By Professor Jamie Vandenberg

Journal articles

Zhao JT; Hill A; Varghese A; Cooper A; Swan H; Laitinen-Forsblom P; Rees M; Skinner J; Campbell TJ; Vandenberg JI, 2009, 'Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype', Journal of Cardiovascular Electrophysiology, 20, pp. 923 - 930, http://dx.doi.org/10.1111/j.1540-8167.2009.01468.x

Pages G; Torres A; Ju P; Bansal PS; Alewood P; Kuchel PW; Vandenberg JI, 2009, 'Structure of the pore-helix of the hERG K(+) channel', European Biophysics Journal, 39, pp. 111 - 120, http://dx.doi.org/10.1007/s00249-009-0433-1

Ju P; Pages G; Riek RP; Chen P-C; Torres A; Bansal PS; Kuyucak S; Kuchel PW; Vandenberg JI, 2009, 'The pore domain outer helix contributes to both activation and inactivation of the hERG K+ channel', The Journal of Biological Chemistry, 284, pp. 1000 - 1006, http://dx.doi.org/10.1074/jbc.M806400200

Kuchel PW; Perrin MJ; Campbell TJ; Vandenberg JI, 2008, 'Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-a-go-go-Related Gene Channels', Molecular Pharmacology, 74, pp. 1443 - 1452

Perrin MJ; Subbiah RN; Vandenberg JI; Hill A, 2008, 'Human ether-a-go-go related gene (hERG) K+ channels: Function and dysfunction', Progress in Biophysics and Molecular Biology, 98, pp. 137 - 148

Bansal PS; Torres A; Crossett B; Wong KK; Koh JM; Geraghty D; Vandenberg JI; Kuchel PW, 2008, 'Substrate specificity of platypus venom L-to-D-peptide isomerase', The Journal of Biological Chemistry, 283, pp. 8969 - 8975, http://dx.doi.org/10.1074/jbc.M709762200

Clarke CE; Veale E; Wyse KR; Vandenberg JI; Mathie A, 2008, 'The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function', The Journal of Biological Chemistry, 283, pp. 16985 - 16992, http://dx.doi.org/10.1074/jbc.M801368200

Otway R; Vandenberg JI; Fatkin D, 2007, 'Atrial Fibrillation-A New Cardiac Channelopathy', Heart Lung and Circulation, 16, pp. 356 - 360, http://dx.doi.org/10.1016/j.hlc.2007.07.003

Fatkin D; Otway R; Vandenberg JI, 2007, 'Genes and atrial fibrillation - A new look at an old problem', Circulation, 116, pp. 782 - 792

Hill A; Sunde M; Campbell TJ; Vandenberg JI, 2007, 'Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1', Biophysical Journal, 92, pp. 3915 - 3929

Hill A; Sunde M; Vandenberg JI, 2007, 'Mechanisms of block of the hERG K+ channel by the scorpion toxin CnErg1', Biophysical Journal, pp. 124A - 124A

Kutteh R; Vandenberg JI; Kuyucak S, 2007, 'Molecular dynamics and continuum electrostatics studies of inactivation in the HERG potassium channel', Journal of Physical Chemistry B, 111, pp. 1090 - 1098

Otway R; Vandenberg JI; Guo G; Varghese A; Castro ML; Liu JJ; Zhao J; Bursill JA; Wyse KR; Crotty H; Baddeley O; Walker BD; Kuchar D; Thorburn CW; Fatkin D, 2007, 'Stretch-sensitive KCNQ1 mutation - A link between genetic and environmental factors in the pathogenesis of atrial fibrillation?', Journal of the American College of Cardiology, 49, pp. 578 - 586

Hill A; Campbell TJ; Bansal PS; Kuchel PW; Vandenberg JI, 2007, 'The S631A mutation causes a mechanistic switch in the block of hERG channels by CnErgl', Biophysical Journal, 93, pp. 32 - 34

Clarke CE; Hill A; Kondo M; Subbiah RN; Campbell TJ; Vandenberg JI, 2006, 'Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels', The Journal of Physiology, 573, pp. 291 - 304

Vandenberg JI; Varghese A; Lu Y; Bursill JA; Mahaut-Smith MP; Huang CL, 2006, 'Temperature dependence of human ether-a-go-go-related gene K+ currents', American Journal of Physiology - Cell Physiology, 291, pp. C165 - C175

Subbiah RN; Campbell TJ; Vandenberg JI, 2005, 'Ion channelopathies: What have they taught us about arrhythmias and anti-arrhythmic therapy', Clinical and Experimental Pharmacology and Physiology, 32, pp. 595 - 595

Lei M; Goddard C; Liu J; Leoni A; Royer A; Fung SS; Xiao G; Ma A; Zhang H; Charpentier F; Vandenberg JI; Colledge WH; Grace AA; Huang SH, 2005, 'Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a', The Journal of Physiology, 567, pp. 387 - 400

Subbiah RN; Kondo M; Campbell TJ; Vandenberg JI, 2005, 'Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed', The Journal of Physiology, 569, pp. 367 - 379

Vandenberg JI; Torres AM; Campbell TJ; Kuchel PW, 2004, 'Erratum: The HERG K⁺ channel: Progress in understanding the molecular basis of its unusual gating kinetics (European Biophysics Journal (2004) 33 (89-97))', European Biophysics Journal, 33, pp. 468

Vandenberg JI; Torres AM; Campbell TJ; Kuchel PW, 2004, 'The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics (vol 33, pg 89, 2004)', EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 33, pp. 468 - 468, http://dx.doi.org/10.1007/s00249-004-0419-y

Vandenberg JI; Torres AM; Campbell TJ; Kuchel PW, 2004, 'The HERG K⁺ channel: Progress in understanding the molecular basis of its unusual gating kinetics', European Biophysics Journal, 33, pp. 89 - 97, http://dx.doi.org/10.1007/s00249-003-0338-3

Davies W; Vandenberg JI; Sayeed R; Trezise AE, 2004, 'Cardiac expression of the cystic fibrosis transmembrane conductanceregulator involves novel Exon 1 usage to produce a uniqueamino-terminal protein', The Journal of Biological Chemistry, 279, pp. 15877 - 15887

Fahmi A; Forhead A; Fowden A; Vandenberg JI, 2004, 'Cortisol influences the ontogeny of both alpha- and beta-subunits ofthe cardiac sodium channel in fetal sheep', Journal of Endocrinology, 180, pp. 449 - 455

Subbiah RN; Campbell TJ; Vandenberg JI, 2004, 'Inherited cardiac arrhythmia syndromes: What have they taught us aboutarrhythmias and anti-arrhythmic therapy?', Clinical and Experimental Pharmacology and Physiology, 31, pp. 906 - 912

Subbiah RN; Clarke CE; Smith DG; Zha J; Campbell TJ; Vandenberg JI, 2004, 'Molecular basis of slow activation of the human ether-a-go-go relatedgene potassium channel', The Journal of Physiology, 558, pp. 417 - 431

Davies W; Vandenberg JI; Sayeed R; Trezise AE, 2004, 'Post-transcriptional regulation of the cystic fibrosis gene in cardiac development and hypertrophy', Biochemical and Biophysical Research Communications, 319, pp. 410 - 418, http://www.sciencedirect.com/science/article/B6WBK-4CDHG1F-6/2/558a466d4fddc279cf3c1ab516bf5708

Martinez-Pinna J; Tolhurst G; Gurung I; Vandenberg JI; Mahaut-Smith MP, 2004, 'Sensitivity limits for voltage control of P2Y receptor-evoked Ca2+mobilization in the rat megakaryocyte', The Journal of Physiology, 555, pp. 61 - 70

Vandenberg JI; Torres M; Campbell TJ; Kuchel PW, 2004, 'The HERGK+ channel: Progress in understanding the molecular basis of its unusual gating kinetics.', European Biophysics Journal With Biophysics Letters, 33, pp. 80 - 97

Balasubramaniam RN; Grace AA; Saumarez R; Vandenberg JI; Huang CL, 2003, 'Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias following targeted disruption of KCNE1', Journal of Physiology - Paris, 552, pp. 535 - 546

Singarayar SB; Bursill JA; Wyse KR; Bauskin AR; Wu WM; Vandenberg JI; Breit SN; Campbell TJ, 2003, 'Extracellular acidosis modulates drug block of Kv4.3 currents by flecainide and quinidine', Journal of Cardiovascular Electrophysiology, 14, pp. 641 - 650

Lu Y; Mahaut-Smith MP; Huang CL; Vandenberg JI, 2003, 'Mutant MiRP1 subunits modulate HERG K+ channel gating: A mechanism for pro-arrhythmia in Long QT Syndrome type 6', Journal of Physiology - Paris, 551, pp. 253 - 262

Vandenberg JI; Kuchel PW, 2003, 'Nobel Prizes for Magnetic Resonance Imaging and Channel Proteins', Medical Journal of Australia, 179, pp. 611 - 613

Torres A; Bansal PS; Alewood P; Bursill JA; Vandenberg JI; Kuchel PW, 2003, 'Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin', FEBS Letters, 539, pp. 138 - 142, http://dx.doi.org/10.1016/S0014-5793(03)00216-3

Torres M; Bansal PS; Sunde M; Clarke CE; Bursill JA; Smith DG; Bauskin AR; Breit SN; Campbell TJ; Alewood P; Kuchel PW; Vandenberg JI, 2003, 'Structure of the HERGK+ channel S5P extracellulal linker: Role of an amphipathic a-helix in C-type inactivation.', Journal of Biochemistry, 278, pp. 42136 - 42148

Zhao J; Pettigrew GJ; Thomas J; Vandenberg JI; Delriviere L; Bolton EM; Carmichael A; Martin JL; Marber MS; Lever AML, 2002, 'Lentiviral vectors for delivery of genes into neonatal and adult ventricular cardiac myocytes in vitro and in vivo', Basic Research in Cardiology, 97, pp. 348 - 358, http://dx.doi.org/10.1007/s00395-002-0360-0

Papadatos GA; Wallerstein PMR; Head CEG; Ratcliff R; Brady PA; Benndorf K; Saumarez RC; Trezise AEO; Huang CLH; Vandenberg JI; Colledge WH; Grace AA, 2002, 'Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a', Proceedings of the National Academy of Sciences of the United States of America, 99, pp. 6210 - 6215, http://dx.doi.org/10.1073/pnas.082121299

Lu Y; Mahaut-Smith MP; Varghese A; Huang CL-H; Kemp PR; Vandenberg JI, 2001, 'Effects of premature stimulation on HERG K+ channels', The Journal of Physiology, 537, pp. 843 - 851, http://dx.doi.org/10.1113/jphysiol.2001.012690

Yu Lu M; Mahaut-Smith P; Varghese A; Huang CLH; Kemp PR; Vandenberg JI, 2001, 'Effects of premature stimulation on HERG K⁺ channels', Journal of Physiology, 537, pp. 843 - 851, http://dx.doi.org/10.1113/jphysiol.2001.012690

Fahmi AI; Patel M; Stevens EB; Fowden AL; John JE; Lee K; Pinnock R; Morgan K; Jackson AP; Vandenberg JI, 2001, 'The sodium channel β-subunits SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart', Journal of Physiology, 537, pp. 693 - 700, http://dx.doi.org/10.1113/jphysiol.2001.012691

Vandenberg J; Sheikh SM; Skepper JN; Chawla S; Elneil S; Huang CL, 2001, 'Normal conduction of surface action potentials in detubulated amphibian skeletal muscle fibres.', The Journal of Physiology, 535, pp. 579 - 590

Sheikh SM; Skepper JN; Chawla S; Vandenberg JI; Elneil S; Huang CL, 2001, 'Normal conduction of surface action potentials in detubulated amphibian skeletal muscle fibres.', J Physiol, 535, pp. 579 - 590, http://dx.doi.org/10.1111/j.1469-7793.2001.t01-1-00579.x

Vandenberg JI; Walker BD; Campbell TJ, 2001, 'HERG K⁺ channels: Friend and foe', Trends in Pharmacological Sciences, 22, pp. 240 - 246, http://dx.doi.org/10.1016/S0165-6147(00)01662-X

Smith GA; Vandenberg JI; Freestone NS; Dixon HBF, 2001, 'The effect of Mg²⁺ on cardiac muscle function: Is CaATP the substrate for priming myofibril cross-bridge formation and Ca²⁺ reuptake by the sarcoplasmic reticulum?', Biochemical Journal, 354, pp. 539 - 551, http://dx.doi.org/10.1042/0264-6021:3540539

Wong KR; Trezise AEO; Crozatier B; Vandenberg JI, 2000, 'Loss of the normal epicardial to endocardial gradient of cftr mRNA expression in the hypertrophied rabbit left ventricle', Biochemical and Biophysical Research Communications, 278, pp. 144 - 149, http://dx.doi.org/10.1006/bbrc.2000.3754

Vandenberg JI; Lummis SCR, 2000, 'Ion channels - A plethora of pharmaceutical targets', Trends in Pharmacological Sciences, 21, pp. 409 - 410, http://dx.doi.org/10.1016/S0165-6147(00)01558-3

Keevil VL; Huang CLH; Chau PL; Sayeed RA; Vandenberg JI, 2000, 'The effect of heptanol on the electrical and contractile function of the isolated, perfused rabbit heart', Pflugers Archiv European Journal of Physiology, 440, pp. 275 - 282, http://dx.doi.org/10.1007/s004240051049

Wong KR; Trezise AEO; Vandenberg JI, 2000, 'Developmental regulation of the gradient of cftr expression in the rabbit heart', Mechanisms of Development, 94, pp. 195 - 197, http://dx.doi.org/10.1016/S0925-4773(00)00312-9

Smith GA; Dixon HBF; Kirschenlohr HL; Grace AA; Metcalfe JC; Vandenberg JI, 2000, 'Ca²⁺ buffering in the heart: Ca²⁺ binding to and activation of cardiac myofibrils', Biochemical Journal, 346, pp. 393 - 402, http://dx.doi.org/10.1042/0264-6021:3460393

Kirschenlohr HL; Grace AA; Vandenberg JI; Metcalfe JC; Smith GA, 2000, 'Estimation of systolic and diastolic free intracellular Ca²⁺ by titration of Ca²⁺ buffering in the ferret heart', Biochemical Journal, 346, pp. 385 - 391, http://dx.doi.org/10.1042/0264-6021:3460385

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