By Professor Jamie Vandenberg

Journal articles

Perry MD; Wong S; Ng CA; Vandenberg JI, 2013, 'Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels', Journal of General Physiology, 142, pp. 275 - 288, http://dx.doi.org/10.1085/jgp.201310975

Sadrieh A; Mann SA; Subbiah RN; Domanski L; Taylor JA; Vandenberg JI; Hill AP, 2013, 'Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram', Journal of Physiology, 591, pp. 4207 - 4222, http://dx.doi.org/10.1113/jphysiol.2013.251710

Ke Y; Ng CA; Hunter MJ; Mann SA; Heide J; Hill AP; Vandenberg JI, 2013, 'Trafficking defects in PAS domain mutant Kv11.1 channels: Roles of reduced domain stability and altered domain-domain interactions', Biochemical Journal, 454, pp. 69 - 77, http://dx.doi.org/10.1042/BJ20130328

Olesen M; Liang B; Soka M; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Vandenberg JI; Svendsen JH; Haunsø S; Preiss T; Seebohm G; Olesen S-P; Schmitt N; Fatkin D, 2013, 'TASK-1 potassium channel mutations in atrial fibrillation', European Heart Journal, 34, pp. 3411, http://dx.doi.org/10.1093/eurheartj/eht309.3411

Huttner IG; Trivedi G; Jacoby A; Mann SA; Vandenberg JI; Fatkin D, 2013, 'A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death', Journal of Molecular and Cellular Cardiology, 61, pp. 123 - 132, http://dx.doi.org/10.1016/j.yjmcc.2013.06.005

Vandenberg J, 2013, '2SDP-03 Ion channel gating and Japanese Puzzle Boxes(2SDP ASB-BSJ Bilateral Symposium 2013,Symposium,The 51th Annual Meeting of the Biophysical Society of Japan)', Seibutsu Butsuri, 53, pp. S99 - S99, http://dx.doi.org/10.2142/biophys.53.s99_3

Martin I; Trivedi G; Jacoby A; Mann S; Vandenberg J; Fatkin D, 2013, 'A Transgenic Zebrafish Model of a Human Cardiac Sodium Channel Mutation Exhibits Bradycardia, Conduction-System Abnormalities and Early Death', Heart, Lung and Circulation, 22, pp. S227 - S227, http://dx.doi.org/10.1016/j.hlc.2013.05.539

Mann S; Sadrieh A; Subbiah R; Domanski L; Taylor J; Vandenberg J; Hill A, 2013, 'Epistatic Interactions of Ion Channels Underlie Variability in Cardiac Electrical Activity. In-silico Analysis of the Electrocardiogram', Heart Lung and Circulation, 22, pp. s95 - s96, http://dx.doi.org/10.1016/j.hlc.2013.05.226

Mann SA; Castro ML; Ohanian M; Guo G; Zodgekar P; Sheu A; Stockhammer K; Thompson T; Playford D; Subbiah R; Kuchar D; Aggarwal A; Vandenberg JI; Fatkin D, 2012, 'R222Q SCN5A mutation is associated with reversible ventricular ectopy and dilated cardiomyopathy.', J Am Coll Cardiol, 60, pp. 1566 - 1573, http://dx.doi.org/10.1016/j.jacc.2012.05.050

Mann SA; Otway R; Guo G; Soka M; Karlsdotter L; Trivedi G; Ohanian M; Zodgekar P; Smith RA; Wouters MA; Subbiah RN; Walker BD; Kuchar D; Sanders P; Griffiths LR; Vandenberg JI; Fatkin D, 2012, 'Epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk', Journal of the American College of Cardiology, 59, pp. 1017 - 1025, http://dx.doi.org/10.1016/j.jacc.2011.11.039

Vandenberg JI; Perry MD; Mann SA; Hill A, 2012, 'hERG K+ CHANNELS: STRUCTURE, FUNCTION, AND CLINICAL SIGNIFICANCE', Physiological Reviews, 92, pp. 1393 - 1478, http://dx.doi.org/10.1152/physrev.00036.2011

Vandenberg JI, 2012, 'Hodgkin and Huxley and the basis for electrical signalling: a remarkable legacy still going strong', The Journal of Physiology, 590, pp. 2569 - 2570, http://dx.doi.org/10.1113/jphysiol.2012.233411

Vandenberg JI; Ng CA, 2012, 'Insights into hERG K+ channel structure and function from NMR studies', European Biophysics Journal With Biophysics Letters, 42, pp. 71 - 79, http://dx.doi.org/10.1007/s00249-012-0808-6

Vandenberg JI, 2012, 'Is medroxyprogesterone safe in women with long QT syndrome?', Heart Rhythm, 9, pp. 1148 - 1149, http://dx.doi.org/10.1016/j.hrthm.2012.02.029

Ng CA; Perry M; Tan P; Hill A; Kuchel PW; Vandenberg JI, 2012, 'The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating', PLoS ONE, 7, pp. e31640, http://dx.doi.org/10.1371/journal.pone.0031640

Heide J; Mann SA; Vandenberg JI, 2012, 'The Schizophrenia-Associated Kv11.1-3.1 Isoform Results in Reduced Current Accumulation during Repetitive Brief Depolarizations', PLoS ONE, 7, pp. e45624, http://dx.doi.org/10.1371/journal.pone.0045624

Tan PS; Perry MD; Ng C; Vandenberg JI; Hill A, 2012, 'Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels', Journal of General Physiology, 140, pp. 293 - 306, http://dx.doi.org/10.1085/jgp.201110761

Szekely D; Vandenberg JI; Dokos S; Hill A, 2011, 'An improved curvilinear gradient method for parameter optimization in complex biological models', Medical and Biological Engineering and Computing, 49, pp. 289 - 296, http://dx.doi.org/10.1007/s11517-010-0667-1

Ng C; Hunter M; Perry M; Mobli M; Ke Y; Kuchel PW; King GF; Stock D; Vandenberg JI; Hunter M, 2011, 'The N-terminal tail of hERG contains an amphipathic alpha-helix that regulates channel deactivation', PLoS One, 6, pp. e16191, http://dx.doi.org/10.1371/journal.pone.0016191

Clarke O; Caputo A; Hill A; Vandenberg JI; Smith B; Gulbis J, 2010, 'Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels', Cell, 141, pp. 1018 - 1029, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20564790

Wang DT; Hill A; Mann SA; Tan P; Vandenberg JI, 2010, 'Mapping the sequence of conformational changes underlying selectivity filter gating in the K(v)11.1 potassium channel', Nature Structural and Molecular Biology, 18, pp. 35 - 41, http://dx.doi.org/10.1038/nsmb.1966

Perrin MJ; Campbell TJ; Hill AP; Vandenberg JI, 2009, 'Insight into Accurate Testing of Drugs which Cause the Acquired Long-QT Syndrome', Heart, Lung and Circulation, 18, pp. S135 - S135, http://dx.doi.org/10.1016/j.hlc.2009.05.306

Zhao JT; Hill A; Varghese A; Cooper A; Swan H; Laitinen-Forsblom P; Rees M; Skinner J; Campbell TJ; Vandenberg JI, 2009, 'Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype', Journal of Cardiovascular Electrophysiology, 20, pp. 923 - 930, http://dx.doi.org/10.1111/j.1540-8167.2009.01468.x

Pages G; Torres A; Ju P; Bansal PS; Alewood P; Kuchel PW; Vandenberg JI, 2009, 'Structure of the pore-helix of the hERG K(+) channel', European Biophysics Journal, 39, pp. 111 - 120, http://dx.doi.org/10.1007/s00249-009-0433-1

Ju P; Pages G; Riek RP; Chen P-C; Torres A; Bansal PS; Kuyucak S; Kuchel PW; Vandenberg JI, 2009, 'The pore domain outer helix contributes to both activation and inactivation of the hERG K+ channel', The Journal of Biological Chemistry, 284, pp. 1000 - 1006, http://dx.doi.org/10.1074/jbc.M806400200

Perrin MJ; Kuchel PW; Campbell TJ; Vandenberg JI, 2008, 'Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-à-go-go-Related Gene Channels', Molecular Pharmacology, 74, pp. 1443 - 1452, http://dx.doi.org/10.1124/mol.108.049056

Perrin MJ; Subbiah RN; Vandenberg JI; Hill A, 2008, 'Human ether-a-go-go related gene (hERG) K+ channels: Function and dysfunction', Progress in Biophysics and Molecular Biology, 98, pp. 137 - 148

Bansal PS; Torres A; Crossett B; Wong KK; Koh JM; Geraghty D; Vandenberg JI; Kuchel PW, 2008, 'Substrate specificity of platypus venom L-to-D-peptide isomerase', The Journal of Biological Chemistry, 283, pp. 8969 - 8975, http://dx.doi.org/10.1074/jbc.M709762200

Clarke CE; Veale E; Wyse KR; Vandenberg JI; Mathie A, 2008, 'The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function', The Journal of Biological Chemistry, 283, pp. 16985 - 16992, http://dx.doi.org/10.1074/jbc.M801368200

Otway R; Vandenberg JI; Fatkin D, 2007, 'Atrial Fibrillation-A New Cardiac Channelopathy', Heart Lung and Circulation, 16, pp. 356 - 360, http://dx.doi.org/10.1016/j.hlc.2007.07.003

Fatkin D; Otway R; Vandenberg JI, 2007, 'Genes and atrial fibrillation: a new look at an old problem.', Circulation, 116, pp. 782 - 792, http://dx.doi.org/10.1161/CIRCULATIONAHA.106.688889

Otway R; Vandenberg JI; Guo G; Varghese A; Castro ML; Liu J; Zhao J; Bursill JA; Wyse KR; Crotty H; Baddeley O; Walker B; Kuchar D; Thorburn C; Fatkin D, 2007, 'Stretch-sensitive KCNQ1 mutation A link between genetic and environmental factors in the pathogenesis of atrial fibrillation?', J Am Coll Cardiol, 49, pp. 578 - 586, http://dx.doi.org/10.1016/j.jacc.2006.09.044

Hill A; Sunde M; Campbell TJ; Vandenberg JI, 2007, 'Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1', Biophysical Journal, 92, pp. 3915 - 3929

Hill A; Sunde M; Vandenberg JI, 2007, 'Mechanisms of block of the hERG K+ channel by the scorpion toxin CnErg1', Biophysical Journal, pp. 124A - 124A

Kutteh R; Vandenberg JI; Kuyucak S, 2007, 'Molecular dynamics and continuum electrostatics studies of inactivation in the HERG potassium channel', Journal of Physical Chemistry B, 111, pp. 1090 - 1098

Hill A; Campbell TJ; Bansal PS; Kuchel PW; Vandenberg JI, 2007, 'The S631A mutation causes a mechanistic switch in the block of hERG channels by CnErgl', Biophysical Journal, 93, pp. 32 - 34

Clarke CE; Hill AP; Zhao J; Kondo M; Subbiah RN; Campbell TJ; Vandenberg JI, 2006, 'Effect of S5P α-helix charge mutants on inactivation of hERG K+ channels', Journal of Physiology, 573, pp. 291 - 304, http://dx.doi.org/10.1113/jphysiol.2006.108332

Vandenberg JI; Varghese A; Lu Y; Bursill JA; Mahaut-Smith MP; Huang CL, 2006, 'Temperature dependence of human ether-a-go-go-related gene K+ currents', American Journal of Physiology - Cell Physiology, 291, pp. C165 - C175

Subbiah RN; Kondo M; Campbell TJ; Vandenberg JI, 2005, 'Tryptophan scanning mutagenesis of the HERG K+ channel: The S4 domain is loosely packed and likely to be lipid exposed', Journal of Physiology, 569, pp. 367 - 379, http://dx.doi.org/10.1113/jphysiol.2005.097386

Subbiah RN; Campbell TJ; Vandenberg JI, 2005, 'Ion channelopathies: What have they taught us about arrhythmias and anti-arrhythmic therapy', Clinical and Experimental Pharmacology and Physiology, 32, pp. 595 - 595

Lei M; Goddard C; Liu J; Leoni A; Royer A; Fung SS; Xiao G; Ma A; Zhang H; Charpentier F; Vandenberg JI; Colledge WH; Grace AA; Huang SH, 2005, 'Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a', The Journal of Physiology, 567, pp. 387 - 400

Vandenberg JI; Torres AM; Campbell TJ; Kuchel PW, 2004, 'Erratum: The HERG K+ channel: Progress in understanding the molecular basis of its unusual gating kinetics (European Biophysics Journal (2004) 33 (89-97))', European Biophysics Journal, 33, pp. 468

Vandenberg JI; Torres AM; Campbell TJ; Kuchel PW, 2004, 'The HERG K+ channel: Progress in understanding the molecular basis of its unusual gating kinetics', European Biophysics Journal, 33, pp. 89 - 97, http://dx.doi.org/10.1007/s00249-003-0338-3

Davies W; Vandenberg JI; Sayeed R; Trezise AE, 2004, 'Cardiac expression of the cystic fibrosis transmembrane conductanceregulator involves novel Exon 1 usage to produce a uniqueamino-terminal protein', The Journal of Biological Chemistry, 279, pp. 15877 - 15887

Fahmi A; Forhead A; Fowden A; Vandenberg JI, 2004, 'Cortisol influences the ontogeny of both alpha- and beta-subunits ofthe cardiac sodium channel in fetal sheep', Journal of Endocrinology, 180, pp. 449 - 455

Subbiah RN; Campbell TJ; Vandenberg JI, 2004, 'Inherited cardiac arrhythmia syndromes: What have they taught us aboutarrhythmias and anti-arrhythmic therapy?', Clinical and Experimental Pharmacology and Physiology, 31, pp. 906 - 912

Subbiah RN; Clarke CE; Smith DG; Zha J; Campbell TJ; Vandenberg JI, 2004, 'Molecular basis of slow activation of the human ether-a-go-go relatedgene potassium channel', The Journal of Physiology, 558, pp. 417 - 431

Davies W; Vandenberg JI; Sayeed R; Trezise AE, 2004, 'Post-transcriptional regulation of the cystic fibrosis gene in cardiac development and hypertrophy', Biochemical and Biophysical Research Communications, 319, pp. 410 - 418, http://www.sciencedirect.com/science/article/B6WBK-4CDHG1F-6/2/558a466d4fddc279cf3c1ab516bf5708

Martinez-Pinna J; Tolhurst G; Gurung I; Vandenberg JI; Mahaut-Smith MP, 2004, 'Sensitivity limits for voltage control of P2Y receptor-evoked Ca2+mobilization in the rat megakaryocyte', The Journal of Physiology, 555, pp. 61 - 70

Vandenberg JI; Torres AM; Campbell TJ; Kuchel PW, 2004, 'The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics', European Biophysics Journal, 33, pp. 468 - 468, http://dx.doi.org/10.1007/s00249-004-0419-y

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