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Journal articles

Copier JS; Bootsma M; Ng CA; Wilde AAM; Bertels RA; Bikker H; Christiaans I; van der Crabben SN; Hol JA; Koopmann TT; Knijnenburg J; Lommerse AAJ; van der Smagt JJ; Bezzina CR; Vandenberg JI; Verkerk AO; Barge-Schaapveld DQCM; Lodder EM, 2023, 'Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance.', Hum Mol Genet, vol. 32, pp. 1072 - 1082,

Tardo DT; Peck M; Subbiah R; Vandenberg JI; Hill AP, 2023, 'The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review', Annals of Noninvasive Electrocardiology, vol. 28, pp. e13015,

Lau C; Flood E; Hunter M; Corbett K; Ng C; Bouwer J; Stewart A; Perozo E; Allen TW; Vandenberg J, 2023, 'Structural basis of rapid inactivation of HERG potassium channels', Biophysical Journal, vol. 122, pp. 446a - 446a,

Bursill CA; Smith NJ; Palpant N; Tan I; Sunde M; Harvey RP; Lewis B; Figtree GA; Vandenberg JI, 2022, 'Don't Turn Off the Tap! The Importance of Discovery Science to the Australian Cardiovascular Sector and Improving Clinical Outcomes Into the Future', Heart Lung and Circulation, vol. 31, pp. 1321 - 1332,

Windley MJ; Farr J; TeBay C; Vandenberg JI; Hill AP, 2022, 'High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol', Journal of Pharmacological and Toxicological Methods, vol. 117, pp. 107192,

Jiang C; Richardson E; Farr J; Hill AP; Ullah R; Kroncke BM; Harrison SM; Thomson KL; Ingles J; Vandenberg JI; Ng CA, 2022, 'A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome', American Journal of Human Genetics, vol. 109, pp. 1199 - 1207,

Ng CA; Ullah R; Farr J; Hill AP; Kozek KA; Vanags LR; Mitchell DW; Kroncke BM; Vandenberg JI, 2022, 'A massively parallel assay accurately discriminates between functionally normal and abnormal variants in a hotspot domain of KCNH2', American Journal of Human Genetics, vol. 109, pp. 1208 - 1216,

TeBay C; McArthur JR; Mangala M; Kerr N; Heitmann S; Perry MD; Windley MJ; Vandenberg JI; Hill AP, 2022, 'Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation', British Journal of Pharmacology, vol. 179, pp. 2631 - 2646,

Kerr NP; Vandenberg JI, 2022, 'The yin and yang of Tbx5 variant effects on sodium channel function', Cardiovascular Research, vol. 118, pp. 929 - 931,

Peters S; Thompson BA; Perrin M; James P; Zentner D; Kalman JM; Vandenberg JI; Fatkin D, 2022, 'Arrhythmic Phenotypes Are a Defining Feature of Dilated Cardiomyopathy-Associated SCN5A Variants: A Systematic Review', Circulation: Genomic and Precision Medicine, vol. 15, pp. E003432,

Ng CA; Vandenberg JI, 2022, 'When it takes two to get one into trouble', Heart Rhythm, vol. 19, pp. 293 - 294,

Jiang C; Richardson E; Farr J; Hill A; Ullah R; Kroncke B; Harrison S; Thomson K; Ingles J; Vandenberg J; Ng C, 2022, 'A Calibrated Functional Patch Clamp Assay to Enhance Clinical Variant Interpretation in KCNH2-Related Long QT Syndrome', Heart, Lung and Circulation, vol. 31, pp. S37 - S37,

Ballouz S; Mangala MM; Perry MD; Heitmann S; Gillis JA; Hill AP; Vandenberg JI, 2021, 'Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events', Cardiovascular Research, vol. 117, pp. 2216 - 2227,

Heitmann S; Shpak A; Vandenberg JI; Hill AP, 2021, 'Arrhythmogenic effects of ultra-long and bistable cardiac action potentials', PLoS Computational Biology, vol. 17,

Ng CA; Farr J; Young P; Windley MJ; Perry MD; Hill AP; Vandenberg JI, 2021, 'Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-Throughput automated patch clamp electrophysiology', Biology Methods and Protocols, vol. 6, pp. bpab003,

Ng C-A; Farr J; Young P; Windley M; Perry M; Hill A; Vandenberg J, 2021, 'HeterozygousKCNH2variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology', ,

Kozek KA; Glazer AM; Ng CA; Blackwell D; Egly CL; Vanags LR; Blair M; Mitchell D; Matreyek KA; Fowler DM; Knollmann BC; Vandenberg JI; Roden DM; Kroncke BM, 2020, 'High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1', Heart Rhythm, vol. 17, pp. 2180 - 2189,

Heitmann S; Vandenberg JI; Hill AP, 2020, 'Arrhythmogenesis as the failure of repolarization', ,

Perry MD; Ng CA; Mangala MM; Ng TYM; Hines AD; Liang W; Xu MJO; Hill AP; Vandenberg JI, 2020, 'Pharmacological activation of IKrin models of long QT Type 2 risks overcorrection of repolarization', Cardiovascular Research, vol. 116, pp. 1434 - 1445,

Ganesan AN; Vanoye CG; Alam F; Waddell-Smith KE; McGavigan AD; Correnti G; Haan E; Brown A; Vandenberg J; George AL, 2020, 'Long QT syndrome type 1 in an Australian indigenous patient', Circulation: Genomic and Precision Medicine, vol. 13, pp. 93 - 94,

Ng CA; Perry MD; Liang W; Smith NJ; Foo B; Shrier A; Lukacs GL; Hill AP; Vandenberg JI, 2020, 'High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants', Heart Rhythm, vol. 17, pp. 492 - 500,

Li Z; Mirams GR; Yoshinaga T; Ridder BJ; Han X; Chen JE; Stockbridge NL; Wisialowski TA; Damiano B; Severi S; Morissette P; Kowey PR; Holbrook M; Smith G; Rasmusson RL; Liu M; Song Z; Qu Z; Leishman DJ; Steidl-Nichols J; Rodriguez B; Bueno-Orovio A; Zhou X; Passini E; Edwards AG; Morotti S; Ni H; Grandi E; Clancy CE; Vandenberg J; Hill A; Nakamura M; Singer T; Polonchuk L; Greiter-Wilke A; Wang K; Nave S; Fullerton A; Sobie EA; Paci M; Musuamba Tshinanu F; Strauss DG, 2020, 'General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy', Clinical Pharmacology and Therapeutics, vol. 107, pp. 102 - 111,

Munawar S; Vandenberg JI; Jabeen I, 2019, 'Molecular docking guided grid-independent descriptor analysis to probe the impact ofwater molecules on conformational changes of hERG inhibitors in drug trapping phenomenon', International Journal of Molecular Sciences, vol. 20,

Lee W; Windley MJ; Perry MD; Vandenberg JI; Hill AP, 2019, 'Protocol-dependent differences in IC50 values measured in human ether-á-go-go–related gene assays occur in a predictable way and can be used to quantify state preference of drug binding', Molecular Pharmacology, vol. 95, pp. 537 - 550,

Tardo D; Peck M; Hill A; Vandenberg J, 2019, 'T Wave Morphology Biomarkers in Congenital and Acquired Long QT Syndrome', Heart, Lung and Circulation, vol. 28, pp. S229 - S229,

Munawar S; Windley MJ; Tse EG; Todd MH; Hill AP; Vandenberg JI; Jabeen I, 2018, 'Experimentally validated pharmacoinformatics approach to predict hERG inhibition potential of new chemical entities', Frontiers in Pharmacology, vol. 9,

Beattie KA; Hill AP; Bardenet R; Cui Y; Vandenberg JI; Gavaghan DJ; de Boer TP; Mirams GR, 2018, 'Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics', Journal of Physiology, vol. 596, pp. 1813 - 1828,

Lau C; Hunter MJ; Stewart A; Perozo E; Vandenberg JI, 2018, 'Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy', Journal of Physiology, vol. 596, pp. 1107 - 1119,

Windley MJ; Lee W; Vandenberg JI; Hill AP, 2018, 'The temperature dependence of kinetics associated with drug block of hERG channels is compound-specific and an important factor for proarrhythmic risk prediction', Molecular Pharmacology, vol. 94, pp. 760 - 769,

Lee W; Mangala M; Windley M; Perry M; Vandenberg J; Hill A, 2018, 'Novel Pre–Clinical Risk Prediction of Acquired Long QT Syndrome', Heart, Lung and Circulation, vol. 27, pp. S180 - S180,

Ng T; Vandenberg J; Perry M, 2018, 'Pharmacological Activation of hERG Potassium Channels in Congenital Long QT Syndrome 2: Activator Compound ICA-105574 and its Effects on Mutant hERG Potassium Channels in Long QT Syndrome 2', Heart, Lung and Circulation, vol. 27, pp. S61 - S61,

Lee W; Windley MJ; Vandenberg JI; Hill AP, 2017, 'In vitro and in silico risk assessment in acquired long QT syndrome: The devil is in the details', Frontiers in Physiology, vol. 8,

Vandenberg JI; Perozo E; Allen TW, 2017, 'Towards a Structural View of Drug Binding to hERG K+ Channels', Trends in Pharmacological Sciences, vol. 38, pp. 899 - 907,

Windley MJ; Abi-Gerges N; Fermini B; Hancox JC; Vandenberg JI; Hill AP, 2017, 'Measuring kinetics and potency of hERG block for CiPA', Journal of Pharmacological and Toxicological Methods, vol. 87, pp. 99 - 107,

Phan K; Ng CA; David E; Shishmarev D; Kuchel PW; Vandenberg JI; Perry MD, 2017, 'The S1 helix critically regulates the finely tuned gating of Kv11.1 channels', Journal of Biological Chemistry, vol. 292, pp. 7688 - 7705,

Grandi E; Sanguinetti MC; Bartos DC; Bers DM; Chen-Izu Y; Chiamvimonvat N; Colecraft HM; Delisle BP; Heijman J; Navedo MF; Noskov S; Proenza C; Vandenberg JI; Yarov-Yarovoy V, 2017, 'Potassium channels in the heart: structure, function and regulation', Journal of Physiology, vol. 595, pp. 2209 - 2228,

Chiamvimonvat N; Chen-Izu Y; Clancy CE; Deschenes I; Dobrev D; Heijman J; Izu L; Qu Z; Ripplinger CM; Vandenberg JI; Weiss JN; Koren G; Banyasz T; Grandi E; Sanguinetti MC; Bers DM; Nerbonne JM, 2017, 'Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics', Journal of Physiology, vol. 595, pp. 2229 - 2252,

Vandenberg JI; Perry MD; Hill AP, 2017, 'Recent advances in understanding and prevention of sudden cardiac death', F1000Research, vol. 6,

Hill AP; Perry MD; Abi-Gerges N; Couderc JP; Fermini B; Hancox JC; Knollmann BC; Mirams GR; Skinner J; Zareba W; Vandenberg JI, 2016, 'Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century', Journal of Physiology, vol. 594, pp. 6893 - 6908,

Mann SA; Imtiaz M; Winbo A; Rydberg A; Perry MD; Couderc JP; Polonsky B; McNitt S; Zareba W; Hill AP; Vandenberg JI, 2016, 'Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes', Journal of Molecular and Cellular Cardiology, vol. 100, pp. 25 - 34,

Ng CA; Gravel AE; Perry MD; Arnold AA; Marcotte I; Vandenberg JI, 2016, 'Tyrosine residues from the s4-s5 linker of kv11.1 channels are critical for slow deactivation', Journal of Biological Chemistry, vol. 291, pp. 17293 - 17302,

Immanuel SA; Sadrieh A; Baumert M; Couderc JP; Zareba W; Hill AP; Vandenberg JI, 2016, 'T-wave morphology can distinguish healthy controls from LQTS patients', Physiological Measurement, vol. 37, pp. 1456 - 1473,

Christensen AH; Chatelain FC; Huttner IG; Olesen MS; Soka M; Feliciangeli S; Horvat C; Santiago CF; Vandenberg JI; Schmitt N; Olesen SP; Lesage F; Fatkin D; Martin I, 2016, 'The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size', Journal of Molecular and Cellular Cardiology, vol. 97, pp. 24 - 35,

Perry MD; Ng CA; Phan K; David E; Steer K; Hunter MJ; Mann SA; Imtiaz M; Hill AP; Ke Y; Vandenberg JI, 2016, 'Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations', Journal of Physiology, vol. 594, pp. 4031 - 4049,

Windley MJ; Mann SA; Vandenberg JI; Hill AP, 2016, 'Temperature effects on kinetics of KV11.1 drug block have important consequences for in silico proarrhythmic risk prediction', Molecular Pharmacology, vol. 90, pp. 1 - 11,

Hodkinson EC; Neijts M; Sadrieh A; Imtiaz MS; Baumert M; Subbiah RN; Hayward CS; Boomsma D; Willemsen G; Vandenberg JI; Hill AP; De Geus E, 2016, 'Heritability of ECG biomarkers in the Netherlands twin registry measured from Holter ECGs', Frontiers in Physiology, vol. 7,

Fermini B; Hancox JC; Abi-Gerges N; Bridgland-Taylor M; Chaudhary KW; Colatsky T; Correll K; Crumb W; Damiano B; Erdemli G; Gintant G; Imredy J; Koerner J; Kramer J; Levesque P; Li Z; Lindqvist A; Obejero-Paz CA; Rampe D; Sawada K; Strauss DG; Vandenberg JI, 2016, 'A new perspective in the field of cardiac safety testing through the comprehensive in vitro proarrhythmia assay paradigm', Journal of Biomolecular Screening, vol. 21, pp. 1 - 11,

Heide J; Zhang F; Bigos KL; Mann SA; Carr VJ; Weickert CS; Green MJ; Weinberger DR; Vandenberg JI, 2016, 'Differential response to risperidone in schizophrenia patients by KCNH2Genotype and drug metabolizer status', American Journal of Psychiatry, vol. 173, pp. 53 - 59,

Lee W; Mann SA; Windley MJ; Imtiaz MS; Vandenberg JI; Hill AP, 2016, 'In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS', Progress in Biophysics and Molecular Biology, vol. 120, pp. 89 - 99,

Perry MD; Vandenberg JI, 2016, 'TECRL: Connecting sequence to consequence for a new sudden cardiac death gene', EMBO Molecular Medicine, vol. 8, pp. 1364 - 1365,

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