By Professor Jamie Vandenberg

Journal articles

Lau CHY; Flood E; Hunter MJ; Williams-Noonan BJ; Corbett KM; Ng CA; Bouwer JC; Stewart AG; Perozo E; Allen TW; Vandenberg JI, 2024, 'Potassium dependent structural changes in the selectivity filter of HERG potassium channels', Nature Communications, 15, http://dx.doi.org/10.1038/s41467-024-51208-w

La Gerche A; Paratz ED; Bray JE; Jennings G; Page G; Timbs S; Vandenberg JI; Abhayaratna W; Chow CK; Dennis M; Figtree GA; Kovacic JC; Maris J; Nehme Z; Parsons S; Pflaumer A; Puranik R; Stub D; Freitas E; Zecchin R; Cartledge S; Haskins B; Ingles J, 2024, 'A Call to Action to Improve Cardiac Arrest Outcomes: A Report From the National Summit for Cardiac Arrest', Heart Lung and Circulation, 33, pp. 1507 - 1522, http://dx.doi.org/10.1016/j.hlc.2024.09.001

Elliott AD; Middeldorp ME; McMullen JR; Fatkin D; Thomas L; Gwynne K; Hill AP; Shang C; Hsu MP; Vandenberg JI; Kalman JM; Sanders P; Abhayaratna W; Al-Falahi Z; Bell J; Burrell L; Delbridge L; Elliott A; Ganesan A; Hall T; Hendriks J; Hill A; Hsu M; Jenkins A; Kalman J; Kilkenny M; Kizana E; La Gerche A; McMullen J; Middeldorp M; Olaiya M; Ritchie R; Sanders P; Thijs V; Vandenberg J, 2024, 'Research Priorities for Atrial Fibrillation in Australia: A Statement From the Australian Cardiovascular Alliance Clinical Arrhythmia Theme', Heart Lung and Circulation, 33, pp. 1523 - 1532, http://dx.doi.org/10.1016/j.hlc.2024.08.008

O'Neill MJ; Ng C-A; Aizawa T; Sala L; Bains S; Winbo A; Ullah R; Shen Q; Tan C-Y; Kozek K; Vanags LR; Mitchell DW; Shen A; Wada Y; Kashiwa A; Crotti L; Dagradi F; Musu G; Spazzolini C; Neves R; Bos JM; Giudicessi JR; Bledsoe X; Gamazon ER; Lancaster MC; Glazer AM; Knollmann BC; Roden DM; Weile J; Roth F; Salem J-E; Earle N; Stiles R; Agee T; Johnson CN; Horie M; Skinner J; Ackerman MJ; Schwartz PJ; Ohno S; Vandenberg JI; Kroncke BM, 2024, 'Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification.', Circulation, http://dx.doi.org/10.1161/CIRCULATIONAHA.124.069828

Ma JG; O’Neill MJ; Richardson E; Thomson KL; Ingles J; Muhammad A; Solus JF; Davogustto G; Anderson KC; Shoemaker MB; Stergachis AB; Floyd BJ; Dunn K; Parikh VN; Chubb H; Perrin MJ; Roden DM; Vandenberg JI; Ng CA; Glazer AM, 2024, 'Multisite Validation of a Functional Assay to Adjudicate SCN5A Brugada Syndrome–Associated Variants', Circulation: Genomic and Precision Medicine, 17, pp. e004569, http://dx.doi.org/10.1161/CIRCGEN.124.004569

Lim S; Mangala MM; Holliday M; Szappanos HC; Barratt-Ross S; Li S; Thorpe J; Liang W; Ranpura GN; Vandenberg JI; Semsarian C; Hill AP; Hool LC, 2024, 'Reduced connexin-43 expression, slow conduction and repolarisation dispersion in a model of hypertrophic cardiomyopathy', DMM Disease Models and Mechanisms, 17, http://dx.doi.org/10.1242/dmm.050407

Clark A; Ferkh A; Vandenberg J; Elhindi J; Thomas L, 2024, 'Altered left atrial metrics in patients with cryptogenic stroke: A systematic review and meta-analysis', European Journal of Clinical Investigation, 54, http://dx.doi.org/10.1111/eci.14175

Thomson KL; Jiang C; Richardson E; Westphal DS; Burkard T; Wolf CM; Vatta M; Harrison SM; Ingles J; Bezzina CR; Kroncke BM; Vandenberg JI; Ng CA, 2024, 'Clinical interpretation of KCNH2 variants using a robust PS3/BS3 functional patch-clamp assay', Human Genetics and Genomics Advances, 5, pp. 100270, http://dx.doi.org/10.1016/j.xhgg.2024.100270

TeBay C; Vandenberg JI, 2024, 'The real-world incidence of severe QT prolongation in patients taking antipsychotic drugs', Heart Rhythm, 21, pp. 329 - 330, http://dx.doi.org/10.1016/j.hrthm.2023.11.012

Austin R; Brown JS; Casauria S; Madelli EO; Mattiske T; Boughtwood T; Metke A; Davis A; Horton AE; Winlaw D; Das D; Soka M; Giannoulatou E; Rath EM; Haan E; Blue GM; Vohra J; Atherton JJ; van Spaendonck-Zwarts K; Cox K; Burnett L; Wallis M; Haas M; Quinn MCJ; Pachter N; Poplawski NK; Stark Z; Bagnall RD; Weintraub RG; Pantaleo SJ; Lunke S; De Fazio P; Thompson T; James P; Chang Y; Fatkin D; Macciocca I; Ingles J; Dunwoodie SL; Semsarian C; McGaughran J; Ades L; Enriquez A; McLean A; Smyth R; Alankarage D; McNamara J; Morgan almog ; Fear V; Medi C; Al-Shinnag M; Fine M; Sy R; Finlay K; Milnes D; Tang D; Garza D; Milward M; Taylor J; Morrish A; Taylor S; Barnett C; Gongolidis L; Morwood J; Tchan M; Gray B; Mountain H; Bodek S; Greer C; Mowat D; Thorpe J; Boggs K; Ng CA; Trainer A; Bogwitz M; Haas M; Nowak N; Trivedi G; Hanna B; Martinez NN; Valente G; Bray A; Harvey R; Ohanian M; Brion MJ; Hayward J; O'Sullivan S; Vandenberg J; Brown J; Herrera C; Overkov A; Verma K; Richardson RB; Hill A; Vidgen M; Hollingsworth G; Patel C; Burns C; Hollway G; Perrin M, 2024, 'A multitiered analysis platform for genome sequencing: Design and initial findings of the Australian Genomics Cardiovascular Disorders Flagship', Genetics in Medicine Open, 2, http://dx.doi.org/10.1016/j.gimo.2024.101842

Aljassar RW; Shen Q; Albash B; Vandenberg JI; Ebrahim MA; Ng CA, 2024, 'Integration of validated functional evidence to support the pathogenicity of KCNH2 variants', Genetics in Medicine Open, 2, http://dx.doi.org/10.1016/j.gimo.2024.101868

Balaji P; Liulu X; Sivakumar S; Chong JJH; Kizana E; Vandenberg JI; Hill AP; Hau E; Qian PC, 2024, 'Mechanistic Insights and Knowledge Gaps in the Effects of Radiation Therapy on Cardiac Arrhythmias', International Journal of Radiation Oncology Biology Physics, http://dx.doi.org/10.1016/j.ijrobp.2024.08.040

O'Neill M; Ng C-A; Aizawa T; Sala L; Bains S; Denjoy I; Winbo A; Ullah R; Shen Q; Tan C-Y; Kozek K; Vanags L; Mitchell D; Shen A; Wada Y; Kashiwa A; Crotti L; Dagradi F; Musu G; Spazzolini C; Neves RA; Bos JM; Giudicessi J; Lancaster M; Glazer AM; Roden DM; Leenhardt A; Salem J-E; Earle N; Stiles R; Agee T; Johnson CN; Horie M; Skinner JR; Extramiana F; Ackerman MJ; Schwartz PJ; Ohno S; Vandenberg JI; Kroncke B, 2024, 'BS-469619-003 GRANULAR VARIANT-SPECIFIC FEATURES IMPROVE KCNH2-LONG QT SYNDROME RISK STRATIFICATION', Heart Rhythm, 21, pp. S52 - S52, http://dx.doi.org/10.1016/j.hrthm.2024.03.363

Heitmann S; Vandenberg JI; Hill AP, 2023, 'Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology', eLife, 12, http://dx.doi.org/10.7554/elife.90027.3

Thorpe J; Perry MD; Contreras O; Hurley E; Parker G; Harvey RP; Hill AP; Vandenberg JI, 2023, 'Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia', Stem Cell Research and Therapy, 14, http://dx.doi.org/10.1186/s13287-023-03405-5

Zeng YC; Sobti M; Quinn A; Smith NJ; Brown SHJ; Vandenberg JI; Ryan RM; O’Mara ML; Stewart AG, 2023, 'Structural basis of promiscuous substrate transport by Organic Cation Transporter 1', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-42086-9

Lee W; Ng B; Mangala MM; Perry MD; Subbiah RN; Vandenberg JI; Hill AP, 2023, 'Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs with Potential to Prolong Cardiac Repolarization', Circulation: Arrhythmia and Electrophysiology, 16, pp. 399 - 410, http://dx.doi.org/10.1161/CIRCEP.122.011574

Copier JS; Bootsma M; Ng CA; Wilde AAM; Bertels RA; Bikker H; Christiaans I; van der Crabben SN; Hol JA; Koopmann TT; Knijnenburg J; Lommerse AAJ; van der Smagt JJ; Bezzina CR; Vandenberg JI; Verkerk AO; Barge-Schaapveld DQCM; Lodder EM, 2023, 'Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance', Human Molecular Genetics, 32, pp. 1072 - 1082, http://dx.doi.org/10.1093/hmg/ddac261

Tardo DT; Peck M; Subbiah R; Vandenberg JI; Hill AP, 2023, 'The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review', Annals of Noninvasive Electrocardiology, 28, http://dx.doi.org/10.1111/anec.13015

G J; Vandenberg JI; Ng C-A, 2023, 'Development of automated patch clamp assays to overcome the burden of variants of uncertain significance in inheritable arrhythmia syndromes', Frontiers in Physiology, 14, pp. 1294741, http://dx.doi.org/10.3389/fphys.2023.1294741

Bursill CA; Smith NJ; Palpant N; Tan I; Sunde M; Harvey RP; Lewis B; Figtree GA; Vandenberg JI, 2022, 'Don't Turn Off the Tap! The Importance of Discovery Science to the Australian Cardiovascular Sector and Improving Clinical Outcomes Into the Future', Heart Lung and Circulation, 31, pp. 1321 - 1332, http://dx.doi.org/10.1016/j.hlc.2022.06.669

Windley MJ; Farr J; TeBay C; Vandenberg JI; Hill AP, 2022, 'High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol', Journal of Pharmacological and Toxicological Methods, 117, http://dx.doi.org/10.1016/j.vascn.2022.107192

Jiang C; Richardson E; Farr J; Hill AP; Ullah R; Kroncke BM; Harrison SM; Thomson KL; Ingles J; Vandenberg JI; Ng CA, 2022, 'A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome', American Journal of Human Genetics, 109, pp. 1199 - 1207, http://dx.doi.org/10.1016/j.ajhg.2022.05.002

Ng CA; Ullah R; Farr J; Hill AP; Kozek KA; Vanags LR; Mitchell DW; Kroncke BM; Vandenberg JI, 2022, 'A massively parallel assay accurately discriminates between functionally normal and abnormal variants in a hotspot domain of KCNH2', American Journal of Human Genetics, 109, pp. 1208 - 1216, http://dx.doi.org/10.1016/j.ajhg.2022.05.003

TeBay C; McArthur JR; Mangala M; Kerr N; Heitmann S; Perry MD; Windley MJ; Vandenberg JI; Hill AP, 2022, 'Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation', British Journal of Pharmacology, 179, pp. 2631 - 2646, http://dx.doi.org/10.1111/bph.15757

Kerr NP; Vandenberg JI, 2022, 'The yin and yang of Tbx5 variant effects on sodium channel function', Cardiovascular Research, 118, pp. 929 - 931, http://dx.doi.org/10.1093/cvr/cvac015

Peters S; Thompson BA; Perrin M; James P; Zentner D; Kalman JM; Vandenberg JI; Fatkin D, 2022, 'Arrhythmic Phenotypes Are a Defining Feature of Dilated Cardiomyopathy-Associated SCN5A Variants: A Systematic Review', Circulation: Genomic and Precision Medicine, 15, pp. E003432, http://dx.doi.org/10.1161/CIRCGEN.121.003432

Ng CA; Vandenberg JI, 2022, 'When it takes two to get one into trouble', Heart Rhythm, 19, pp. 293 - 294, http://dx.doi.org/10.1016/j.hrthm.2021.10.017

Ballouz S; Mangala MM; Perry MD; Heitmann S; Gillis JA; Hill AP; Vandenberg JI, 2021, 'Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events', Cardiovascular Research, 117, pp. 2216 - 2227, http://dx.doi.org/10.1093/cvr/cvaa280

Heitmann S; Shpak A; Vandenberg JI; Hill AP, 2021, 'Arrhythmogenic effects of ultra-long and bistable cardiac action potentials', PLoS Computational Biology, 17, pp. e1008683, http://dx.doi.org/10.1371/JOURNAL.PCBI.1008683

Ng CA; Farr J; Young P; Windley MJ; Perry MD; Hill AP; Vandenberg JI, 2021, 'Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-Throughput automated patch clamp electrophysiology', Biology Methods and Protocols, 6, pp. 1 - 9, http://dx.doi.org/10.1093/biomethods/bpab003

Ng C-A; Farr J; Young P; Windley M; Perry M; Hill A; Vandenberg J, 2021, 'HeterozygousKCNH2variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology', , http://dx.doi.org/10.1101/2021.02.02.427891

Kozek KA; Glazer AM; Ng CA; Blackwell D; Egly CL; Vanags LR; Blair M; Mitchell D; Matreyek KA; Fowler DM; Knollmann BC; Vandenberg JI; Roden DM; Kroncke BM, 2020, 'High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1', Heart Rhythm, 17, pp. 2180 - 2189, http://dx.doi.org/10.1016/j.hrthm.2020.05.041

Perry MD; Ng CA; Mangala MM; Ng TYM; Hines AD; Liang W; Xu MJO; Hill AP; Vandenberg JI, 2020, 'Pharmacological activation of IKrin models of long QT Type 2 risks overcorrection of repolarization', Cardiovascular Research, 116, pp. 1434 - 1445, http://dx.doi.org/10.1093/cvr/cvz247

Ganesan AN; Vanoye CG; Alam F; Waddell-Smith KE; McGavigan AD; Correnti G; Haan E; Brown A; Vandenberg J; George AL, 2020, 'Long QT syndrome type 1 in an Australian indigenous patient', Circulation: Genomic and Precision Medicine, 13, pp. 93 - 94, http://dx.doi.org/10.1161/CIRCGEN.119.002813

Ng CA; Perry MD; Liang W; Smith NJ; Foo B; Shrier A; Lukacs GL; Hill AP; Vandenberg JI, 2020, 'High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants', Heart Rhythm, 17, pp. 492 - 500, http://dx.doi.org/10.1016/j.hrthm.2019.09.020

Li Z; Mirams GR; Yoshinaga T; Ridder BJ; Han X; Chen JE; Stockbridge NL; Wisialowski TA; Damiano B; Severi S; Morissette P; Kowey PR; Holbrook M; Smith G; Rasmusson RL; Liu M; Song Z; Qu Z; Leishman DJ; Steidl-Nichols J; Rodriguez B; Bueno-Orovio A; Zhou X; Passini E; Edwards AG; Morotti S; Ni H; Grandi E; Clancy CE; Vandenberg J; Hill A; Nakamura M; Singer T; Polonchuk L; Greiter-Wilke A; Wang K; Nave S; Fullerton A; Sobie EA; Paci M; Musuamba Tshinanu F; Strauss DG, 2020, 'General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy', Clinical Pharmacology and Therapeutics, 107, pp. 102 - 111, http://dx.doi.org/10.1002/cpt.1647

Heitmann S; Vandenberg J; Hill A, 2020, 'Arrhythmogenesis as the failure of repolarization', , http://dx.doi.org/10.1101/2020.07.02.185694

Munawar S; Vandenberg JI; Jabeen I, 2019, 'Molecular docking guided grid-independent descriptor analysis to probe the impact ofwater molecules on conformational changes of hERG inhibitors in drug trapping phenomenon', International Journal of Molecular Sciences, 20, http://dx.doi.org/10.3390/ijms20143385

Lee W; Windley MJ; Perry MD; Vandenberg JI; Hill AP, 2019, 'Protocol-dependent differences in IC50 values measured in human ether-á-go-go–related gene assays occur in a predictable way and can be used to quantify state preference of drug binding', Molecular Pharmacology, 95, pp. 537 - 550, http://dx.doi.org/10.1124/mol.118.115220

Tardo D; Peck M; Hill A; Vandenberg J, 2019, 'T Wave Morphology Biomarkers in Congenital and Acquired Long QT Syndrome', Heart, Lung and Circulation, 28, pp. S229 - S229, http://dx.doi.org/10.1016/j.hlc.2019.06.223

Munawar S; Windley MJ; Tse EG; Todd MH; Hill AP; Vandenberg JI; Jabeen I, 2018, 'Experimentally validated pharmacoinformatics approach to predict hERG inhibition potential of new chemical entities', Frontiers in Pharmacology, 9, pp. 1035, http://dx.doi.org/10.3389/fphar.2018.01035

Beattie KA; Hill AP; Bardenet R; Cui Y; Vandenberg JI; Gavaghan DJ; de Boer TP; Mirams GR, 2018, 'Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics', Journal of Physiology, 596, pp. 1813 - 1828, http://dx.doi.org/10.1113/JP275733

Lau C; Hunter MJ; Stewart A; Perozo E; Vandenberg JI, 2018, 'Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy', Journal of Physiology, 596, pp. 1107 - 1119, http://dx.doi.org/10.1113/JP274888

Windley MJ; Lee W; Vandenberg JI; Hill AP, 2018, 'The temperature dependence of kinetics associated with drug block of hERG channels is compound-specific and an important factor for proarrhythmic risk prediction', Molecular Pharmacology, 94, pp. 760 - 769, http://dx.doi.org/10.1124/mol.117.111534

Lee W; Mangala M; Windley M; Perry M; Vandenberg J; Hill A, 2018, 'Novel Pre–Clinical Risk Prediction of Acquired Long QT Syndrome', Heart, Lung and Circulation, 27, pp. S180 - S180, http://dx.doi.org/10.1016/j.hlc.2018.06.309

Ng T; Vandenberg J; Perry M, 2018, 'Pharmacological Activation of hERG Potassium Channels in Congenital Long QT Syndrome 2: Activator Compound ICA-105574 and its Effects on Mutant hERG Potassium Channels in Long QT Syndrome 2', Heart, Lung and Circulation, 27, pp. S61 - S61, http://dx.doi.org/10.1016/j.hlc.2018.06.039

Lee W; Windley MJ; Vandenberg JI; Hill AP, 2017, 'In vitro and in silico risk assessment in acquired long QT syndrome: The devil is in the details', Frontiers in Physiology, 8, pp. 934, http://dx.doi.org/10.3389/fphys.2017.00934

Vandenberg JI; Perozo E; Allen TW, 2017, 'Towards a Structural View of Drug Binding to hERG K⁺ Channels', Trends in Pharmacological Sciences, 38, pp. 899 - 907, http://dx.doi.org/10.1016/j.tips.2017.06.004

Windley MJ; Abi-Gerges N; Fermini B; Hancox JC; Vandenberg JI; Hill AP, 2017, 'Measuring kinetics and potency of hERG block for CiPA', Journal of Pharmacological and Toxicological Methods, 87, pp. 99 - 107, http://dx.doi.org/10.1016/j.vascn.2017.02.017

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