By Professor Michael John Rogers

Book Chapters

Munoz MA; Rogers MJ, 2021, 'Cellular and molecular actions of bisphosphonates', in Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, pp. 921 - 942, http://dx.doi.org/10.1016/B978-0-12-821666-8.00025-6

Munoz MA; Rogers MJ, 2020, 'Bisphosphonates and bone cells-molecular mechanisms', in Encyclopedia of Bone Biology, pp. 565 - 578, http://dx.doi.org/10.1016/b978-0-12-801238-3.11261-9

Cremers S; Drake MT; Ebetino FH; Rogers MJ; Bilezikian JP; Russell RGG, 2020, 'Chapter 72 Clinical and translational pharmacology of bisphosphonates', in Principles of Bone Biology, pp. 1671 - 1687, http://dx.doi.org/10.1016/b978-0-12-814841-9.00072-5

Cremers S; Drake MT; Ebetino FH; Rogers MJ; Bilezikian JP; Russell RG, 2019, 'Clinical and translational pharmacology of bisphosphonates', in Principles of Bone Biology, pp. 1671 - 1687, http://dx.doi.org/10.1016/B978-0-12-814841-9.00072-5

Junankar S; Rogers MJ, 2015, 'Chapter 51 Cellular and molecular actions of bisphosphonates', in Bone Cancer, Elsevier, pp. 615 - 627, http://dx.doi.org/10.1016/b978-0-12-416721-6.00051-0

Junankar S; Rogers MJ, 2014, 'Cellular and molecular actions of bisphosphonates', in Bone Cancer: Primary Bone Cancers and Bone Metastases: Second Edition, Elsevier/Academic Press, San Diego, California, pp. 615 - 627, http://dx.doi.org/10.1016/B978-0-12-416721-6.00051-0

Roelofs AJ; Ebetino FH; Reszka AA; Russell RGG; Rogers MJ, 2008, 'Bisphosphonates: Mechanisms of Action', in Principles of Bone Biology: Volume 1-2, Third Edition, pp. 1737 - 1767, http://dx.doi.org/10.1016/B978-0-12-373884-4.00095-1

Roelofs AJ; Ebetino FH; Reszka AA; Russell RGG; Rogers MJ, 2008, 'Chapter 81 Bisphosphonates Mechanisms of Action', in Principles of Bone Biology, Elsevier, pp. 1737 - 1767, http://dx.doi.org/10.1016/b978-0-12-373884-4.00095-1

Coleman RE; Rogers MJ, 2006, 'Mechanisms of Action of Bisphosphonates', in Textbook of Bone Metastases, pp. 323 - 343, http://dx.doi.org/10.1002/0470011610.ch25

McGowan NWA; Harmey D; Coxon FP; Stenbeck G; Rogers MJ; Grigoriadis AE, 2005, 'Bacterial toxins and bone remodelling', in Bacterial Protein Toxins, Cambridge University Press, pp. 147 - 168, http://dx.doi.org/10.1017/cbo9780511546280.008

Coxon FP; Frith JC; Benford HL; Rogers MJ, 2003, 'Isolation and Purification of Rabbit Osteoclasts', in Bone Research Protocols, Springer Nature, pp. 89 - 99, http://dx.doi.org/10.1385/1-59259-366-6:89

Fleisch H; Reszka A; Rodan G; Rogers M, 2002, 'Bisphosphonates', in Principles of Bone Biology, Elsevier, pp. 1361 - XLIII, http://dx.doi.org/10.1016/b978-012098652-1.50180-3

Rogers MJ; Russell RGG, 1996, 'Mechanisms of Action of Bisphosphonates as Inhibitors of Bone Resorption', in Medical Intelligence Unit, Springer Berlin Heidelberg, pp. 147 - 177, http://dx.doi.org/10.1007/978-3-662-22505-9_7

Journal articles

Munoz MA; Skinner OP; Masle-Farquhar E; Jurczyluk J; Xiao Y; Fletcher EK; Kristianto E; Hodson MP; O’Donoghue SI; Kaur S; Brink R; Zahra DG; Deenick EK; Perry KA; Robertson AAB; Mehr S; Hissaria P; Mulders-Manders CM; Simon A; Rogers MJ, 2022, 'Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency', Journal of Clinical Investigation, 132, http://dx.doi.org/10.1172/JCI160929

Munoz MA; Fletcher EK; Skinner OP; Jurczyluk J; Kristianto E; Hodson MP; Sun S; Ebetino FH; Croucher DR; Hansbro PM; Center JR; Rogers MJ, 2021, 'Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages', eLife, 10, http://dx.doi.org/10.7554/eLife.72430

Brown AJ; Sharpe LJ; Rogers MJ, 2021, 'Oxysterols: From physiological tuners to pharmacological opportunities', British Journal of Pharmacology, 178, pp. 3089 - 3103, http://dx.doi.org/10.1111/bph.15073

McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Corr A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG, 2021, 'Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002))', Cell, 184, pp. 1940, http://dx.doi.org/10.1016/j.cell.2021.03.010

Kamble S; Valtchev P; Dao A; Pelras T; Rogers MJ; Savage PB; Dehghani F; Schindeler A, 2021, 'Synthesis and characterization of bone binding antibiotic-1 (Bba-1), a novel antimicrobial for orthopedic applications', Molecules, 26, http://dx.doi.org/10.3390/molecules26061541

McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG; Corr A, 2021, 'Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption', Cell, 184, pp. 1330 - 1347.e13, http://dx.doi.org/10.1016/j.cell.2021.02.002

Munoz M; Fletcher E; Skinner O; Jurczyluk J; Kristianto E; Hodson M; Sun S; Ebetino F; Croucher D; Hansbro P; Center J; Rogers M, 2021, 'Bisphosphonate drugs have actions outside the skeleton and inhibit the mevalonate pathway in alveolar macrophages', , http://dx.doi.org/10.1101/2021.08.09.455652

Rogers MJ; Mönkkönen J; Munoz MA, 2020, 'Molecular mechanisms of action of bisphosphonates and new insights into their effects outside the skeleton', Bone, 139, http://dx.doi.org/10.1016/j.bone.2020.115493

Skinner OP; Jurczyluk J; Baker PJ; Masters SL; Rios Wilks AG; Clearwater MS; Robertson AAB; Schroder K; Mehr S; Munoz MA; Rogers MJ, 2019, 'Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes', Journal of Allergy and Clinical Immunology, 143, pp. 2315 - 2317.e3, http://dx.doi.org/10.1016/j.jaci.2019.02.013

Munoz MA; Jurczyluk J; Simon A; Hissaria P; Arts RJW; Coman D; Boros C; Mehr S; Rogers MJ, 2019, 'Defective protein prenylation in a spectrum of patients with mevalonate kinase deficiency', Frontiers in Immunology, 10, http://dx.doi.org/10.3389/fimmu.2019.01900

Lee NJ; Ali N; Zhang L; Qi Y; Clarke I; Enriquez RF; Brzozowska M; Lee IC; Rogers MJ; Laybutt DR; Center JR; Baldock PA; Herzog H, 2019, 'Osteoglycin, a novel coordinator of bone and glucose homeostasis', Obesity Research & Clinical Practice, 13, pp. 256 - 256, http://dx.doi.org/10.1016/j.orcp.2018.11.063

Rogers MJ; Munoz MA, 2018, 'From vesicle to cytosol', eLife, 7, pp. e38847, http://dx.doi.org/10.7554/eLife.38847

Lee NJ; Ali N; Qi J; Clarke RF; Enriquez RF; Brzozowska M; Lee IC; Rogers MJ; Laybutt DR; Center JR; Baldock PA; Herzog H, 2018, 'Osteoglycin, an Osteoblast-derived Regulator of Bone Mass and Glucose Homeostasis', Molecular Metabolism, http://dx.doi.org/10.1016/j.molmet.2018.05.004

Chai RC; McDonald MM; Terry RL; Kovačić N; Down JM; Pettitt JA; Mohanty ST; Shah S; Haffari G; Xu J; Gillespie MT; Rogers MJ; Price JT; Croucher PI; Quinn JMW, 2017, 'Melphalan modifies the bone microenvironment by enhancing osteoclast formation', Oncotarget, 8, pp. 68047 - 68058, http://dx.doi.org/10.18632/oncotarget.19152

Munoz MA; Jurczyluk J; Mehr S; Chai RC; Arts RJW; Sheu A; McMahon C; Center JR; Singh-Grewal D; Chaitow J; Campbell DE; Quinn JMW; Alexandrov K; Tnimov Z; Tangye SG; Simon A; Phan TG; Rogers MJ, 2017, 'Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency', Journal of Allergy and Clinical Immunology, 140, pp. 873 - 875.e6, http://dx.doi.org/10.1016/j.jaci.2017.02.033

Jurczyluk J; Munoz MA; Skinner OP; Chai RC; Ali N; Palendira U; Quinn JMW; Preston A; Tangye SG; Brown AJ; Argent E; Ziegler JB; Mehr S; Rogers MJ, 2016, 'Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases', Immunology and Cell Biology, 94, pp. 994 - 999, http://dx.doi.org/10.1038/icb.2016.58

Jurczyluk J; Munoz MA; Skinner OP; Chai RC; Ali N; Palendira U; Quinn JMW; Preston A; Tangye SG; Brown AJ; Argent E; Ziegler JB; Mehr S; Rogers MJ, 2016, 'Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases', IMMUNOLOGY AND CELL BIOLOGY, 94, pp. 994 - 999, http://dx.doi.org/10.1038/icb.2016.58

Lawson MA; McDonald MM; Kovacic N; Khoo WH; Terry RL; Down J; Kaplan W; Paton-Hough J; Fellows C; Pettitt JA; Dear TN; Van Valckenborgh E; Baldock PA; Rogers MJ; Eaton CL; Vanderkerken K; Pettit AR; Quinn JMW; Zannettino ACW; Phan TG; Croucher PI, 2015, 'Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms9983

Ali N; Jurczyluk J; Shay G; Tnimov Z; Alexandrov K; Munoz MA; Skinner OP; Pavlos NJ; Rogers MJ, 2015, 'A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton', Small GTPases, 6, pp. 202 - 211, http://dx.doi.org/10.1080/21541248.2015.1085485

Croucher PI; Parker BS; Corcoran N; Rogers MJ, 2015, 'Bone turnover markers and prostate cancer: Not just a measure of bone disease?', European Urology, 68, pp. 51 - 52, http://dx.doi.org/10.1016/j.eururo.2014.10.041

Junankar S; Shay G; Jurczyluk J; Ali N; Down J; Pocock N; Parker A; Nguyen A; Sun S; Kashemirov B; McKenna CE; Croucher PI; Swarbrick A; Weilbaecher K; Phan TG; Rogers MJ, 2015, 'Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer', Cancer Discovery, 5, pp. 35 - 42, http://dx.doi.org/10.1158/2159-8290.CD-14-0621

Das S; Edwards PA; Crockett JC; Rogers MJ, 2014, 'Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1841, pp. 569 - 573, http://dx.doi.org/10.1016/j.bbalip.2013.12.010

Rumpler M; Würger T; Roschger P; Zwettler E; Sturmlechner I; Altmann P; Fratzl P; Rogers MJ; Klaushofer K, 2013, 'Osteoclasts on bone and dentin in vitro: Mechanism of trail formation and comparison of resorption behavior', Calcified Tissue International, 93, pp. 526 - 539, http://dx.doi.org/10.1007/s00223-013-9786-7

Su X; Floyd DH; Hughes A; Xiang J; Schneider JG; Uluckan O; Heller E; Deng H; Zou W; Craft CS; Wu K; Hirbe AC; Grabowska D; Eagleton MC; Townsley S; Collins L; Piwnica-Worms D; Steinberg TH; Novack DV; Conley PB; Hurchla MA; Rogers M; Weilbaecher KN, 2012, 'The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling', Journal of Clinical Investigation, 122, pp. 3579 - 3592, http://dx.doi.org/10.1172/JCI38576

Naylor AJ; Azzam E; Smith S; Croft A; Poyser C; Duffield JS; Huso DL; Gay S; Ospelt C; Cooper MS; Isacke C; Goodyear SR; Rogers MJ; Buckley CD, 2012, 'The mesenchymal stem cell marker CD248 (Endosialin) is a negative regulator of bone formation in mice', Arthritis and Rheumatism, 64, pp. 3334 - 3343, http://dx.doi.org/10.1002/art.34556

Whyte LS; Ford L; Ridge SA; Cameron GA; Rogers MJ; Ross RA, 2012, 'Cannabinoids and bone: Endocannabinoids modulate human osteoclast function in vitro', British Journal of Pharmacology, 165, pp. 2584 - 2597, http://dx.doi.org/10.1111/j.1476-5381.2011.01519.x

Roelofs AJ; Stewart CA; Sun S; Błazewska KM; Kashemirov BA; McKenna CE; Russell RGG; Rogers MJ; Lundy MW; Ebetino FH; Coxon FP, 2012, 'Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo', Journal of Bone and Mineral Research, 27, pp. 835 - 847, http://dx.doi.org/10.1002/jbmr.1543

Hughes A; Kleine-Albers J; Helfrich MH; Ralston SH; Rogers MJ, 2012, 'A Class III semaphorin (Sema3e) inhibits mouse osteoblast migration and decreases osteoclast formation in vitro', Calcified Tissue International, 90, pp. 151 - 162, http://dx.doi.org/10.1007/s00223-011-9560-7

Moriceau G; Roelofs AJ; Brion R; Redini F; Ebetion FH; Rogers MJ; Heymann D, 2012, 'Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth', Cancer, 118, pp. 750 - 760, http://dx.doi.org/10.1002/cncr.26336

Coxon FP; Rogers MJ; Crockett JC, 2012, 'Isolation and purification of rabbit osteoclasts', Methods in Molecular Biology, 816, pp. 145 - 158, http://dx.doi.org/10.1007/978-1-61779-415-5_10

Błaewska KM; Ni F; Haiges R; Kashemirov BA; Coxon FP; Stewart CA; Baron R; Rogers MJ; Seabra MC; Ebetino FH; McKenna CE, 2011, 'Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors', European Journal of Medicinal Chemistry, 46, pp. 4820 - 4826, http://dx.doi.org/10.1016/j.ejmech.2011.04.063

Crockett JC; Mellis DJ; Shennan KIJ; Duthie A; Greenhorn J; Wilkinson DI; Ralston SH; Helfrich MH; Rogers MJ, 2011, 'Signal peptide mutations in RANK prevent downstream activation of NF-κB', Journal of Bone and Mineral Research, 26, pp. 1926 - 1938, http://dx.doi.org/10.1002/jbmr.399

Rogers MJ; Crockett JC; Coxon FP; Mönkkönen J, 2011, 'Biochemical and molecular mechanisms of action of bisphosphonates', Bone, 49, pp. 34 - 41, http://dx.doi.org/10.1016/j.bone.2010.11.008

Thompson K; Keech F; McLernon DJ; Vinod K; May RJ; Simpson WG; Rogers MJ; Reid DM, 2011, 'Fluvastatin does not prevent the acute-phase response to intravenous zoledronic acid in post-menopausal women', Bone, 49, pp. 140 - 145, http://dx.doi.org/10.1016/j.bone.2010.10.177

Coxon FP; Taylor A; Stewart CA; Baron R; Seabra MC; Ebetino FH; Rogers MJ, 2011, 'The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates', Bone, 49, pp. 111 - 121, http://dx.doi.org/10.1016/j.bone.2011.03.686

Crockett JC; Rogers MJ; Coxon FP; Hocking LJ; Helfrich MH, 2011, 'Bone remodelling at a glance', Journal of Cell Science, 124, pp. 991 - 998, http://dx.doi.org/10.1242/jcs.063032

Taylor A; Mules EH; Seabra MC; Helfrich MH; Rogers MJ; Coxon FP, 2011, 'Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function', Small GTPases, 2, pp. 131 - 142, http://dx.doi.org/10.4161/sgtp.2.3.16488

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