By Professor Stuart Graham Tangye

Journal articles

Suan D; Kräutler NJ; Maag JLV; Butt D; Bourne K; Hermes JR; Avery DT; Young C; Statham A; Elliott M; Dinger ME; Basten A; Tangye SG; Brink R, 2017, 'CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity', Immunity, 47, pp. 1142 - 1153.e4, http://dx.doi.org/10.1016/j.immuni.2017.11.022

Infantino S; Light A; O'donnell K; Bryant V; Avery DT; Elliott M; Tangye SG; Belz G; Mackay F; Richard S; Tarlinton D, 2017, 'Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation', Nature Communications, 8, http://dx.doi.org/10.1038/s41467-017-01009-1

Tangye SG; Pelham SJ; Deenick EK; Ma CS, 2017, 'Cytokine-mediated regulation of human lymphocyte development and function: Insights from primary immunodeficiencies', Journal of Immunology, 199, pp. 1949 - 1958, http://dx.doi.org/10.4049/jimmunol.1700842

Kearney CJ; Vervoort SJ; Ramsbottom KM; Freeman AJ; Michie J; Peake J; Casanova JL; Picard C; Tangye SG; Ma CS; Johnstone RW; Randall KL; Oliaro J, 2017, 'DOCK8 drives Src-dependent NK Cell effector function', Journal of Immunology, 199, pp. 2118 - 2127, http://dx.doi.org/10.4049/jimmunol.1700751

Munoz MA; Jurczyluk J; Mehr S; Chai RC; Arts RJW; Sheu A; McMahon C; Center JR; Singh-Grewal D; Chaitow J; Campbell DE; Quinn JMW; Alexandrov K; Tnimov Z; Tangye SG; Simon A; Phan TG; Rogers MJ, 2017, 'Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency', Journal of Allergy and Clinical Immunology, 140, pp. 873 - 875.e6, http://dx.doi.org/10.1016/j.jaci.2017.02.033

Tangye SG; Forbes LR; Leiding J; Preece K; Kumar AR; Gambineri E; Milner JD; Cooper MA; Seppänen M, 2017, 'Low IgE is insufficiently sensitive to guide genetic testing of STAT3 gain-of-function mutations', Clinical Chemistry, 63, pp. 1539 - 1540, http://dx.doi.org/10.1373/clinchem.2017.273458

Deenick EK; Tangye SG, 2017, 'The TORC that Gets the GC Cycling', Immunity, 46, pp. 974 - 976, http://dx.doi.org/10.1016/j.immuni.2017.06.003

Tangye S, 2017, 'HYPERACTIVATION OF PI3 KINASE CAUSES DEFECTS IN HUMAN B-CELL DEVELOPMENT AND DIFFERENTIATION', The Journal of Immunology, 198, pp. 59.1 - 59.1, http://dx.doi.org/10.4049/jimmunol.198.supp.59.1

Cottineau J; Kottemann MC; Lach FP; Kang YH; Vély F; Deenick EK; Lazarov T; Gineau L; Wang Y; Farina A; Chansel M; Lorenzo L; Piperoglou C; Ma CS; Nitschke P; Belkadi A; Itan Y; Boisson B; Jabot-Hanin F; Picard C; Bustamante J; Eidenschenk C; Boucherit S; Aladjidi N; Lacombe D; Barat P; Qasim W; Hurst JA; Pollard AJ; Uhlig HH; Fieschi C; Michon J; Bermudez VP; Abel L; De Villartay JP; Geissmann F; Tangye SG; Hurwitz J; Vivier E; Casanova JL; Smogorzewska A; Jouanguy E, 2017, 'Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency', Journal of Clinical Investigation, 127, pp. 1991 - 2006, http://dx.doi.org/10.1172/JCI90727

Tangye SG, 2017, 'Pathogenic CD4 ⁺ T cells regulating B-cell differentiation in autoimmunity: Not exactly Tfh cells', Immunology and Cell Biology, 95, pp. 419 - 421, http://dx.doi.org/10.1038/icb.2017.20

Phan TG; Tangye SG, 2017, 'Memory B cells: total recall', Current Opinion in Immunology, 45, pp. 132 - 140, http://dx.doi.org/10.1016/j.coi.2017.03.005

Tangye SG; Pillay B; Randall KL; Avery DT; Tri GP; Gray P; Ziegler JB; Smart JM; Peake J; Arkwright PD; Hambleton S; Orange J; Goodnow CC; Uzel G; Casanova J-L; Lugo Reyes SO; Freeman AF; Su HC; Ma CS, 2017, 'Dedicator of cytokinesis 8-deficient CD4(+) T cells are biased to a T(H)2 effector fate at the expense of T(H)1 and T(H)17 cells', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139, pp. 933 - 949, http://dx.doi.org/10.1016/j.jaci.2016.07.016

Tangye SG; Pillay B; Randall KL; Avery DT; Phan TG; Gray P; Ziegler JB; Smart JM; Peake J; Arkwright PD; Hambleton S; Orange J; Goodnow CC; Uzel G; Casanova JL; Lugo Reyes SO; Freeman AF; Su HC; Ma CS, 2017, 'Dedicator of cytokinesis 8–deficient CD4⁺ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells', Journal of Allergy and Clinical Immunology, 139, pp. 933 - 949, http://dx.doi.org/10.1016/j.jaci.2016.07.016

Moens L; Schaballie H; Bosch B; Voet A; Bossuyt X; Casanova JL; Boisson-Dupuis S; Tangye SG; Meyts I, 2017, 'AD Hyper-IgE Syndrome Due to a Novel Loss-of-Function Mutation in STAT3: a Diagnostic Pursuit Won by Clinical Acuity', Journal of Clinical Immunology, 37, pp. 12 - 17, http://dx.doi.org/10.1007/s10875-016-0351-9

Abolhassani H; Edwards ESJ; Ikinciogullari A; Jing H; Borte S; Buggert M; Du L; Matsuda-Lennikov M; Romano R; Caridha R; Bade S; Zhang Y; Frederiksen J; Fang M; Bal SK; Haskologlu S; Dogu F; Tacyildiz N; Matthews HF; McElwee JJ; Gostick E; Price DA; Palendira U; Aghamohammadi A; Boisson B; Rezaei N; Karlsson AC; Lenardo MJ; Casanova JL; Hammarström L; Tangye SG; Su HC; Pan-Hammarström Q, 2017, 'Combined immunodeficiency and Epstein-Barr virus- induced B cell malignancy in humans with inherited CD70 deficiency', Journal of Experimental Medicine, 214, pp. 91 - 106, http://dx.doi.org/10.1084/jem.20160849

Tangye SG; Palendira U; Edwards ESJ, 2017, 'Human immunity against EBV-lessons from the clinic', Journal of Experimental Medicine, 214, pp. 269 - 283, http://dx.doi.org/10.1084/jem.20161846

Kane A; Lau A; Brink R; Tangye SG; Deenick EK, 2016, 'B-cell–specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome', Journal of Allergy and Clinical Immunology, 138, pp. 1455 - 1458.e3, http://dx.doi.org/10.1016/j.jaci.2016.05.018

Jurczyluk J; Munoz MA; Skinner OP; Chai RC; Ali N; Palendira U; Quinn JMW; Preston A; Tangye SG; Brown AJ; Argent E; Ziegler JB; Mehr S; Rogers MJ, 2016, 'Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases', Immunology and Cell Biology, 94, pp. 994 - 999, http://dx.doi.org/10.1038/icb.2016.58

Jurczyluk J; Munoz MA; Skinner OP; Chai RC; Ali N; Palendira U; Quinn JMW; Preston A; Tangye SG; Brown AJ; Argent E; Ziegler JB; Mehr S; Rogers MJ, 2016, 'Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases', IMMUNOLOGY AND CELL BIOLOGY, 94, pp. 994 - 999, http://dx.doi.org/10.1038/icb.2016.58

Meli AP; Fontés G; Avery DT; Leddon SA; Tam M; Elliot M; Ballesteros-Tato A; Miller J; Stevenson MM; Fowell DJ; Tangye SG; King IL, 2016, 'The Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance', Immunity, 45, pp. 831 - 846, http://dx.doi.org/10.1016/j.immuni.2016.09.018

Wang Y; Ma CS; Ling Y; Bousfiha A; Camcioglu Y; Jacquot S; Payne K; Crestani E; Roncagalli R; Belkadi A; Kerner G; Lorenzo L; Deswarte C; Chrabieh M; Patin E; Vincent QB; Müller-Fleckenstein I; Fleckenstein B; Ailal F; Quintana-Murci L; Fraitag S; Alyanakian MA; Leruez-Ville M; Picard C; Puel A; Bustamante J; Boisson-Dupuis S; Malissen M; Malissen B; Abel L; Hovnanian A; Notarangelo LD; Jouanguy E; Tangye SG; Béziat V; Casanova JL, 2016, 'Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLT PR mutations', Journal of Experimental Medicine, 213, pp. 2413 - 2435, http://dx.doi.org/10.1084/jem.20160576

vijayan D; redzwan M; avery DT; wirasinha RC; brink R; walters G; adelstein S; kobayashi M; gray P; elliott M; king C; vinuesa C; ghilardi N; ma CS; Tangye SG; batten M, 2016, 'IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice', Journal of Immunology, 197, pp. 3008 - 3017, http://dx.doi.org/10.4049/jimmunol.1600652

Pelham SJ; Lenthall HC; Deenick EK; Tangye SG, 2016, 'Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome', Journal of Allergy and Clinical Immunology, 138, pp. 1210 - 1213.e5, http://dx.doi.org/10.1016/j.jaci.2016.04.020

Ma CS; Tangye SG, 2016, 'Cytotoxic T cells that escape exhaustion', NATURE, 537, pp. 312 - 314, http://dx.doi.org/10.1038/nature19428

Moens L; Kane A; Tangye SG, 2016, 'Naïve and memory B cells exhibit distinct biochemical responses following BCR engagement', Immunology and Cell Biology, 94, pp. 774 - 786, http://dx.doi.org/10.1038/icb.2016.41

Woon HG; Braun A; Li J; Smith C; Edwards J; Sierro F; Feng CG; Khanna R; Elliot M; Bell A; Hislop AD; Tangye SG; Rickinson AB; Gebhardt T; Britton WJ; Palendira U, 2016, 'Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs', PLoS Pathogens, 12, http://dx.doi.org/10.1371/journal.ppat.1005799

Ma CS; Wong N; Rao G; Nguyen A; Avery DT; Payne K; Torpy J; O'Young P; Deenick E; Bustamante J; Puel A; Okada S; Kobayashi M; Martinez-Barricarte R; Elliott M; Kilic SS; Baghdadi JE; Minegishi Y; Bousfiha A; Robertson N; Hambleton S; Arkwright PD; French M; Blincoe AK; Hsu P; Campbell DE; Stormon MO; Wong M; Adelstein S; Fulcher DA; Cook MC; Stepensky P; Boztug K; Beier R; Ikincioğullari A; Ziegler JB; Gray P; Picard C; Boisson-Dupuis S; Phan TG; Grimbacher B; Warnatz K; Holland SM; Uzel G; Casanova JL; Tangye SG, 2016, 'Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4⁺ T cells into distinct effector subsets', Journal of Experimental Medicine, 213, pp. 1589 - 1608, http://dx.doi.org/10.1084/jem.20151467

Ma CS, 2016, 'Human T Follicular Helper Cells in Primary Immunodeficiency: Quality Just as Important as Quantity', Journal of Clinical Immunology, 36, pp. 40 - 47, http://dx.doi.org/10.1007/s10875-016-0257-6

Gray PE; O’Brien TA; Wagle M; Tangye SG; Palendira U; Roscioli T; Choo S; Sutton R; Ziegler JB; Frith K, 2015, 'Cerebral Vasculitis in X-linked Lymphoproliferative Disease Cured by Matched Unrelated Cord Blood Transplant', Journal of Clinical Immunology, 35, pp. 604 - 609, http://dx.doi.org/10.1007/s10875-015-0194-9

Ma CS; Wong N; Rao G; Avery DT; Torpy J; Hambridge T; Bustamante J; Okada S; Stoddard JL; Deenick EK; Pelham SJ; Payne K; Boisson-Dupuis S; Puel A; Kobayashi M; Arkwright PD; Kilic SS; El Baghdadi J; Nonoyama S; Minegishi Y; Mahdaviani SA; Mansouri D; Bousfiha A; Blincoe AK; French MA; Hsu P; Campbell DE; Stormon MO; Wong M; Adelstein S; Smart JM; Fulcher DA; Cook MC; Phan TG; Stepensky P; Boztug K; Kansu A; Ikincioʇullari A; Baumann U; Beier R; Roscioli T; Ziegler JB; Gray P; Picard C; Grimbacher B; Warnatz K; Holland SM; Casanova JL; Uzel G; Tangye SG, 2015, 'Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies', Journal of Allergy and Clinical Immunology, 136, pp. 993 - 1006.e1, http://dx.doi.org/10.1016/j.jaci.2015.05.036

Kreins AY; Ciancanelli MJ; Okada S; Kong XF; Ramírez-Alejo N; Kilic SS; El Baghdadi J; Nonoyama S; Mahdaviani SA; Ailal F; Bousfiha A; Mansouri D; Nievas E; Ma CS; Rao G; Bernasconi A; Kuehn HS; Niemela J; Stoddard J; Deveau P; Cobat A; Azbaoui SE; Sabri A; Lim CK; Sundin M; Avery DT; Halwani R; Grant AV; Boisson B; Bogunovic D; Itan Y; Moncada-Velez M; Martinez-Barricarte R; Migaud M; Deswarte C; Alsina L; Kotlarz D; Klein C; Muller-Fleckenstein I; Fleckenstein B; Cormier-Daire V; Rose-John S; Picard C; Hammarstrom L; Puel A; Al-Muhsen S; Abel L; Chaussabel D; Rosenzweig SD; Minegishi Y; Tangye SG; Bustamante J; Casanova JL; Boisson-Dupuis S, 2015, 'Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome', Journal of Experimental Medicine, 212, pp. 1641 - 1662, http://dx.doi.org/10.1084/jem.20140280

Tangye SG; Brink R; Goodnow CC; Phan TG, 2015, 'SnapShot: Interactions between B Cells and T Cells', Cell, 162, pp. 926 - 926.e1, http://dx.doi.org/10.1016/j.cell.2015.07.055

Okada S; Markle JG; Deenick EK; Mele F; Averbuch D; Lagos M; Alzahrani M; Al-Muhsen S; Halwani R; Ma CS; Wong N; Soudais C; Henderson LA; Marzouqa H; Shamma J; Gonzalez M; Martinez-Barricarte R; Okada C; Avery DT; Latorre D; Deswarte C; Jabot-Hanin F; Torrado E; Fountain J; Belkadi A; Itan Y; Boisson B; Migaud M; Lindestam Arlehamn CS; Sette A; Breton S; Cluskey J; Rossjohn J; De Villartay JP; Moshous D; Hambleton S; Latour S; Arkwright PD; Picard C; Lantz O; Engelhard D; Kobayashi M; Abel L; Cooper AM; Notarangelo LD; Boisson-Dupuis S; Puel A; Sallusto F; Bustamante J; Tangye SG; Casanova JL, 2015, 'Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations', Science, 349, pp. 606 - 613, http://dx.doi.org/10.1126/science.aaa4282

Tangye SG, 2015, 'Advances in IL-21 biology-enhancing our understanding of human disease', Current Opinion in Immunology, 34, pp. 107 - 115, http://dx.doi.org/10.1016/j.coi.2015.02.010

Wilson RP; Ives ML; Rao G; Lau A; Payne K; Kobayashi M; Arkwright PD; Peake J; Wong M; Adelstein S; Smart JM; French MA; Fulcher DA; Picard C; Bustamante J; Boisson-Dupuis S; Gray P; Stepensky P; Warnatz K; Freeman AF; Rossjohn J; McCluskey J; Holland SM; Casanova JL; Uzel G; Ma CS; Tangye SG; Deenick EK, 2015, 'STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function', Journal of Experimental Medicine, 212, pp. 855 - 864, http://dx.doi.org/10.1084/jem.20141992

Suan D; Nguyen A; Moran I; Bourne K; Hermes JR; Arshi M; Hampton HR; Tomura M; Miwa Y; Kelleher AD; Kaplan W; Deenick EK; Tangye SG; Brink R; Chtanova T; Phan TG, 2015, 'T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses', Immunity, 42, pp. 704 - 718, http://dx.doi.org/10.1016/j.immuni.2015.03.002

Tangye SG, 2015, 'Thucydides and longer-lived plasma cells', Blood, 125, pp. 1684 - 1685, http://dx.doi.org/10.1182/blood-2015-01-622514

Butt D; Chan TD; Bourne K; Hermes JR; Nguyen A; Statham A; O'Reilly LA; Strasser A; Price S; Schofield P; Christ D; Basten A; Ma CS; Tangye SG; Phan TG; Rao VK; Brink R, 2015, 'FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production', Immunity, 42, pp. 890 - 902, http://dx.doi.org/10.1016/j.immuni.2015.04.010

Tangye SG, 2014, 'XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP', Journal of Clinical Immunology, 34, pp. 772 - 779, http://dx.doi.org/10.1007/s10875-014-0083-7

Kuehn HS; Ouyang W; Lo B; Deenick EK; Niemela JE; Avery DT; Schickel JN; Tran DQ; Stoddard J; Zhang Y; Frucht DM; Dumitriu B; Scheinberg P; Folio LR; Frein CA; Price S; Koh C; Heller T; Seroogy CM; Huttenlocher A; Rao VK; Su HC; Kleiner D; Notarangelo LD; Rampertaap Y; Olivier KN; McElwee J; Hughes J; Pittaluga S; Oliveira JB; Meffre E; Fleisher TA; Holland SM; Lenardo MJ; Tangye SG; Uzel G, 2014, 'Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4', Science, 345, pp. 1623 - 1627, http://dx.doi.org/10.1126/science.1255904

Hutchinson AT; Jones DR; McCauley Winter P; Tangye SG; Raison RL, 2014, 'Cell membrane associated free kappa light chains are found on a subset of tonsil and in vitro-derived plasmablasts', Human Immunology, http://dx.doi.org/10.1016/j.humimm.2014.08.196

Tangye SG, 2014, 'XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP', Journal of Clinical Immunology, http://dx.doi.org/10.1007/s10875-014-0083-7

Reynaud CA; Tangye S, 2014, 'Editorial overview: Lymphocyte activation and effector functions', Current Opinion in Immunology, 28, pp. v - vii, http://dx.doi.org/10.1016/j.coi.2014.04.001

Kane A; Deenick EK; Ma CS; Cook MC; Uzel G; Tangye SG, 2014, 'STAT3 is a central regulator of lymphocyte differentiation and function', Current Opinion in Immunology, 28, pp. 49 - 57, http://dx.doi.org/10.1016/j.coi.2014.01.015

Tangye SG, 2014, 'The right ''Job'' for STAT3 mutant mice!', Blood, 123, pp. 2907 - 2909, http://dx.doi.org/10.1182/blood-2014-04-563726

Koganti S; Hui-Yuen J; McAllister S; Gardner B; Grasser F; Palendira U; Tangye SG; Freeman AF; Bhaduri-McIntosh S, 2014, 'STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation', Proceedings of the National Academy of Sciences of the United States of America, 111, pp. 4946 - 4951, http://dx.doi.org/10.1073/pnas.1400683111

Hutchinson AT; Jones DR; McCauley Winter P; Tangye SG; Raison RL, 2014, 'Cell membrane associated free kappa light chains are found on a subset of tonsil and in vitro-derived plasmablasts', Human Immunology, 75, pp. 986 - 990, http://dx.doi.org/10.1016/j.humimm.2014.08.196

Moens L; Tangye SG, 2014, 'Cytokine-mediated regulation of plasma cell generation: IL-21 takes center stage', Frontiers in Immunology, 5, http://dx.doi.org/10.3389/fimmu.2014.00065

Lucas CL; Kuehn HS; Zhao F; Niemela JE; Deenick EK; Palendira U; Avery DT; Moens L; Cannons JL; Biancalana M; Stoddard J; Ouyang W; Frucht DM; Rao VK; Atkinson TP; Agharahimi A; Hussey AA; Folio LR; Olivier KN; Fleisher TA; Pittaluga S; Holland SM; Cohen JI; Oliveira JB; Tangye SG; Schwartzberg PL; Lenardo MJ; Uzel G, 2014, 'Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency', Nature Immunology, 15, pp. 88 - 97, http://dx.doi.org/10.1038/ni.2771

Reynaud CA; Tangye S, 2014, 'Editorial overview: Lymphocyte activation and effector functions.', Current opinion in immunology, 28

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