By Professor John Pimanda

Journal articles

Narula J; Williams CJ; Tiwari A; Marks-Bluth J; Pimanda JE; Igoshin OA, 2013, 'Mathematical model of a gene regulatory network reconciles effects of genetic perturbations on hematopoietic stem cell emergence', Developmental Biology, 379, pp. 258 - 269, http://dx.doi.org/10.1016/j.ydbio.2013.04.016

Hesson LB; Patil V; Sloane MA; Nunez AC; Liu J; Pimanda JE; Ward RL, 2013, 'Reassembly of Nucleosomes at the MLH1 Promoter Initiates Resilencing Following Decitabine Exposure', PLoS Genetics, 9, http://dx.doi.org/10.1371/journal.pgen.1003636

Beck D; Thoms JAI; Perera D; Schütte J; Unnikrishnan A; Knezevic K; Kinston SJ; Wilson NK; O'Brien TA; Göttgens B; Wong JWH; Pimanda JE, 2013, 'Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes', Blood, 122, pp. e12 - e22, http://dx.doi.org/10.1182/blood-2013-03-490425

Oram SH; Thoms J; Sive J; Calero-Nieto FJ; Kinston SJ; Schuette J; Knezevic K; Lock RB; Pimanda JE; Gottgens B, 2013, 'Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia', Leukemia, 27, pp. 1348 - 1357, http://dx.doi.org/10.1038/leu.2013.2

Hesson LB; Wong JWH; Sloane MA; Pimanda JE; Bourke MJ; Hawkins NJ; Ward RL, 2012, 'Nucleosome occupancy at unmethylated promoter CpG islands represents a novel mechanism of epigenetic gene silencing in cancer', CANCER RESEARCH, 72, http://dx.doi.org/10.1158/1538-7445.AM2012-990

Pimanda JE, 2012, 'Cell signalling pathways that mediate haematopoietic stem cell specification', The International Journal of Biochemistry & Cell Biology, 44, pp. 2175 - 2184

Pimanda JE, 2012, 'Concise Review: Blood Relatives: Formation and Regulation of Hematopoietic Stem Cells by the Basic Helix-Loop-Helix Transcription Factors Stem Cell Leukemia and Lymphoblastic Leukemia-Derived Sequence 1', Stem Cells, 30, pp. 1053 - 1058

Pereira LA; Wong MS; Mossmann AK; Sourris K; Janes ME; Knezevic K; Hirst CE; Lim S; Pimanda JE; Stanley E; Elefanty A, 2012, 'Pdgfrá and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells', Steam cell research, 8, pp. 165 - 179, http://dx.doi.org/10.1016/j.scr.2011.09.007

Liu J; Hesson L; Meagher AP; Bourke MJ; Hawkins NJ; Rand KN; Molloy PL; Pimanda JE; Ward RL, 2012, 'Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa', CANCER PREVENTION RESEARCH, 5, pp. 921 - 929, http://dx.doi.org/10.1158/1940-6207.CAPR-11-0577

Beck D; Brandl MB; boelen L; Unnikrishnan A; Pimanda JE; Wong JWH, 2012, 'Signal analysis for genome-wide maps of histone modifications measured by ChIP-seq', Bioinformatics, 28, pp. 1062 - 1069

Pimanda J; Thoms J; Birger Y; Foster S; Knezevic K; Kirschenbaum Y; Chandrakanthan V; Lock R; MacKenzie K; Gottgens B; Izraeli S, 2011, 'ERG PROMOTES T-ACUTE LYMPHOBLASTIC LEUKEMIA AND IS TRANSCRIPTIONALLY REGULATED IN LEUKEMIC CELLS BY A STEM CELL ENHANCER', EXPERIMENTAL HEMATOLOGY, 39, pp. S108 - S108, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293801700179&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Liu JJ; Hesson LB; Rand KN; Molloy PL; Pimanda J; Ward RL, 2011, 'Analysis of global and repeat sequence DNA methylation in the blood and normal colonic mucosa of colorectal cancer patients, healthy individuals and patients with folate deficiency', CANCER RESEARCH, 71, http://dx.doi.org/10.1158/1538-7445.AM2011-91

Knezevic K; Wilson N; Bee T; Janes M; Kinston SJ; Polderdijk S; Kolb-Kokocinski A; Ottersbach K; Pencovich N; Groner Y; De bruijn M; Gottgens B; Pimanda JE, 2011, 'A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis', Molecular and Cellular Biology, 31, pp. 2817 - 2826, http://dx.doi.org/10.1128/MCB.01305-10

Chong J; Chandrakanthan V; Xaymardan M; Asli NS; Li J; Ahmed I; Heffernan C; Menon M; Scarlett C; Rashidianfar A; Biben C; Zoellner H; Colvin EK; Pimanda JE; Biankin AV; Zhou B; Pu WT; Prall OWJ; Harvey RP, 2011, 'Adult cardiac-resident MSC-like stem cells with a proepicardial origin', Cell Stem Cell, 9, pp. 527 - 540, http://dx.doi.org/10.1016/j.stem.2011.10.002

Taoudi S; Bee T; Hilton A; Knezevic K; Scott J; Scott J; Willson TA; Collin C; Thomas T; Voss AK; Kile BT; Alexander WS; Pimanda JE; Hilton DJ, 2011, 'ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification', Genes and Development, 25, pp. 251 - 262

Thoms JAI; Birger Y; Foster S; Knezevic K; Kirshenbaum Y; Chandrakanthan V; Jonquieres G; Spensberger D; Wong JW; Oram SH; Kinston SJ; Groner Y; Lock RB; MacKenzie KL; Gottgens B; Izraeli S; Pimanda JE, 2011, 'ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer', Blood, 117, pp. 7079 - 7089, http://dx.doi.org/10.1182/blood-2010-12-317990

Oram SH; Thoms JAI; Pridans C; Janes ME; Kinston SJ; Anand S; Landry JR; Lock RB; Jayaraman PS; Huntly BJ; Pimanda JE; Gottgens B, 2010, 'A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients', Oncogene, 29, pp. 5796 - 5808, http://dx.doi.org/10.1038/onc.2010.320

Wilson N; Foster S; Wang XL; Knezevic K; Schutte J; Kaimakis P; Chilarska P; Kinston S; Ouwehand AC; Dzierzak E; Pimanda JE; De bruijn M; Gottgens B, 2010, 'Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.', Cell Stem Cell, 7, pp. 532 - 544

Bachmann PS; Piazza RG; Janes M; Wong NC; Davies C; Mogavero A; Bhadri V; Szymanska B; Geninson G; Magistroni V; Cazaniga G; Biondi A; Miranda-saavedra D; Gottgens B; Saffery R; Craig JM; Marshall GM; Gambacorti-passerini C; Pimanda JE; Lock RB, 2010, 'Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition', Blood, 116, pp. 3013 - 3022, http://dx.doi.org/10.1182/blood-2010-05-284968

Pimanda JE; Gottgens B, 2010, 'Gene regulatory networks governing etic stem cell development and identity', International Journal of Developmental Biology, 54, pp. 1201 - 1211, http://dx.doi.org/10.1387/ijdb.093038jp

Wang B; Chen J; Santiago FS; Janes ME; Kavurma MM; Chong BH; Pimanda JE; Khachigian LM, 2010, 'Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.', Arteriosclerosis, Thrombosis and Vascular Biology, 30, pp. 536 - 545, http://dx.doi.org/10.1161/ATVBAHA.109.193821

Lock RB; Bachmann PS; Piazza RG; Davies C; James M; Wong NC; Bhadri VA; Mogavero A; Magistroni V; Gambacorti-Passerini C; Saffery R; Craig JM; Pimanda JE; Marshall GM, 2009, 'Epigenetic Silencing of the Pro-Apoptotic Bim Gene in Glucocorticoid Poor-Responsive Pediatric Acute Lymphoblastic Leukemia, and Its Reversal by Histone Deacetylase Inhibition.', Blood, 114, pp. 939 - 939, http://dx.doi.org/10.1182/blood.v114.22.939.939

Pimanda JE; Chan W; Wilson N; Smith A; Kinston S; Knezevic K; Janes M; Landry J; Kolb-Kokocinski A; Frampton J; Tannahill D; Ottersbach K; Follows G; Goettgens B; Lacaud G; Kouskoff V, 2008, 'Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code', Blood, 112, pp. 4512 - 4522

Landry J; Kinston S; Knezevic K; De bruijn M; Wilson N; Nottingham W; Peitz M; Edenhofer F; Pimanda JE; Ottersbach K; Gottgens B, 2008, 'Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.', Blood, 111, pp. 3005 - 3014, http://dx.doi.org/10.1182/blood-2007-07-098830

Pimanda JE; Ottersbach K; Knezevic K; Kinston S; Chan W; Wilson N; Landry J; Wood A; Kolb-Kokocinski A; Green AR; Tannahill D; Lacaud G; Kouskoff V; Gottgens B, 2007, 'Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development', Proceedings of the National Academy of Sciences of the United States of America, 104, pp. 17692 - 17697

Chan W; Follows G; Lacaud G; Pimanda JE; Landry J; Kinston S; Knezevic K; Piltz S; Donaldson I; Gambardella L; Sablitzky F; Green AR; Kouskoff V; Gottgens B, 2007, 'The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.', Blood, 109, pp. 1908 - 1916, http://dx.doi.org/10.1182/blood-2006-05-023226

Pimanda JE; Ottersbach K; Knezevic K; Kinston S; Chan W; Wilson N; Landry J; Kolb-Kokocinski A; Green AR; Tannahill D; Gottgens B, 2007, 'The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity.', Proceedings of the National Academy of Sciences of the United States of America, 104, pp. 840 - 845, http://dx.doi.org/10.1073/pnas.0607196104

Pimanda JE; Donaldson IJ; Bruijn MF; Kinston SJ; Knezevic K; Huckle L; Piltz S; Landry J-R; Green AR; Tannahill D; Gottgens B, 2006, 'Genome-Wide Computational Screen for Blood Stem Cell Enhancers Integrates RUNX1 and the BMP Signaling Pathway into the SCL Transcriptional Network.', Blood, 108, pp. 4196 - 4196, http://dx.doi.org/10.1182/blood.v108.11.4196.4196

Schneppenheim R; Kremer hovinga J; Becker T; Budder U; Karpman D; Brockhaus W; Hrachovinová I; Korczowski B; Oyen F; Rittich S; von Rosen J; Tjønnfjord G; Pimanda JE; Wienker G; Lämmle B, 2006, 'A common origin of the 4143insA ADAMTS13 mutation', Thrombosis and Haemostasis, 96, pp. 3 - 6

Pimanda JE; Chan W; Donaldson I; Bowen M; Green AR; Gottgens B, 2006, 'Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer', Blood, 107, pp. 4737 - 4745

Pimanda JE; Silberstein L; Dominici M; Dekel B; Bowen M; Oldham M; Brandt S; Tannahill D; Gottgens B; Green AR, 2006, 'Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 stem cell enhancer are active in bone cells', Molecular and Cellular Biology, 26, pp. 2615 - 2625, http://dx.doi.org/10.1128/MCB.26.7.2615-2625.2006

Rainis L; Toki T; Pimanda JE; Rosenthal E; Machol E; Strehl S; Gottgens B; Ito E; Izraeli S, 2005, 'The proto-oncogene ERG in megakaryoblastic leukemias.', Cancer research, 65, pp. 7596 - 7602

Pimanda JE; Maekawa A; Wind T; Paxton J; Chesterman CN; Hogg PJ, 2004, 'Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13', Blood, 103, pp. 627 - 629

Pimanda JE; Ganderton TR; Maekawa A; Yap C; Lawler J; Kershaw G; Chesterman CN; Hogg PJ, 2004, 'Role of thrombospondin-1 in control of von Willebrand factor multimer size in mice', The Journal of Biological Chemistry, 279, pp. 21439 - 21448

Pimanda JE; Chesterman CN; Hogg PJ, 2003, 'A perspective on the measurement of ADAMTS13 in thrombotic thrombocytopaenic purpura', European Journal of Haematology, 70, pp. 257 - 262

Pimanda JE; Lowe HC; Hogg PJ; Chesterman CN; Khachigian LM, 2003, 'Novel and Emerging Therapies in Cardiology and Haematology', Current Drug Targets, 3, pp. 101 - 103

Pimanda JE; Hogg PJ, 2002, 'Control of von Willebrand factor multimer size and implications for disease', Blood Reviews, 16, pp. 185 - 192

Pimanda JE; Annis D; Raftery M; Mosher D; Chesterman CN; Hogg PJ, 2002, 'The von Willebrand factor-reducing activity of thrombospondin-1 is located in the calcium-binding/C-terminal sequence and requires a free thiol at position 974.', Blood, 100, pp. 2832 - 2838

Pimanda JE; Xie LJ; Chesterman CN; Hog PJ, 2001, 'Control of von Willebrand factor multimer size.', BLOOD, 98, pp. 40A - 40A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172134100161&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers

Schnegg-Kaufmann A; Thoms JA; Bhuyan GS; Hampton HR; Vaughan L; Rutherford K; Kakadia PM; Lee HM; Johansson EM; Failes T; Arndt GM; Koval J; Davidson S; Lindenmann R; Warburton P; Rodriguez-Meira A; Mead AJ; Unnikrishnan A; Hertzberg M; Polizzotto MN; Bohlander SK; Papaemmanuil E; Faridani O; Jolly CJ; Zanini F; Pimanda JE, 2022, 'Single cell genotyping of matched stem/progenitor and mature blood cells in treatment naive and AZA-treated MDS and CMML reveals significant contribution of mutated clones to blood production', in SWISS MEDICAL WEEKLY, E M H SWISS MEDICAL PUBLISHERS LTD, pp. 29S - 29S, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000912385900040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Anande G; Unnikrishnan A; Deshpande N; Mareschal S; Batcha AMN; Herold T; Lehmann S; Wilkins M; Wong J; Pimanda J, 2019, 'Identification of Recurrent Alternative RNA Splicing in Adverse-Risk Acute Myeloid Leukemia', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), FL, Orlando, 07 December 2019 - 10 December 2019, http://dx.doi.org/10.1182/blood-2019-129537

Unnikrishnan A; Lim XY; Joshi S; Nunez AC; Vaughan L; Pickford R; Hough S; Davidson S; Fong C; Kenealy M; Hiwase DK; Pasalic L; Mohammed S; Lee L; Passam FH; Spring K; Rebeiro P; Ling S; Fuller S; Presgrave P; Roncolato F; Larsen S; Enjeti AK; Stevenson WS; Tiley C; Campbell PJ; Lemech C; Olivier J; Hertzberg M; Polizzotto MN; Pimanda J, 2019, 'In Vivo Assessment of Intracellular Dynamics Comparing Injection Versus Oral Azacitidine in a Phase IIb Investigator Initiated Clinical Trial', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), FL, Orlando, 07 December 2019 - 10 December 2019, http://dx.doi.org/10.1182/blood-2019-123921

Chacon D; Braytee A; Huang Y; Thoms J; Subramanian S; Sauerland MC; Bohlander SK; Braess J; Woermann BJ; Berdel WE; Hiddemann W; Gabrys B; Metzeler KH; Herold T; Pimanda J; Beck D, 2019, 'Prospective Identification of Acute Myeloid Leukemia Patients Who Benefit from Gene-Expression Based Risk Stratification', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), FL, Orlando, 07 December 2019 - 10 December 2019, http://dx.doi.org/10.1182/blood-2019-129519

Carmichael C; Wang J; Nguyen T; De Maziere C; Milne A; Goossens S; Davis M; Zadeh S; Vo A; McCormack M; Shields B; Haigh K; Huang Y; Thoms J; Knezevic K; Ritchie M; Berx G; Pimanda J; Kile B; Haigh J, 2019, 'ALTERED EXPRESSION OF EPITHELIAL TO MESENCHYMAL TRANSITION MODULATORS IN ACUTE MYELOID LEUKAEMIA - A MODEL OF LSD1 CORRUPTION', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, pp. S44 - S44, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000844545400062&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Carmichael C; Wang J; Nguyen T; De Maziere C; Milne A; Goossens S; Davis M; Zadeh S; Vo A; McCormack M; Shields B; Haigh K; Huang Y; Thoms J; Knezevic K; Ritchie M; Berx G; Pimanda J; Kile B; Haigh J, 2019, '2008 - ALTERED EXPRESSION OF EPITHELIAL TO MESENCHYMAL TRANSITION MODULATORS IN ACUTE MYELOID LEUKAEMIA - A MODEL OF LSD1 CORRUPTION', in Experimental Hematology, Elsevier BV, pp. S44 - S44, http://dx.doi.org/10.1016/j.exphem.2019.06.282

Jing D; Huang Y; Liu X; Sia K; Poulos RC; Span M; Zhang C; Mi J; Wong JWH; Beck D; Pimanda JE; Lock RB, 2018, 'Lymphocyte-specific chromatin accessibility predetermines glucocorticoid resistance in acute lymphoblastic leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, IL, Chicago, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), IL, Chicago, 14 April 2018 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-3173

Ali A; Penneroux J; Dal Bello R; Masse A; Quentin S; Unnikrishnan A; Hernandez L; Raffoux E; Benabelali R; Renneville A; Preudhomme C; Pimanda J; Dombret H; Soulier J; Fenaux P; Clappier E; Ades L; Itzykson R, 2017, 'Granulomonocytic Progenitors (GMPs) Are Key Target Cells of Azacitidine in MDS and AML', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 59th Annual Meeting of the American-Society-of-Hematology (ASH), GA, Atlanta, 09 December 2017 - 12 December 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000432419401234&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Kang YC; Glaros E; Thomas S; Qiao Q; Brownlee C; Pimanda J; Chandrakanthan V, 2017, 'Identification of Novel Embryonic Vascular Stem-like cells and their role in Coronary Vasculature development and repair', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, SINGAPORE, Natil Univ Singapore, Singapore, pp. S48 - S49, presented at 18th International Congress of Developmental Biology, SINGAPORE, Natil Univ Singapore, Singapore, 18 June 2017 - 22 June 2017, http://dx.doi.org/10.1016/j.mod.2017.04.088

Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J; Tursky ML; Huang Y; Ali Z; Olivier S; Galbraith S; Kulasekararaj A; Tobiasson M; Karimi M; Pellagatti A; Wilson S; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen S; Mufti G; Hellstrom-Lindberg E; MacKenzie K; Wong J; Campbell P; Pimanda J, 2016, 'Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes', Ferrata Storti Foundation, Copenhagen, Denmark, pp. 157 - 158, presented at 21st Congress Of The European Hematology Association (EHA), Copenhagen, Denmark, 09 June 2016 - 12 June 2016, https://synapse.mskcc.org/synapse/works/97032

Khanna A; Stringer B; Ensbey K; Jahaan Z; Boyd A; McDonald K; Day B; Pimanda J, 2015, 'Clinical relevance of DNA damage modulator checkpoint kinase 1 (CHK1) and cancerous inhibitor of protein phosphatase 2A (CIP2A) in human gliomas', in ANNALS OF ONCOLOGY, OXFORD UNIV PRESS, SINGAPORE, Singapore, pp. 34 - 34, presented at Asia Congress of the European-Society-for-Medical-Oncology (ESMO), SINGAPORE, Singapore, 18 December 2015 - 21 December 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000367158700117&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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