 671 - 673, http://dx.doi.org/10.1097/00041433-200112000-00012

Upston JM; Witting PK; Brown AJ; Stocker R; Keaney JF, 2001, 'Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbits', Free Radical Biology and Medicine, 31, pp. 1245 - 1253, http://dx.doi.org/10.1016/S0891-5849(01)00721-3

Lyons MA; Maeda N; Brown AJ, 2001, '7-ketocholesterol metabolism is dependent upon sterol 27-hydroxylase in human hepatic cells but not in sterol 27-hydroxylase knockout mice.', HEPATOLOGY, 34, pp. 471A - 471A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000171224701188&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gatto LM; Lyons MA; Brown AJ; Samman S, 2001, 'Trans fatty acids and cholesterol metabolism: Mechanistic studies in rats and rabbits fed semipurified diets', International Journal of Food Sciences and Nutrition, 52, pp. 435 - 441, http://dx.doi.org/10.1080/09637480120078320

Burnett JR; Moses EA; Croft KD; Brown AJ; Grainger K; Vasikaran SD; Leitersdorf E; Watts GF, 2001, 'Clinical and biochemical features, molecular diagnosis and long-term management of a case of cerebrotendinous xanthomatosis', Clinica Chimica Acta, 306, pp. 63 - 69, http://dx.doi.org/10.1016/S0009-8981(01)00391-6

Hamilton JA; Jessup W; Brown AJ; Whitty G, 2001, 'Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL', Biochemical Journal, 355, pp. 207 - 214, http://dx.doi.org/10.1042/bj3550207

HAMILTON JA; JESSUP W; BROWN AJ; WHITTY G, 2001, 'Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL', Biochemical Journal, 355, pp. 207 - 214, http://dx.doi.org/10.1042/bj3550207

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