By Professor Peter Gunning

Journal articles

Chen Y; Gu M; Gunning PW; Russell SM, 2016, 'Dense small molecule labeling enables activator-dependent STORM by proximity mapping', Histochemistry and Cell Biology, 146, pp. 255 - 266, http://dx.doi.org/10.1007/s00418-016-1451-6

Janco M; Bonello TT; Byun A; Coster ACF; Lebhar H; Dedova I; Gunning PW; Böcking T, 2016, 'The impact of tropomyosins on actin filament assembly is isoform specific', BioArchitecture, 6, pp. 61 - 75, http://dx.doi.org/10.1080/19490992.2016.1201619

Brayford S; Bryce NS; Schevzov G; Haynes EM; Bear JE; Hardeman EC; Gunning PW, 2016, 'Tropomyosin promotes lamellipodial persistence by collaborating with Arp2/3 at the leading edge', Current Biology, 26, pp. 1312 - 1318, http://dx.doi.org/10.1016/j.cub.2016.03.028

Bonello TT; Janco M; Hook J; Byun A; Appaduray M; Dedova I; Hitchcock-DeGregori S; Hardeman EC; Stehn JR; Böcking T; Gunning PW, 2016, 'A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics', Scientific Reports, 6, pp. 19816, http://dx.doi.org/10.1038/srep19816

Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P; Zhang L, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020

Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC, 2016, 'Corrigendum to An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake [Traic, (2015), 16, 7, 691-711]', Traffic, 17, pp. 80 - 81, http://dx.doi.org/10.1111/tra.12342

Dugina V; Alieva I; Khromova N; Kireev I; Gunning PW; Kopnin P, 2016, 'Interaction of microtubules with the actin cytoskeleton via cross-talk of EB1-containing +TIPs and γ-actin in epithelial cells', Oncotarget, 7, pp. 72699 - 72715, http://dx.doi.org/10.18632/oncotarget.12236

Knothe Tate ML; Gunning PW; Sansalone V, 2016, 'Emergence of form from function: role of stem cell mechanoadaptation in sealing of cell fate', Bioarchitecture

Coombes JD; Schevzov G; Kan CY; Petti C; Maritz MF; Whittaker S; Mackenzie KL; Gunning PW, 2015, 'Ras Transformation Overrides a Proliferation Defect Induced by Tpm3.1 Knockout', Cellular and Molecular Biology Letters, 20, pp. 626 - 646, http://dx.doi.org/10.1515/cmble-2015-0037

Glass JJ; Phillips PA; Gunning PW; Stehn JR, 2015, 'Hypoxia alters the recruitment of tropomyosins into the actin stress fibres of neuroblastoma cells', BMC Cancer, 15, http://dx.doi.org/10.1186/s12885-015-1741-8

Gunning PW; Hardeman EC; Lappalainen P; Mulvihill DP, 2015, 'Tropomyosin - master regulator of actin filament function in the cytoskeleton', Journal of Cell Science, 128, pp. 2965 - 2974, http://dx.doi.org/10.1242/jcs.172502

Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC; Yang Ai S, 2015, 'An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake', Traffic, 16, pp. 691 - 711, http://dx.doi.org/10.1111/tra.12282

Canales CP; Wong ACY; Gunning PW; Housley GD; Hardeman EC; Palmer SJ, 2015, 'The role of GTF2IRD1 in the auditory pathology of Williams-Beuren Syndrome', European Journal of Human Genetics, 23, pp. 774 - 780, http://dx.doi.org/10.1038/ejhg.2014.188

Prunotto M; Bruschi M; Gunning P; Gabbiani G; Weibel F; Ghiggeri GM; Petretto A; Scaloni A; Bonello T; Schevzov G; Alieva I; Bochaton-Piallat ML; Candiano G; Dugina V; Chaponnier C, 2015, 'Stable incorporation of α-smooth muscle actin into stress fibers is dependent on specific tropomyosin isoforms', Cytoskeleton, 72, pp. 257 - 267, http://dx.doi.org/10.1002/cm.21230

Jalilian I; Heu C; Cheng H; Freittag H; Desouza M; Stehn JR; Bryce NS; Whan RM; Hardeman EC; Fath T; Schevzov G; Gunning PW, 2015, 'Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton', PLoS ONE, 10, pp. e0126214, http://dx.doi.org/10.1371/journal.pone.0126214

Schevzov G; Kee AJ; Wang B; Sequeira VB; Hook J; Coombes JD; Lucas CA; Stehn JR; Musgrove EA; Cretu A; Assoian R; Fath T; Hanoch T; Seger R; Pleines I; Kile BT; Hardeman EC; Gunning PW, 2015, 'Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments', Molecular Biology of the Cell, 26, pp. 2475 - 2490, http://dx.doi.org/10.1091/mbc.E14-10-1453

Geeves MA; Hitchcock-DeGregori SE; Gunning PW, 2015, 'A systematic nomenclature for mammalian tropomyosin isoforms', Journal of Muscle Research and Cell Motility, 36, pp. 147 - 153, http://dx.doi.org/10.1007/s10974-014-9389-6

Bryce NS; De Laurentiis A; Failes T; Arndt GM; Stehn JR; Hardeman EC; Gunning PW, 2015, 'Identification of the possible states of organisation of the actin cytoskeleton using high content image screening of a high diversity chemical library.', MOLECULAR BIOLOGY OF THE CELL, 26, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209928400229&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hu M; Kramer B; Zhang GY; Wang YM; Watson D; Howden B; McCowage G; Alexander IE; Gunning P; Alexander SI, 2015, 'Methyl-guanine-methyl-transferase transgenic bone marrow transplantation allows N, N-bis (2-chloroethyl)-nitrosourea driven donor mixed-chimerism without graft-versus-host disease, and with donor-specific allograft tolerance', Transplantation, 99, pp. 2476 - 2484, http://dx.doi.org/10.1097/TP.0000000000000825

Hardeman EC; Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Gunning PW, 2015, 'Recruitment kinetics of tropomyosin is independent of actin filaments', MOLECULAR BIOLOGY OF THE CELL, 26, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209928500840&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gunning PW; Ghoshdastider U; Whitaker S; Popp D; Robinson RC, 2015, 'The evolution of compositionally and functionally distinct actin filaments', Journal of Cell Science, 128, pp. 2009 - 2019, http://dx.doi.org/10.1242/jcs.165563

Lim CY; Bi X; Wu D; Kim JB; Gunning PW; Hong W; Han W, 2015, 'Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms6951

Pleines I; Woods J; Turro E; Foad N; Chappaz S; Lane RM; Manning H; Schevzov G; Westbury SK; Mumford AD; Favier R; Gunning P; Ouwehand WH; Tijssen MR; Kile BT, 2014, 'Mutations in Tropomyosin 4 Cause Macrothrombocytopenia in Mice and Humans', BLOOD, 124, http://dx.doi.org/10.1182/blood.V124.21.571.571

Caldwell BJ; Lucas C; Kee AJ; Gaus K; Gunning PW; Hardeman EC; Yap AS; Gomez GA, 2014, 'Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens', Cytoskeleton, 71, pp. 663 - 676, http://dx.doi.org/10.1002/cm.21202

Stehn JR; Chen D; Currier MA; Eaves D; Desouza M; Moosavian M; Cripe TP; Gunning PW, 2014, 'Synergistic anti-neuroblastoma efficacy using combinatorial cytoskeletal inhibitors', CANCER RESEARCH, 74, http://dx.doi.org/10.1158/1538-7445.PEDCAN-B50

Vindin H; Bischof L; Gunning P; Stehn J, 2014, 'Validation of an algorithm to quantify changes in actin cytoskeletal organization', Journal of Biomolecular Screening, 19, pp. 354 - 368, http://dx.doi.org/10.1177/1087057113503494

Masedunskas A; Appaduray M; Gunning PW; Hardeman EC, 2014, 'Lighting up microtubule cytoskeleton dynamics in skeletal muscle', IntraVital, 3, pp. e29293-1-e29293-5, http://dx.doi.org/10.4161/intv.29293

Curthoys NM; Freittag H; Connor A; Desouza M; Brettle M; Poljak A; Hall A; Hardeman E; Schevzov G; Gunning PW; Fath T, 2014, 'Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells', Molecular and Cellular Neuroscience, 58, pp. 11 - 21, http://dx.doi.org/10.1016/j.mcn.2013.10.011

Desouza M; Nguyen M; Gunning PW; Stehn JR, 2013, 'Targeting the actin cytoskeleton of neuroblastoma: Elucidating the mechanism by which a novel class of anti-cancer compounds induces tumor cell death.', MOLECULAR CANCER THERAPEUTICS, 12, http://dx.doi.org/10.1158/1535-7163.TARG-13-C208

Koestler SA; Steffen A; Nemethova M; Winterhoff M; Luo N; Holleboom JM; Krupp J; Jacob S; Vinzenz M; Schur F; Schlüter K; Gunning PW; Winkler C; Schmeiser C; Faix J; Stradal TEB; Small JV; Rottner K, 2013, 'Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin', Molecular Biology of the Cell, 24, pp. 2861 - 2875, http://dx.doi.org/10.1091/mbc.E12-12-0857

Vindin H; Gunning P, 2013, 'Cytoskeletal tropomyosins: Choreographers of actin filament functional diversity', Journal of Muscle Research and Cell Motility, 34, pp. 261 - 274, http://dx.doi.org/10.1007/s10974-013-9355-8

Pleines I; Chappaz S; Lane R; Kostadima MA; Schevzov G; Ghevaert C; Gunning P; Ouwehand WH; Kile BT, 2013, 'Tropomyosin 4 is a novel regulator of platelet production in mice and humans', JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, pp. 159 - 160, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000331833601360&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Schevzov G; Kee A; Hook J; Pleines I; Kile B; Hardeman E; Gunning P, 2013, 'Distinct actin filament networks modulate different cell signaling cascades', MOLECULAR BIOLOGY OF THE CELL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Suchowerska A; Chen B; Mueller J; Ittner A; Hardeman E; Ittner L; Janitz M; Gunning P; Fath T, 2013, 'Increased levels of actin filaments containing the tropomyosin Tm5NM1 regulate excitotoxicity in the mouse', MOLECULAR BIOLOGY OF THE CELL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wang B; Schevzov G; Coombes J; Hook J; Kee A; Lucas C; Stehn J; Sequeira V; Seger R; Hardeman E; Gunning P, 2013, 'Regulation of cell proliferation mediated by the actin filament regulator Tropomyosin 5NM1', MOLECULAR BIOLOGY OF THE CELL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Masedunskas A; Appaduray M; Hardeman EC; Gunning PW, 2013, 'What makes a model system great?: A case for intravital microscopy for studying the actin cytoskeleton', IntraVital, 2, pp. 1 - 9, http://dx.doi.org/10.4161/intv.26287

Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PR; Sequeira VB; Butler TL; Allanson M; Fath T; Hill TA; McCluskey A; Schevzov G; Palmer S; Hardeman EC; Winlaw D; Reeve VE; Dixon I; Weninger W; Cripe TP; Gunning PW, 2013, 'A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells', Cancer research, 73, pp. 5169 - 5182, http://dx.doi.org/10.1158/0008-5472.CAN-12-4501

Lee AS; Anderson JE; Joya JE; Head SI; Pather N; Kee AJ; Gunning PW; Hardeman EC, 2013, 'Aged skeletal muscle retains the ability to fully regenerate functional architecture', BioArchitecture, 3, pp. 25 - 37, http://dx.doi.org/10.4161/bioa.24966

Lees JG; Ching YW; Adams DH; Bach CT; Samuel MS; Kee AJ; Hardeman EC; Gunning P; Cowin AJ; O'Neill GM, 2013, 'Tropomyosin regulates cell migration during skin wound healing', Journal of Investigative Dermatology, 133, pp. 1330 - 1339, http://dx.doi.org/10.1038/jid.2012.489

Gunning P, 2013, 'Welcome to BioArchitecture 2013', BioArchitecture, 3, pp. 1 - 1, http://dx.doi.org/10.4161/bioa.24027

Schevzov G; Coombes J; Hook J; Wang B; Kee A; Lucas C; Szokolai R; Sequeira V; Stehn J; Musgrove E; Hardeman E; Gunning P, 2012, 'Regulation of cell proliferation mediated by the actin filament stabilizing protein, Tropomyosin 5NM1.', MOLECULAR BIOLOGY OF THE CELL, 23, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348601219&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gunning P, 2012, 'A reflection on 2011 and looking forward to 2012', BioArchitecture, 2, pp. 1-1, http://dx.doi.org/10.4161/bioa.20320

Schevzov G; Curthoys NM; Gunning P; Fath T, 2012, 'Chapter Two – Functional Diversity of Actin Cytoskeleton in Neurons and its Regulation by Tropomyosin', International Review of Cell and Molecular Biology, 298, pp. 33 - 94, http://dx.doi.org/10.1016/B978-0-12-394309-5.00002-X

Palmer SJ; Taylor KM; Santucci N; Widagdo J; Chan Y-KA; Yeo J-L; Gunning PW; Hardeman EC, 2012, 'GTF2IRD2 from the Williams-Beuren critical region encodes a mobile element-derived fusion protein that antagonizes the action of its related family members', Journal of Cell Science, 125, pp. 5040 - 5050, http://dx.doi.org/10.1242/​jcs.102798

Angrisano F; Riglar D; Sturm A; Volz J; Delves MJ; Zuccala E; Turnbull L; Dekiwadia C; Olshina MA; Marapana DS; Wong W; Mollard V; Bradin CH; Tonkin CJ; Gunning P; Ralph SA; Whitchurch CB; Sinden RE; Cowman AF; McFadden GI; Baum J, 2012, 'Spatial localisation of actin filaments across developmental stages of the malaria parasite', PLoS ONE, 7, pp. Article number e32188, http://dx.doi.org/10.1371/journal.pone.0032188

Widagdo J; Taylor KM; Gunning PW; Hardeman EC; Palmer SJ, 2012, 'SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation', PLoS ONE, 7, pp. e49283 pg 1 - e49283 pg 10, http://dx.doi.org/10.1371/journal.pone.0049283

Desouza M; Gunning P; Stehn JR, 2012, 'The actin cytoskeleton as a sensor and mediator of apoptosis', BioArchitecture, 23, pp. 75 - 87, http://dx.doi.org/10.4161/bioa.20975

Gunning P, 2012, 'The organization and regulation of biological space', BioArchitecture, 2, pp. 200 - 203, http://dx.doi.org/10.4161/bioa.22726

Gunning P, 2011, 'Welcome to the first issue of Bioarchitecture', BioArchitecture, 1, pp. 1, http://dx.doi.org/10.4161/bioa.1.1.15419

Tojkander S; Gateva G; Schevzov G; Hotulainen P; Naumanen P; Martin C; Gunning P; Lappalainen P, 2011, 'A Molecular Pathway for Myosin II Recruitment to Stress Fibers', Current Biology, 21, pp. 539 - 550, http://dx.doi.org/10.1061/j.cub.2011.03.007

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