By Dr Siiri Iismaa

Journal articles

McGrath-Cadell L; Iismaa SE; Hesselson S; Muller DW; Fatkin D; Giannoulatou E; Kovacic JC; Graham RM, 2021, 'Recent Updates on Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia', International Journal of Integrative Cardiology, 3, http://dx.doi.org/10.47275/2690-862x-121

McGrath-Cadell L; Hesselson S; Tarr I; Iismaa S; Bax M; Junday K; Dunwoodie S; Fatkin D; Kovacic J; Muller D; Giannoulatou E; Graham B, 2021, 'Spontaneous Coronary Artery Dissection (SCAD) and a Family History of Aortic Artery Dissection—A Case Series', Heart Lung and Circulation, 30, pp. s252, http://dx.doi.org/10.1016/j.hlc.2021.06.350

Bogush N; Tan L; Naib H; Faizullabhoy E; Calvert JW; Iismaa SE; Gupta A; Ramchandran R; Martin DIK; Graham RM; Husain A; Naqvi N, 2020, 'DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling', Scientific Reports, 10, pp. 21918, http://dx.doi.org/10.1038/s41598-020-78825-x

Nicks AM; Kesteven SH; Li M; Wu J; Chan AY; Naqvi N; Husain A; Feneley MP; Smith NJ; Iismaa SE; Graham RM, 2020, 'Pressure overload by suprarenal aortic constriction in mice leads to left ventricular hypertrophy without c-Kit expression in cardiomyocytes', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-72273-3

Carss KJ; Baranowska AA; Armisen J; Webb TR; Hamby SE; Premawardhana D; Al-Hussaini A; Wood A; Wang Q; Deevi SVV; Vitsios D; Lewis SH; Kotecha D; Bouatia-Naji N; Hesselson S; Iismaa SE; Tarr I; McGrath-Cadell L; Muller DW; Dunwoodie SL; Fatkin D; Graham RM; Giannoulatou E; Samani NJ; Petrovski S; Haefliger C; Adlam D, 2020, 'Spontaneous Coronary Artery Dissection: Insights on Rare Genetic Variation From Genome Sequencing', Circulation Genomic and Precision Medicine, 13, pp. E003030, http://dx.doi.org/10.1161/CIRCGEN.120.003030

Zhang J; Grosso Jasutkar H; Yan R; Woo JM; Lee KW; Im JY; Junn E; Iismaa SE; Mouradian MM, 2020, 'Transglutaminase 2 Depletion Attenuates α-Synuclein Mediated Toxicity in Mice', Neuroscience, 441, pp. 58 - 64, http://dx.doi.org/10.1016/j.neuroscience.2020.05.047

Suzuki AS; Yagi R; Kimura MY; Iwamura C; Shinoda K; Onodera A; Hirahara K; Tumes DJ; Koyama-Nasu R; Iismaa SE; Graham RM; Motohashi S; Nakayama T, 2020, 'Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation', Frontiers in Immunology, 11, http://dx.doi.org/10.3389/fimmu.2020.01536

Griffin KJ; Newell LM; Simpson KR; Beckers CML; Drinkhill MJ; Standeven KF; Cheah LT; Iismaa SE; Grant PJ; Jackson CL; Pease RJ, 2020, 'Transglutaminase 2 limits the extravasation and the resultant myocardial fibrosis associated with factor XIII-A deficiency', Atherosclerosis, 294, pp. 1 - 9, http://dx.doi.org/10.1016/j.atherosclerosis.2019.12.013

Mishra K; Junday K; Wong CMY; Chan AY; Hesselson S; Muller DW; Iismaa SE; Mehta A; Graham RM, 2019, 'Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection', Stem Cell Research, 41, http://dx.doi.org/10.1016/j.scr.2019.101584

McGrath-Cadell L; Hesselson S; Iismaa SE; Mishra K; Wong CMY; Fatkin D; Dunwoodie SL; Harvey R; Holloway CJ; Muller DWM; Giannoulatou E; Graham RM, 2019, 'P5540Familial clustering of spontaneous coronary artery dissection', European Heart Journal, 40, pp. ehz746.0486, http://dx.doi.org/10.1093/eurheartj/ehz746.0486

Kaidonis X; Niu W; Chan AY; Kesteven S; Wu J; Iismaa SE; Feneley M; Graham RM, 2019, 'Abstract 579: Involvement of the Alpha 1A-Adrenergic Receptor in the Cardiac Adaptation to Physiological Stress', Circulation Research, 125, http://dx.doi.org/10.1161/res.125.suppl_1.579

Lorand L; Iismaa SE, 2019, 'Correction to: Transglutaminase diseases: from biochemistry to the bedside (The FASEB Journal, (2019), 33, 1, (3-12), 10.1096/fj.201801544R)', FASEB Journal, 33, pp. 4653, http://dx.doi.org/10.1096/fj.201801544RERR

Adlam D; Olson TM; Combaret N; Kovacic JC; Iismaa SE; Al-Hussaini A; O'Byrne MM; Bouajila S; Georges A; Mishra K; Braund PS; d'Escamard V; Huang S; Margaritis M; Nelson CP; de Andrade M; Kadian-Dodov D; Welch CA; Mazurkiewicz S; Jeunemaitre X; Wong CMY; Giannoulatou E; Sweeting M; Muller D; Wood A; McGrath-Cadell L; Fatkin D; Dunwoodie SL; Harvey R; Holloway C; Empana JP; Jouven X; Olin JW; Gulati RMD; Tweet MS; Hayes SN; Samani NJ; Graham RM; Motreff P; Bouatia-Naji N; Nikpay M; Goel A; Won HH; Hall LM; Willenborg C; Kanoni S; Saleheen D; Kyriakou T; Hopewell JC; Webb TR; Zeng L; Dehghan A; Alver M; Armasu SM; Auro K; Bjonnes A; Chasman DI; Chen S; Ford I; Franceschini N; Gieger C; Grace C; Gustafsson S; Huang J; Hwang SJ; Kim YK; Kleber ME; Lau KW; Lu X; Lu Y; Lyytikäinen LP; Mihailov E; Morrison A; Pervjakova N; Qu L; Rose LM; Salfati E; Saxena R; Scholz M; Smith AV; Tikkanen E; Uitterlinden A; Yang X; Zhang W; Zhao W; de Andrade M; de Vries PS; van Zuydam NR; Anand SS; Bertram L; Beutner F; Dedoussis G; Frossard P; Gauguier D; Goodall AH; Gottesman O; Haber M; Han BG; Huang J, 2019, 'Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection', Journal of the American College of Cardiology, 73, pp. 58 - 66, http://dx.doi.org/10.1016/j.jacc.2018.09.085

Poole LG; Pant A; Baker KS; Kopec AK; Cline-Fedewa HM; Iismaa SE; Flick MJ; Luyendyk JP, 2019, 'Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) crosslinking via tissue transglutaminase', Journal of Thrombosis and Haemostasis, 17, pp. 113 - 125, http://dx.doi.org/10.1111/jth.14330

Lorand L; Iismaa SE, 2019, 'Transglutaminase diseases: From biochemistry to the bedside', FASEB Journal, 33, pp. 3 - 12, http://dx.doi.org/10.1096/fj.201801544R

McGrath-Cadell L; Hesselson S; Iismaa S; Mishra K; Wong C; Fatkin D; Dunwoodie S; Harvey R; Holloway C; Muller D; Giannoulatou E; Graham R, 2019, 'Familial Clustering of Spontaneous Coronary Artery Dissection', Heart Lung and Circulation, 28, pp. s330, http://dx.doi.org/10.1016/j.hlc.2019.06.454

Iismaa SE; Li M; Kesteven S; Wu J; Chan AY; Holman SR; Calvert JW; Haq AU; Nicks AM; Naqvi N; Husain A; Feneley MP; Graham RM, 2018, 'Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice', Scientific Reports, 8, pp. 6114, http://dx.doi.org/10.1038/s41598-018-24525-6

Iismaa SE; Kaidonis X; Nicks AM; Bogush N; Kikuchi K; Naqvi N; Harvey RP; Husain A; Graham RM, 2018, 'Comparative regenerative mechanisms across different mammalian tissues', Npj Regenerative Medicine, 3, pp. 6, http://dx.doi.org/10.1038/s41536-018-0044-5

Mižíková I; Pfeffer T; Nardiello C; Surate Solaligue DE; Steenbock H; Tatsukawa H; Silva DM; Vadász I; Herold S; Pease RJ; Iismaa SE; Hitomi K; Seeger W; Brinckmann J; Morty RE, 2018, 'Targeting transglutaminase 2 partially restores extracellular matrix structure but not alveolar architecture in experimental bronchopulmonary dysplasia', FEBS Journal, 285, pp. 3056 - 3076, http://dx.doi.org/10.1111/febs.14596

Coleman JLJ; Mouat MA; Wu J; Jancovski N; Bassi JK; Chan AY; Humphreys DT; Mrad N; Yu ZY; Ngo T; Iismaa S; Dos Remedios CG; Feneley MP; Allen AM; Graham RM; Smith NJ, 2018, 'Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control', Biology of Sex Differences, 9, pp. 14, http://dx.doi.org/10.1186/s13293-018-0173-y

Iismaa SE, 2016, 'The prostate-specific protein, transglutaminase 4 (TG4), is an autoantigen associated with male subfertility', Annals of Translational Medicine, 4, http://dx.doi.org/10.21037/atm.2016.10.02

Naqvi N; Singh R; Iismaa SE; Li M; Calvert JW; Martin DIK; Harvey RP; Graham RM; Husain A, 2015, 'Cardiomyocytes Replicate and their Numbers Increase in Young Hearts', Cell, 163, pp. 783 - 784, http://dx.doi.org/10.1016/j.cell.2015.10.038

Cannon L; Yu ZY; Marciniec T; Waardenberg AJ; Iismaa SE; Nikolova-Krstevski V; Neist E; Ohanian M; Qiu MR; Rainer S; Harvey RP; Feneley MP; Graham RM; Fatkin D, 2015, 'Irreversible triggers for hypertrophic cardiomyopathy are established in the early postnatal period', Journal of the American College of Cardiology, 65, pp. 560 - 569, http://dx.doi.org/10.1016/j.jacc.2014.10.069

Li M; Iismaa SE; Naqvi N; Nicks A; Husain A; Graham RM, 2014, 'Thyroid hormone action in postnatal heart development', Stem Cell Research, 13, pp. 582 - 591, http://dx.doi.org/10.1016/j.scr.2014.07.001

Yu ZY; Tan JC; McMahon AC; Iismaa SE; Xiao H; Kesteven SH; Reichelt ME; Mohl MC; Smith NJ; Fatkin D; Allen D; Head SI; Graham RM; Feneley MP, 2014, 'RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility', Plos One, 9, pp. e99024, http://dx.doi.org/10.1371/journal.pone.0099024

Naqvi N; Li M; Calvert JW; Tejada T; Lambert JP; Wu J; Kesteven SH; Holman SR; Matsuda T; Lovelock JD; Howard WW; Iismaa SE; Chan AY; Crawford BH; Wagner MB; Martin DIK; Lefer DJ; Graham RM; Husain A, 2014, 'A proliferative burst during preadolescence establishes the final cardiomyocyte number', Cell, 157, pp. 795 - 807, http://dx.doi.org/10.1016/j.cell.2014.03.035

Lismaa SE; Aplin M; Holman S; Yiu T; Jackson K; Burchfield JG; Mitchell CJ; O'Reilly L; Davenport A; Cantley J; Schmitz-Peiffer C; Biden TJ; Cooney GJ; Graham RM, 2013, 'Glucose Homeostasis in Mice Is Transglutaminase 2 Independent', PLoS One, 8, pp. Article numbere63346, http://dx.doi.org/10.1371/journal.pone.0063346

Tong L; Png E; AiHua H; Yong SS; Yeo HL; Riau A; Mendoz E; Charausia SS; Lim CT; Yiu TW; Iismaa SE, 2013, 'Molecular mechanism of transglutaminase-2 in corneal epithelial migration and adhesion', Biochimica et Biophysica ACTA - Molecular Cell Research, 1833, pp. 1304 - 1315, http://dx.doi.org/10.1016/j.bbamcr.2013.02.030

Yu Z; Tan J; McMahon A; Iismaa S; Xiao X; Kesteven S; Reichelt M; Mohl M; Dai Y; Sketchley A; Yang L; Gong H; Fatkin D; Allen D; Head S; Graham R; Feneley M, 2013, 'Studies of a Mouse Model of Cardiac α1A-Adrenergic Receptor Overexpression Provide Evidence For a Critical Role of RhoA/ROCK Signalling in Cardiac Contractility', Heart, Lung and Circulation, 22, pp. S59 - S59, http://dx.doi.org/10.1016/j.hlc.2013.05.143

Iismaa SE; Aplin M; Yiu T-W; Wu J; Du X-J; Graham RM, 2012, '877 TransglutaminAse 2 is cardioprotective following MyoCardal INFARCTION, but plays no role in cardiac hyPERtrophy', Journal of Hypertension, 30, pp. e256 - e256, http://dx.doi.org/10.1097/01.hjh.0000420443.49005.96

Zhao X; Park J; Ho D; Gao S; Yan L; Ge H; Iismaa S; Lin L; Tian B; Vatner DE; Graham RM; Vatner SF, 2012, 'Cardiomyocyte overexpression of the á 1A-adrenergic receptor in the rat phenocopies second but not first window preconditioning', American Journal of Physiology - Heart and Circulatory Physiology, 302, pp. H1614 - H1624, http://dx.doi.org/10.1152/ajpheart.01072.2011

Ling D; Marshall GM; Liu PY; Xu N; Nelson CA; Iismaa SE; Liu T, 2012, 'Enhancing the anticancer effect of the histone deacetylase inhibitor by activating transglutaminase.', Eur J Cancer, 48, pp. 3278 - 3287, http://dx.doi.org/10.1016/j.ejca.2012.02.067

Iismaa SE; Basso M; Berlin J; Xia L; Sleiman SF; Kuo T; Haskew-Layton R; Kim E; Antonyak MA; Cerione RA; Willis D; Cho S, 2012, 'Transglutaminase 2 Inhibition Protects against Oxidative Stress-Induced Neuronal Death Downstream of Pathological ERK Activation', Journal of Neuroscience, 32, pp. 11157 - 11157, http://dx.doi.org/10.1523/JNEUROSCI.2552-12.2012

Basso M; Berlin J; Xia L; Sleiman SF; Ko B; Haskew-Layton R; Kim E; Antonyak MA; Cerione RA; Iismaa SE; Willis D; Cho S; Ratan R, 2012, 'Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation', Journal of Neuroscience, 32, pp. 6561 - 6569, http://dx.doi.org/10.1523/JNEUROSCI.3353-11.2012

Mohl MC; Iismaa SE; Xiao X-H; Friedrich O; Wagner S; Nikolova-Krstevski V; Wu J; Yu Z-Y; Feneley M; Fatkin D; Allen DG; Graham RM, 2011, 'Regulation of murine cardiac contractility by activation of α(1A)-adrenergic receptor-operated Ca(2+) entry.', Cardiovasc Res, 91, pp. 310 - 319, http://dx.doi.org/10.1093/cvr/cvr081

Wouters MA; Iismaa S; Fan SW; Haworth NL; Haworth , 2011, 'Thiol-based redox signalling: Rust never sleeps', International Journal of Biochemistry and Cell Biology, 43, pp. 1079 - 1085, http://dx.doi.org/10.1016/j.biocel.2011.04.002

Olsen K; Iismaa SE; Sapinoro R; Kottman RM; Kulkarni AA; Johnson G, 2011, 'Transglutaminase 2 and its role in pulmonary fibrosis', American Journal of Respiratory and Critical Care Medicine, 184, pp. 699 - 707

Mohl M; Xiao X-H; Prosser H; Iismaa S; Feneley M; Graham R, 2010, 'Involvement of a Novel a1A-Adrenergic Receptor-Coupled Signaling Pathway in Cardiac Contractility', FASEB JOURNAL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675506325&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Zhao X; Vatner DE; Park M; Yan L; IIsmaa S; Graham R; Vatner SF, 2010, 'Transgenic Rats with Cardiac Overexpression of alpha1A Adrenergic Receptors are protected from Myocardial Ischemia by a Nitric Oxide Mechanism', FASEB JOURNAL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675500791&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Tee AEL; Marshall GM; Liu PY; Xu N; Haber M; Norris MD; Iismaa SE; Liu T, 2010, 'Opposing effects of two tissue transglutaminase protein isoforms in neuroblastoma cell differentiation.', J Biol Chem, 285, pp. 3561 - 3567, http://dx.doi.org/10.1074/jbc.M109.053041

McConoughey S; Basso SJ; Nietsetskaya Z; Sleiman SF; Smirnova T; Langley B; Mahishi L; Cooper AJ; Antonyak MA; Cerione RA; Li B; Starkov A; Chaturvedi R; Beale M; Coppola G; Geschwind D; Ryu H; Li XR; Iismaa SE; Pallos J; Pasternack R; Hils M; Fan J; Raymond LA; Marsh JL; Thompson LM; Ratan R, 2010, 'Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease', EMBO Journal, 2, pp. 349 - 370

Tatsukawa H; Fukaya Y; Frampton G; Martinez-Fuentes A; Suzuki K; Kuo T; Nagatsuma K; Shimokado K; Okuno M; Wu J; Iismaa SE; Matsuura T; Tsukamoto H; Zern M; Graham RM; Kojima S, 2009, 'Role of Transglutaminase 2 in Liver Injury via Cross-linking and Silencing of Transcription Factor Sp1', Gastroenterology, 136, pp. 1783 - 1795, http://dx.doi.org/10.1053/j.gastro.2009.01.007

Iismaa SE; Mearns BM; Lorand L; Graham RM, 2009, 'Transglutaminases and disease: Lessons from genetically engineered mouse models and inherited disorders', Physiological Reviews, 89, pp. 991 - 1023

Begg GE; Holman SR; Stokes PH; Matthews JM; Graham RM; Iismaa SE, 2006, 'Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity', JOURNAL OF BIOLOGICAL CHEMISTRY, 281, pp. 12603 - 12609, http://dx.doi.org/10.1074/jbc.M600146200

Iismaa S; Begg G; Graham RM, 2006, 'Cross-linking transglutaminases with G protein-coupled receptor signaling.', Science S Stke, 353, pp. pe34, http://dx.doi.org/10.1126/stke.3532006pe34

Begg G; Carrington L; Stokes P; Matthews JM; Wouters MA; Husain A; Lorand L; Iismaa SE; Graham RM, 2006, 'Mechanism of allosteric regulation of transglutaminase 2 by GTP', Proceedings of the National Academy of Sciences of the United States of America, 103, pp. 19683 - 19688

Begg G; Holman S; Stokes P; Matthews J; Graham RM; Iismaa SE; Holman , 2006, 'Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity', The Journal of Biological Chemistry, 281, pp. 12603 - 12609, http://dx.doi.org/10.1074/jbc.M600146200

Begg G; Iismaa S; Carrington L; Holman S; Graham RM; Holman , 2005, 'Allosteric inactivation of transglutaminase 2 by GTP involves stabilisation of a conformational substate and formation of a critical Cys/Tyr H-bond', Biophysical Journal, 88, pp. 15A - 15A

Begg G; Iismaa SE; Carrington L; Holman S; Husain A; Graham RM; Holman , 2005, 'Allosteric regulation of the transamidase activity of transglutaminase 2 by guanine nucleotide', FEBS Journal, 272, pp. 408 - 408

Krasnikov B; Ratan R; Gibson G; Iismaa SE; Cooper A, 2005, 'Transglutaminase activity in non-synaptosomal mouse brain and liver mitochondria', Journal of Neurochemistry, 94, pp. 41 - 41

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