By Professor Michael John Rogers

Journal articles

Itzstein C; Coxon FP; Rogers MJ, 2011, 'The regulation of osteoclast function and bone resorption by small GTPases', Small GTPases, 2, pp. 117 - 130, http://dx.doi.org/10.4161/sgtp.2.3.16453

Mellis⁎ DJG; Duthie A; Rogers MJ; Helfrich MH; Crockett JC, 2011, 'Assessment of signalling downstream of the mutant rank protein that causes familial expansile osteolysis', Bone, 48, pp. S128 - S128, http://dx.doi.org/10.1016/j.bone.2011.03.251

Das⁎ S; Crockett JC; Rogers MJ, 2011, 'Upregulation of endogenous FPP synthase in cultured cells causes resistance to bisphosphonate', Bone, 48, pp. S231 - S231, http://dx.doi.org/10.1016/j.bone.2011.03.549

Roelofs AJ; Thompson K; Ebetino FH; Rogers MJ; Coxon FP, 2010, 'Bisphosphonates: Molecular mechanisms of action and effects on bone cells, monocytes and macrophages', Current Pharmaceutical Design, 16, pp. 2950 - 2960, http://dx.doi.org/10.2174/138161210793563635

Hocking LJ; Mellis DJ; McCabe PS; Helfrich MH; Rogers MJ, 2010, 'Functional interaction between Sequestosome-1/p62 and Autophagy-Linked FYVE-containing protein WDFY3 in human osteoclasts', Biochemical and Biophysical Research Communications, 402, pp. 543 - 548, http://dx.doi.org/10.1016/j.bbrc.2010.10.076

Ford LA; Roelofs AJ; Anavi-Goffer S; Mowat L; Simpson DG; Irving AJ; Rogers MJ; Rajnicek AM; Ross RA, 2010, 'A role for L-α-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells', British Journal of Pharmacology, 160, pp. 762 - 771, http://dx.doi.org/10.1111/j.1476-5381.2010.00743.x

McKenna CE; Kashemirov BA; Błazewska KM; Mallard-Favier I; Stewart CA; Rojas J; Lundy MW; Ebetino FH; Baron RA; Dunford JE; Kirsten ML; Seabra MC; Bala JL; Marma MS; Rogers MJ; Coxon FP, 2010, 'Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid', Journal of Medicinal Chemistry, 53, pp. 3454 - 3464, http://dx.doi.org/10.1021/jm900232u

Roelofs AJ; Coxon FP; Ebetino FH; Lundy MW; Henneman ZJ; Nancollas GH; Sun S; Blazewska KM; Bala JLF; Kashemirov BA; Khalid AB; McKenna CE; Rogers MJ, 2010, 'Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo', Journal of Bone and Mineral Research, 25, pp. 606 - 616, http://dx.doi.org/10.1359/jbmr.091009

Guenther A; Gordon S; Tiemann M; Burger R; Bakker F; Green JR; Baum W; Roelofs AJ; Rogers MJ; Gramatzki M, 2010, 'The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation', International Journal of Cancer, 126, pp. 239 - 246, http://dx.doi.org/10.1002/ijc.24758

Mellis DJ; Das S; Helfrich M; Rogers MJ; Crockett JC, 2010, 'A mutation that prevents rank trimer formation does not prevent signalling downstream of rank', Bone, 47, pp. S137 - S138, http://dx.doi.org/10.1016/j.bone.2010.04.310

Hughes A; Crombie P; Tosh D; Coxon F; Aspden RM; Helfrich M; Rogers MJ, 2010, 'Expression, activation and regulation of the small GTPase Rap1 in bone cells', Bone, 47, pp. S139 - S140, http://dx.doi.org/10.1016/j.bone.2010.04.315

Khalid A; Goodyear S; Rogers M; Ross R; Aspden R, 2010, 'Loss of the cannabinoid receptor CB2 alters the mechanical but not the material properties of bone', Bone, 47, pp. S85 - S86, http://dx.doi.org/10.1016/j.bone.2010.04.172

Coxon F; Roelofs A; Boyde A; Lundy M; McKenna C; Blazewska K; Sun S; Kashemirov B; Duan X; Russell G; Khalid A; Rogers M; Ebetino F, 2010, 'The Ability of Bisphosphonates and Their Analogues to Penetrate the Osteocyte Network is Dependent on Affinity for Bone', Bone, 46, pp. S22 - S22, http://dx.doi.org/10.1016/j.bone.2010.01.041

Itzstein⁎ C; Taylor A; Coxon FP; Rogers MJ, 2010, 'The small GTPase Rab14 is required for osteoclast polarisation and bone resorption', Bone, 47, pp. S67 - S67, http://dx.doi.org/10.1016/j.bone.2010.04.129

Whyte LS; Ryberg E; Sims NA; Ridge SA; Mackie K; Greasley PJ; Ross RA; Rogers MJ, 2009, 'The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo', Proceedings of the National Academy of Sciences of the United States of America, 106, pp. 16511 - 16516, http://dx.doi.org/10.1073/pnas.0902743106

Räikkönen J; Crockett JC; Rogers MJ; Mönkkönen H; Auriola S; Mönkkönen J, 2009, 'Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro', British Journal of Pharmacology, 157, pp. 427 - 435, http://dx.doi.org/10.1111/j.1476-5381.2009.00160.x

Hirbe AC; Roelofs AJ; Floyd DH; Deng H; Becker SN; Lanigan LG; Apicelli AJ; Xu Z; Prior JL; Eagleton MC; Piwnica-Worms D; Rogers MJ; Weilbaecher K, 2009, 'The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts', Bone, 44, pp. 908 - 916, http://dx.doi.org/10.1016/j.bone.2009.01.010

Sutherland KA; Rogers HL; Tosh D; Rogers MJ, 2009, 'RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro', Arthritis Research and Therapy, 11, http://dx.doi.org/10.1186/ar2681

Baron RA; Tavaré R; Figueiredo AC; Błazewska KM; Kashemirov BA; McKenna CE; Ebetino FH; Taylor A; Rogers MJ; Coxon FP; Seabra MC, 2009, 'Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase', Journal of Biological Chemistry, 284, pp. 6861 - 6868, http://dx.doi.org/10.1074/jbc.M806952200

Roelofs AJ; Jauhiainen M; Mönkkönen H; Rogers MJ; Mönkkönen J; Thompson K, 2009, 'Peripheral blood monocytes are responsible for γδ T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP', British Journal of Haematology, 144, pp. 245 - 250, http://dx.doi.org/10.1111/j.1365-2141.2008.07435.x

Roelofs AJ; Boyde A; Lundy MW; McKenna CE; Blazewska K; Sun ST; Kashemirov BA; Russell RGG; Ebetino FH; Rogers MJ; Coxon FP, 2009, 'Bone mineral affinity influences the distribution of a bisphosphonate and a lower affinity analogue in vivo', Bone, 44, pp. S430 - S431, http://dx.doi.org/10.1016/j.bone.2009.03.377

Thompson K; Keech F; McLernon D; Vinod K; Tosh D; Simpson WG; Rogers MJ; Reid DM, 2009, 'Fluvastatin does not prevent the acute-phase response to intravenous zoledronic acid in post-menopausal women', Bone, 44, pp. S236 - S237, http://dx.doi.org/10.1016/j.bone.2009.03.093

Mellis DJ; Guerrini MM; Greenhorn J; Vezzoni P; Villa A; Rogers MJ; Helfrich MH; Crockett JC, 2009, 'Functional analysis of mutations in rank that result in diseases with opposite phenotypes', Bone, 44, pp. S325 - S325, http://dx.doi.org/10.1016/j.bone.2009.03.617

Whyte L; Ryberg E; Sims NA; Ridge S; Mackie K; Greasley P; Ross RA; Rogers MJ, 2009, 'GPR55: A novel cannabinoid receptor involved in the regulation of osteoclast function and bone mass', Bone, 44, pp. S138 - S138, http://dx.doi.org/10.1016/j.bone.2009.01.305

Moriceau G; Roelofs AJ; Brion R; Ebetino HF; Rogers M; Heymann D, 2009, 'Synergistic effect of apomine and lovastatin on osteosarcoma cell growth', Bone, 44, pp. S273 - S273, http://dx.doi.org/10.1016/j.bone.2009.03.479

Boyde A; Lundy MW; Coxon FP; McKenna CE; Roelofs A; Bala J; Rogers MJ; Blazewska K; Russell RGG; Ebetino FH, 2009, 'The differential distribution in vivo of fluorescently-labeled bisphosphonate analogues with different mineral affinity to bone surfaces', Bone, 44, pp. S57 - S57, http://dx.doi.org/10.1016/j.bone.2009.01.016

Kashemirov BA; Bala JLF; Chen X; Ebetino FH; Xia Z; Russell RGG; Coxon FP; Roelofs AJ; Rogers MJ; McKenna CE, 2008, 'Fluorescently labeled risedronate and related analogues: "Magic linker" synthesis', Bioconjugate Chemistry, 19, pp. 2308 - 2310, http://dx.doi.org/10.1021/bc800369c

Fournier PGJ; Daubiné F; Lundy MW; Rogers MJ; Ebetino FH; Clézardin P, 2008, 'Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo', Cancer Research, 68, pp. 8945 - 8953, http://dx.doi.org/10.1158/0008-5472.CAN-08-2195

Guerrini MM; Sobacchi C; Cassani B; Abinun M; Kilic SS; Pangrazio A; Moratto D; Mazzolari E; Clayton-Smith J; Orchard P; Coxon FP; Helfrich MH; Crockett JC; Mellis D; Vellodi A; Tezcan I; Notarangelo LD; Rogers MJ; Vezzoni P; Villa A; Frattini A, 2008, 'Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations', American Journal of Human Genetics, 83, pp. 64 - 76, http://dx.doi.org/10.1016/j.ajhg.2008.06.015

Guerrini MM; Sobacchi C; Cassani B; Abinun M; Kilic SS; Pangrazio A; Moratto D; Mazzolari E; Clayton-Smith J; Orchard P; Coxon FP; Helfrich MH; Crockett JC; Mellis D; Vellodi A; Tezcan I; Notarangelo LD; Rogers MJ; Vezzoni P; Villa A; Frattini A, 2008, 'Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations', AMERICAN JOURNAL OF HUMAN GENETICS, 83, pp. 64 - 76, http://dx.doi.org/10.1016/j.ajhg.2008.06.015

Ory B; Moriceau G; Trichet V; Blanchard F; Berreur M; Redini F; Rogers M; Heymann D, 2008, 'Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells', JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 12, pp. 928 - 941, http://dx.doi.org/10.1111/j.1582-4934.2008.00141.x

Russell RGG; Watts NB; Ebetino FH; Rogers MJ, 2008, 'Mechanisms of action of bisphosphonates: Similarities and differences and their potential influence on clinical efficacy', Osteoporosis International, 19, pp. 733 - 759, http://dx.doi.org/10.1007/s00198-007-0540-8

Coxon FP; Thompson K; Roelofs AJ; Ebetino FH; Rogers MJ, 2008, 'Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells', Bone, 42, pp. 848 - 860, http://dx.doi.org/10.1016/j.bone.2007.12.225

Dunford JE; Kwaasi AA; Rogers MJ; Barnett BL; Ebetino FH; Russell RGG; Oppermann U; Kavanagh KL, 2008, 'Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: Time-dependent inhibition of human farnesyl pyrophosphate synthase', Journal of Medicinal Chemistry, 51, pp. 2187 - 2195, http://dx.doi.org/10.1021/jm7015733

Holmes S; Smith S; Borthwick L; Dunford J; Rogers M; Bishop N; Grabowski PS, 2008, 'CMT3 alters mitochondrial function in murine osteoclast lineage cells', Biochemical and Biophysical Research Communications, 365, pp. 840 - 845, http://dx.doi.org/10.1016/j.bbrc.2007.11.054

Ory B; Moriceau G; Trichet V; Blanchard F; Berreur M; Rédini F; Rogers M; Heymann D, 2008, 'Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells', Journal of Cellular and Molecular Medicine, 12, pp. 928 - 941, http://dx.doi.org/10.1111/j.1582-4934.2008.00141.x

Tavare R; Baron R; Taylor A; Seabra MC; Blazewska KM; McKenna CE; Kashemirov BA; Ebetino FH; Rogers MJ; Coxon FP, 2008, 'Characterisation of the inhibition of rab prenylation by phosphonocarboxylates', Bone, 42, pp. S88 - S89, http://dx.doi.org/10.1016/j.bone.2007.12.167

A. Stewart C; Baron R; Blazewska KM; Kashemirov BA; Ebetino FH; Navea JR; Rogers MJ; McKenna CE; Coxon FP, 2008, 'Differential inhibition of rab geranylgeranyl transferase by stereoisomers of phosphonocarboxylates', Bone, 42, pp. S87 - S87, http://dx.doi.org/10.1016/j.bone.2007.12.164

Coxon FP; Bala JL; Kashemirov BA; Lundy MW; Chen X; Xia Z; Dunford JE; Russell GG; Roelofs AJ; Rogers MJ; McKenna CE; Ebetino FH, 2008, 'Fluorescently labeled risedronate and related analogs: Design and evaluation as imaging probes', Bone, 42, pp. S36 - S36, http://dx.doi.org/10.1016/j.bone.2007.12.054

Roelofs AJ; Jauhiainen M; Monkkonen H; Rogers MJ; Monkkonen J; Thompson K, 2008, 'Nitrogen-containing bisphosphonates induce IPP/DMAPP accumulation selectively in peripheral blood monocytes due to efficient drug uptake', Bone, 42, pp. S84 - S85, http://dx.doi.org/10.1016/j.bone.2007.12.159

Dunford JE; Kwaasi AA; Kavanagh KL; Rogers MJ; Oppermann U; Barnett BB; Ebetino FH; Graham R; Russell G, 2008, 'Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase', Bone, 42, pp. S71 - S71, http://dx.doi.org/10.1016/j.bone.2007.12.129

Stewart CA; Baron R; Marma MS; Blazewska KM; Kashemirov BA; Ebetino FH; McKenna CE; Rogers MJ; Coxon FP, 2008, 'Structure activity relationships of phosphonocarboxylate inhibitors of rab geranylgeranyl transferase', Bone, 42, pp. S86 - S87, http://dx.doi.org/10.1016/j.bone.2007.12.163

Roelofs AJ; Coxon FP; Ebetino FH; Bala JF; Kashemirov BA; McKenna CE; Rogers MJ, 2008, 'Use of a fluorescent analogue of risedronate to study localisation and cellular uptake of bisphosphonates in vivo', Bone, 42, pp. S85 - S85, http://dx.doi.org/10.1016/j.bone.2007.12.160

Kuokkanen J; Crockett JC; Rogers MJ; Mönkkönen H; Auriola S; Mönkkönen J, 2008, 'Zoledronic Acid-Induced IPP/ApppI Formation In Vivo and In Vitro', Bone, 42, pp. S38 - S39, http://dx.doi.org/10.1016/j.bone.2007.12.060

Samanna V; Ma T; Mak TW; Rogers M; Chellaiah MA, 2007, 'Actin polymerization modulates CD44 surface expression, MMP-9 activation, and osteoclast function', Journal of Cellular Physiology, 213, pp. 710 - 720, http://dx.doi.org/10.1002/jcp.21137

Crockett JC; Schütze N; Tosh D; Jatzke S; Duthie A; Jakob F; Rogers MJ, 2007, 'The matricellular protein CYR61 inhibits osteoclastogenesis by a mechanism independent of αvβ3 and α vβ5', Endocrinology, 148, pp. 5761 - 5768, http://dx.doi.org/10.1210/en.2007-0473

Hughes A; Rogers MJ; Idris AI; Crockett JC, 2007, 'A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo', Calcified Tissue International, 81, pp. 403 - 413, http://dx.doi.org/10.1007/s00223-007-9078-1

Thompson K; Rogers MJ, 2007, 'The molecular mechanisms of action of bisphosphonates', Clinical Reviews in Bone and Mineral Metabolism, 5, pp. 130 - 144, http://dx.doi.org/10.1007/s12018-007-9004-0

Sobacchi C; Frattini A; Guerrini MM; Abinun M; Pangrazio A; Susani L; Bredius R; Mancini G; Cant A; Bishop N; Grabowski P; Del Fattore A; Messina C; Errigo G; Coxon FP; Scott DI; Teti A; Rogers MJ; Vezzoni P; Villa A; Helfrich MH, 2007, 'Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL', Nature Genetics, 39, pp. 960 - 962, http://dx.doi.org/10.1038/ng2076

Roelofs AJ; Edwards CM; Russell RGG; Ebetino FH; Rogers MJ; Hulley PA, 2007, 'Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase', Journal of Pharmacology and Experimental Therapeutics, 322, pp. 228 - 235, http://dx.doi.org/10.1124/jpet.106.116467

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