By Professor Stuart Graham Tangye

Journal articles

Tangye SG; Brink R, 2012, 'A helping hand from neutrophils in T cell-independent antibody responses?', Nature Immunology, 13, pp. 111 - 113, http://dx.doi.org/10.1038/ni.2214

Cliffe S; Bloch D; Suryani S; Kamsteeg E; Avery D; Palendira U; Church J; Wainstein B; Trizzino A; Lefranc G; Akatcherian C; Megarbane A; Gilissen C; Moshous D; Reichenbach J; Misbah S; Salzer U; Abinun M; Ong P; Stepensky P; Ruga E; Ziegler JB; Wong M; Tangye SG; Lindeman R; Buckley M; Roscioli T, 2012, 'Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome', Journal of Allergy and Clinical Immunology, 130, pp. 735 - 742, http://dx.doi.org/10.1016/j.jaci.2012.02.054

Tangye SG, 2012, 'Defects in lymphocyte function and interactions in primary immunodeficiencies: insights into disease pathogenesis', Pathology, 44, pp. S39 - S39, http://dx.doi.org/10.1016/s0031-3025(16)32689-7

Palendira U; Bell A; Ma CS; Abbott RJM; Phan TG; Riminton DS; Choo S; Smart J; Lougaris V; Giliani S; Buckley RH; Grimbacher B; Alvaro F; Klion AD; Nichols K; Adelstein S; Rickinson A; Tangye SG, 2012, 'Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus', Journal of Experimental Medicine, 209, pp. 913 - 924, http://dx.doi.org/10.1084/jem.20112391

Ma C; Avery D; Chan A; Batten ML; Bustamante J; Boisson-Dupuis S; Arkwright PD; Kreins AY; Averbuch D; Engelhard D; Magdorf K; Kilic S; Minegishi Y; Gray PE, 2012, 'Functional STAT3 deficiency compromises the generation of human T follicular helper cells', Blood, 119, pp. 3997 - 4008, http://dx.doi.org/10.1182/blood-2011-11-392985

Crequer A; Troeger A; Patino E; Ma CS; Picard C; Pedergnana V; Fieschi C; Lim A; Abhyankar A; Gineau L; Mueller-Fleckenstein I; Schmidt M; Taieb A; Kreuger J; Abela L; Tangye SG; Orth G; Williams DA; Casanova J-L; Jouanguy E, 2012, 'Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections', Journal of Clinical Investigation, 122, pp. 3239 - 3247, http://dx.doi.org/10.1172/JCI62949

Chang PP; Barral P; Fitch J; Pratama A; Ma CS; Kallies A; Hogan JJ; Cerundolo V; Tangye SG; Bittman R; Nutt SL; Brink R; Godfrey DI; Batista FD; Vinuesa C, 2012, 'Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses', Nature Immunology, 13, pp. 35 - 43, http://dx.doi.org/10.1038/ni.2166

Hill ER; McAllister SC; Tangye S; Bhaduri-McIntosh S, 2012, 'Signal transducer and activator of transcription 3 (STAT3) controls susceptibility to Epstein-Barr virus reactivation in B cells', Infectious Agents and Cancer, 7, http://dx.doi.org/10.1186/1750-9378-7-s1-p42

Tangye SG; Deenick EK; Palendira U; Ma CS, 2012, 'T cell-B cell interactions in primary immunodeficiencies', Annals of the New York Academy of Sciences, 1250, pp. 1 - 13, http://dx.doi.org/10.1111/j.1749-6632.2011.06361.x

Ma CS; Deenick EK; Batten ML; Tangye SG, 2012, 'The origins, function, and regulation of T follicular helper cells', Journal of Experimental Medicine, 209, pp. 1241 - 1253, http://dx.doi.org/10.1084/jem.20120994

McGuire HM; Vogelzang A; Ma CS; Hughes WE; Silveira PA; Tangye SG; Christ DU; Fulcher DA; Falcone M; King C, 2011, 'A subset of interleukin-21(+) chemokine receptor CCR9(+) T helper cells target accessory organs of the digestive system in autoimmunity', Immunity, 34, pp. 602 - 615, http://www.ncbi.nlm.nih.gov/pubmed/21511186

Cho JH; Kim HO; Webster KE; Palendira U; Hahm B; King C; Tangye SG; Sprent J; Kim KS, 2011, 'Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells', Blood, 118, pp. 116 - 128, http://dx.doi.org/10.1182/blood-2010-11-317396

Chevalier N; Jarrossay D; Ho E; Avery D; Ma CS; Yu D; Sallusto F; Tangye SG; MacKay CR, 2011, 'CXCR5 expressing human central memory CD4 T Cells and their relevance for humoral immune responses', Journal of Immunology, 186, pp. 5556 - 5568, http://www.ncbi.nlm.nih.gov/pubmed/21471443

Randall KL; Chang SS; Ma CS; Fung I; Mei Y; Yabas M; Tan A; Arkwright PD; Suwairi WA; Reyes S; Yamazaki-Nakashimada MA; Garcia-Cruz D; Smart J; Picard C; Okada S; Jouanguy E; Casanova J-L; Lambert T; Cornall RJ; Russell S; Oliaro J; Tangye SG; Bertram EM; Goodnow CC, 2011, 'DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice', Journal of Experimental Medicine, 208, pp. 2305 - 2320, http://dx.doi.org/10.1084/jem.20110345

Recher M; Berglund L; Avery D; Cowan M; Gennery AR; Smart J; Peake J; Wong MB; Pai S-Y; Baxi S; Walter J; Palendira U; Tangye GA; Rice M; Brothers S; Al-Herz W; Ottegen H; Eibel H; Puck JM; Cattaneo F; Ziegler JB; Giliani S; Tangye SG; Notarangelo LD, 2011, 'IL-21 is the primary common gamma chain-binding cytokine required for human B-cell differentation in vivo', Blood, 118, pp. 6824 - 6835, http://dx.doi.org/10.1182/blood-2011-06-362533

Palendira U; Low C; Chan A; Hislop A; Ho E; Phan TG; Deenick EK; Cook MC; Riminton DS; Choo S; Loh R; Booth CA; Gaspar HB; Moretta A; Khanna ; Rickinson A; Tangye SG, 2011, 'Molecular pathogeneiss of EBV infection as revealed by analysis of XLP carriers with heterozygous expression of SAP', PLoS Biology, 9, pp. 1 - 17, http://dx.doi.org/10.1371/journal.pbio.1001187

Tangye SG, 2011, 'Plasmacytoid DCs induce gutsy plasma cells', Immunity, 34, pp. 144 - 146, http://www.ncbi.nlm.nih.gov/pubmed/21349426

Deenick EK; Ma CS; Brink R; Tangye SG, 2011, 'Regulation of T follicular helper cell formation and function by antigen presenting cells', Current Opinion in Immunology, 23, pp. 111 - 118, http://dx.doi.org/10.1016/j.coi.2010.10.007

Cannons J; Tangye SG; Schwartzberg P, 2011, 'SLAM family receptors and SAP adaptors in immunity', Annual Review of Immunology, 29, pp. 665 - 705

Tangye SG, 2011, 'Staying alive: Regulation of plasma cell survival', Trends in Immunology, 32, pp. 595 - 602, http://dx.doi.org/10.1016/j.it.2011.09.001

Randall KL; Lambe T; Johnson A; Treanor B; Kucharska E; Domaschenz H; Whittle B; Tze LE; Enders A; Crockford TL; Bouriez-Jones T; Alston D; Cyster JG; Lenardo MJ; MacKay F; Deenick EK; Tangye SG; Chan TD; Camidge T; Brink R; Vinuesa CG; Batista FD; Cornall RJ; Goodnow CC, 2010, 'Erratum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production (Nature Immunology (2009) 10 (1283-1291))', Nature Immunology, 11, pp. 644, http://dx.doi.org/10.1038/ni0710-644a

Tangye SG; Tarlinton DM, 2010, 'Memory B cells: Effectors of long-lived immune responses (European Journal of Immunology (2009) 39, (8) DOI 10.1002/eji.200939531)', European Journal of Immunology, 40, pp. 302, http://dx.doi.org/10.1002/eji.200990326

Tangye SG; Tarlinton DM, 2010, 'Memory B cells: Effectors of long-lived immune responses (vol 39, pg 2065, 2009)', EUROPEAN JOURNAL OF IMMUNOLOGY, 40, pp. 302 - 302, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000274041800032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Avery D; Deenick EK; Ma CS; Suryani S; Simpson N; Chew G; Chan TD; Palendira U; Bustamante J; Boisson-Dupuis S; Choo S; Bleasel KE; Peake J; King C; French MA; Engelhard D; Al-Hajjar S; Al-Muhsen S; Magdorf K; Roesler J; Arkwright PD; Hissaria P; Riminton DS; Wong M; Brink R; Fulcher DA; Casanova J-L; Cook MC; Tangye SG, 2010, 'B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans', Journal of Experimental Medicine, 207, pp. 155 - 171, http://dx.doi.org/10.1084/jem.20091706

Tindall EA; Severi G; Hoang HN; Ma CS; Fernandez P; Southey MC; English DR; Hopper JL; Heyns CF; Tangye SG; Giles GG; Hayes V, 2010, 'Comprehensive analysis of the cytokine-rich chromosome 5q31.1 region suggests a role for IL-4 gene variants in prostate cancer risk', Carcinogenesis, 31, pp. 1748 - 1754, http://dx.doi.org/10.1093/carcin/bgq081

Suryani S; Fulcher DA; Santner-Nanan B; Nanan R; Wong MB; Shaw P; Gibson J; Williams A; Tangye SG, 2010, 'Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells', Blood, 115, pp. 519 - 529, http://dx.doi.org/10.1182/blood-2009-07-234799

Simpson N; Gatenby P; Wilson A; Malik S; Fulcher DA; Tangye SG; Manku H; Vyse TJ; Roncador G; Huttley G; Goodnow CC; Vinuesa C; Cook MC, 2010, 'Expansion of circulating T cells resembling follicular T helper cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus', Arthritis Care & Research, 62, pp. 234 - 244

Deenick EK; Chan A; Ma CS; Gatto D; Schwartzberg P; Brink R; Tangye SG, 2010, 'Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling', Immunity, 33, pp. 241 - 253, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20691615

Ma CS; Tangye SG; Deenick EK, 2010, 'Human Th9 cells: inflammatory cytokines modulate IL-9 production through the induction of IL-21', Immunology and Cell Biology, 88, pp. 621 - 623, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20531361

Hislop A; Palendira U; Leese AM; Arkwright PD; Rohrlich PS; Tangye SG; Gaspar HB; Lankester AC; Moretta A; Rickinson A, 2010, 'Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets', Blood, 116, pp. 3249-57, http://dx.doi.org/10.1182/blood-2009-09-238832

Tangye SG; Palendira U; Low C; Deenick EK; Chan A; Ma CS; Brink R; Alvaro F; Cook MC; Sean Riminton D; Nichols KE; Schwartzberg PL, 2010, 'Sap is necessary for mediating antigen-specific effector functions of CD4+ AND CD8+ T cells', Pathology, 42, pp. S45 - S45, http://dx.doi.org/10.1097/01268031-201042001-00085

Suryani S; Tangye SG, 2010, 'Therapeutic implications of advances in our understanding of transitional B-cell development in humans', Expert Review of Clinical Immunology, 6, pp. 765 - 775, http://dx.doi.org/10.1586/eci.10.55

Randall KL; Lambe T; Johnson A; Treanor B; Kucharska E; Domaschenz H; Whittle B; Tze LE; Enders A; Crockford TL; Bouriez-Jones T; Alston D; Cyster JG; Lenardo MJ; Mackay F; Deenick EK; Tangye SG; Chan TD; Camidge T; Brink R; Vinuesa C; Batista FD; Cornall RJ; Goodnow CC, 2009, 'Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production', Nature Immunology, 10, pp. 1283 - 1291, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19898472

Ma CS; Suryani S; Avery D; Chan A; Nanan R; Santner-Nanan B; Tangye SG; Deenick E, 2009, 'Early commitment of naive human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12', Immunology and Cell Biology, 87, pp. 590 - 600, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19721453

Ma CS; Tangye SG, 2009, 'Helping the Helpers!', Immunity, 31, pp. 12 - 14

Tangye SG; Cook MC; Fulcher DA, 2009, 'Insights into the role of STAT3 in human lymphocyte differentiation as revealed by the hyper-IgE syndrome', Journal of Immunology, 182, pp. 21 - 28

Fulcher DA; Avery D; Fewings N; Berglund L; Wong S; Riminton D; adelstein S; Tangye SG, 2009, 'Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency', Clinical and Experimental Immunology, 157, pp. 365 - 369

Tangye SG; Tarlinton D, 2009, 'Memory B cells: effectors of long-lived immune responses', European Journal of Immunology, 39, pp. 2065 - 2075

Tangye SG; Cook MC, 2009, 'Primary immune deficiencies affecting lymphocyte differentiation: Lessons from the spectrum of resulting infections', International Immunology, 21, pp. 1003 - 1011

Good K; Avery D; Tangye SG, 2009, 'Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells', Journal of Immunology, 182, pp. 890 - 901, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19124732

Deenick EK; Tangye SG, 2008, 'Autoimmunity: IL-21: A new player in Th17-cell differentiation (Immunology and Cell Biology (2007) 85, (503-505) DOI: 10.1038/sj.icb.7100114)', Immunology and Cell Biology, 86, pp. 478, http://dx.doi.org/10.1038/sj.icb.7100152

Ma CS; Chew G; Simpson N; Priyadarshi A; Wong M; Grimbacher B; Fulcher DA; Tangye SG; Cook M, 2008, 'Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3', Journal of Experimental Medicine, 205, pp. 1551 - 1557

Chaganti S; Ma C; Bell A; Croom-Carter D; Hislop A; Tangye SG; Rickinson A, 2008, 'Epstein-Barr virus persistence in the absence of conventional memory B cells: IgM(+)IgD(+)CD27(+) B cells harbor the virus in X-linked lymphoproliferative disease patients', Blood, 112, pp. 672 - 679, http://dx.doi.org/10.1182/blood-2007-10-116269

Rosen DM; Cao W; Avery D; Tangye SG; Liu Y; Houchins J; Lanier L, 2008, 'Functional consequences of interactions between-human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells', Journal of Immunology, 180, pp. 6508 - 6517

Avery D; Bryant V; Ma C; Malefyt R; Tangye SG, 2008, 'IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4', Journal of Immunology, 181, pp. 1767 - 1779

Deenick E; Tangye SG, 2008, 'Immunology: Helpful T cells are sticky', Nature, 455, pp. 745 - 746

Avery D; Ma C; Bryant V; Santner-Nanan B; Nanan R; Wong MB; Fulcher DA; Cook M; Tangye SG, 2008, 'STAT3 is required for IL-21-induced secretion of IgE from human naive B cells', Blood, 112, pp. 1784 - 1793

King CK; Tangye SG; MacKay CR, 2008, 'T follicular helper (T-FH) cells in normal and dysregulated immune responses', Annual Review of Immunology, 26, pp. 741 - 766, http://dx.doi.org/10.1146/annurev.immunol.26.021607.090344

Tangye SG; Avery DT; Bryant VL; Ma CS, 2007, 'Follicular CD4+T helper cells induce human B cells to undergo Ig isotype switching and differentiation to Ig-secreting cells through the production of IL-21', JOURNAL OF IMMUNOLOGY, 178, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209758202295&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mackay F; Groom JR; Tangye SG, 2007, 'An important role for B-cell activation factor and B cells in the pathogenesis of Sjogren`s syndrome', Current Opinion in Rheumatology, 19, pp. 406 - 413

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