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Chronic pain in an animal model of multiple sclerosis
Chronic pain is a common debilitating symptom affecting between 50% and 80% of MS patients. However, despite its widespread occurrence, chronic pain is a rarely studied symptom of this disease.
Gtf2ird1 and the molecular and cellular basis of human behaviour
Williams-Beuren Syndrome (WBS) is a neurdevelopmental genetic disorder characterized by specific cognitive and behavioural defects resulting in a unique debilitating personality profile.
The genetic control of skin proliferation in the face
The human face is a highly complex structure and the finished physiognomy and skin surface is of deep social and psychological significance because so much of human social behaviour is focused on facial recognition, the language of facial expression and the subjective perception of facial beauty.
The role of epigenetic modifications in longterm memory of irradiation in cancer survivors
Improvements in childhood cancer treatments have lead to a survival rate of more than 80%, but 2/3 of the survivors further develop at least one severe complication, notably metabolic disorders. Radiation therapy seems to be the most prominent risk factor.
Shaped and Stimulus-Responsive Droplets for Improved Delivery
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This project is focused on applications like controlled delivery of softeners, nutrients, and drugs from droplets like those in a shampoo, food, or drug formulation.
Sustainable Health Financing in Fiji and Timor-Leste (Shift Study)
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Universal health coverage (UHC), which implies all people have access to needed services without the risk of financial ruin, has become a major goal for health reform in many countries.
Breast cancer Mortality Evaluation of BreastScreen Aotearoa (New Zealand)
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BreastScreen Aotearoa (BSA) is the national breast screening programmen in New Zealand which aims to reduce cancer mortality through early diagnosis.
Trends in non-communicable disease risk factors and premature mortality in Pacific Island countries and predictive modelling of effects of inaction and control interventions
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Non-communicable diseases (NCDs) are a major cause of illness and premature adult mortality (diseas burden) in many Pacific Island Countries (PICs).
Bioinformatics: application of Next-generation sequencing to viral infections
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We are an interdisciplinary group interested in understanding how viruses evolve under the host immune response.
We take advantage of next generation sequencing technologies to study viral populations including low frequency variants.
Computational models to study the immune response against viral infections
Project 1: Mathematical modelling of T cell trafficking in the liver
This project aims to design a mathematical model to study the trafficking of CD8 T cells in the full body of mice in the absence or presence of antigen.
Immunisation in Under Studied and Special Risk Populations: “Closing the Gap in Knowledge through a Multidisciplinary Approach”
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This NHMRC CRE in Population Health Research commenced in 2012 and is focused on immunisation for vulnerable or marginalised population subgroups at increased disease risk.
Role of post-translational modifications in mitochondria in the regulation of lipid accumulation and insulin action
Mitochondria are the major site for fuel oxidation in cells and strategies that stimulate mitochondria to burn more calories may prove beneficial for preventing obesity and insulin resistance.
Interrogating molecular targets responsible for the beneficial metabolic effects of specific dietary fat subtypes
There is a clear relationship between excess intake of dietary fat (particularly animal-based fats such as lard) and the development of obesity and insulin resistance.
How is cellular energy metabolism altered in cancer?
Cancer cells reprogram their metabolism to use fuel (fat, protein and glucose) in a different way to normal cells. This adaptation is thought to allow cancer cells to make the building blocks (proteins, DNA, lipids) they need to grow and divide rapidly.
Can the response of different mouse strains to a high fat diet help find therapeutic targets to treat fatty liver disease?
Excess fat in the diet typically leads to weight gain and inappropriate deposition of lipid in organs such as liver and skeletal muscle.
Optimising dissolved air flotation (DAF) for algae removal by bubble modification in drinking water and advanced wastewater systems
Algal and cyanobacteria blooms are of particular concern in drinking water resources due to their adverse impact on treatment processes, as well as their potential to release harmful toxins and taste and odour compounds into water supplies.
Monitoring organic matter in drinking water systems using fluorescence spectroscopy
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Potable source water frequently has a high organic matter (OM) content originating from decaying plants, soil and peat, bacterial activity, algal blooms and upstream treated effluent discharges.
Switching on Brain Transporters to Switch off Brain Seizures
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Brain function is a delicate balance of neuronal excitation and inhibition. The schematic diagram above illustrates inhbitory neuronal responses mediated via the neurotransmitter GABA, and how these are affected by the neuronal Cl- transporters KCC2 and NKCC1.
Post-implementation economic evaluation of childhood vaccination programs
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This project will de
Efficacy and cost-effectiveness of long-lasting microbial larvicides for malaria mosquito control
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In the past decade, massive scale-up of insecticide-treated nets (ITN) and indoor residual spraying (IRS), together with the introduction of artemisinin-combination treatments, have led to substantial reductions in malaria prevalence and incidence in African highlands.
Examining the effectiveness of mask use as source infection control for people with influenza-like-illness in Beijing, China
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This study will determine whether mask use by people with influenza-like-illness (ILI) while at home protects other family members from respiratory infections.
The Second Australian Study of Health and Relationships
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The Australian Study of Health and Relationships (ASHR) is our most important study of sexual and reproductive health.
Evaluating the Guideline Enhancement Tool (GET): an innovative clinical training tool to enhance the use of Hypertension Guidelines in General Practice
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The aim of this project is to evaluate the feasibility and effectiveness of an innovative clinical training tool designed to enhance General Practitioners' use of Hypertension guidelines. The tool is named the ‘Guideline Enhancement Tool’ (GET) and is designed to:
Positive life pathways for vulnerable adolescents: The role of a life management program approach
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A team of researchers at the School of Public Health and Community Medicine together with the Ted Noffs Foundation and academics from the Centre for Social Research in Health and the School of Social Sciences have been awarded an Australian Research Council Linkage Grant, funded this year for thr