This project will provide important information regarding the pharmacological mechanisms by which NPY acts to suppress seizures in animal models of epilepsy. It will provide strategies regarding potential new treatments of absence epilepsy.

This project will produce an easy-to-use prototype system for guiding blind and visually impaired (BVI) people both indoors and outdoors and delivering location based information.

To achieve high economical efficiency, modern chemical plants are becoming increasingly complex, to an extent that cannot be effectively managed by existing process modelling and control techniques.

The aims of this research are to assess the effects of immune modulation by inducing immune tolerance and manipulating regulatory T cells on pain behaviours following nervous system injury.

The actin cytoskeleton has long been known to be a key regulator of cell proliferation linking biochemical sensing of the environment with cell cycle progression.

Fouling reduces throughput and productivity of membrane systems and as such increases operating costs and reduces profitability of water treatment industries. This work aims to reduce fouling by reducing the amount of solute at a membrane surface by destabilizing flow control.

We have recently built the first protein 'methylation network' for any species. This project will study the dynamics of this network during the cell cycle and will identify protein complexes which have methylation-associated interactions.

The aim of the project is to reveal the mechanisms of the stabilisation of lifted jet flames in hot oxidiser. Such flames occur in several important combustion devices, notably diesel engines.

The project will develop a robust approach to use maximum entropy methods to model likelihood functions for a Bayesian analysis of chemical data.

The project will contribute fundamental knowledge towards the development of the clean and highly efficient homogeneous charge compression ignition engine concept.

A potential target for anti-cancer drugs is the actin cytoskeleton; however, it has been unattainable because the toxicity associated with disabling this target has been unacceptable.

Alternative fuels such as renewable ethanol have much potential for a sustainable transportation future, yet engines are not optimised for these fuels, and engine design is hindered by the lack of understanding of key governing phenomena.

Colorectal cancer is the second most commonly diagnosed cancer in Australia, with more than 13500 cases recorded annually. Oxaliplatin is an effective chemotherapy for the treatment of colorectal cancer.

DNA methylation provides a mechanism by which external environmental factors can modify gene expression.

Cancer of unknown primary (CUP) is a diagnosis used to describe patients with metastatic cancer with no identifiable primary site of origin at the time of presentation. CUP is the fourth most common cause of cancer death in NSW, but little is known about its risk factors or management.

This proposal seeks to establish state-of-the-art, high-speed laser diagnostics facilities that provide Australian researchers with unique capabilities to make real-time and space-resolved measurements of reactive species and polluting particles in combustion systems.