By Dr Siiri Iismaa

Journal articles

Krasnikov B; Kim SY; McConoughey S; Ryu H; Xu H; Stavrovskaya I; Iismaa S; Mearns BM; Ratan R; Blass J; Gibson G; Cooper A, 2005, 'Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria', Biochemistry, 44, pp. 7830 - 7843

Iismaa SE; Graham RM, 2003, 'Dissecting cardiac hypertrophy and signalling pathways: evidence for an interaction between multifunctional G proteins and prostanoids', Corc Res, 92, pp. 1059 - 1061

Iismaa SE; Holman S; Wouters MA; Lorand L; Graham RM; Husain A; Holman , 2003, 'Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases', Proceedings of the National Academy of Sciences of the United States of America, 22, pp. 12636 - 12641

Murthy SN; Iismaa SE; Begg G; Freymann DM; Graham RM; Lorand L, 2002, 'Conserved tryptophan in the core domain of transglutaminase is essential for catalytic activity.', Proceedings of the National Academy of Sciences of the United States of America, 99, pp. 2738 - 2742

Mearns BM; Nanda N; Michalicek J; Iismaa SE; Graham RM, 2002, 'Impaired wound healing and altered fibroblast cytoskeletal dynamics in Gh knockout mice.', Minerva Biotecnologica, 14, pp. 218

Iismaa SE, 2002, 'Structure and function of tissue transglutaminase.', Minerva Biotecnologica, 14, pp. 113 - 119

Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/tissue transglutaminase II', The Journal of Biological Chemistry, pp. 20673 - 20678

Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/Transglutaminase II', The Journal of Biological Chemistry, pp. 20673 - 20678

Iismaa S; Wu M; Nanda N; Church WB; Graham RM, 2000, 'GTP binding and signaling by Gh/transglutaminase II involves distinct residues in a unique GTP-binding pocket.', The Journal of Biological Chemistry, 275, pp. 18259 - 18265

Nanda N; Iismaa SE; Copeland NG; Gilbert DM; Jenkins NA; Graham RM; Sutrave P, 1999, 'Organisation and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2)', Archives of Biochemistry and Biophysics, 366, pp. 151 - 156

Harrison C; Raftery MJ; Walsh J; Alewood P; Iismaa S; Thliveris S; Geczy C, 1999, 'Oxidation regulates the inflammatory properties of the murine S100 protein S100A8', The Journal of Biological Chemistry, 274, pp. 8561 - 8569

Yen T; Harrison CA; Devery JM; Leong S; Iismaa SE; Yoshimura T; Geczy CL, 1997, 'Induction of the S100 Chemotactic Protein, CP-10, in Murine Microvascular Endothelial Cells by Proinflammatory Stimuli', Blood, 90, pp. 4812 - 4821, http://dx.doi.org/10.1182/blood.v90.12.4812

Yen T; Harrison C; Devery JM; Leong S; Iismaa S; Yoshimura T; Geczy C, 1997, 'Induction of the S100 chemotactic protein CP10, in murine microvascular endothelial cells by proinflammatory stimuli', Blood, 90, pp. 4812 - 4821

Iismaa S; Chung L; Wu M; Teller DC; Yee VC; Graham RM, 1997, 'The core domain of the tissue transglutaminase, Gh, hydrolyzes GTP and ATP', Biochemistry, 36, pp. 11655 - 11664

Chen S; Lin F; Iismaa S; Lee KN; Birckbichler PJ; Graham RM, 1996, 'α1-adrenergic receptor signaling via G(h) is subtype specific and independent of its transglutaminase activity', Journal of Biological Chemistry, 271, pp. 32385 - 32391, http://dx.doi.org/10.1074/jbc.271.50.32385

Chen S; Lin F; Iismaa SE; Lee K; Birckbichler PJ; Graham RM, 1996, 'Alpha1-Adrenergic receptor signalling via Gh is subtype-specific and independent of its transglutaminase activity', The Journal of Biological Chemistry, 271, pp. 32385 - 32391

Vázquez A; Shen B; Negaard K; Iismaa S; Burgess B, 1994, 'Overexpression of ferredoxin I in azotobacter vinelandii', Protein Expression and Purification, 5, pp. 96 - 102, http://dx.doi.org/10.1006/prep.1994.1014

Iismaa SE; hu S; Kocher M; Lackmann M; Harrison CA; Thliveris S; Geczy CL, 1994, 'Recombinant and Cellular Expression of the Murine Chemotactic Protein, CP-10', DNA and Cell Biology, 13, pp. 183 - 192, http://dx.doi.org/10.1089/dna.1994.13.183

Le O; Shen B; Iismaa SE; Burgess BK, 1993, 'Azotobacter vinelandii mutS: Nucleotide sequence and mutant analysis', Journal of Bacteriology, 175, pp. 7707 - 7710, http://dx.doi.org/10.1128/jb.175.23.7707-7710.1993

IISMAA SE; HU SP; KOCHER M; GECZY CL, 1993, 'CELLULAR EXPRESSION OF CP-10 IN MURINE MYELOID CELLS', JOURNAL OF LEUKOCYTE BIOLOGY, pp. 49 - 49, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993ME18500098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

HU SP; IISMAA S; HUME D; GECZY C, 1993, 'EFFECT OF CSF-1, LPS, INF-GAMMA ON CP-10 EXPRESSION IN BONE-MARROW DERIVED-MACROPHAGES', JOURNAL OF LEUKOCYTE BIOLOGY, pp. 50 - 50, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993ME18500099&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lackmann M; Rajasekariah P; Iismaa SE; Jones G; Cornish CJ; Hu S; Simpson RJ; Moritz RL; Geczy CL, 1993, 'Identification of a Chemotactic Domain of the Pro-inflammatory S100 Protein CP-10', Journal of Immunology, 150, pp. 2981 - 2991

Soman J; Iismaa S; David Stout C, 1991, 'Crystallographic analysis of two site-directed mutants of Azotobacter vinelandii ferredoxin', Journal of Biological Chemistry, 266, pp. 21558 - 21562

Iismaa SE; Vázquez AE; Jensen GM; Stephens PJ; Butt JN; Armstrong FA; Burgess BK, 1991, 'Site-directed mutagenesis of Azotobacter vinelandii ferredoxin I: Changes in [4Fe-4S] cluster reduction potential and reactivity', Journal of Biological Chemistry, 266, pp. 21563 - 21571

Martin AE; Burgess BK; Iismaa SE; Smartt CT; Jacobson MR; Dean DR, 1989, 'Construction and characterization of an Azotobacter vinelandii strain with mutations in the genes encoding flavodoxin and ferredoxin I', Journal of Bacteriology, 171, pp. 3162 - 3167, http://dx.doi.org/10.1128/jb.171.6.3162-3167.1989

Iismaa SE; Ealing PM; Scott KF; Watson JM, 1989, 'Molecular linkage of the nifl fix and nod gene regions in Rhixobium leguminosarum biovear trifolii', Molecular Microbiology, 3, pp. 1753 - 1764, http://dx.doi.org/10.1111/j.1365-2958.1989.tb00161.x

Iismaa SE; Watson JM, 1989, 'The nifA gene product from Rhizobium leguminosarum biovar trifolii lacks the N‐terminal domain found in other NifA proteins', Molecular Microbiology, 3, pp. 943 - 955, http://dx.doi.org/10.1111/j.1365-2958.1989.tb00244.x

Burgess B; Martin A; Iismaa S; Stout C; Cash V; Dean D; Jensen G; Stephens P, 1989, 'Site directed mutagenesis of Azotobacter vinelandii ferredoxin I: [FeS] cluster driven protein rearrangement', Journal of Inorganic Biochemistry, 36, pp. 229 - 229, http://dx.doi.org/10.1016/0162-0134(89)84244-8

Iismaa SE; Watson JM, 1987, 'A gene upstream of the rhizobium trifolii nifa gene encodes a ferredoxin-like protein', Nucleic Acids Research, 15, pp. 3180, http://dx.doi.org/10.1093/nar/15.7.3180

Conference Papers

McGrath-Cadell L; Hesselson S; Tarr I; Rath E; Troup M; Gao Y; Junday K; Bax M; Iismaa SE; Collins N; Muller DWM; Kovacic JC; Giannoulatou E; Graham RM, 2025, 'Spontaneous coronary artery dissection and a family history of aortic dissection: a genetic association study', in EUROPEAN JOURNAL OF HUMAN GENETICS, SPRINGERNATURE, ITALY, Milan, pp. 690 - 690, presented at 58th Conference of the European-Society-of-Human-Genetics (ESHG), ITALY, Milan, 24 May 2025 - 27 May 2025

Tarr I; Hesselson S; Troup M; Young P; Gao Y; Bax M; Junday K; Muller DWM; Iismaa S; Fatkin D; Kovacic J; Graham R; Giannoulatou E, 2025, 'Understanding the common genetic architecture of spontaneous coronary artery dissection using geneticallyrelated phenotypes', in EUROPEAN JOURNAL OF HUMAN GENETICS, SPRINGERNATURE, ITALY, Milan, pp. 1065 - 1065, presented at 58th Conference of the European-Society-of-Human-Genetics (ESHG), ITALY, Milan, 24 May 2025 - 27 May 2025

Nicks AM; Holman SR; Chan AY; Pang C-HJ; Tsang M; Naqvi N; Husain A; Li M; Humphreys DT; Smith NJ; Iismaa SE; Graham RM, 2021, 'A Standardized Method to Isolate and Purify Cardiomyocytes from Individual Mouse Hearts Irrespective of Postnatal Age', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, MA, Boston, presented at Annual Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium, MA, Boston, 12 November 2021 - 15 November 2021

Tarr I; Hesselson S; Iismaa S; Troup M; Young P; Mishra K; Wong C; Junday K; Humphreys D; Dunwoodie S; Fatkin D; Muller D; Graham RM; Giannoulatou E, 2021, 'Disease-Specific and Comorbidity-Related Polygenic Risk in Spontaneous Coronary Artery Dissection', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, MA, Boston, presented at Annual Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium, MA, Boston, 12 November 2021 - 15 November 2021

Poole L; Pant A; Baker KS; Kopec AK; Cline-Fedewa HM; Iismaa SE; Flick MJ; Luyendyk JP, 2018, 'Thrombin-Mediated Fibrin Polymer Formation Does Not Exacerbate Experimental Hepatic Fibrosis', in HEPATOLOGY, WILEY, CA, San Francisco, pp. 121A - 121A, presented at Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, CA, San Francisco, 09 November 2018 - 13 November 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446020500192&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Nicks AM; Humphreys DT; Holman SR; Chan AY; Djordjevic D; Naqvi N; Husain A; Smith NJ; Ho JW; Iismaa SE; Graham RM, 2018, 'Transcription Factors Driving Postnatal Cardiomyocyte Maturation', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000528619405230&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Nicks AM; Holman SR; Chan A; Humphreys DT; Smith NJ; Ho JW; Naqvi N; Husain A; Graham RM; Iismaa SE, 2016, 'Distinct Transcriptomic Signatures Across Postnatal Cardiomyocyte Development', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, LA, New Orleans, presented at Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium, LA, New Orleans, 12 November 2016 - 16 November 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396816606015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Yu Z; Lismaa S; Tan JC; Marcininec T; McMahon AC; Sharp D; Kesteven SH; Xiao X; Reichelt M; Wang ZM; Williamson DJ; Graham RM; Fenely M, 2007, 'Cardiac restricted alpha 1A-Adrenergic receptor overexpression in the adult rodent heart induces a hypersensitive contractile response to adrenergic stimulation with reduced baseline contractility but no hypertrophy', in Circulation, Lippincott Williams & Wilkins, Philadelphia, PA, USA, pp. 195 - 195, presented at 80th Annual Scientific Session of the American-Heart-Association, Orlando, Florida, USA, 04 November 2007 - 07 November 2007

Conference Abstracts

Weddell J; Rogerson MC; Gallagher R; Hesselson S; Iismaa SE; Graham RM; Jackson AC; Redfern J; Buckley T; Murphy BM, 2024, 'Cognitive and physical fatigue: the experience and consequences of brain fog after spontaneous coronary artery dissection, a qualitative study', in European Heart Journal, Oxford University Press (OUP), Vol. 45, pp. ehae666.3374, http://dx.doi.org/10.1093/eurheartj/ehae666.3374

Clarke S; Murphy B; Le Grande M; Rogerson M; Hesselson S; Iismaa S; Graham R; Hester R; Jackson A, 2024, 'Fear of recurrence and its association with mental health outcomes after spontaneous coronary artery dissection (SCAD)', in European Heart Journal, Oxford University Press (OUP), Vol. 45, pp. ehae666.2958, http://dx.doi.org/10.1093/eurheartj/ehae666.2958

Adiam D; Berrandou TE; Georges A; Nelson CP; Giannoulatou E; Ma L; Blencowe M; Turley T; Yang M-L; Iismaa S; Tarr I; Muller D; Hesselson S; Junday K; Fatkin D; Combaret N; Saw J; Webb T, 2022, 'GWAS Meta-Analysis in SCAD, a Women Predominant Ischemic Heart Disease, Reveals Common Variants and Genes Related to Artery Integrity and Tissue-Mediated Coagulation', in Circulation, Lippincott, Williams & Wilkins, IL, Chicago, Vol. 146, presented at Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium, IL, Chicago, 05 November 2022 - 06 November 2022, https://www.ahajournals.org/doi/10.1161/circ.146.suppl_1.12681

Yu Z-Y; Gong H; Kesteven S; Guo Y; Wu J; Li J; Iismaa S; Kaidonis X; Graham RM; Cox CD; Feneley MP; Martinac B, 2022, 'Piezo1 and TRPM4 work in tandem to initiate cardiac hypertrophic signalling in response to pressure overload', in Biophysical Journal, Elsevier, Vol. 121, pp. 493a, http://dx.doi.org/10.1016/j.bpj.2021.11.321

Tarr I; Hesselson S; Iismaa S; Troup M; Young P; Mishra K; Wong C; Junday K; Humphreys D; Dunwoodie S; Fatkin D; Muller D; Graham RM; Giannoulatou E, 2021, 'Abstract 11949: Disease-Specific and Comorbidity-Related Polygenic Risk in Spontaneous Coronary Artery Dissection', in Circulation, Wolters Kluwer, Vol. 144, pp. a11949 - a11949, http://dx.doi.org/10.1161/circ.144.suppl_1.11949

McGrath-Cadell L; Hesselson S; Tarr I; Iismaa SE; Bax M; Junday K; Dunwoodie SE; Fatkin D; Kovacic J; Muller DWM; Giannoulatou E; Graham RM, 2021, 'Spontaneous Coronary Artery Dissection (SCAD) and a family history of aortic artery dissection, a case series', in EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, Vol. 42, pp. 2787 - 2787

McGrath-Cadell L; Hesselson S; Iismaa SE; Mishra K; Wong CMY; Fatkin D; Dunwoodie SL; Harvey R; Holloway CJ; Muller DWM; Giannoulatou E; Graham RM, 2019, 'Familial clustering of spontaneous coronary artery dissection', in EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, FRANCE, Paris, Vol. 40, pp. 3414 - 3414, presented at Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, FRANCE, Paris, 31 August 2019 - 04 September 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000507313003083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Kaidonis X; Niu W; Chan AY; Kesteven S; Wu J; Iismaa SE; Feneley M; Graham RM, 2019, 'Involvement of the Alpha 1A-Adrenergic Receptor in the Cardiac Adaptation to Physiological Stress', in CIRCULATION RESEARCH, LIPPINCOTT WILLIAMS & WILKINS, MA, Boston, Vol. 125, presented at 14th Annual American-Heart-Association's Basic Cardiovascular Sciences (BCVS) Scientific Sessions - Integrative Approaches to Complex Cardiovascular Diseases, MA, Boston, 29 July 2019 - 01 August 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000511467800348&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Nicks AM; Li M; Wu J; Kesteven SH; Fenely MP; Smith NJ; Iismaa SE; Graham RM, 2014, 'A SURGICAL MODEL OF HYPERTENSION AND LEFT VENTRICULAR HYPERTROPHY IN MICE BY SUPRARENAL AORTIC CONSTRICTION', in HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, AUSTRALIA, Adelaide, Vol. 65, pp. E39 - E39, presented at 36th Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia (HBPRCA), AUSTRALIA, Adelaide, 26 November 2014 - 28 November 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352490400055&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints

Wu J; Nicks AM; Skowno JJ; Feneley MP; Iismaa SE; Graham RM, 2021, Anesthesia and Intubation of 10-Day Old C57BL/6J Mouse Pups for Cardiothoracic Surgery, http://dx.doi.org/10.21203/rs.3.rs-1144085/v1

Bogush N; Tan L; Naib H; Faizullabhoy E; Calvert JW; Iismaa SE; Gupta A; Ramchandran R; Martin DIK; Graham RM; Husain A; Naqvi N, DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling, http://dx.doi.org/10.21203/rs.3.rs-73803/v1

Murtha LA; Hardy SA; Mabotuwana NS; Bigland MJ; Bailey T; Raguram K; Liu S; Ngo DT; Sverdlov AL; Tomin T; Birner-Gruenberger R; Hume RD; Iismaa SE; Humphreys DT; Patrick R; Chong JJH; Lee RJ; Harvey RP; Graham RM; Rainer PP; Boyle AJ, Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction, http://dx.doi.org/10.21203/rs.3.rs-3055737/v1

Adlam D; Berrandou T-E; Georges A; Nelson CP; Giannoulatou E; Henry J; Ma L; Blencowe M; Turley TN; Yang M-L; Braund PS; Sadeg-Sayoud I; Iismaa SE; Kosel ML; Zhou X; Hamby SE; Cheng J; Liu L; Tarr I; Muller DWM; d’Escamard V; King A; Brunham LR; Baranowska-Clarke AA; Debette S; Amouyel P; Olin JW; Patil S; Hesselson SE; Junday K; Kanoni S; Aragam K; Butterworth AS; CARDIoGRAMPlusC4D ; MEGASTROKE ; group ISGCIAW; Tweet MS; Gulati R; Combaret N; investigators DR; Kadian-Dodov D; Kalman J; Fatkin D; Saw J; Webb TR; Hayes SN; Yang X; Ganesh SK; Olson TM; Kovacic JC; Graham RM; Samani NJ; Bouatia-Naji N, Genome-wide association meta-analysis of spontaneous coronary artery dissection reveals common variants and genes related to artery integrity and tissue-mediated coagulation, http://dx.doi.org/10.1101/2022.07.05.22277238

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