By Professor Jamie Vandenberg

Conference Papers

Windley M; Abi-Gerges N; Fermini B; Hancox J; Vandenberg J; Hill A, 2017, 'Successes and Challenges of Performing hERG Studies for CiPA', in JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, ELSEVIER SCIENCE INC, pp. 197 - 197, http://dx.doi.org/10.1016/j.vascn.2017.09.095

Windley M; Mann S; Vandenberg J; Hill A, 2017, 'Temperature Effects on Kinetics of hERG Drug Block: Implications for In Silico Proarrhythmic Risk Prediction', in JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, ELSEVIER SCIENCE INC, pp. 203 - 203, http://dx.doi.org/10.1016/j.vascn.2017.09.116

Vandenberg JI; Conigrave A; King GF; Kirk K, 2013, 'From kinetics to imaging: an NMR odyssey--a festschrift symposium in honour of Philip William Kuchel.', in Eur Biophys J, Germany, pp. 1 - 2, Germany, http://dx.doi.org/10.1007/s00249-012-0883-8

Vandenberg JI; Kuchel PW, 2010, 'Proteins, membranes and cells: the structure-function nexus', in European Biophysics Journal, Springer, pp. 1 - 1, http://dx.doi.org/10.1007/s00249-009-0535-9

Hill AP; Varghese A; Dokos S; Mann S; Vandenberg JI, 2009, 'Developing In Silico Descriptions Of Herg Channel Gating', in BIOPHYSICAL JOURNAL, CELL PRESS, pp. 191A - 191A, http://dx.doi.org/10.1016/j.bpj.2008.12.897

Otway RT; Vandenberg JI; Guo G; Fatkin D, 2007, 'Interaction between a KCNQ1 mutation and cell stretch in familial atrial fibrillation', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, MD, Baltimore, pp. 463A - 463A, presented at 51st Annual Meeting of the Biophysical-Society, MD, Baltimore, 03 March 2007 - 07 March 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243972403011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Vandenberg JI; Bansal PS; Torres AM; Kuchel PW; Alewood PA, 2005, 'Molecular basis of CnErg1 binding to HERG K+ channels', in JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, ENGLAND, Bristol Univ, Bristol, pp. 172 - 173, presented at 4th Mammalian Myocardium Meeting, ENGLAND, Bristol Univ, Bristol, 17 July 2005 - 20 July 2005, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000230435000030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Varghese A; Lu Y; Smith MM; Huang CLH; Vandenberg JI, 2003, 'Temperature dependence of HERG inactivation', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, TEXAS, SAN ANTONIO, pp. 544A - 544A, presented at 47th Annual Meeting of the Biophysical-Society, TEXAS, SAN ANTONIO, 01 March 2003 - 05 March 2003, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183123802674&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Fahmi AI; Vandenberg J, 2002, 'The sodium channel beta subunit, SCN3b, increases the expression levels of SCN5a and is heterogeneously expressed in sheep cardiac tissue', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, pp. 91A - 91A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000173252700447&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lu Y; Mahaut-Smith MP; Huang CLH; Vandenberg JI, 2001, 'Effects of temperature on HERG K+ channel response to premature stimuli', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, pp. 213A - 213A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000166692200975&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wallerstein PMR; Vandenberg JI; Huang CLH; Saumarez RC; Grace AA, 2001, 'Intraventricular conduction delay, electrogram fractionation and arrhythmias in the KCNE1 mutant mouse', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, pp. 644A - 645A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000166692202930&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Varghese A; Lu Y; Huang CLH; Mahaut-Smith MP; Vandenberg JI, 2001, 'Modeling the effects of premature stimuli on HERG K+ channels', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, pp. 638A - 638A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000166692202903&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Furness RB; Fowden AL; Forhead AJ; Vandenberg JI, 2000, 'Developmental regulation of cardiac erg potassium channel mRNA expression in fetal sheep during late gestation', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. 66P - 66P

Lu Y; Mahaut-Smith MP; Huang CLH; Vandenberg JI, 2000, 'MiRP1 alters activation of HERG K+ channels stably transfected in a mammalian cell line', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. 120P - 120P, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000089787600154&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lu Y; Mahaut-Smith MP; Huang CLH; Kemp PR; Vandenberg JI, 2000, 'Effects of premature stimuli on HERG-encoded K+ currents under action potential clamp conditions', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. 93P - 94P, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000088237300117&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Paul LEA; Huang CL; Grace AA; Saumarez RC; Vandenberg JI, 1999, 'Analysis of Purkinje system contributions to conduction in the perfused heart', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, pp. A85 - A85, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000081085900490&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lowe MD; Grace AA; Vandenberg JI; Kaumann AJ, 1998, 'Electrophysiological effects mediated through the putative beta 4-adrenoceptor', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, pp. 491 - 491, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000076594402610&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lowe MD; Grace AA; Vandenberg JI; Kaumann AJ, 1998, 'Electrophysiological effects mediated through the putative beta(4)-adrenoceptor in ventricular myocardium', in NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, SPRINGER VERLAG, pp. R623 - R623

Trezise AEO; Wong KR; Vandenberg JI, 1997, 'Distribution of cftr mRNA in rabbit left ventricular myocardium.', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P74 - P75, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997YJ42400087&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Smith GA; Kirschenlohr HL; Grace AA; Metcalfe JC; Vandenberg JI, 1997, 'Buffering of the cardiac calcium transient by exogenous calcium indicators', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P132 - P132, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997XD09100189&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Vandenberg JI; Grace AA; Zinkin MP; Lowe MD; Saumarez RC, 1997, 'Anthopleurin A causes cardiac electrogram fractionation following premature stimulation.', in BIOPHYSICAL JOURNAL, CELL PRESS, pp. MP129 - MP129, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997WE74700264&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Bethell HW; Vandenberg JI; Smith GA; Grace AA, 1996, 'Ischemic potassium flux is driven by an early net inward current', in CIRCULATION, AMER HEART ASSOC, pp. 3081 - 3081, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996VN11903073&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wright AR; Rees SA; Vandenberg JI; Twist VW; Powell T, 1996, 'Simultaneous recording of Na+/Ca2+ exchange current and swelling activated Cl- current from isolated guinea-pig atrial myocytes', in BIOPHYSICAL JOURNAL, CELL PRESS, pp. MP287 - MP287, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996TZ68201170&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

VANDENBERG JI; REES SA; TWIST VW; WRIGHT AR; POWELL T, 1995, 'A SWELLING-ACTIVATED CHLORIDE CONDUCTANCE CONTRIBUTES TO ACTION-POTENTIAL SHORTENING IN GUINEA-PIG VENTRICULAR MYOCYTES DURING CELL SWELLING', in CIRCULATION, AMER HEART ASSOC, pp. 3059 - 3059, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TB48003039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

HALL JA; KIRK J; POTTS JR; RAE CD; VANDENBERG JI; KIRK K, 1995, 'SWELLING-ACTIVATED TRANSPORT OF DIVERSE SOLUTES IN A HUMAN CANCER CELL-LINE', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P96 - P96, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TB77500148&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

REDWOOD S; BETHELL HWL; VANDENBERG JI; CAMM AJ; GRACE AA, 1994, 'MAGNESIUM HAS CONCENTRATION AND TIME-DEPENDENT EFFECTS ON ACTION-POTENTIAL DURATION DURING MYOCARDIAL-ISCHEMIA', in CIRCULATION, AMER HEART ASSOC, pp. 524 - 524, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994PN41702852&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

REES SA; YOSHIDA A; TWIST VW; VANDENBERG JI; POWELL T, 1994, 'SWELLING ACTIVATED DELAYED RECTIFIER POTASSIUM CURRENT IN GUINEA-PIG VENTRICULAR MYOCYTES', in HEART AND VESSELS, SPRINGER VERLAG, JAPAN, TOKYO, pp. 145 - 146, presented at Tokyo-Womens-Medical-College International Symposium 94 - Ion Channels and Cellular Function of the Heart: Molecular Mechanisms Underlying the Regulation of Cardiac Cellular Function, JAPAN, TOKYO, 08 July 1994 - 10 July 1994, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995RA84700047&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

VANDENBERG JI; YOSHIDA A; KIRK K; POWELL T, 1994, 'SWELLING-ACTIVATED CHLORIDE CURRENTS IN GUINEA-PIG CARDIAC MYOCYTES', in HEART AND VESSELS, SPRINGER VERLAG, JAPAN, TOKYO, pp. 144 - 144, presented at Tokyo-Womens-Medical-College International Symposium 94 - Ion Channels and Cellular Function of the Heart: Molecular Mechanisms Underlying the Regulation of Cardiac Cellular Function, JAPAN, TOKYO, 08 July 1994 - 10 July 1994, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995RA84700046&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

VANDENBERG JI; YOSHIDA A; KIRK K; TWIST VW; POWELL T, 1994, 'CELL SWELLING ACTIVATES A CHLORIDE CURRENT IN GUINEA-PIG VENTRICULAR MYOCYTES', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P83 - P83, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994NA54100147&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

BETHELL HWL; VANDENBERG JI; GRACE AA, 1994, 'PROLONGATION OF THE MONOPHASIC ACTION-POTENTIAL DURING ACIDOSIS AND SHORTENING DURING ISCHEMIA', in JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER SCIENCE INC, pp. A46 - A46

GRACE AA; VANDENBERG JI, 1993, 'ANGIOTENSIN-II ENHANCES CARDIAC PHI REGULATION IN THE PRESENCE OF HCO3- VIA 3 ACID-BASE TRANSPORT MECHANISMS', in CIRCULATION, AMER HEART ASSOC, pp. 331 - 331, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993MA68201813&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

GRACE AA; METCALFE JC; BETHELL HW; VANDENBERG JI, 1993, 'ANGIOTENSIN-II STIMULATES PROTON EXTRUSION DURING REPERFUSION', in CIRCULATION, AMER HEART ASSOC, pp. 430 - 430, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993MA68202344&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

VANDENBERG JI; CARTER ND; GRACE AA, 1993, 'SARCOLEMMAL CARBONIC-ANHYDRASE AND REGULATION OF CARDIAC PH', in CIRCULATION, AMER HEART ASSOC, pp. 39 - 39, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993MA68200239&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

GRACE AA; METCALFE JC; WEISSBERG PL; VANDENBERG JI, 1993, 'ANGIOTENSIN-II STIMULATES ACID EXTRUSION IN ISOLATED PERFUSED FERRET HEART', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P415 - P415, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993KG43100411&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

VANDENBERG JI; METCALFE JC; GRACE AA, 1993, 'THE RECOVERY OF INTRACELLULAR PH DURING RESPIRATORY-ACIDOSIS IN THE ISOLATED PERFUSED FERRET HEART', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P414 - P414, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993KG43100410&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

VANDENBERG JI; METCALFE JC; GRACE AA, 1992, 'MECHANISMS OF INTRACELLULAR PH RECOVERY FOLLOWING GLOBAL-ISCHEMIA IN THE PERFUSED HEART', in CIRCULATION, AMER HEART ASSOC, pp. S9 - S9, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992JT66000023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

VANDENBERG JI; METCALFE JC; GRACE AA, 1992, 'CONTRIBUTION OF LACTATE EFFLUX TO PHI RECOVERY FOLLOWING GLOBAL-ISCHEMIA IN THE PERFUSED FERRET HEART', in JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, pp. S54 - S54, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992JJ55600084&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

GRACE AA; METCALFE JC; WEISSBERG PL; VANDENBERG JI, 1992, 'RELATIVE CONTRIBUTION OF THE NA+-H+ ANTIPORT AND HCO3--DEPENDENT MECHANISMS TO PROTON EFFLUX DURING INTRACELLULAR ACIDOSIS IN PERFUSED HEART', in JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, pp. S54 - S54, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992JJ55600082&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Grace AA; Kirschenlohr HL; Smith GA; Metcalfe JC; Weissberg PL; Vandenberg JI, 1992, 'HCO3^--dependence of recovery from intracellular acidosis in the perfused ferret heart during Na⁺-H⁺ antiport inhibition', in Journal of Physiology

GRACE AA; KIRSCHENLOHR HL; SMITH GA; METCALFE JC; WEISSBERG PL; VANDENBERG JI, 1992, 'HCO3--DEPENDENCE OF RECOVERY FROM INTRACELLULAR ACIDOSIS IN THE PERFUSED FERRET HEART DURING NA+-H+ ANTIPORT INHIBITION', in JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, pp. P141 - P141, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992HD60500136&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

HOEIJMAKERS HWM; VANDENBERG JI, 1991, 'APPLICATION OF AN EULER-EQUATION METHOD TO A SHARP-EDGED DELTA-WING CONFIGURATION WITH VORTEX FLOW', in COLLECTION OF TECHNICAL PAPERS - AIAA 9TH APPLIED AERODYNAMICS CONFERENCE, VOLS 1 AND 2, AMER INST AERONAUTICS & ASTRONAUTICS, MD, BALTIMORE, pp. 838 - 850, presented at 9TH APPLIED AERODYNAMICS CONF, MD, BALTIMORE, 23 September 1991 - 25 September 1991, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991BW68G00020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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