Select Publications
Conference Papers
2017, 'Identification of Novel Embryonic Vascular Stem-like cells and their role in Coronary Vasculature development and repair', in MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, SINGAPORE, Natil Univ Singapore, Singapore, pp. S48 - S49, presented at 18th International Congress of Developmental Biology, SINGAPORE, Natil Univ Singapore, Singapore, 18 June 2017 - 22 June 2017, http://dx.doi.org/10.1016/j.mod.2017.04.088
,2016, 'Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes', Ferrata Storti Foundation, Copenhagen, Denmark, pp. 157 - 158, presented at 21st Congress Of The European Hematology Association (EHA), Copenhagen, Denmark, 09 June 2016 - 12 June 2016, https://synapse.mskcc.org/synapse/works/97032
,2015, 'Clinical relevance of DNA damage modulator checkpoint kinase 1 (CHK1) and cancerous inhibitor of protein phosphatase 2A (CIP2A) in human gliomas', in ANNALS OF ONCOLOGY, OXFORD UNIV PRESS, SINGAPORE, Singapore, pp. 34 - 34, presented at Asia Congress of the European-Society-for-Medical-Oncology (ESMO), SINGAPORE, Singapore, 18 December 2015 - 21 December 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000367158700117&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2015, 'An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML', in An Integrative Genomics Approach Uncovers the Basis of Resistance to, USA, presented at ASH Annual Meeting, USA, 05 December 2015 - 08 December 2015
,2015, 'A Tissue-Specific Transcriptional Element for C/ebpa Is Required for HSC Maintenance and Neutrophil Development', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 57th Annual Meeting of the American-Society-of-Hematology, FL, Orlando, 05 December 2015 - 08 December 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368019001053&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2014, 'Identification of a Prognostic Gene Expression Signature for AZA Response in MDS and CMML Patients', in BLOOD, AMER SOC HEMATOLOGY, CA, San Francisco, presented at 56th Annual Meeting of the American-Society-of-Hematology, CA, San Francisco, 06 December 2014 - 09 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349243501166&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2014, 'Integrative Analysis of Lincrna Expression and Clinical Annotations Reveals a Signature of 17 Genes with Prognostic Significance in Acute Myeloid Leukemia (AML)', in BLOOD, AMER SOC HEMATOLOGY, CA, San Francisco, presented at 56th Annual Meeting of the American-Society-of-Hematology, CA, San Francisco, 06 December 2014 - 09 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349243503093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2013, 'ENRICHING HEMANGIOBLAST AND HEMOGENIC ENDOTHELIAL CELLS USING REGULATORY ELEMENTS OF THE ENDOGLIN GENE', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, AUSTRIA, Vienna, pp. S72 - S72, presented at 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), AUSTRIA, Vienna, 22 August 2013 - 25 August 2013, http://dx.doi.org/10.1016/j.exphem.2013.05.281
,2013, 'GENOME-WIDE ANALYSIS OF TRANSCRIPTIONAL REGULATORS IN HUMAN HSCS REVEALS A DENSELY INTERCONNECTED NETWORK OF CODING AND NON-CODING GENES', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, AUSTRIA, Vienna, pp. S17 - S17, presented at 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), AUSTRIA, Vienna, 22 August 2013 - 25 August 2013, http://dx.doi.org/10.1016/j.exphem.2013.05.063
,2013, 'Model Comparisons for RNA-Seq Data', in Proceedings of the 28th International Workshop on Statistical Modelling, Palermo, Italy, pp. 563 - 566, presented at 28th International Workshop on Statistical Modelling, Palermo, Italy, 08 July 2013 - 12 July 2014
,2012, 'Dyskerin Is Upregulated During Erythroid Differentiation of Human Hematopoietic Progenitor Cells and Hyperactivates Telomerase in Erythroid Precursor Cells', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.980.980
,2012, 'Inactivation of the deubiquitinase USP44 is an early event in the formation of colorectal cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2012-LB-375
,2010, 'A RUNX1-SMAD6 RHEOSTAT CONTROLS RUNX1 LEVELS AND REGULATES HEMATOPOIESIS IN THE DEVELOPING EMBRYO', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, AUSTRALIA, Melbourne, pp. S17 - S18, presented at 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, AUSTRALIA, Melbourne, 15 September 2010 - 18 September 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281168900035&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2009, 'Epigenetic Silencing of the Pro-Apoptotic Bim Gene in Glucocorticoid Poor-Responsive Pediatric Acute Lymphoblastic Leukemia, and Its Reversal by Histone Deacetylase Inhibition', in BLOOD, AMER SOC HEMATOLOGY, LA, New Orleans, pp. 387 - 388, presented at 51st Annual Meeting of the American-Society-of-Hematology, LA, New Orleans, 05 December 2009 - 08 December 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000272725801119&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2007, 'GATA2, Fli1 and SCL form a recursively wired gene regulatory circuit in developing blood stem cells', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, GERMANY, Hamburg, pp. 55 - 56, presented at 36th Annual Meeting of the International-Society-for-Experimental-Hematology, GERMANY, Hamburg, 28 September 2007 - 30 September 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000249535200149&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2007, 'GATA2, FLI1 and SCL form a recursively wired gene regulatory circuit in developing blood stem cells', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, GERMANY, Hamburg, pp. 25 - 25, presented at 36th Annual Meeting of the International-Society-for-Experimental-Hematology, GERMANY, Hamburg, 28 September 2007 - 30 September 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000249535200059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2006, 'Genome-wide computational screen for blood stem cell enhancers integrates RUNX1 and the BMP signaling pathway into the SCL transcriptional network.', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, pp. 129B - 129B, presented at 48th Annual Meeting of the American-Society-of-Hematology, FL, Orlando, 09 December 2006 - 12 December 2006, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000242440400476&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2006, 'Genome-wide computational screen for bloon stem cell enhancers integrates RUNX1 and the BMP signaling pathway into the SCL transcriptional network', in BLOOD CELLS MOLECULES AND DISEASES, ACADEMIC PRESS INC ELSEVIER SCIENCE, ENGLAND, St Johns Coll, Oxford, pp. 172 - 173, presented at 15th Conference on Hemoglobin Switching, ENGLAND, St Johns Coll, Oxford, 14 September 2006 - 18 September 2006, http://dx.doi.org/10.1016/j.bcmd.2006.10.119
,2004, 'A role for SCL in developing bone? the SCL+19 core enhancer targets expression to cells of developing bone, osteocytes, chondrocytes and bone lining cells', in BLOOD, AMER SOC HEMATOLOGY, CA, San Diego, pp. 136B - 136B, presented at 46th Annual Meeting of the American-Society-of-Hematology, CA, San Diego, 04 December 2004 - 07 December 2004, http://dx.doi.org/10.1182/blood.V104.11.4199.4199
,2002, 'The von Willebrand factor reducing activity of thrombospondin-1 centers around a free thiol at position 974.', in BLOOD, AMER SOC HEMATOLOGY, PENNSYLVANIA, PHILADELPHIA, pp. 257A - 258A, presented at 44th Annual Meeting of the American-Society-of-Hematology, PENNSYLVANIA, PHILADELPHIA, 06 December 2002 - 10 December 2002, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179184700981&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,Conference Proceedings (Editor of)
2017, 'Genetic Fate Mapping of Mesenchymal Stem-Like Cells in the Aorta-Gonad Mesonephros (AGM) and Their Contribution to Definitive Hematopoiesis', ELSEVIER SCIENCE BV, SINGAPORE, Natil Univ Singapore, Singapore, Vol. 145, presented at 18th International Congress of Developmental Biology, SINGAPORE, Natil Univ Singapore, Singapore, 18 June 2017 - 22 June 2017, http://dx.doi.org/10.1016/j.mod.2017.04.109
,Conference Presentations
2017, 'DECLINED PRESENTATION MESENCHYMAL STEM CELL-LIKE CELL MEDIATED HEMATOPOIETIC STEM CELL GENERATION FROM NON-HEMOGENIC ENDOTHELIAL CELLS', https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000972742900274&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2014, 'Keeping glioblastoma (GBM) in check by targeting the CHK1-STAT3-CIP2A axis', presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2014 - 09 April 2014, http://dx.doi.org/10.1158/1538-7445.AM2014-1600
,2012, 'Activity of a Heptad of Transcription Factors Is Associated with Stem Cell Programs and Clinical Outcome in Acute Myeloid Leukaemia', presented at 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), GA, Atlanta, 08 December 2012 - 11 December 2012, http://dx.doi.org/10.1182/blood.V120.21.3525.3525
,Conference Abstracts
2022, 'Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and Sumoylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia', in BLOOD, AMER SOC HEMATOLOGY, LA, New Orleans, Vol. 140, presented at 64th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), LA, New Orleans, 10 December 2022 - 13 December 2022, http://dx.doi.org/10.1182/blood-2022-165713
,2022, 'BIOPHYSICAL REGULATION OF IN-VITRO GASTRULATION USING INDUCED PLURIPOTENT STEM CELLS', in TISSUE ENGINEERING PART A, MARY ANN LIEBERT, INC, Vol. 28, pp. S518 - S519, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000821187302276&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2020, 'The PNT Domain of ERG Regulates Hematopoietic Stemness and is Required for the Maintenance of ERG-Induced Leukemia', in CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, CIG MEDIA GROUP, LP, Vol. 20, pp. S180 - S181, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000564055100083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2020, 'Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers with low mutational burden', in JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, HI, Honolulu, Vol. 204, presented at Annual Meeting of the American-Association-of-Immunologists - Immunology 2020, HI, Honolulu, 08 May 2020 - 12 May 2020, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000589972403119&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2020, 'AML-079: The PNT Domain of ERG Regulates Hematopoietic Stemness and is Required for the Maintenance of ERG-Induced Leukemia', in Clinical Lymphoma Myeloma and Leukemia, Elsevier BV, Vol. 20, pp. S180 - S181, http://dx.doi.org/10.1016/s2152-2650(20)30713-8
,2017, 'A NOVEL MASS SPECTROMETRY METHOD REVEALS THE INTRACELLULAR PHARMACOKINETICS OF AZACYTIDINE THERAPY IN VIVO', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, SPAIN, Madrid, Vol. 102, pp. 258 - 259, presented at 22nd Congress of the European-Hematology-Association, SPAIN, Madrid, 22 June 2017 - 25 June 2017
,2017, 'Mapping the Lncrna-Landscape of Human Hematopoiesis and Leukemia Reveals Stem Cell Non-Coding Gene Expression Programs', in ANNALS OF HEMATOLOGY, SPRINGER, Vol. 96, pp. S51 - S51, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394105400047&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2016, 'INTEGRATIVE ANALYSIS OF LINCRNA EXPRESSION IN 922 ACUTE MYELOID LEUKEMIA PATIENTS REVEALS MULTIPLE PROGNOSTIC GENE SIGNATURES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, Vol. 101, pp. 208 - 209, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600457&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2016, 'INTEGRATIVE GENOMICS IDENTIFIES THE MOLECULAR BASIS OF RESISTANCE TO AZACITIDINE THERAPY IN MYELODYSPLASTIC SYNDROMES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, Vol. 101, pp. 157 - 158, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600349&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2016, 'PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113
,2015, 'CHARACTERISTICS OF STROMAL STEM CELLS IN THE FOETAL LIVER', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, JAPAN, Kyoto, Vol. 43, pp. S90 - S90, presented at 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), JAPAN, Kyoto, 17 September 2015 - 19 September 2015, http://dx.doi.org/10.1016/j.exphem.2015.06.234
,2015, 'GENETIC FATE MAPPING OF MESENCHYMAL STEM-LIKE CELLS IN THE AORTA-GONAD MESONEPHROS (AGM) AND THEIR CONTRIBUTION TO DEVELOPMENTAL HEMATOPMESIS', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, JAPAN, Kyoto, Vol. 43, pp. S46 - S46, presented at 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), JAPAN, Kyoto, 17 September 2015 - 19 September 2015, http://dx.doi.org/10.1016/j.exphem.2015.06.054
,2014, 'Keeping GBM in check by targeting CHK1-CIP2A axis', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, Vol. 32, presented at 50th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 30 May 2014 - 03 June 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000358613202702&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2012, 'Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-3125
,Preprints
2024, Clinical Response to Azacitidine in Myelodysplastic Neoplasms is Associated with Distinct DNA Methylation Changes in Haematopoietic Stem and Progenitor cellsin vivo, http://dx.doi.org/10.1101/2024.07.19.24310679
,2024, Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and SUMOylation Blockade in MDS/AML, http://dx.doi.org/10.1101/2024.04.17.589858
,2023, Dysregulated expression ofHoxa1isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromes, http://dx.doi.org/10.1101/2023.04.24.538176
,2023, Cell Type-Specific Regulation by a Heptad of Transcription Factors in Human Hematopoietic Stem and Progenitor Cells, http://dx.doi.org/10.1101/2023.04.18.537282
,2022, A single amino acid at PNT domain of ERG mediates its leukemogenic activity through interaction with the NCoR-HDAC3 co-repressor complex, http://dx.doi.org/10.21203/rs.3.rs-1426447/v1
,2022, Single cell genotyping of matched bone marrow and peripheral blood cells in treatment naive and AZA-treated MDS and CMML, http://dx.doi.org/10.1101/2022.01.20.476890
,2021, Analysing high-throughput sequencing data in Python with HTSeq 2.0, http://arxiv.org/abs/2112.00939v1
,2021, Defined microenvironments trigger in vitro gastrulation in human pluripotent stem cells, http://dx.doi.org/10.1101/2021.10.28.466327
,2020, Demethylation and upregulation of an oncogene post hypomethylating treatment, http://dx.doi.org/10.1101/2020.07.21.20157776
,2020, Induction of a SALL4-dependency for targeted cancer therapy, http://dx.doi.org/10.1101/2020.07.10.197434
,2018, In search of non-coding driver mutations by deep sequencing of regulatory elements in colorectal cancer, http://dx.doi.org/10.1101/249300
,