By Professor Michael John Rogers

Journal articles

Van Wesenbeeck L; Odgren PR; Coxon FP; Frattini A; Moens P; Perdu B; MacKay CA; Van Hul E; Timmermans JP; Vanhoenacker F; Jacobs R; Peruzzi B; Teti A; Helfrich MH; Rogers MJ; Villa A; Van Hul W, 2007, 'Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans', Journal of Clinical Investigation, 117, pp. 919 - 930, http://dx.doi.org/10.1172/JCI30328

Desai B; Rogers MJ; Chellaiah MA, 2007, 'Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells', Molecular Cancer, 6, http://dx.doi.org/10.1186/1476-4598-6-18

Taylor A; Rogers MJ; Tosh D; Coxon FP, 2007, 'A novel method for efficient generation of transfected human osteoclasts', Calcified Tissue International, 80, pp. 132 - 136, http://dx.doi.org/10.1007/s00223-006-0245-6

Roelofs AJ; Thompson K; Gordon S; Rogers MJ; Boyce ; Roodman ; Suva ; Coleman ; Weilbaecher ; Bruland ; Vessella ; Lipton , 2006, 'Molecular mechanisms of action of bisphosphonates: Current status', Clinical Cancer Research, 12, http://dx.doi.org/10.1158/1078-0432.CCR-06-0843

Coxon FP; Thompson K; Rogers MJ, 2006, 'Recent advances in understanding the mechanism of action of bisphosphonates', Current Opinion in Pharmacology, 6, pp. 307 - 312, http://dx.doi.org/10.1016/j.coph.2006.03.005

Kavanagh KL; Guo K; Dunford JE; Wu X; Knapp S; Ebetino FH; Rogers MJ; Russell RGG; Oppermann U, 2006, 'The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs', Proceedings of the National Academy of Sciences of the United States of America, 103, pp. 7829 - 7834, http://dx.doi.org/10.1073/pnas.0601643103

Thompson K; Rogers MJ; Coxon FP; Crockett JC, 2006, 'Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis', Molecular Pharmacology, 69, pp. 1624 - 1632, http://dx.doi.org/10.1124/mol.105.020776

Dunford JE; Rogers MJ; Ebetino FH; Phipps RJ; Coxon FP, 2006, 'Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases', Journal of Bone and Mineral Research, 21, pp. 684 - 694, http://dx.doi.org/10.1359/jbmr.060118

Thompson K; Rojas-Navea J; Rogers MJ, 2006, 'Alkylamines cause Vγ9Vδ2 T-cell activation and proliferation by inhibiting the mevalonate pathway', Blood, 107, pp. 651 - 654, http://dx.doi.org/10.1182/blood-2005-03-1025

Thompson K; Kikuvi TM; Rogers MJ, 2006, 'Alkylamines prevent osteoclast formation and activity by inhibiting the mevalonate pathway', Bone, 38, pp. 31 - 31, http://dx.doi.org/10.1016/j.bone.2006.01.124

Kavanagh KL; Guo K; Wu X; Knapp S; Ebetino FH; Dunford JE; Rogers MJ; Russell RGG; Oppermann U, 2006, 'Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase', Bone, 38, pp. 53 - 53, http://dx.doi.org/10.1016/j.bone.2005.12.050

Thompson K; Rogers MJ; Coxon FP; Crockett JC, 2006, 'Cytosolic entry of Bisphosphonates into macrophages and osteoclasts requires fluid-phase endocytosis and endosomal acidification', Bone, 38, pp. 47 - 47, http://dx.doi.org/10.1016/j.bone.2005.12.035

Coxon FP; Dunford JE; Rogers MJ, 2006, 'Inhibition of post-translational prenylation causes sustained activation of RAC, Cdc42 and Rho GTPases', Bone, 38, pp. 45 - 45, http://dx.doi.org/10.1016/j.bone.2005.12.031

Dunford JE; Kavanagh K; Oppermann U; Ebetino FH; Russell RGG; Rogers MJ, 2006, 'Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates', Bone, 38, pp. 47 - 48, http://dx.doi.org/10.1016/j.bone.2005.12.037

Ebetino FH; Kashemirov B; McKenna CE; Evdokimov A; Pokross M; Barnett BL; Dunford J; Kavanagh K; Rogers MJ; Lundy MW; Oppermann U; Russell RGG, 2006, 'Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase', Bone, 38, pp. 49 - 50, http://dx.doi.org/10.1016/j.bone.2005.12.042

Garrioch S; Roelofs AJ; Ebetino FH; Rogers MJ, 2006, 'Prevention of breast cancer cell adhesion to bone in vitro by bisphosphonates is mediated by their inhibitory effect on protein prenylation', Bone, 38, pp. 59 - 60, http://dx.doi.org/10.1016/j.bone.2005.12.066

Coxon FP; Thompson K; Ebetino FH; Rogers MJ, 2006, 'Resorbing osteoclasts increase the availability of mineral-bound bisphosphonates to non-resorbing cells', Bone, 38, pp. 45 - 46, http://dx.doi.org/10.1016/j.bone.2005.12.032

Coxon FP; Navea JR; Stewart CA; Al Jaber J; Ebetino FH; McKenna CE; Kashemirov BA; Mallard I; Rogers MJ, 2006, 'Structure-activity relationships of bisphosphonate analogues', Bone, 38, pp. 46 - 46, http://dx.doi.org/10.1016/j.bone.2005.12.033

Coxon FP; Navea JR; Stewart CA; Thompson K; Roelofs A; Ebetino FH; McKenna CE; Kashemirov BA; Bala J; Rogers MJ, 2006, 'Target enzyme specificity, potency and potential lack of side-effects of novel phosphonocarboxylate analogues of bisphosphonates', Bone, 38, pp. 46 - 47, http://dx.doi.org/10.1016/j.bone.2005.12.034

Guenther A; Gordon S; Bakker F; Burger R; Tiemann M; Green JR; Rogers M; Gramatzki M, 2005, 'Zoledronate Exerts Direct Antiproliferative and Apoptotic Effects on Human Myeloma Cells In Vitro and In Vivo.', Blood, 106, pp. 3387 - 3387, http://dx.doi.org/10.1182/blood.v106.11.3387.3387

Coxon FP; Ebetino FH; Mules EH; Seabra MC; McKenna CE; Rogers MJ, 2005, 'Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo', Bone, 37, pp. 349 - 358, http://dx.doi.org/10.1016/j.bone.2005.04.021

Luckman SP; Hughes DE; Coxon FP; Russell GG; Rogers MJ, 2005, 'JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998).', Journal of Bone and Mineral Research the Official Journal of the American Society for Bone and Mineral Research, 20, pp. 1265 - 1274, http://dx.doi.org/10.1359/jbmr.2005.20.7.1265

Rogers MJ, 2004, 'From molds and macrophages to mevalonate: A decade of progress in understanding the molecular mode of action of bisphosphonates', Calcified Tissue International, 75, pp. 451 - 461, http://dx.doi.org/10.1007/s00223-004-0024-1

Guenther A; Gordon S; Bakker F; Burger R; Green JR; Rogers M; Gramatzki M, 2004, 'Zoledronic Acid Inhibits Protein Prenylation in Plasmacytoma Tumors In Vivo and Enhances Survival in the INA-6 SCID Mouse Model.', Blood, 104, pp. 3360 - 3360, http://dx.doi.org/10.1182/blood.v104.11.3360.3360

Thompson K; Rogers MJ, 2004, 'Statins Prevent Bisphosphonate-Induced γ,δ-T-Cell Proliferation and Activation in Vitro', Journal of Bone and Mineral Research, 19, pp. 278 - 288, http://dx.doi.org/10.1359/JBMR.0301230

Rogers MJ, 2003, 'New insights into the molecular mechanisms of action of bisphosphonates', Current Pharmaceutical Design, 9, pp. 2643 - 2658, http://dx.doi.org/10.2174/1381612033453640

Mburu P; Mustapha M; Varela A; Weil D; El-Amraoui A; Holme RH; Rump A; Hardisty RE; Blanchard S; Coimbra RS; Perfettini I; Parkinson N; Mallon AM; Glenister P; Rogers MJ; Paige AJ; Moir L; Clay J; Rosenthal A; Liu XZ; Blanco G; Steel KP; Petit C; Brown SDM, 2003, 'Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31', Nature Genetics, 34, pp. 421 - 428, http://dx.doi.org/10.1038/ng1208

Frith JC; Rogers MJ, 2003, 'Antagonistic effects of different classes of bisphosphonates in osteoclasts and macrophages in vitro', Journal of Bone and Mineral Research, 18, pp. 204 - 212, http://dx.doi.org/10.1359/jbmr.2003.18.2.204

Coxon FP; Frith JC; Benford HL; Rogers MJ, 2003, 'Isolation and purification of rabbit osteoclasts.', Methods in Molecular Medicine, 80, pp. 89 - 99, http://dx.doi.org/10.1385/1-59259-366-6:89

Staal A; Frith JC; French MH; Swartz J; Güngör T; Harrity TW; Tamasi J; Rogers MJ; Feyen JHM, 2003, 'The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity', Journal of Bone and Mineral Research, 18, pp. 88 - 96, http://dx.doi.org/10.1359/jbmr.2003.18.1.88

Coxon FP; Rogers MJ, 2003, 'The role of prenylated small GTP-binding proteins in the regulation of osteoclast function', Calcified Tissue International, 72, pp. 80 - 84, http://dx.doi.org/10.1007/s00223-002-2017-2

Gordon S; Helfrich MH; Sati HIA; Greaves M; Ralston SH; Culligan DJ; Soutar RL; Rogers MJ, 2002, 'Pamidronate causes apoptosis of plasma cells in vivo in patients with multiple myeloma', British Journal of Haematology, 119, pp. 475 - 483, http://dx.doi.org/10.1046/j.1365-2141.2002.03824.x

Green JR; Rogers MJ, 2002, 'Pharmacologic profile of zoledronic acid: A highly potent inhibitor of bone resorption', Drug Development Research, 55, pp. 210 - 224, http://dx.doi.org/10.1002/ddr.10071

Rogers MJ; Russell RG; Watts NB, 2002, 'Meeting report from what is new in bisphosphonates: Sixth workshop on bisphosphonates', BoneKEy-Osteovision, http://dx.doi.org/10.1138/2002041

Lehenkari PP; Kellinsalmi M; Näpänkangas JP; Ylitalo KV; Mönkkönen J; Rogers MJ; Azhayev A; Kalervo Väänänen H; Hassinen IE, 2002, 'Further insight into mechanism of action of clodronate: Inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite', Molecular Pharmacology, 61, pp. 1255 - 1262, http://dx.doi.org/10.1016/s0026-895x(24)12222-5

Thompson K; Dunford JE; Rogers MJ; Ebetino FH, 2002, 'Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase', Biochemical and Biophysical Research Communications, 290, pp. 869 - 873, http://dx.doi.org/10.1006/bbrc.2001.6289

Lehenkari PP; Kellinsalmi M; Näpänkangas JP; Ylitalo KV; Mönkkönen J; Rogers MJ; Azhayev A; Väänänen HK; Hassinen IE, 2002, 'Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite', Molecular Pharmacology, 61, pp. 1255 - 1262, http://dx.doi.org/10.1016/s0026-895x(24)12222-5

Mönkkönen H; Rogers MJ; Makkonen N; Niva S; Auriola S; Mönkkönen J, 2001, 'The cellular uptake and metabolism of clodronate in RAW 264 macrophages', Pharmaceutical Research, 18, pp. 1550 - 1555, http://dx.doi.org/10.1023/A:1013026313647

Suri S; Mönkkönen J; Taskinen M; Pesonen J; Blank MA; Phipps RJ; Rogers MJ, 2001, 'Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: A model of bisphosphonate-induced gastrointestinal toxicity', Bone, 29, pp. 336 - 343, http://dx.doi.org/10.1016/S8756-3282(01)00589-0

Frith JC; Mönkkönen J; Auriola S; Mönkkönen H; Rogers MJ, 2001, 'The Molecular Mechanism of Action of the Antiresorptive and Antiinflammatory Drug Clodronate: Evidence for the Formation in Vivo of a Metabolite That Inhibits Bone Resorption and Causes Osteoclast and Macrophage Apoptosis', Arthritis and Rheumatism, 44, pp. 2201 - 2210, http://dx.doi.org/10.1002/1529-0131(200109)44:9<2201::AID-ART374>3.0.CO;2-E

Benford HL; McGowan NWA; Helfrich MH; Nuttall ME; Rogers MJ, 2001, 'Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro', Bone, 28, pp. 465 - 473, http://dx.doi.org/10.1016/S8756-3282(01)00412-4

Coxon FP; Helfrich MH; Larijani B; Muzylak M; Dunford JE; Marshall D; McKinnon AD; Nesbitt SA; Horton MA; Seabra MC; Ebetino FH; Rogers MJ, 2001, 'Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages', Journal of Biological Chemistry, 276, pp. 48213 - 48222, http://dx.doi.org/10.1074/jbc.m106473200

Dunford JE; Thompson K; Coxon FP; Luckman SP; Hahn FM; Poulter CD; Ebetino FH; Rogers MJ, 2001, 'Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates', Journal of Pharmacology and Experimental Therapeutics, 296, pp. 235 - 242, http://dx.doi.org/10.1016/s0022-3565(24)38786-5

Shipman CM; Vanderkerken K; Rogers MJ; Lippitt JM; Asosingh K; Hughes DE; Van Camp B; Russell RGG; Croucher PI, 2000, 'The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma', British Journal of Haematology, 111, pp. 283 - 286, http://dx.doi.org/10.1046/j.1365-2141.2000.02310.x

Mönkkönen H; Moilanen P; Mönkkönen J; Frith JC; Rogers MJ; Auriola S, 2000, 'Analysis of an adenine nucleotide-containing metabolite of clodronate using ion pair high-performance liquid chromatography-electrospray ionisation mass spectrometry', Journal of Chromatography B Biomedical Sciences and Applications, 738, pp. 395 - 403, http://dx.doi.org/10.1016/S0378-4347(99)00559-9

Paige AJW; Kiernan BW; Varela A; Rogers MJC; Hughes D; Steel KP; Brown SDM, 2000, 'A deletion on chromosome 4 cosegregates with the whirler deafness mutation: Exclusion of Orm1 as a candidate', Mammalian Genome, 11, pp. 51 - 57, http://dx.doi.org/10.1007/s003350010010

Coxon FP; Helfrich MH; Van't Hof R; Sebti S; Ralston SH; Hamilton A; Rogers MJ, 2000, 'Protein geranylgeranylation is required for osteoclast formation, function, and survival: Inhibition by bisphosphonates and GGTI-298', Journal of Bone and Mineral Research, 15, pp. 1467 - 1476, http://dx.doi.org/10.1359/jbmr.2000.15.8.1467

Rogers MJ, 2000, 'Statins: Lower lipids and better bones?', Nature Medicine, 6, pp. 21 - 23, http://dx.doi.org/10.1038/71484

Rogers MJC; Fleming J; Kiernan BW; Mburu P; Varela A; Brown SDM; Steel KP, 1999, 'Genetic mapping of the whirler mutation', Mammalian Genome, 10, pp. 513 - 519, http://dx.doi.org/10.1007/s003359901032

Makkonen N; Salminen A; Rogers MJ; Frith JC; Urtti A; Azhayeva E; Mönkkönen J, 1999, 'Contrasting effects of alendronate and clodronate on RAW 264 macrophages: The role of a bisphosphonate metabolite', European Journal of Pharmaceutical Sciences, 8, pp. 109 - 118, http://dx.doi.org/10.1016/S0928-0987(98)00065-7

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