Select Publications
Journal articles
2024, 'Potassium dependent structural changes in the selectivity filter of HERG potassium channels', Nature Communications, 15, http://dx.doi.org/10.1038/s41467-024-51208-w
,2024, 'A Call to Action to Improve Cardiac Arrest Outcomes: A Report From the National Summit for Cardiac Arrest', Heart Lung and Circulation, 33, pp. 1507 - 1522, http://dx.doi.org/10.1016/j.hlc.2024.09.001
,2024, 'Research Priorities for Atrial Fibrillation in Australia: A Statement From the Australian Cardiovascular Alliance Clinical Arrhythmia Theme', Heart Lung and Circulation, 33, pp. 1523 - 1532, http://dx.doi.org/10.1016/j.hlc.2024.08.008
,2024, 'Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification.', Circulation, http://dx.doi.org/10.1161/CIRCULATIONAHA.124.069828
,2024, 'Multisite Validation of a Functional Assay to Adjudicate SCN5A Brugada Syndrome–Associated Variants', Circulation: Genomic and Precision Medicine, 17, pp. e004569, http://dx.doi.org/10.1161/CIRCGEN.124.004569
,2024, 'Reduced connexin-43 expression, slow conduction and repolarisation dispersion in a model of hypertrophic cardiomyopathy', DMM Disease Models and Mechanisms, 17, http://dx.doi.org/10.1242/dmm.050407
,2024, 'Altered left atrial metrics in patients with cryptogenic stroke: A systematic review and meta-analysis', European Journal of Clinical Investigation, 54, http://dx.doi.org/10.1111/eci.14175
,2024, 'Clinical interpretation of KCNH2 variants using a robust PS3/BS3 functional patch-clamp assay', Human Genetics and Genomics Advances, 5, pp. 100270, http://dx.doi.org/10.1016/j.xhgg.2024.100270
,2024, 'The real-world incidence of severe QT prolongation in patients taking antipsychotic drugs', Heart Rhythm, 21, pp. 329 - 330, http://dx.doi.org/10.1016/j.hrthm.2023.11.012
,2024, 'A multitiered analysis platform for genome sequencing: Design and initial findings of the Australian Genomics Cardiovascular Disorders Flagship', Genetics in Medicine Open, 2, http://dx.doi.org/10.1016/j.gimo.2024.101842
,2024, 'Cardiovascular Workforce Sustainability Sector Consultation: Recommendations From an Australian Stakeholder Summit', Heart Lung and Circulation, http://dx.doi.org/10.1016/j.hlc.2024.10.012
,2024, 'Integration of validated functional evidence to support the pathogenicity of KCNH2 variants', Genetics in Medicine Open, 2, http://dx.doi.org/10.1016/j.gimo.2024.101868
,2024, 'Mechanistic Insights and Knowledge Gaps in the Effects of Radiation Therapy on Cardiac Arrhythmias', International Journal of Radiation Oncology Biology Physics, http://dx.doi.org/10.1016/j.ijrobp.2024.08.040
,2024, 'BS-469619-003 GRANULAR VARIANT-SPECIFIC FEATURES IMPROVE KCNH2-LONG QT SYNDROME RISK STRATIFICATION', Heart Rhythm, 21, pp. S52 - S52, http://dx.doi.org/10.1016/j.hrthm.2024.03.363
,2023, 'Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology', eLife, 12, http://dx.doi.org/10.7554/elife.90027.3
,2023, 'Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia', Stem Cell Research and Therapy, 14, http://dx.doi.org/10.1186/s13287-023-03405-5
,2023, 'Structural basis of promiscuous substrate transport by Organic Cation Transporter 1', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-42086-9
,2023, 'Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs with Potential to Prolong Cardiac Repolarization', Circulation: Arrhythmia and Electrophysiology, 16, pp. 399 - 410, http://dx.doi.org/10.1161/CIRCEP.122.011574
,2023, 'Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance', Human Molecular Genetics, 32, pp. 1072 - 1082, http://dx.doi.org/10.1093/hmg/ddac261
,2023, 'The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review', Annals of Noninvasive Electrocardiology, 28, http://dx.doi.org/10.1111/anec.13015
,2023, 'Development of automated patch clamp assays to overcome the burden of variants of uncertain significance in inheritable arrhythmia syndromes', Frontiers in Physiology, 14, pp. 1294741, http://dx.doi.org/10.3389/fphys.2023.1294741
,2022, 'Don't Turn Off the Tap! The Importance of Discovery Science to the Australian Cardiovascular Sector and Improving Clinical Outcomes Into the Future', Heart Lung and Circulation, 31, pp. 1321 - 1332, http://dx.doi.org/10.1016/j.hlc.2022.06.669
,2022, 'High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol', Journal of Pharmacological and Toxicological Methods, 117, http://dx.doi.org/10.1016/j.vascn.2022.107192
,2022, 'A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome', American Journal of Human Genetics, 109, pp. 1199 - 1207, http://dx.doi.org/10.1016/j.ajhg.2022.05.002
,2022, 'A massively parallel assay accurately discriminates between functionally normal and abnormal variants in a hotspot domain of KCNH2', American Journal of Human Genetics, 109, pp. 1208 - 1216, http://dx.doi.org/10.1016/j.ajhg.2022.05.003
,2022, 'Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation', British Journal of Pharmacology, 179, pp. 2631 - 2646, http://dx.doi.org/10.1111/bph.15757
,2022, 'The yin and yang of Tbx5 variant effects on sodium channel function', Cardiovascular Research, 118, pp. 929 - 931, http://dx.doi.org/10.1093/cvr/cvac015
,2022, 'Arrhythmic Phenotypes Are a Defining Feature of Dilated Cardiomyopathy-Associated SCN5A Variants: A Systematic Review', Circulation: Genomic and Precision Medicine, 15, pp. E003432, http://dx.doi.org/10.1161/CIRCGEN.121.003432
,2022, 'When it takes two to get one into trouble', Heart Rhythm, 19, pp. 293 - 294, http://dx.doi.org/10.1016/j.hrthm.2021.10.017
,2021, 'Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events', Cardiovascular Research, 117, pp. 2216 - 2227, http://dx.doi.org/10.1093/cvr/cvaa280
,2021, 'Arrhythmogenic effects of ultra-long and bistable cardiac action potentials', PLoS Computational Biology, 17, pp. e1008683, http://dx.doi.org/10.1371/JOURNAL.PCBI.1008683
,2021, 'Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-Throughput automated patch clamp electrophysiology', Biology Methods and Protocols, 6, pp. 1 - 9, http://dx.doi.org/10.1093/biomethods/bpab003
,2021, 'HeterozygousKCNH2variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology', , http://dx.doi.org/10.1101/2021.02.02.427891
,2020, 'High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel K
2020, 'Pharmacological activation of I
2020, 'Long QT syndrome type 1 in an Australian indigenous patient', Circulation: Genomic and Precision Medicine, 13, pp. 93 - 94, http://dx.doi.org/10.1161/CIRCGEN.119.002813
,2020, 'High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants', Heart Rhythm, 17, pp. 492 - 500, http://dx.doi.org/10.1016/j.hrthm.2019.09.020
,2020, 'General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy', Clinical Pharmacology and Therapeutics, 107, pp. 102 - 111, http://dx.doi.org/10.1002/cpt.1647
,2020, 'Arrhythmogenesis as the failure of repolarization', , http://dx.doi.org/10.1101/2020.07.02.185694
,2019, 'Molecular docking guided grid-independent descriptor analysis to probe the impact ofwater molecules on conformational changes of hERG inhibitors in drug trapping phenomenon', International Journal of Molecular Sciences, 20, http://dx.doi.org/10.3390/ijms20143385
,2019, 'Protocol-dependent differences in IC
2019, 'T Wave Morphology Biomarkers in Congenital and Acquired Long QT Syndrome', Heart, Lung and Circulation, 28, pp. S229 - S229, http://dx.doi.org/10.1016/j.hlc.2019.06.223
,2018, 'Experimentally validated pharmacoinformatics approach to predict hERG inhibition potential of new chemical entities', Frontiers in Pharmacology, 9, pp. 1035, http://dx.doi.org/10.3389/fphar.2018.01035
,2018, 'Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics', Journal of Physiology, 596, pp. 1813 - 1828, http://dx.doi.org/10.1113/JP275733
,2018, 'Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy', Journal of Physiology, 596, pp. 1107 - 1119, http://dx.doi.org/10.1113/JP274888
,2018, 'The temperature dependence of kinetics associated with drug block of hERG channels is compound-specific and an important factor for proarrhythmic risk prediction', Molecular Pharmacology, 94, pp. 760 - 769, http://dx.doi.org/10.1124/mol.117.111534
,2018, 'Novel Pre–Clinical Risk Prediction of Acquired Long QT Syndrome', Heart, Lung and Circulation, 27, pp. S180 - S180, http://dx.doi.org/10.1016/j.hlc.2018.06.309
,2018, 'Pharmacological Activation of hERG Potassium Channels in Congenital Long QT Syndrome 2: Activator Compound ICA-105574 and its Effects on Mutant hERG Potassium Channels in Long QT Syndrome 2', Heart, Lung and Circulation, 27, pp. S61 - S61, http://dx.doi.org/10.1016/j.hlc.2018.06.039
,2017, 'In vitro and in silico risk assessment in acquired long QT syndrome: The devil is in the details', Frontiers in Physiology, 8, pp. 934, http://dx.doi.org/10.3389/fphys.2017.00934
,2017, 'Towards a Structural View of Drug Binding to hERG K+ Channels', Trends in Pharmacological Sciences, 38, pp. 899 - 907, http://dx.doi.org/10.1016/j.tips.2017.06.004
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