Select Publications
Journal articles
2007, 'Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans', Journal of Clinical Investigation, 117, pp. 919 - 930, http://dx.doi.org/10.1172/JCI30328
,2007, 'Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells', Molecular Cancer, 6, http://dx.doi.org/10.1186/1476-4598-6-18
,2007, 'A novel method for efficient generation of transfected human osteoclasts', Calcified Tissue International, 80, pp. 132 - 136, http://dx.doi.org/10.1007/s00223-006-0245-6
,2006, 'Molecular mechanisms of action of bisphosphonates: Current status', Clinical Cancer Research, 12, http://dx.doi.org/10.1158/1078-0432.CCR-06-0843
,2006, 'Recent advances in understanding the mechanism of action of bisphosphonates', Current Opinion in Pharmacology, 6, pp. 307 - 312, http://dx.doi.org/10.1016/j.coph.2006.03.005
,2006, 'The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs', Proceedings of the National Academy of Sciences of the United States of America, 103, pp. 7829 - 7834, http://dx.doi.org/10.1073/pnas.0601643103
,2006, 'Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis', Molecular Pharmacology, 69, pp. 1624 - 1632, http://dx.doi.org/10.1124/mol.105.020776
,2006, 'Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases', Journal of Bone and Mineral Research, 21, pp. 684 - 694, http://dx.doi.org/10.1359/jbmr.060118
,2006, 'Alkylamines cause Vγ9Vδ2 T-cell activation and proliferation by inhibiting the mevalonate pathway', Blood, 107, pp. 651 - 654, http://dx.doi.org/10.1182/blood-2005-03-1025
,2006, 'Alkylamines prevent osteoclast formation and activity by inhibiting the mevalonate pathway', Bone, 38, pp. 31 - 31, http://dx.doi.org/10.1016/j.bone.2006.01.124
,2006, 'Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase', Bone, 38, pp. 53 - 53, http://dx.doi.org/10.1016/j.bone.2005.12.050
,2006, 'Cytosolic entry of Bisphosphonates into macrophages and osteoclasts requires fluid-phase endocytosis and endosomal acidification', Bone, 38, pp. 47 - 47, http://dx.doi.org/10.1016/j.bone.2005.12.035
,2006, 'Inhibition of post-translational prenylation causes sustained activation of RAC, Cdc42 and Rho GTPases', Bone, 38, pp. 45 - 45, http://dx.doi.org/10.1016/j.bone.2005.12.031
,2006, 'Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates', Bone, 38, pp. 47 - 48, http://dx.doi.org/10.1016/j.bone.2005.12.037
,2006, 'Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase', Bone, 38, pp. 49 - 50, http://dx.doi.org/10.1016/j.bone.2005.12.042
,2006, 'Prevention of breast cancer cell adhesion to bone in vitro by bisphosphonates is mediated by their inhibitory effect on protein prenylation', Bone, 38, pp. 59 - 60, http://dx.doi.org/10.1016/j.bone.2005.12.066
,2006, 'Resorbing osteoclasts increase the availability of mineral-bound bisphosphonates to non-resorbing cells', Bone, 38, pp. 45 - 46, http://dx.doi.org/10.1016/j.bone.2005.12.032
,2006, 'Structure-activity relationships of bisphosphonate analogues', Bone, 38, pp. 46 - 46, http://dx.doi.org/10.1016/j.bone.2005.12.033
,2006, 'Target enzyme specificity, potency and potential lack of side-effects of novel phosphonocarboxylate analogues of bisphosphonates', Bone, 38, pp. 46 - 47, http://dx.doi.org/10.1016/j.bone.2005.12.034
,2005, 'Zoledronate Exerts Direct Antiproliferative and Apoptotic Effects on Human Myeloma Cells In Vitro and In Vivo.', Blood, 106, pp. 3387 - 3387, http://dx.doi.org/10.1182/blood.v106.11.3387.3387
,2005, 'Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo', Bone, 37, pp. 349 - 358, http://dx.doi.org/10.1016/j.bone.2005.04.021
,2005, 'JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998).', Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 20, pp. 1265 - 1274, http://dx.doi.org/10.1359/jbmr.2005.20.7.1265
,2004, 'From molds and macrophages to mevalonate: A decade of progress in understanding the molecular mode of action of bisphosphonates', Calcified Tissue International, 75, pp. 451 - 461, http://dx.doi.org/10.1007/s00223-004-0024-1
,2004, 'Zoledronic Acid Inhibits Protein Prenylation in Plasmacytoma Tumors In Vivo and Enhances Survival in the INA-6 SCID Mouse Model.', Blood, 104, pp. 3360 - 3360, http://dx.doi.org/10.1182/blood.v104.11.3360.3360
,2004, 'Statins Prevent Bisphosphonate-Induced γ,δ-T-Cell Proliferation and Activation in Vitro', Journal of Bone and Mineral Research, 19, pp. 278 - 288, http://dx.doi.org/10.1359/JBMR.0301230
,2003, 'New insights into the molecular mechanisms of action of bisphosphonates', Current Pharmaceutical Design, 9, pp. 2643 - 2658, http://dx.doi.org/10.2174/1381612033453640
,2003, 'Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31', Nature Genetics, 34, pp. 421 - 428, http://dx.doi.org/10.1038/ng1208
,2003, 'Antagonistic effects of different classes of bisphosphonates in osteoclasts and macrophages in vitro', Journal of Bone and Mineral Research, 18, pp. 204 - 212, http://dx.doi.org/10.1359/jbmr.2003.18.2.204
,2003, 'Isolation and purification of rabbit osteoclasts.', Methods in molecular medicine, 80, pp. 89 - 99, http://dx.doi.org/10.1385/1-59259-366-6:89
,2003, 'The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity', Journal of Bone and Mineral Research, 18, pp. 88 - 96, http://dx.doi.org/10.1359/jbmr.2003.18.1.88
,2003, 'The role of prenylated small GTP-binding proteins in the regulation of osteoclast function', Calcified Tissue International, 72, pp. 80 - 84, http://dx.doi.org/10.1007/s00223-002-2017-2
,2002, 'Pamidronate causes apoptosis of plasma cells in vivo in patients with multiple myeloma', British Journal of Haematology, 119, pp. 475 - 483, http://dx.doi.org/10.1046/j.1365-2141.2002.03824.x
,2002, 'Pharmacologic profile of zoledronic acid: A highly potent inhibitor of bone resorption', Drug Development Research, 55, pp. 210 - 224, http://dx.doi.org/10.1002/ddr.10071
,2002, 'Meeting report from what is new in bisphosphonates: Sixth workshop on bisphosphonates', BoneKEy-Osteovision, http://dx.doi.org/10.1138/2002041
,2002, 'Further insight into mechanism of action of clodronate: Inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite', Molecular Pharmacology, 61, pp. 1255 - 1262, http://dx.doi.org/10.1124/mol.61.5.1255
,2002, 'Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase', Biochemical and Biophysical Research Communications, 290, pp. 869 - 873, http://dx.doi.org/10.1006/bbrc.2001.6289
,2001, 'Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages', Journal of Biological Chemistry, 276, pp. 48213 - 48222, http://dx.doi.org/10.1074/jbc.M106473200
,2001, 'The cellular uptake and metabolism of clodronate in RAW 264 macrophages', Pharmaceutical Research, 18, pp. 1550 - 1555, http://dx.doi.org/10.1023/A:1013026313647
,2001, 'Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: A model of bisphosphonate-induced gastrointestinal toxicity', Bone, 29, pp. 336 - 343, http://dx.doi.org/10.1016/S8756-3282(01)00589-0
,2001, 'The Molecular Mechanism of Action of the Antiresorptive and Antiinflammatory Drug Clodronate: Evidence for the Formation in Vivo of a Metabolite That Inhibits Bone Resorption and Causes Osteoclast and Macrophage Apoptosis', Arthritis and Rheumatism, 44, pp. 2201 - 2210, http://dx.doi.org/10.1002/1529-0131(200109)44:9<2201::AID-ART374>3.0.CO;2-E
,2001, 'Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro', Bone, 28, pp. 465 - 473, http://dx.doi.org/10.1016/S8756-3282(01)00412-4
,2001, 'Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates', Journal of Pharmacology and Experimental Therapeutics, 296, pp. 235 - 242
,2000, 'The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma', British Journal of Haematology, 111, pp. 283 - 286, http://dx.doi.org/10.1046/j.1365-2141.2000.02310.x
,2000, 'Analysis of an adenine nucleotide-containing metabolite of clodronate using ion pair high-performance liquid chromatography-electrospray ionisation mass spectrometry', Journal of Chromatography B: Biomedical Sciences and Applications, 738, pp. 395 - 403, http://dx.doi.org/10.1016/S0378-4347(99)00559-9
,2000, 'A deletion on chromosome 4 cosegregates with the whirler deafness mutation: Exclusion of Orm1 as a candidate', Mammalian Genome, 11, pp. 51 - 57, http://dx.doi.org/10.1007/s003350010010
,2000, 'Protein geranylgeranylation is required for osteoclast formation, function, and survival: Inhibition by bisphosphonates and GGTI-298', Journal of Bone and Mineral Research, 15, pp. 1467 - 1476, http://dx.doi.org/10.1359/jbmr.2000.15.8.1467
,2000, 'Statins: Lower lipids and better bones?', Nature Medicine, 6, pp. 21 - 23, http://dx.doi.org/10.1038/71484
,1999, 'Genetic mapping of the whirler mutation', Mammalian Genome, 10, pp. 513 - 519, http://dx.doi.org/10.1007/s003359901032
,1999, 'Contrasting effects of alendronate and clodronate on RAW 264 macrophages: The role of a bisphosphonate metabolite', European Journal of Pharmaceutical Sciences, 8, pp. 109 - 118, http://dx.doi.org/10.1016/S0928-0987(98)00065-7
,1999, 'Alendronate mechanism of action: Geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro', Proceedings of the National Academy of Sciences of the United States of America, 96, pp. 133 - 138, http://dx.doi.org/10.1073/pnas.96.1.133
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