By Professor Jamie Vandenberg

Preprints

O'Neill MJ; Ng C-A; Aizawa T; Sala L; Bains S; Winbo A; Ullah R; Shen Q; Tan C-Y; Kozek K; Vanags LR; Mitchell DW; Shen A; Wada Y; Kashiwa A; Crotti L; Dagradi F; Musu G; Spazzolini C; Neves R; Bos JM; Giudicessi JR; Bledsoe X; Gamazon ER; Lancaster M; Glazer AM; Knollmann BC; Roden DM; Weile J; Roth F; Salem J-E; Earle N; Stiles R; Agee T; Johnson CN; Horie M; Skinner J; Ackerman MJ; Schwartz PJ; Ohno S; Vandenberg JI; Kroncke BM, 2024, Multiplexed Assays of Variant Effect and Automated Patch-clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification., http://dx.doi.org/10.1101/2024.02.01.24301443

Heitmann S; Vandenberg J; Hill A, 2024, Independent derivations of the axis of arrhythmia for predicting drug-induced torsades de pointes, http://dx.doi.org/10.1101/2024.09.18.613631

Lau CHY; Flood E; Hunter MJ; Williams-Noonan BJ; Corbett KM; Ng C-A; Bouwer JC; Stewart AG; Perozo E; Allen TW; Vandenberg JI, 2023, Potassium dependent structural changes in the selectivity filter of HERG potassium channels, http://dx.doi.org/10.1101/2023.12.14.571769

Heitmann S; Vandenberg JI; Hill AP, 2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, http://dx.doi.org/10.7554/eLife.90027

Heitmann S; Vandenberg JI; Hill AP, 2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, http://dx.doi.org/10.7554/elife.90027.2

Heitmann S; Vandenberg JI; Hill AP, 2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, http://dx.doi.org/10.7554/elife.90027.1

Heitmann S; Vandenberg J; Hill A, 2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, http://dx.doi.org/10.1101/2023.04.19.537441

Thomson K; Jiang C; Richardson E; Westphal D; Burkard T; Wolf C; Vatta M; Harrison S; Ingles J; Bezzina C; Kroncke B; Vandenberg J; Ng C-A, 2023, Clinical interpretation ofKCNH2variants using a robust PS3/BS3 functional patch clamp assay, http://dx.doi.org/10.1101/2023.10.08.23296707

Thorpe J; Perry M; Contreras O; Hurley E; Parker G; Harvey R; Hill A; Vandenberg J, 2023, Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia, http://dx.doi.org/10.21203/rs.3.rs-2744099/v1

Lim S; Mangala M; Holliday M; Szappanos HC; Ross S; Liang W; Ranpura G; Vandenberg J; Semsarian C; Hill A; Hool L, 2023, Slow conduction and spatial dispersion of repolarization are intrinsic properties of cardiomyocyte electrophysiology that contribute to proarrhythmia in an iPSC model of hypertrophic cardiomyopathy, http://dx.doi.org/10.1101/2023.07.20.549952

Copier JS; Bootsma M; Ng C; Wilde AAM; Bertels RA; Bikker H; Christiaans I; van der Crabben SN; Hol JA; Koopmann TT; Knijnenburg J; Lommerse AAJ; van der Smagt JJ; Bezzina CR; Vandenberg JI; Verkerk AO; Barge-Schaapveld DQCM; Lodder EM, 2022, Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance, http://dx.doi.org/10.1101/2022.08.05.502917

Jiang C; Richardson E; Farr J; Hill A; Ullah R; Kroncke B; Harrison S; Thomson K; Ingles J; Vandenberg J; Ng C-A, 2021, A calibrated functional patch clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome, http://dx.doi.org/10.1101/2021.12.13.472492

Vandenberg J; Lau C; Flood E; Hunter M; Ng C-A; Bouwer J; Stewart A; Perozo E; Allen T, 2021, Structural Basis for Rapid Voltage Dependent Inactivation of HERG Potassium Channels, http://dx.doi.org/10.21203/rs.3.rs-1105661/v1

Kozek KA; Glazer AM; Ng C-A; Blackwell D; Egly CL; Vanags LR; Blair M; Mitchell D; Matreyek KA; Fowler DM; Knollmann BC; Vandenberg J; Roden DM; Kroncke BM, 2020, High-throughput discovery of trafficking-deficient variants in the cardiac potassium channelKCNH2: Deep mutational scan ofKCNH2trafficking, http://dx.doi.org/10.1101/2020.02.17.952606

Lee W; Windley MJ; Perry MD; Vandenberg JI; Hill AP, 2019, Protocol-dependent differences in IC₅₀ values measured in hERG assays occur in a predictable way and can be used to quantify state preference of drug binding, http://dx.doi.org/10.1101/534867

Windley MJ; Farr J; Vandenberg JI; Hill AP, Translating the Measurement of Herg Kinetics and Drug Block for Cipa to a High Throughput Platform, http://dx.doi.org/10.2139/ssrn.4065593

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